Changes in hemorheology with fetal intravascular transfusion.

Abstract:

OBJECTIVE:Our aim was to determine the changes in fetal hemorheologic parameters caused by fetal intravascular transfusion for alloimmune anemia. STUDY DESIGN:Fetal blood samples were collected before and after 95 fetal transfusions in 31 women. Fetal hematocrit, whole-blood viscosity at a variety of shear rates, plasma viscosity, fetal fibrinogen, and fetal plasma proteins were measured. RESULTS:Fetal whole-blood viscosity increased, sometimes massively, with transfusion. The rise in viscosity was principally dependent on the rise in hematocrit, with a linear rise in hematocrit producing a linear rise in the logarithm of whole-blood viscosity, but was also affected by the amount of adult plasma proteins present in the donor blood. CONCLUSIONS:Rises in fetal whole-blood viscosity during transfusion can be minimized by using donor blood that has been serum depleted to a high hematocrit (> 90%) and by restricting the end hematocrit to 50% to 55%.

journal_name

Am J Obstet Gynecol

authors

Welch R,Rampling MW,Anwar A,Talbert DG,Rodeck CH

doi

10.1016/s0002-9378(94)70271-3

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

726-32

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002937894005466

journal_volume

170

pub_type

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