Abstract：
:The extracellular pH of living tissue in the retina and elsewhere in the brain is lower than the pH of the surrounding milieu. We have shown that the pH gradient between the in vitro retina and the superfusion solution is regulated by a circadian (24-h) clock so that it is smaller in the subjective day than in the subjective night. We show here that the circadian changes in retinal pH result from a clock-mediated change in the generation of H+ that accompanies energy production. To demonstrate this, we suppressed energy metabolism and recorded the resultant reduction in the pH difference between the retina and superfusate. The magnitude of the reduction in the pH gradient correlated with the extent of energy metabolism suppression. We also examined whether the circadian-induced increase in acid production during the subjective night results from an increase in energy metabolism or from the selective activation of glycolysis compared with oxidative phosphorylation. We found that the selective suppression of either oxidative phosphorylation or glycolysis had almost identical effects on the dynamics and extent of H+ production during the subjective day and night. Thus the proportion of glycolysis and oxidative phosphorylation is maintained the same regardless of circadian time, and the pH difference between the tissue and superfusion solution can therefore be used to evaluate total energy production. We conclude that circadian clock regulation of retinal pH reflects circadian regulation of retinal energy metabolism.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Dmitriev AV,Mangel SCdoi
10.1152/jn.00881.2003subject
Has Abstractpub_date
2004-06-01 00:00:00pages
2404-12issue
6eissn
0022-3077issn
1522-1598pii
00881.2003journal_volume
91pub_type
杂志文章abstract：:Evidence for a persistent Na+ current (I(NaP)) in the apical dendrite of neocortical neurons was sought with the use of fluorescence imaging to measure changes in intradendritic Na+ concentration. Neurons in neocortical brain slices were filled iontophoretically through an intracellular recording microelectrode with t...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.78.2.1188
更新日期：1997-08-01 00:00:00
abstract：:We have examined the role of dorsal horn cells that respond to Lissauer tract stimulation in regulating primary afferent depolarization (PAD). PAD was monitored by recording the dorsal root potential (DRP) in the roots of the lumbar cord. Recordings were made of the discharges of Lissauer tract-responsive cells, and t...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.80.2.667
更新日期：1998-08-01 00:00:00
abstract：:1. The mismatch response, or mismatch negativity (MMN), is a neurophysiologic response to stimulus change. In humans and other animals, the MMN may underlie the ability to discriminate acoustic differences, a fundamental aspect of auditory perception. 2. This study investigated the role of the thalamus in the generati...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1994.72.3.1270
更新日期：1994-09-01 00:00:00
abstract：:The same set of stimuli and analytic methods that was used to study the dynamics of horizontal cells () was applied to a study of the response dynamics and signal processing in amacrine cells in the retina of the kissing gourami, Helostoma rudolfi. The retina contains two major classes of amacrine cells that could be ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.78.4.2018
更新日期：1997-10-01 00:00:00
abstract：:We used positron emission tomography to study motor learning by trial and error. Subjects learned sequences of eight finger movements. Tones generated by a computer told the subjects whether any particular move was correct or incorrect. A control condition was used in which the subjects generated moves, but there was ...
