Abstract：
:Despite that burnout presents a serious burden for modern society, there are no diagnostic criteria. Additional difficulty is the differential diagnosis with depression. Consequently, there is a need to dispose of a burnout biomarker. Epigenetic studies suggest that DNA methylation is a possible mediator linking individual response to stress and psychopathology and could be considered as a potential biomarker of stress-related mental disorders. Thus, the aim of this review is to provide an overview of DNA methylation mechanisms in stress, burnout and depression. In addition to state-of-the-art overview, the goal of this review is to provide a scientific base for burnout biomarker research. We performed a systematic literature search and identified 25 pertinent articles. Among these, 15 focused on depression, 7 on chronic stress and only 3 on work stress/burnout. Three epigenome-wide studies were identified and the majority of studies used the candidate-gene approach, assessing 12 different genes. The glucocorticoid receptor gene (NR3C1) displayed different methylation patterns in chronic stress and depression. The serotonin transporter gene (SLC6A4) methylation was similarly affected in stress, depression and burnout. Work-related stress and depressive symptoms were associated with different methylation patterns of the brain derived neurotrophic factor gene (BDNF) in the same human sample. The tyrosine hydroxylase (TH) methylation was correlated with work stress in a single study. Additional, thoroughly designed longitudinal studies are necessary for revealing the cause-effect relationship of work stress, epigenetics and burnout, including its overlap with depression.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Bakusic J,Schaufeli W,Claes S,Godderis Ldoi
10.1016/j.jpsychores.2016.11.005subject
Has Abstractpub_date
2017-01-01 00:00:00pages
34-44eissn
0022-3999issn
1879-1360pii
S0022-3999(16)30494-9journal_volume
92pub_type
杂志文章,评审abstract：OBJECTIVE:This review aimed to examine evidence for the role of hormonal changes in the onset and course of depressive symptomatology and to assess the possible future role of hormonal therapies in the treatment of depression. METHODS:A Medline and PsycINFO search of the literature published between 1965 and 2006 was ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychores.2006.12.019
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:Fibromyalgia (FM) is a chronic musculoskeletal pain disorder characterized by widespread pain. This study focuses on patients' attributions of illness and of symptom onset. METHODS:Semi-structured interviews were conducted with 56 women to elicit patients' views on what triggered their FM. The transcripts of...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.12.014
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:The objectives were to give an overview of studies on the validity of the Toronto Alexithymia Scale (TAS-20) and to present data regarding the validity of the TAS-20. METHODS:The literature on the psychometric properties of the TAS-20 was reviewed and a study was conducted of its psychometric properties in a...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/s0022-3999(02)00348-3
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:High levels of dietary sugar consumption may result in dysregulated glucose metabolism and lead to elevated cardiovascular disease risk via autonomic nervous system and cardiovascular dysfunction. Altered cardiovascular function can be examined using perturbation tasks such as mental challenge. This study ex...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.10.008
更新日期：2013-02-01 00:00:00
abstract：OBJECTIVE:Multiple sclerosis (MS) is associated with various psychological problems, including depression and anxiety. Whilst MS support groups are intended to improve mental health, this goal is not always achieved. Taking a social identity approach, we hypothesise that it is the level of subjective identification wit...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2013.02.002
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To test the hypothesis that elderly persons who feel ikigai (a sense of life worth living) have a lower risk of incident functional disability than those who do not. Recent studies have suggested that ikigai impacts on mortality. However, its impact upon disability is unknown. The aim of the present study was...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2017.02.013
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:Electrical injuries can produce physical, neurological, and neuropsychological sequelae that exist even in the total absence of a theoretical current path that includes the brain. Diffuse electrical injury (DEI) is a rarely occurring class of electrical injury (EI) that can occur even after low-voltage contac...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2004.06.001
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:Disordered eating behavior in young adults with type 1 diabetes is overrepresented and associated with significant negative health consequences. Thus, determining the key correlates of these behaviors is essential. The aim of the present study was to determine the association between executive function and d...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2018.05.001
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVES:This study aimed to describe the psychological functioning of interstitial cystitis/bladder pain syndrome patients utilizing MMPI-2-RF scoring. METHODS:The MMPI-2 was administered to 60 individuals who reported a diagnosis of IC. Responses were scored in the MMPI-2-RF format. Fifty-one protocols were deemed...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.09.010
更新日期：2014-11-01 00:00:00
abstract：:Thirty-six subjects affected with hypersomnia associated with mood disorders, 31 with a diagnosis of dysthymia, 4 with a diagnosis of bipolar disorder and one with a diagnosis of major recurrent depression underwent standardized polysomnographic procedures including night 1, MSLT and night 2 (uninterrupted). 36.1% of ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(94)90134-1
更新日期：1994-01-01 00:00:00
abstract：:Seventy-five patients with recent-onset dyspepsia and endoscopically visible duodenal ulcer underwent psychological evaluation. Following ranitidine treatment, they were reinterviewed periodically for 12 to 76 months (mean 38.6). Ulcer symptoms were present during a mean of 14.9% of follow-up months. Patients did sign...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(96)00196-1
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVE:Maternal prenatal symptoms of depression and anxiety have been associated with altered neurodevelopmental outcomes in the child. These effects may be mediated in part by altered placental function, with increased fetal 5-hydroxytryptamine (5-HT) exposure being one possible mechanism. The current study aimed t...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2013.07.002
更新日期：2013-10-01 00:00:00
abstract：:We report a case of delusional pregnancy with polydipsia in a female patient with paranoid schizophrenia. The contribution of psychological and physiological factors in the development of the delusion of pregnancy and polydipsia and the possible interactions between the two phenomena are discussed. ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(96)00372-8
