Abstract:
:We investigated the postnatal development of axon sensitivity to the withdrawal of oxygen, glucose, or the combined withdrawal of oxygen + glucose in the isolated rat optic nerve (a CNS white matter tract). Removal of either oxygen or glucose for 60 min resulted in irreversible injury in optic nerves from adult rats, assessed by loss of the evoked compound action potential (CAP). Optic nerves at ages
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Fern R,Davis P,Waxman SG,Ransom BRdoi
10.1152/jn.1998.79.1.95subject
Has Abstractpub_date
1998-01-01 00:00:00pages
95-105issue
1eissn
0022-3077issn
1522-1598journal_volume
79pub_type
杂志文章abstract::Precise motion control is critical to human survival on Earth and in space. Motion sensation is inherently imprecise, and the functional implications of this imprecision are not well understood. We studied a "vestibular" manual control task in which subjects attempted to keep themselves upright with a rotational hand ...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00565.2018
更新日期:2018-12-01 00:00:00
abstract::1. The active stiffness of ventral superficial abdominal muscle (VSM) of the hermit crab, Pagurus pollicarus, was measured with ramp stretches of different amplitudes and velocities. Active stiffness was calculated by subtracting the peak force produced by passive stretch and the isometric force just before stretch fr...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1989.62.5.997
更新日期:1989-11-01 00:00:00
abstract::1. Neuron-specific expression of alternately spliced exons of the gene encoding the Phe-Met-Arg-Phe-NH2 (FMRFamide) family of neuropeptides and the role of encoded peptides in synaptic transmission were examined in an identified cardiorespiratory interneuron, the visceral white interneuron (VWI), in the snail Lymnaea....
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1993.69.3.915
更新日期:1993-03-01 00:00:00
abstract::1. Previous studies indicate that after transection of the rostral spinal cord, larval lamprey begin to recover locomotor behavior 2 wk posttransection and recovery is complete at approximately 8 wk. To examine the mechanisms underlying behavioral recovery after spinal cord transection, in the present study the time c...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1994.72.2.847
更新日期:1994-08-01 00:00:00
abstract::Weight predictions used to scale lifting forces adapt quickly when repeatedly lifting unusually weighted objects and are readily updated by explicit information provided about weight. In contrast, weight predictions used when making perceptual judgments about weight are more resistant to change and are largely unaffec...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.01051.2015
更新日期:2016-09-01 00:00:00
abstract::Single neurons were recorded from the ventral posteromedial thalamic nucleus (VPM) of urethan-anesthetized rats. Six of these animals were intact, 28 sustained kainic acid (KA) lesions of trigeminal nucleus principalis (PrV), and 9 received similar lesions of trigeminal subnucleus interpolaris (SpVi). Four animals sus...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1987.57.5.1577
更新日期:1987-05-01 00:00:00
abstract::We investigated the role of the superior colliculus (SC) in saccade target selection in rhesus monkeys who were trained to perform a direction-discrimination task. In this task, the monkey discriminated between opposed directions of visual motion and indicated its judgment by making a saccadic eye movement to one of t...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.5.2527
更新日期:2001-11-01 00:00:00
abstract::The Wilson-Cowan equations were originally shown to produce limit cycle oscillations for a range of parameters. Others subsequently showed that two coupled Wilson-Cowan oscillators could produce chaos, especially if the oscillator coupling was from inhibitory interneurons of one oscillator to excitatory neurons of the...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00323.2019
更新日期:2019-12-01 00:00:00
abstract::Dual whole cell patch-clamp recordings in rat nucleus accumbens, the main component of the ventral striatum, were made to assess the presence of synaptic interconnections between medium-sized spiny neurons, a group of GABAergic and peptidergic neurons that constitute the principal cells of the striatum. Neurons were s...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00892.2003
更新日期:2004-03-01 00:00:00
abstract::The uppermost layer (stratum griseum superficiale, SGS) of the superior colliculus (SC) provides an important gateway from the retina to the visual extrastriate and visuomotor systems. The majority of attention has been given to the role of this "visual" SC in saccade generation and target selection and it is generall...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00059.2007
更新日期:2007-07-01 00:00:00
abstract::Is faster or stronger sniffing important for the olfactory system? Odorant molecules are captured by sniffing. The features of sniffing constrain both the temporality and intensity of the input to the olfactory structures. In this context, it is clear that variations in both the sniff frequency and flow rate have a ma...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00672.2011
更新日期:2011-12-01 00:00:00
abstract::Odorants induce specific modulation of mitral/tufted (MT) cells' firing rate in the mammalian olfactory bulb (OB), inducing temporal patterns of neuronal discharge embedded in an oscillatory local field potential (LFP). While most studies have examined anesthetized animals, little is known about the firing rate and te...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00095.2008
更新日期:2008-07-01 00:00:00
abstract::A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of ∼100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00625.2011
更新日期:2012-04-01 00:00:00
