Abstract:
:This study investigates the function of the hypothalamic-pituitary-adrenal (HPA)-axis and the availability of L-tryptophan and tyrosine to the brain in postpartum women and in women taking long-term oral contraceptives. To this end, we have measured the following parameters in 50 women (i.e. 9 normal controls, 10 women taking oral contraceptives, and 31 postpartum females): plasma cortisol, L-tryptophan, tyrosine and the amino acids (CAA) known to compete with them for transport through the blood-brain barrier. We have determined the effects of 1 mg of dexamethasone on the above-mentioned biological markers in postpartum females. Plasma cortisol and tyrosine were significantly higher and lower, respectively, in puerperium and in women under contraceptive therapy as opposed to normal controls. L-Tryptophan was significantly lower in postpartum females, whilst the L-tryptophan/CAA ratio did not differ across the three study groups. Postpartum females revealed a significant negative relationship between the availability of L-tryptophan to the brain and postpartum mood, as measured by Zung's Depression and Anxiety Scales and State Anxiety Inventory. Dexamethasone had a significant suppressive effect on L-tryptophan/CAA and tyrosine/CAA ratios, with cortisol nonsuppression appearing in 82% of the postpartum females. :The possible role of amino acid availability and a functional hypothalamic-pituitary-adrenal axis in the mood disturbances often reported in postpartum women and in users of the oral contraceptive was examined by measuring amino acids and doing a dexamethasone suppression test. Plasma cortisol, tryptophan, tyrosine, their competing amino acids in brain uptake (CAA), and the effect of 1mg dexamethasone were determined in 10 women taking oral contraceptives, 31 women 3 days postpartum, and 9 controls. The pill contained 30 mcg ethinyl estradiol and .075 mg gestodene (2 women), and 30 mg ethinyl estradiol and .15 mg desogestrel (8 women). The subject also took self-rating mood scales: Zung Depression, Zung Anxiety, Beck Depression and State Anxiety Inventory. Cortisol was significantly higher in postpartum women and pill users than in normal controls. Tryptophan, valine, isoleucine and leucine were lower in postpartum women. Tyrosine and tyrosine CAA were lower in postpartum women and pill users. 80% of the postpartum group had negative dexamethasone suppression tests, i.e., cortisol 5 mcg/dl 24 hours after 1 mg dexamethasone. After dexamethasone valine was significantly higher and tryptophan/CAA and tyrosine/CAA ratios were lower, as a result of slightly lower tryptophan and tyrosine and slightly higher CAAs. Furthermore, effects on the amino acid ratios were only evident in women exhibiting dexamethasone suppression. There was a significant negative correlation between depression and anxiety scores and the tryptophan/CAA ratio. The results indicated first that the dexamethasone suppression test is an invalid marker for major depression, and also that availability of the amino acid precursors of brain neurotransmitters may affect mood in the puerperium.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Maes M,Claes M,Schotte C,Delbeke L,Jacquemyn Y,Verkerk R,De Meester I,Scharpé Sdoi
10.1016/0022-3999(92)90028-zsubject
Has Abstractpub_date
1992-02-01 00:00:00pages
191-7issue
2eissn
0022-3999issn
1879-1360pii
0022-3999(92)90028-Zjournal_volume
36pub_type
杂志文章abstract:BACKGROUND:Stroke can negatively impact the health-related quality of life (HRQoL). Anxiety or depression after stroke have been associated with poorer HRQoL, higher mortality and greater dependence in activities of daily living. We aimed to analyze HRQoL, anxiety and depressive symptoms in patients with and without at...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2020.110353
更新日期:2021-01-02 00:00:00
abstract:OBJECTIVE:Little is known about whether illness perceptions affect health outcomes in primary care patients. The aim of this study was to examine if patients' illness perceptions were associated with their self-rated health in a 2-year follow-up period. METHODS:One thousand seven hundred eighty-five primary care patie...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2006.09.003
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to examine the behavioral and psychological responses of pregnant women during the 2003 severe acute respiratory syndrome (SARS) outbreak in Hong Kong. METHODS:Ethnographic interviews were first conducted to identify the common psychological and behavioral responses to the ou...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2006.08.005
更新日期:2006-11-01 00:00:00
abstract::The effect of exercise training on quality of life and exercise capacity was studied in 67 patients with mild to moderate chronic heart failure (CHF; age: 65.6+/-8.3 years; left ventricular ejection fraction: 26.5+/-9.6%). Patients were randomly allocated to either a training group or to a control group. After interve...