journal_title：Journal of neurophysiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1152/jn.1997.77.3.1325
更新日期：1997-03-01 00:00:00
abstract：:Depolarization-induced suppression of inhibition (DSI) is a form of retrograde signaling at GABAergic synapses that is initiated by the calcium- and depolarization-dependent release of endocannabinoids from postsynaptic neurons. In the neocortex, pyramidal neurons (PNs) appear to use DSI as a mechanism for regulating ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00351.2004
更新日期：2004-10-01 00:00:00
abstract：:It has been suggested that successively presented sounds that are perceived as separate auditory streams are represented by separate populations of neurons. Mostly, spectral separation in different peripheral filters has been identified as the cue for segregation. However, stream segregation based on temporal cues is ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00496.2010
更新日期：2011-01-01 00:00:00
abstract：:1. Evidence from single-unit recordings suggests that neurons in the medial superior temporal visual area (MST) carry directional signals that influence psychophysical judgements of motion direction. We tested this hypothesis by electrically stimulating clusters of directionally selective neurons in MST (the dorsomedi...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1995.73.2.437
更新日期：1995-02-01 00:00:00
abstract：:In this tribute to Reggie Edgerton, I briefly review the spinal mechanisms that coordinate locomotion and the interaction between the different sensory mechanisms that help coordinate the locomotor movements and the central locomotor network. The step cycle has four distinct parts, the support phase, the lift off, the...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00656.2020
更新日期：2020-12-23 00:00:00
abstract：:It has been suggested that some cortically blind patients can process the emotional valence of visual stimuli via a fast, subcortical pathway from the superior colliculus (SC) that reaches the amygdala via the pulvinar. We provide in vivo evidence for connectivity between the SC and the amygdala via the pulvinar in bo...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01016.2014
更新日期：2015-09-01 00:00:00
abstract：:An important question in neuroscience is whether and how temporal patterns and fluctuations in neuronal spike trains contribute to information processing in the cortex. We have addressed this issue in the memory-related circuits of the prefrontal cortex by analyzing spike trains from a database of 229 neurons recorded...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00949.2002
更新日期：2003-11-01 00:00:00
abstract：:One feature of neuronal discharge proposed to play a role in coding temporal information is the relative refractory period that follows each action potential. In neurons innervating hair cells, there is an extended refractory period that can last
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.01107.2003
更新日期：2004-08-01 00:00:00
abstract：:We investigated the precision of spike timing in a model of gap junction-coupled oscillatory neurons. The model incorporated the known physiology, morphology, and connectivity of the weakly electric fish's high-frequency and extremely precise pacemaker nucleus (Pn). Two neuron classes, pacemaker and relay cells, were ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2000.83.2.984
更新日期：2000-02-01 00:00:00
abstract：:1. In the intact cat eye, the responses of ganglion cells to light stimulation were recorded extracellularly and the actions of iontophoretically applied 2-amino-4-phosphonobutyrate (APB), a potent agonist at ON-bipolars, and of strychnine, a glycine antagonist, were investigated. 2. Under light-adapted conditions, th...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1988.59.6.1657
更新日期：1988-06-01 00:00:00
abstract：:An acute experimental arthritis was induced in the right knee joint of adult cats anesthetized with chloralose, and the activity of single fine afferent units of the medial articular nerve was recorded from filaments of the saphenous nerve. All units included in this study were sensitive to local mechanical probing of...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1985.54.5.1109
更新日期：1985-11-01 00:00:00
abstract：:Mesencephalic trigeminal (M-V) neurons are primary somatosensory neurons with somata located within the CNS, instead of in peripheral sensory ganglia. In amphibians, these unipolar cells are found within the optic tectum and have a single axon that runs along the mandibular branch of the trigeminal nerve. The axon has...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.91317.2008
更新日期：2009-07-01 00:00:00
abstract：:CA1 inhibitory interneurons at the stratum lacunosum-moleculare and radiatum junction (LM/RAD-INs) display subthreshold membrane potential oscillations (MPOs) involving voltage-dependent Na(+) and A-type K(+) currents. LM/RAD-INs also express other voltage-gated K(+) currents, although their properties and role in MPO...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00848.2009
更新日期：2010-06-01 00:00:00
