Abstract：
OBJECTIVE:Recent evidence shows that bipolar disorder might be associated with a purinergic system dysfunction. This study aimed at (i) testing the association between bipolar disorder and uric acid serum levels, and (ii) clarifying whether this relationship is mediated by metabolic syndrome and other relevant metabolic parameters. METHODS:Patients consecutively admitted to a Mental Health Inpatient Unit, with a diagnosis of bipolar disorder or other severe mental disorders, and an appropriate healthy control sample, were included in this cross-sectional, exploratory study. We performed linear regression analyses, to explore factors associated with uric acid levels, and formal tests of mediation to assess mediating effect of candidate variables. RESULTS:176 individuals with mental disorders and 89 healthy controls met inclusion criteria. Bipolar disorder was the only diagnostic subgroup significantly associated with increased uric acid levels. Furthermore, male gender, metabolic syndrome, as well as abdominal circumference and triglycerides levels, had a significant effect on uric acid. Relevant mediation analyses showed that the estimated effect between bipolar disorder and uric acid levels was only partially mediated by metabolic abnormalities. CONCLUSION:This study suggests a direct association between bipolar disorder and uric acid levels, only partially mediated by metabolic abnormalities. It seems consistent with results of previous studies highlighting a purinergic dysfunction in bipolar disorder and the role that purinergic modulators, lowering uric acid levels, could have in clinical practice.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Bartoli F,Crocamo C,Gennaro GM,Castagna G,Trotta G,Clerici M,Carrà Gdoi
10.1016/j.jpsychores.2016.03.014subject
Has Abstractpub_date
2016-05-01 00:00:00pages
56-59eissn
0022-3999issn
1879-1360pii
S0022-3999(16)30066-6journal_volume
84pub_type
杂志文章abstract：OBJECTIVE:The goal of this investigation was to determine in healthy adults the effect of expectation manipulations on the development of motion sickness, as indicated by abnormal gastric myoelectric activity and subjective reports of symptoms of motion sickness. METHOD:Eighty participants, moderately susceptible to m...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/S0022-3999(03)00130-2
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Little is known about how patients rate their health perceptions. Our objectives were to identify systematic multivariate patterns of perceptions using cluster analysis, and to investigate associations among the clusters, psychosocial characteristics and medication nonadherence. METHODS:Demographic, clinica...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/S0022-3999(03)00508-7
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVES:Liaison Psychiatric Services for Older Adults in the UK have been established over the last decade, with rather divergent team composition and involvement. The latest documents (National Dementia Strategy, Who Cares Wins) set the gold standard for liaison services for older adults in England, requiring a pro...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2011.11.018
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Social support facilitates a woman's transition to motherhood. This major developmental transition can be stressful as it includes adaptation of self as well as learning new infant care practice skills. Although a number of instruments have been developed to measure social support, none have been developed o...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.109813
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to examine the relationship between alexithymia and perinatal depressive symptoms and the stability of the alexithymia construct in a sample of low-income, predominantly Latina women during pregnancy and the early postpartum period. METHODS:Seventy-seven pregnant women completed...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2006.09.012
更新日期：2007-02-01 00:00:00
abstract：:Blood pressure and heart rate responses were monitored while 30 medical, dental or graduate students completed four laboratory tasks. On a second day, subjects wore an ambulatory blood pressure monitor, and during this day they completed the real-world challenge of presenting their research in front of a small audienc...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(90)90033-z
更新日期：1990-01-01 00:00:00
abstract：:To date therefore, no consistent hormonal abnormality has been linked with premenstrual affective, physical or behavioural changes and, in turn, no consistent adverse behaviour has been positively linked with any particular menstrual cycle phase. At the same time, the proportion of actively menstruating women reported...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(85)90049-2
更新日期：1985-01-01 00:00:00
abstract：:A decreased sensitivity to painful stimuli and high scores for alexithymia and depression have been observed in patients with eating disorders. We investigated the relationship between these factors in 22 patients with anorexia nervosa, 18 patients with bulimia nervosa, and 32 healthy subjects. Alexithymia was assesse...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(96)00088-8
更新日期：1996-07-01 00:00:00
abstract：:In a retrospective comparison study of rates of postnatal depression using two self-rating instruments, a significantly higher incidence of postnatal depression was found among subjects who had undergone Caesarean section than in those who had a vaginal delivery. The excess of cases of postnatal depression among the C...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(94)90084-1
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:Adults with cystic fibrosis (CF) face unique challenges with regard to the attainment and maintenance of social support. Although social support has been shown to improve treatment outcomes in other patient-populations, research on social support in adults with CF is limited. In fact, no studies have examined...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.109858
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:Modern health worries (MHW) are concerns about health risks from features of modern life (e.g. additives in food, contaminated water supply, drug resistant bacteria, etc.). We investigated the role of MHW for care seeking for all purposes at the general practitioner (GP) and studied the role of neuroticism, s...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.07.007
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:Dispositional optimism has been associated with a lower risk of cardiovascular mortality, but the underlying mechanisms are still largely unknown. We therefore studied whether dispositional optimism was associated with healthy lifestyle and dietary habits. METHODS:In 773 (87.1%) of 887 Dutch elderly communit...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2007.07.014
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVES:Chronic fatigue syndrome (CFS) is a controversial illness, with apparent disagreements between medical authorities and patient support organisations regarding safe and effective treatments. The aim of this study was to measure the extent of different views regarding treatments, comparing patient support orga...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2016.07.008
