Abstract：
OBJECTIVE:An interaction between the endothelin-1 gene (EDN1), blood pressure (BP) and social determinants has been previously found. Using a well-characterized cohort of participants, the impact of associations between genetic factors and job strain on BP was evaluated. METHODS:A cross-sectional analysis of five polymorphisms covering the EDN1, of which 2 were previously reported to be associated with BP, was performed. Study subjects had previously completed a baseline evaluation including 24-h ambulatory BP monitoring and an assessment of job strain. This report presents the findings for 184 subjects who gave DNA samples for genetic analysis. One-way analysis of variance (ANOVA) was performed between each genetic marker and 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP), as well as two-way ANOVAs to test the interaction effect with job strain. RESULTS:Trends for relationships were observed between SBP and two polymorphisms: rs10478694 and rs5369. An interaction between job strain and those heterozygous for two polymorphisms showed higher SBP (P=.029 and .008) and a tendency for higher DBP. All findings were more significant when analyses were confined to the 139 Caucasian subjects. CONCLUSION:This is the first study to report an interaction between the EDN1 gene, job strain and BP, supporting previous evidence of a role of this gene in the interaction between environmental stress and ambulatory BP. Given the limited sample size, the results should be considered preliminary, and further studies are required.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Tobe SW,Baker B,Hunter K,Kiss A,Perkins N,Gomez L,Feng Y,Wigg K,Barr CLdoi
10.1016/j.jpsychores.2011.01.003subject
Has Abstractpub_date
2011-08-01 00:00:00pages
97-101issue
2eissn
0022-3999issn
1879-1360pii
S0022-3999(11)00004-3journal_volume
71pub_type
杂志文章abstract：OBJECTIVE:The purpose of this study is to examine whether mental vulnerability is a risk factor for the development of ischemic heart disease (IHD) after adjustment for well-established risk factors. METHODS:In three prospective cohort studies in Copenhagen County, Denmark, we recorded the level of mental vulnerabilit...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2005.05.013
更新日期：2006-02-01 00:00:00
abstract：:In a preliminary study using only self-report measures, university students completed questionnaires about their bowel symptoms and trait anxiety. Results showed that students with irritable bowel syndrome (IBS) reported higher trait anxiety than asymptomatic controls. Among the students with IBS, there were no signif...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00141-4
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE AND METHODS:The relationship between psychological distress measured by the General Health Questionnaire 30 (GHQ-30) and risk factors for coronary heart disease, angina, electrocardiogram (ECG) abnormalities and chronic sputum was modelled using logistic regression on baseline data from a community study of 1...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(02)00352-5
更新日期：2002-12-01 00:00:00
abstract：:This study investigates the function of the hypothalamic-pituitary-adrenal (HPA)-axis and the availability of L-tryptophan and tyrosine to the brain in postpartum women and in women taking long-term oral contraceptives. To this end, we have measured the following parameters in 50 women (i.e. 9 normal controls, 10 wome...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(92)90028-z
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:This semiprospective case-control study was performed to investigate the relationship between harmony-seeking personality and the occurrence of prostate cancer. METHODS:Out of 217 consecutive participants admitted to hospital for biopsy, 86 and 81 were classified into the case and control groups, respectivel...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2005.04.006
更新日期：2005-09-01 00:00:00
abstract：:Chronic fatigue syndrome (CFS) is a poorly understood condition. Possible etiological factors include infectious agents, psychiatric disorders, and personality characteristics. We examined personality dimensions in 30 nondepressed patients with CFS, 20 patients with major depressive disorder (MDD), and 15 healthy cont...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章
doi：10.1016/s0022-3999(98)00120-2
更新日期：1999-04-01 00:00:00
abstract：:The association between mood state and treatment outcome after In Vitro Fertilization/Embryo Transfer (IVF/ET) was assessed in a prospective sample of 330 women, of whom 113 were first time participants (inductees) and 217 were repeat cycle women (veterans). Initial evaluation of mood state indicated a significantly h...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(93)90004-y
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Untreated depression during pregnancy may have adverse outcomes for the mother and her child. Screening for depression in the general pregnant population is thus recommended. The Edinburgh Depression Scale (EDS) is widely used for postpartum depression screening. There is no consensus on which EDS cutoff val...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2010.07.008
更新日期：2011-04-01 00:00:00
abstract：:This cross-sectional study reveals that a significant proportion (35%) of the sampled population of factory workers experienced measurable health problems in the form of anxiety, sleep disturbance, depression, somatic complaints and other clinical indicators of stress. Job stress and social support levels experienced ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(91)90071-u
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVE:Screening for depression and anxiety in people with cystic fibrosis (CF) is recommended but this alone can miss the opportunity to assess and promote positive mental health and wellbeing. This cross-sectional study assessed positive mental health and wellbeing, and associations with physical health and health...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2018.11.016
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:There is a considerable body of research linking elements of Leventhal's Common Sense Model (CSM) to emotional well-being/distress outcomes among people with physical illness. The present study aims to consolidate this literature and examine the evidence for the role of coping strategies within this literatur...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychores.2015.10.006
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVES:To compare the frequency of anxiety/depressive symptoms and use of anxiolytic-hypnotics/antidepressants in smokers with and without COPD and to identify characteristics associated with having unmedicated symptoms. METHODS:Cross-sectional analysis of ambulatory, current/former smokers ≥10 pack years enrolled...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.01.002
更新日期：2019-03-01 00:00:00
abstract：:The relation of stress and family environment to symptom severity in children with atopic dermatitis (AD) was examined. Forty-four children with severe AD and their families completed questionnaires measuring life events, chronic everyday problems and family environment. Measures of symptom severity were collected dur...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(87)90016-x
