The in vitro hydroxylation of 4'-chloro-4-biphenylol by a mushroom tyrosinase preparation.

Abstract:

:Incubation of 4'-chloro-4-biphenylol with a mushroom tyrosinase preparation gave the catechol, 4'-chloro-3,4-biphenyldiol as the sole in vitro metabolite. This compound was identical with the major rat urinary metabolite of 4'-chloro-4-biphenylol and thus confirms the structure assigned to the metabolite. This result also demonstrates a possible degradation pathway of hydroxylated chlorobiphenyls which are themselves the major metabolic degradation products of polychlorinated biphenyls.

journal_name

Can J Microbiol

authors

Safe S,Ellis BE,Hutzinger O

doi

10.1139/m76-014

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

104-6

issue

1

eissn

0008-4166

issn

1480-3275

journal_volume

22

pub_type

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