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Effectiveness of a placebo intervention on visually induced nausea in women - A randomized controlled pilot study.

Abstract：

OBJECTIVE:Improvement of nausea by placebo interventions has recently been demonstrated in clinical trials and experimental settings. However, many questions regarding placebo effects on nausea remain unanswered. For example, nausea reduction in women could only be achieved when the placebo intervention was "enhanced" by conditioning, while men responded primarily to verbally suggested improvement. It is unclear whether these findings are generalizable or were due to situational variables. In this pilot study, we investigated the effects of sham acupuncture point stimulation and verbal suggestions on visually-induced nausea in a female population. METHODS:In a within-subjects design, 21 healthy female volunteers underwent both a placebo condition and a natural history condition (control condition) in a randomized order on two separate days. On both days, nausea was induced through optokinetic stimulation. On the placebo day, participants received sham acupuncture point stimulation together with positive verbal suggestions of nausea improvement. Expected and perceived nausea severity as well as symptoms of motion sickness were repeatedly assessed. RESULTS:Twenty participants completed both testing days. Participants developed significantly less nausea on the placebo day compared to the control day (p<0.001), and the effect size of placebo-induced nausea reduction was large (partial η2=0.71). Symptoms of motion sickness were also reduced (p=0.003). Expectation of nausea decreased following the placebo intervention as compared to no treatment (p=0.030), indicating successful expectancy manipulation. CONCLUSION:Sham acupuncture point stimulation combined with verbal suggestions induced a significant placebo effect on visually-induced nausea in women.

journal_name

J Psychosom Res

journal_title

Journal of psychosomatic research

authors

Müller V,Remus K,Hoffmann V,Tschöp MH,Meissner K

doi

10.1016/j.jpsychores.2016.09.012

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

9-11

eissn

0022-3999

issn

1879-1360

pii

S0022-3999(16)30415-9

journal_volume

pub_type

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Effectiveness of a placebo intervention on visually induced nausea in women - A randomized controlled pilot study.