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Effects of progestins and relaxin on glycodelin gene expression in human endometrial cells.

Abstract：

OBJECTIVE:Glycodelin is an endometrial protein proposed to play an important role in embryonic implantation. We examined the effects of progestins and relaxin on glycodelin transcription, synthesis, and secretion. STUDY DESIGN:Northern blotting, metabolic labeling, and fluorography were used to assess glycodelin messenger ribonucleic acid and protein synthesis in endometrial tissue and cells. Luciferase reporter constructs transfected into endometrial adenocarcinoma cells (Ishikawa cells) were used to determine whether progestins or relaxin could activate the glycodelin gene promoter. RESULTS:Progestins but not relaxin stimulated glycodelin secretion in primary epithelial cell cultures. A 452-base pair fragment of the glycodelin gene promoter was activated 4.3 +/- 0.7 times normal by 10-nmol/L promegestone; however, addition of relaxin to the same construct repressed progestin-stimulate promoter activation by >30%. CONCLUSION:Glycodelin transcription, synthesis, and secretion by endometrial epithelial cells were stimulated by progestins. However, relaxin failed to stimulate production of this immunomodulatory protein and, in fact, repressed progestin-stimulated activation of the glycodelin gene promoter.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Taylor RN,Vigne JL,Zhang P,Hoang P,Lebovic DI,Mueller MD

doi

10.1016/s0002-9378(00)70333-4

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

841-7; discussion 847-9

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(00)70333-4

journal_volume

182

pub_type

杂志文章

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