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:Felt security in close relationships may affect individual adaptation responses to existential threat in severe illness. We examined the contribution of attachment security to demoralization, a state of existential distress involving perceived pointlessness and meaninglessness in advanced cancer. METHOD:A m...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2018.11.018
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:Little is known about whether illness perceptions affect health outcomes in primary care patients. The aim of this study was to examine if patients' illness perceptions were associated with their self-rated health in a 2-year follow-up period. METHODS:One thousand seven hundred eighty-five primary care patie...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2006.09.003
更新日期：2007-02-01 00:00:00
abstract：OBJECTIVE:Despite a lack of evidence, there is an assumption that patients with more complex psychiatric histories (CPH) prior to bariatric surgery have poor post-surgical weight loss and worsening psychiatric symptoms following surgery. Consequently, those with CPH are excluded from bariatric surgery in many bariatric...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2016.04.008
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:Phantom bite syndrome (PBS) is characterized by a persistent uncomfortable sensation of occlusion without an evident occlusal discrepancy. The aims of this retrospective cross-sectional study were to assess psychiatric comorbidities and evaluate psychopharmacological outcomes of PBS. METHODS:The database of ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.11.010
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVE:Twenty-five years ago, this journal published two articles reporting the development and initial validation of the 20-Item Toronto Alexithymia Scale (TAS-20). Since then the literature on alexithymia has burgeoned with the vast majority of this research using the TAS-20, including multiple language translatio...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,评审
doi：10.1016/j.jpsychores.2020.109940
更新日期：2020-01-23 00:00:00
abstract：OBJECTIVE:To compare resilience in women with SLE and healthy women and determine whether sociodemographic factors and depressive symptoms were associated with resilience in patients with SLE. METHODS:This was a cross-sectional study. Participants were 123 women with SLE according to the ACR criteria and 132 age-match...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.05.002
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:Hostility has been established as a risk factor for the development of coronary artery disease. Putatively pathogenic hemodynamic and neuroendocrine responses to psychological stressors are associated with hostility, but the cerebral effects of hostility and their relationship to these responses are unknown. ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(00)00100-8
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:Adherence to immunosuppressants (IS) is crucial to prevent allograft rejection. Even though there is evidence that non-adherence to IS among kidney transplant recipients is common, it is rarely routinely assessed in clinical practice. Especially, little is known about how physicians estimate patients' adheren...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2015.09.001
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVES:The objectives of this study were to investigate longitudinal predictors of fear of recurrence in survivors of head and neck cancer (HNC) using Leventhal's Common Sense Model (CSM) as a framework. The research questions were as follows: (a) to what extent do HNC patients report fear of cancer recurrence? (b)...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2008.03.014
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to examine the effectiveness of mindfulness-based stress reduction (MBSR) on depression, anxiety and psychological distress across populations with different chronic somatic diseases. METHODS:A systematic review and meta-analysis were performed to examine the effects of MBSR ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jpsychores.2009.10.005
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:Asylum seekers who have experienced persecution, war and torture show high prevalence rates of stress-related mental disorders. After arrival in the host country, the early stages of resettlement seem to be a particularly vulnerable phase characterized by social instability. This longitudinal study aimed to e...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2020.109977
更新日期：2020-05-01 00:00:00
abstract：:This study investigated whether the level of somatic complaint increases as men make the supposedly stressful passage from work to retirement. For 171 retirees, pre- to post-retirement changes in the sum of selected somatic complaints from the Cornell Medical Index were compared with changes over a comparable time int...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(83)90110-1
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:Living with food allergy is a unique and potentially life-threatening stressor that requires constant vigilance to food-related stimuli, but little is known about whether adolescents with food allergies are at increased risk for psychopathology-concurrently and over time. METHODS:Data came from the prospecti...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:Modern health worries (MHW) are concerns about health risks from features of modern life (e.g. additives in food, contaminated water supply, drug resistant bacteria, etc.). We investigated the role of MHW for care seeking for all purposes at the general practitioner (GP) and studied the role of neuroticism, s...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.07.007
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:To determine the relative contribution of demographic variables, objective testing and psychological factors in explaining the variance in dizziness severity and handicap. METHODS:One-hundred and eighty-five consecutive patients on the waiting list to attend a diagnostic appointment in a tertiary neuro-otolo...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2020.109969
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:There is wide variability in latency to attend hospital following a myocardial infarction (MI). The present study assessed possible psychological factors that may be implicated in delayed presentation. METHOD:Seventy-two patients who had experienced a confirmed MI were interviewed in hospital, 3-5 days post-...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(01)00265-3
更新日期：2001-10-01 00:00:00
abstract：:A prospective 4-year follow-up study was conducted to compare the psychosocial adjustment process and survival rate of 59 stoma patients with 64 bowel-resected nonstoma patients. Adjustment was assessed at 4 months. 1 year, and 4 years after surgery by the Psychosocial Adjustment to Illness Scale, a self-report questi...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(96)00288-7
更新日期：1997-03-01 00:00:00
