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Implications of vitamin D deficiency in pregnancy and lactation.

Abstract：

:Vitamin D is an essential fat soluble vitamin and a key modulator of calcium metabolism in children and adults. Because calcium demands increase in the third trimester of pregnancy, vitamin D status becomes crucial for maternal health, fetal skeletal growth, and optimal maternal and fetal outcomes. Vitamin D deficiency is common in pregnant women (5-50%) and in breastfed infants (10-56%), despite the widespread use of prenatal vitamins, because these are inadequate to maintain normal vitamin D levels (>or=32 ng/mL). Adverse health outcomes such as preeclampsia, low birthweight, neonatal hypocalcemia, poor postnatal growth, bone fragility, and increased incidence of autoimmune diseases have been linked to low vitamin D levels during pregnancy and infancy. Studies are underway to establish the recommended daily doses of vitamin D in pregnant women. This review discusses vitamin D metabolism and the implications of vitamin D deficiency in pregnancy and lactation.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Mulligan ML,Felton SK,Riek AE,Bernal-Mizrachi C

doi

10.1016/j.ajog.2009.09.002

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

429.e1-9

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(09)01003-5

journal_volume

202

pub_type

杂志文章

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