更新日期：1997-05-01 00:00:00
abstract：:Recent theoretical approaches to the etiology of eating disorders and body image disturbances have begun to focus on multifactorial models. In the current study, the Tripartite Influence model was examined in a large sample of college females (ages 18-22). This model proposes that three primary core sources of influen...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(02)00499-3
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVES:To compare the frequency of anxiety/depressive symptoms and use of anxiolytic-hypnotics/antidepressants in smokers with and without COPD and to identify characteristics associated with having unmedicated symptoms. METHODS:Cross-sectional analysis of ambulatory, current/former smokers ≥10 pack years enrolled...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.01.002
更新日期：2019-03-01 00:00:00
abstract：:Several studies have reported raised levels of psychopathology based on self-rating scales in patients with spasmodic torticollis. Recent publications have also proposed that psychopathology, especially symptoms of depression, might be a reaction to dystonia or constitute a nonspecific reaction pattern. To determine t...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00229-8
更新日期：1998-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to determine the basic psychometric properties, reliability, and validity of the Kidney Disease Quality of Life-Short Form (KDQOL-SF) questionnaire in kidney transplant patients. METHODS:The reliability and validity of the instrument were determined in 418 kidney transplant patients...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2005.09.009
更新日期：2006-05-01 00:00:00
abstract：:To determine whether women seeking treatment for symptomatic premenstrual change have ongoing psychological disturbance, we undertook a cross-sectional, comparative study across four groups of reproductive-age women. Subjects were 35 patients with symptomatic premenstrual change and no psychiatric history, 35 women wi...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(94)00139-v
更新日期：1995-04-01 00:00:00
abstract：OBJECTIVE:The question addressed here is: Can a discrete sleep disordered breathing (SDB) play a role in the insomnia complaint of postmenopausal chronic insomniacs? To respond to the query, two groups of individuals derived from a cohort of postmenopausal chronic insomniacs recruited mostly from the community were enl...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0022-3999(02)00463-4
更新日期：2002-07-01 00:00:00
abstract：:Significant advances in this past decade have improved our understanding of erectile physiology. A variety of tests are available for diagnosing impotence. SRE testing provides objective physiological information that is useful for indexing erectile capability and formulating a rational treatment plan. As such, SRE te...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/s0022-3999(97)00014-7
更新日期：1997-06-01 00:00:00
abstract：:To develop a model of how stress and other psychosocial constructs may interact to explain recurrences of genital herpes, assessments of major and minor life stress, locus of control, arousal or stimulation seeking, and social support were given to 153 university students (33% male; 67% female) who were seropositive f...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(91)90004-8
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:To examine the associations between a wide range of mental disorders and subsequent onset of stroke. Lifecourse timing of stroke was examined using retrospectively reconstructed data from cross-sectional surveys. METHODS:Data from the World Mental Health Surveys were accessed. This data was collected from g...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2015.05.008
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:There is a concern about negative cognitive effects of systemic chemotherapy. We prospectively explored self-reported cognitive problems in testicular cancer patients (TCPs) treated with and without chemotherapy. METHODS:One hundred and twenty-two TCPs were interviewed about concentration and memory problems...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2010.12.004
更新日期：2011-05-01 00:00:00
abstract：:Recent concerns in occupational health have shown a shift in emphasis from the study of diseases with well-established pathology toward the investigation of conditions characterized by a range of nonspecific symptoms. Exposure to potential hazards differing widely in terms of their physical nature or chemical composit...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00085-8
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVES:To evaluate coping styles and quality of life in youth with Type 1 diabetes with and without eating disorders and to identify relationships between these variables in each group. METHODS:Adolescents were evaluated for eating disorders with a two-stage diagnostic procedure. Adolescents with and without eatin...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2005.02.010
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVE:Disturbances in sleep continuity are common among individuals with major depressive disorder (MDD) and can impact the course of depression and response to treatment. Several studies have examined depressive symptom severity among sleep-disordered patients with obstructive sleep apnea (OSA). In contrast, littl...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jpsychores.2009.03.011
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To explore the effect of perceived stress and coping behaviors on quality of life and clinical outcomes in patients with ulcerative colitis. METHODS:This is a prospective cohort study in a tertiary inflammatory bowel disease center in China. A total of 263 ulcerative colitis patients were enrolled consecutiv...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2018.07.013
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:Individuals with medical conditions are likely to have elevated health anxiety; however, research has not demonstrated how medical status impacts response patterns on health anxiety measures. Measurement bias can undermine the validity of a questionnaire by overestimating or underestimating scores in groups o...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.12.014
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:Cannabis is a widely used substance that may be becoming more socially accepted, legally tolerated, and utilized by younger individuals. This review explores the relationship between cannabis and the onset of psychosis as well as the policy ramifications of current research. METHOD:This article synthesizes p...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychores.2010.04.002
更新日期：2010-12-01 00:00:00
abstract：:This study aimed to provide a detailed analysis of the experience of food craving in a healthy, non-clinical group of women. Twenty-five women who reported food cravings prospectively recorded their experiences over a period of 5 weeks using a Food Craving Record. The average number of cravings recorded was just under...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(94)90068-x
更新日期：1994-11-01 00:00:00
