Physiologic benefits of a stress reduction program for healthy middle-aged Army officers.

Abstract:

:Stress reduction programs (SRPs) can reduce morbidity and mortality in patients with coronary artery disease (CAD). This study evaluated the effect of an SRP on metabolic and hormonal risk factors for CAD. Twenty army officers participating in an SRP, Group I, and a comparison group of seventeen SRP nonparticipants, Group C, volunteered to undergo measurement of dehydroepiandrosterone-sulfate (DHEA-S), cortisol, DHEA-S/cortisol ratio, testosterone, apolipoprotein-A1, apolipoprotein-B, triglycerides, cholesterol, fibrinogen, and leukocyte count both before and after the SRP period. No differences in the changes in biochemical risk factors for CAD were found between participant and nonparticipant except for DHEA-S. While Group C had a marked reduction in DHEA-S levels, Group I had a small increase. Previous studies indicate DHEA-S is inversely associated with extent of CAD and age-adjusted DHEA-S levels below 3.78 mumol/l confer an increased risk for CAD mortality. SRP participation appears to effect DHEA-S levels, possibly partially accounting for the benefits observed in SRPs among CAD patients.

journal_name

J Psychosom Res

authors

Littman AB,Fava M,Halperin P,Lamon-Fava S,Drews FR,Oleshansky MA,Bielenda CC,MacLaughlin RA

doi

10.1016/0022-3999(93)90136-4

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

345-54

issue

4

eissn

0022-3999

issn

1879-1360

journal_volume

37

pub_type

杂志文章
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