abstract：:Individuals with cerebral palsy (CP) experience impairments in the control of head and neck movements, suggesting dysfunction in brain stem circuitry. To examine if brain stem circuitry is altered in CP, we compared reflexes evoked in the sternocleidomastoid (SCM) muscle by trigeminal nerve stimulation in adults with ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00185.2018
更新日期：2018-09-01 00:00:00
abstract：:In mesial temporal lobe (MTL) epilepsy, which typically involves the hippocampus (HPC), epileptiform events are enhanced during slow wave sleep (SWS). It remains unclear how and why the electroencephalographic (EEG) states that constitute SWS might predispose the HPC to this type of pathological activity. Recently our...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.90795.2008
更新日期：2009-09-01 00:00:00
abstract：:Cortical activity contributes significantly to the high variability of sensory responses of interconnected pyramidal neurons, which has crucial implications for sensory coding. Yet, largely because of technical limitations of in vivo intracellular recordings, the coupling of a pyramidal neuron's synaptic inputs to the...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00398.2017
更新日期：2017-12-01 00:00:00
abstract：:1. We examined the role of gamma-aminobutyric acid (GABA)-mediated inhibition in shaping excitatory tuning curves and creating selectivity for frequency-modulated (FM) sweeps in 29 neurons in the central nucleus of the inferior colliculus (ICC) of the pallid bat, with the use of single-unit recording coupled with the ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1996.76.2.1059
更新日期：1996-08-01 00:00:00
abstract：:We investigated the postnatal development of axon sensitivity to the withdrawal of oxygen, glucose, or the combined withdrawal of oxygen + glucose in the isolated rat optic nerve (a CNS white matter tract). Removal of either oxygen or glucose for 60 min resulted in irreversible injury in optic nerves from adult rats, ...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1998.79.1.95
更新日期：1998-01-01 00:00:00
abstract：:Fear conditioning studies have led to the view that the amygdala contains neurons that signal threat and in turn elicit defensive behaviors through their brain stem and hypothalamic targets. In agreement with this model, a prior unit-recording study in rats performing a seminaturalistic foraging task revealed that man...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00807.2018
更新日期：2019-05-01 00:00:00
abstract：:M current relaxations recorded in PC12 cells were subjected to nonstationary noise analysis (NSNA) to obtain estimates of single-channel current (i), channel number (N), and open probability (Po) for the channels responsible for M current. The analysis was constrained such that N and single-channel conductance were th...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1997.77.4.2131
更新日期：1997-04-01 00:00:00
abstract：:Octopus cells in the posteroventral cochlear nucleus (PVCN) of mammals are biophysically specialized to detect coincident firing in the population of auditory nerve fibers that provide their synaptic input and to convey its occurrence with temporal precision. The precision in the timing of action potentials depends on...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2001.86.5.2299
更新日期：2001-11-01 00:00:00
abstract：:We characterized the electroresponsive and morphological properties of neurons in the bed nucleus of the stria terminalis (BNST). Previously, Rainnie and colleagues distinguished three cell types in the anterolateral region of BNST (BNST-AL): low-threshold bursting cells (LTB; type II) and regular spiking neurons that...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00408.2013
更新日期：2013-11-01 00:00:00
abstract：:Express saccades represent the fastest possible eye movements to visual targets with reaction times that approach minimum sensory-motor conduction delays. Previous work in monkeys has identified two specific neural signals in the superior colliculus (SC: a midbrain sensorimotor integration structure involved in gaze c...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00047.2015
更新日期：2015-08-01 00:00:00
abstract：:Cellular mechanisms underlying defense reactions induced by noxious heat and acids were studied in frogs (Rana pipiens) by measuring whole cell membrane currents in cultured dorsal root ganglion (DRG) neurons. Seventy-eight of 82 DRG neurons exposed to 3-s ramps of increasing temperature to 48 degrees C exhibited an i...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.2002.88.4.1843
更新日期：2002-10-01 00:00:00
abstract：:1. The physiological properties of cells in the superior olivary complex (SOC) were studied in 400-microns brain slices taken through the mouse auditory brain stem. Coronal sections were prepared from fresh brain tissue and were placed fully submerged in an oxygenated saline solution. The boundaries of the medial nucl...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.1991.65.2.230
更新日期：1991-02-01 00:00:00
abstract：:Many laboratories have reported the successful regeneration of neurons across damaged portions of the spinal cord. Associated improvements in hindlimb locomotor movements have been attributed to the formation of functional neuronal connections with the locomotor central pattern generator (CPG). However, regenerating a...
journal_title：Journal of neurophysiology
pub_type： 杂志文章
doi：10.1152/jn.00814.2006
更新日期：2007-03-01 00:00:00