journal_title:Journal of psychosomatic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0022-3999(97)00309-7
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVES:Chronic fatigue syndrome (CFS) is a controversial illness, with apparent disagreements between medical authorities and patient support organisations regarding safe and effective treatments. The aim of this study was to measure the extent of different views regarding treatments, comparing patient support orga...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2016.07.008
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:This article addresses three reliability issues that are problematic in the construction of scales intended for use in psychosomatic research, illustrates how these problems may lead to errors, and suggests solutions. METHODS:We used psychometric results and present five computational studies. The first, thi...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章,评审
doi:10.1016/j.jpsychores.2010.11.002
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:We examined distinctiveness of different aspects of body-image disturbance in persons categorized with eating/weight disorders. We compared dissatisfaction with weight/shape, overvaluation of weight/shape, preoccupation with weight/shape, and fear of weight gain - in three study groups of persons categorized ...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2019.109757
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Improvement of nausea by placebo interventions has recently been demonstrated in clinical trials and experimental settings. However, many questions regarding placebo effects on nausea remain unanswered. For example, nausea reduction in women could only be achieved when the placebo intervention was "enhanced" ...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jpsychores.2016.09.012
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:Recent evidence shows that bipolar disorder might be associated with a purinergic system dysfunction. This study aimed at (i) testing the association between bipolar disorder and uric acid serum levels, and (ii) clarifying whether this relationship is mediated by metabolic syndrome and other relevant metaboli...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2016.03.014
更新日期:2016-05-01 00:00:00
abstract::This report describes the construction of a questionnaire to measure three dimensions of human eating behavior. The first step was a collation of items from two existing questionnaires that measure the related concepts of 'restrained eating' and 'latent obesity', to which were added items newly written to elucidate th...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(85)90010-8
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To test age- and sex-specific associations between adverse life events and functional bodily symptoms (FBS) in the general population. METHODS:In a population-based cohort, 964 participants (mean age 55 years SD 11, 48% male) completed two measurements waves of the present study. Lifetime exposure to 12 adve...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2015.05.013
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:The research findings regarding the role of psychiatric illness in breast cancer are not yet clear. This report investigates the differences between patients with invasive breast carcinoma (IBC) and patients with benign breast disease regarding the psychiatric history and the current prebiopsy psychopathology...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/S0022-3999(03)00070-9
更新日期:2004-01-01 00:00:00
abstract::This study was designed to evaluate the efficacy of a brief, structured pain management program to improve control over chest pain episodes in patients diagnosed with coronary artery disease. Twenty-six male veterans who attended the three-session program were compared with twenty-six matched controls. Results indicat...
journal_title:Journal of psychosomatic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0022-3999(94)90102-3
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Chronic fatigue syndrome (CFS) is associated with a high use of health care services. To reduce the related costs for patients and society, it will be useful to know which factors determine CFS patients' amount of health care use. Little is known, however, about these factors. METHOD:The present study retro...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2008.03.015
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To investigate the role of stressful events, social support, attachment security and alexithymia in triggering or exacerbating psoriasis. METHODS:Outpatients experiencing a recent onset or exacerbation of psoriasis (n=40) were compared with outpatients with skin conditions in which psychosomatic factors are ...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(02)00574-3
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine whether or not conversion symptoms are lateralized. Studies have shown a predominant left-oriented manifestation of symptoms for most somatoform disorders. The reports in the literature on the lateralization of conversion symptoms, however, are rather conflicting. Th...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(00)00075-1
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:Rheumatoid arthritis (RA) has been associated with a variety of emotional stressors, but findings remain inconclusive if RA is related to childhood trauma, which is known to have long-lasting negative consequences for physical health decades into adulthood. We investigated the association between childhood tr...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2012.10.007
更新日期:2013-04-01 00:00:00
abstract::Forty-eight subjects classified as either Type A (coronary-prone) or Type B (coronary-resistant) exchanged points worth money with a computer-simulated opponent while an electrocardiogram was computer-monitored and scored. Type A's were more aggressive during the socioeconomic exchanges than were Type B's. The more ag...