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:Glandular fever is associated with an approximate fivefold increase in fatigue at 6 months. Reduced levels of fitness and illness beliefs may be important predictors of fatigue following glandular fever. We therefore developed a brief psycho-educational intervention aimed at improving recovery from infectiou...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0022-3999(03)00370-2
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:Modern health worries (MHWs) refer to perceived risk to personal health from technological changes and features of modern life, and is associated with health outcomes. The present objective was to test the hypotheses of (i) associations between MHWs and a global measure of typical somatization symptoms, refer...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2020.110163
更新日期：2020-08-01 00:00:00
abstract：:Stress reduction programs (SRPs) can reduce morbidity and mortality in patients with coronary artery disease (CAD). This study evaluated the effect of an SRP on metabolic and hormonal risk factors for CAD. Twenty army officers participating in an SRP, Group I, and a comparison group of seventeen SRP nonparticipants, G...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(93)90136-4
更新日期：1993-05-01 00:00:00
abstract：:The association between mood state and treatment outcome after In Vitro Fertilization/Embryo Transfer (IVF/ET) was assessed in a prospective sample of 330 women, of whom 113 were first time participants (inductees) and 217 were repeat cycle women (veterans). Initial evaluation of mood state indicated a significantly h...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(93)90004-y
更新日期：1993-07-01 00:00:00
abstract：:Endometriosis is a common gynecological condition associated with debilitaing pain and poor mental health. This review examines the evidence for psychological and mind-body (PMB) interventions to improve endometriosis pain, psychological distress, sleep and fatigue. Electronic databases searched included PsychINFO, ME...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.109756
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:Fear of progression (FoP) is a frequent symptom among cancer patients, but data among hematological cancer survivors are scarce. Furthermore, theory assumes that FoP serves as link between bodily symptoms and different aspects of quality of life. However, this model has not been tested with the bodily symptom...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2019.109844
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To report sex-specific associations between cigarette smoking and DSM-IV disorders, symptoms, and mental health services use related to depression and anxiety in a nationally representative sample of U.S. adolescents. METHODS:Data on two samples were drawn from the 1999-2004 National Health and Nutrition Exa...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.01.013
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:Some peer reviewers may inappropriately, or coercively request that authors include references to the reviewers' own work. The objective of this study was to evaluate whether, compared to reviews for a journal with single-blind peer review, reviews for a journal with open peer review included (1) fewer self-c...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2015.08.004
更新日期：2015-12-01 00:00:00
abstract：:Anxiety is commonly experienced by patients following myocardial infarction. The role of anxiety in the recovery/rehabilitation process is not well understood, but anxiety is thought to be one of the factors determining outcome. It is important, therefore, to understand the possible effects on anxiety of changing disc...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(89)90009-3
更新日期：1989-01-01 00:00:00
abstract：:Thirty eight children and adolescents between the ages of 10 and 17 years were examined for an association between diabetic control and psychological health determined by questionnaires to examine self concept, locus of control and family cohesion and adaptability. The group as a whole had a high score on the self est...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(87)90057-2
更新日期：1987-01-01 00:00:00
abstract：:This study investigated differences between overweight binge eating women who reported the onset of binge eating prior to or following the onset of dieting (binged first [BF], or dieted first [DF]). Of overweight binge eating subjects enrolled in a treatment study, 38.7% indicated binge eating first, and 48.1% dieting...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/s0022-3999(97)00261-4
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:Untreated depression during pregnancy may have adverse outcomes for the mother and her child. Screening for depression in the general pregnant population is thus recommended. The Edinburgh Depression Scale (EDS) is widely used for postpartum depression screening. There is no consensus on which EDS cutoff val...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2010.07.008
更新日期：2011-04-01 00:00:00
abstract：:The impact of a post myocardial infarction education programme was assessed by comparing the increase in knowledge of patients and spouses about CHD in two hospitals, one (A) with and the other (B) without such a programme. Subjects completed the same two questionnaires twice, once within 4 days of admission and again...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(88)90074-8
更新日期：1988-01-01 00:00:00
abstract：:Four patients who had suffered a myocardial infarction were given biofeedback training in order to assess (1) the possibility of increasing heart rate variability with the help of a feedback; (2) the possible cardiac consequences, from the clinical viewpoint, of biofeedback treatment. A biofeedback procedure alternate...
journal_title：Journal of psychosomatic research
pub_type： 临床试验,杂志文章
doi：10.1016/0022-3999(82)90086-1
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVE:With the increasing prevalence of multiple conditions in older age, the high prevalence of mental disorders, and the many social challenges facing elderly people, a high-risk patient group in need of interdisciplinary (biological, psychological, and social) care is emerging. The INTERMED interview is an integ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2010.09.003
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:Given the importance of fatigue in cancer, stroke and HIV, we sought to assess the measurement properties of a single, well-described fatigue scale in these populations. We hypothesized that the psychometric properties of the Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) subscale would ...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/j.jpsychores.2012.10.011
更新日期：2013-01-01 00:00:00
abstract：:Eating disorders in diabetes mellitus may be associated with serious diabetic complications. This study examines the prevalence of complications and the usefulness of the Eating Attitudes Test (EAT) in screening for eating disorders in a group of insulin-dependent diabetic women. Coping strategies for dealing with dia...
journal_title：Journal of psychosomatic research
pub_type： 杂志文章
doi：10.1016/0022-3999(95)00534-x
更新日期：1996-01-01 00:00:00
