Abstract:
OBJECTIVE:To assess undiagnosed and comorbid disorders in patients referred to a tertiary care center with a presumed diagnosis of chronic fatigue syndrome (CFS). METHODS:Patients referred for chronic unexplained fatigue entered an integrated diagnostic pathway, including internal medicine assessment, psychodiagnostic screening, physiotherapeutic assessment and polysomnography+multiple sleep latency testing. Final diagnosis resulted from a multidisciplinary team discussion. Fukuda criteria were used for the diagnosis of CFS, DSM-IV-TR criteria for psychiatric disorders, ICSD-2 criteria for sleep disorders. RESULTS:Out of 377 patients referred, 279 (74.0%) were included in the study [84.9% female; mean age 38.8years (SD 10.3)]. A diagnosis of unequivocal CFS was made in 23.3%. In 21.1%, CFS was associated with a sleep disorder and/or psychiatric disorder, not invalidating the diagnosis of CFS. A predominant sleep disorder was found in 9.7%, 19.0% had a psychiatric disorder and 20.8% a combination of both. Only 2.2% was diagnosed with a classical internal disease. In the total sample, a sleep disorder was found in 49.8%, especially obstructive sleep apnea syndrome, followed by psychophysiologic insomnia and periodic limb movement disorder. A psychiatric disorder was diagnosed in 45.2%; mostly mood and anxiety disorder. CONCLUSIONS:A multidisciplinary approach to presumed CFS yields unequivocal CFS in only a minority of patients, and reveals a broad spectrum of exclusionary or comorbid conditions within the domains of sleep medicine and psychiatry. These findings favor a systematic diagnostic approach to CFS, suitable to identify a wide range of diagnostic categories that may be subject to dedicated care.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Mariman A,Delesie L,Tobback E,Hanoulle I,Sermijn E,Vermeir P,Pevernagie D,Vogelaers Ddoi
10.1016/j.jpsychores.2013.07.010subject
Has Abstractpub_date
2013-11-01 00:00:00pages
491-6issue
5eissn
0022-3999issn
1879-1360pii
S0022-3999(13)00276-6journal_volume
75pub_type
杂志文章abstract::Thirty-seven patients hospitalized for cardiac disorders were classified by cluster analysis in four groups based on their patterns of perception of health during the first year of recovery. Striking differences were found in the four patterns obtained. The groups were compared for variables of demographic background,...
journal_title:Journal of psychosomatic research
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journal_title:Journal of psychosomatic research
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更新日期:2011-04-01 00:00:00
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更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jpsychores.2004.08.004
更新日期:2005-02-01 00:00:00
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