journal_title:Journal of psychosomatic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0022-3999(83)90109-5
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:There is a considerable body of research linking elements of Leventhal's Common Sense Model (CSM) to emotional well-being/distress outcomes among people with physical illness. The present study aims to consolidate this literature and examine the evidence for the role of coping strategies within this literatur...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jpsychores.2015.10.006
更新日期:2015-12-01 00:00:00
abstract::Thirty eight children and adolescents between the ages of 10 and 17 years were examined for an association between diabetic control and psychological health determined by questionnaires to examine self concept, locus of control and family cohesion and adaptability. The group as a whole had a high score on the self est...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(87)90057-2
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to examine whether mental vulnerability is a risk factor for the development of ischemic heart disease (IHD) after adjustment for well-established risk factors. METHODS:In three prospective cohort studies in Copenhagen County, Denmark, we recorded the level of mental vulnerabilit...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2005.05.013
更新日期:2006-02-01 00:00:00
abstract::Nature and frequency of somatic complaints, severity of anxiety and depression, and nature of psychiatric symptoms and disorders were evaluated in 81 adequately treated cancer patients, disease-free or with residual disease, using a controlled, prospective follow-up design. Patients were included in the index group (n...
journal_title:Journal of psychosomatic research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0022-3999(98)00013-0
更新日期:1998-09-01 00:00:00
abstract::Sixty-seven patients suffering from spasmodic torticollis, a neurological disorder in which involuntary contractions of the head produce an abnormal head posture, completed a booklet of questionnaires aiming to assess psychosocial adjustment. Twenty-four per cent of the patients were moderately to severely depressed. ...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(91)90044-o
更新日期:1991-01-01 00:00:00
abstract::This article reviews the evidence regarding the efficacy of nonpharmacological interventions for the treatment of late-life insomnia. Outcome data from more than a dozen treatment studies conducted with community-dwelling older adults indicate that behavioral approaches produce reliable and durable therapeutic benefit...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章,评审
doi:10.1016/s0022-3999(98)00077-4
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVES:In patients treated with percutaneous coronary intervention (PCI) in the drug-eluting stent era, we compared women's and men's health status 6 and 12 months post-PCI and investigated whether predictors of poor health status at 12 months are similar for women and men. METHODS:Consecutive patients (n=692; 28%...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2006.01.003
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Untreated depression during pregnancy may have adverse outcomes for the mother and her child. Screening for depression in the general pregnant population is thus recommended. The Edinburgh Depression Scale (EDS) is widely used for postpartum depression screening. There is no consensus on which EDS cutoff val...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/j.jpsychores.2010.07.008
更新日期:2011-04-01 00:00:00
abstract::Generalized expectancies about control are examined as a possible independent risk factor for coronary artery disease in a sample of subjects undergoing coronary angiography. This characteristic is also examined as a possible underlying component of the Type A behavior pattern which may contribute to the latter's asso...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(91)90116-6
更新日期:1991-01-01 00:00:00
abstract::Chronic pain may be non-organic and also may be non-psychogenic as well. This report pertains to the socio-demographic, clinical, psychometric description and follow-up of 21 such cases. Though these are not different from psychogenic pain disorder as regards clinical presentation, idiopathic pain is more often observ...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/0022-3999(86)90050-4
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:This study examines sociocultural influences affecting both body image and body change methods in adolescent boys. METHODS:Twenty boys in grade 7 (aged 12-13) and twenty boys in grade 9 (aged 14-15) were individually interviewed. The influence of parents, siblings, friends and the media on both body image an...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(00)00159-8
更新日期:2000-09-01 00:00:00
abstract::This study investigated differences between overweight binge eating women who reported the onset of binge eating prior to or following the onset of dieting (binged first [BF], or dieted first [DF]). Of overweight binge eating subjects enrolled in a treatment study, 38.7% indicated binge eating first, and 48.1% dieting...
journal_title:Journal of psychosomatic research
pub_type: 杂志文章
doi:10.1016/s0022-3999(97)00261-4
更新日期:1998-03-01 00:00:00