abstract::1. The purpose of this study is to analyze the kinematics of stepping from the point of view of limb control by attempting to dissociate the various neuronal and mechanical factors that shape actual movements observed experimentally. The cat hindlimb, like the primate arm, is a multijointed mechanical system with redu...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1995.74.6.2266
更新日期:1995-12-01 00:00:00
abstract::1. Cellular properties were studied before and after bath application of the dihydropyridine L-type calcium channel antagonist nimodipine in aging and young rabbit hippocampal CA1 pyramidal cells in vitro. Various concentrations of nimodipine, ranging from 10 nM to 10 microM, were tested to investigate age- and concen...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1992.68.6.2100
更新日期:1992-12-01 00:00:00
abstract::1. Red rod photoreceptors in the toad retina, which are known to be physiologically coupled, were examined for interreceptor contacts. 2. A dense network of large gap junctions was found between the inner segments of red rods, this being the only specialized site of contact that was observed between rods. Each red rod...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1979.42.1.292
更新日期:1979-01-01 00:00:00
abstract::Microelectrode studies in monkeys performing short-term memory tasks show the sustained elevated discharge of cortical neurons during the retention of recalled sensory information. Cortical cells that are part of memory networks are assumed to receive numerous inputs of excitatory as well as inhibitory nature and loca...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.77.4.2219
更新日期:1997-04-01 00:00:00
abstract::Gain-of-function variants in voltage-gated sodium channel NaV1.7 that increase firing frequency and spontaneous firing of dorsal root ganglion (DRG) neurons have recently been identified in 5-10% of patients with idiopathic small fiber neuropathy (I-SFN). Our previous in vitro observations suggest that enhanced sodium...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00360.2019
更新日期:2020-02-01 00:00:00
abstract::Direct electrical coupling between neurons can be the result of both electrotonic current transfer through gap junctions and extracellular fields. Intracellular recordings from CA1 pyramidal neurons of rat hippocampal slices showed two different types of small-amplitude coupling potentials: short-duration (5 ms) bipha...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1997.78.6.3107
更新日期:1997-12-01 00:00:00
abstract::Individuals with chronic spinal cord injury (SCI) often demonstrate multijoint reflex activity that is clinically classified as an extensor spasm. These responses are commonly observed in conjunction with an imposed extension movement of the hips, such as movement from a sit to a supine position. Coincidentally, affer...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00677.2003
更新日期:2004-08-01 00:00:00
abstract::We have used a slice preparation of the infant rat midbrain to examine converging inputs onto neurons in the deeper multisensory layers of the superior colliculus (dSC). Electrical stimulation of the superficial visual layers (sSC) and of the auditory nucleus of the brachium of the inferior colliculus (nBIC) evoked ro...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00450.2004
更新日期:2004-11-01 00:00:00
abstract::The thalamic reticular nucleus (nRt) provides a major source of inhibition in the thalamo-cortical circuit and is critically involved in the generation of spindle oscillations. Here we describe the properties of thalamic giant depolarizing potentials (tGDPs) that were observed in nRt during early development. tGDPs pe...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00646.2006
更新日期:2007-03-01 00:00:00
abstract::Individuation refers to individuals' use of spatial and temporal properties to register an object as a distinct perceptual event relative to other stimuli. Although behavioral studies have examined both spatial and temporal individuation, neuroimaging investigations of individuation have been restricted to the spatial...
journal_title:Journal of neurophysiology
pub_type: 杂志文章,收录出版
doi:10.1152/jn.00534.2013
更新日期:2014-02-01 00:00:00
abstract::Attention is known to affect the response properties of sensory neurons in visual cortex. These effects have been traditionally classified into two categories: 1) changes in the gain (overall amplitude) of the response; and 2) changes in the tuning (selectivity) of the response. We performed an extensive series of beh...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00776.2011
更新日期:2012-03-01 00:00:00
abstract::The effects of neuronal density on morphological and functional attributes of the evolving networks were studied in cultured dissociated hippocampal neurons. Plating at different densities affected connectivity among the neurons, such that sparse networks exhibited stronger synaptic connections between pairs of record...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00914.2009
更新日期:2010-08-01 00:00:00
abstract::Activation of muscarinic receptors and GABA(B) receptors causes presynaptic inhibition of glutamatergic synaptic potentials at excitatory feedback connections in cortical structures. These effects may regulate dynamics in cortical structures, with presynaptic inhibition allowing extrinsic afferent input to dominate du...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.86.4.1792
更新日期:2001-10-01 00:00:00
abstract::Following peripheral nerve injury, moderate daily exercise conducted on a level treadmill results in enhanced axon regeneration and modest improvements in functional recovery. If the exercise is conducted on an upwardly inclined treadmill, even more motor axons regenerate successfully and reinnervate muscle targets. W...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.00129.2016
更新日期:2016-09-01 00:00:00
abstract::In most of the bulbospinal respiratory neurons, threshold depolarization increased during the early period of their spontaneous burst discharge but decreased again at the end of a burst. In some vagal respiratory neurons, however, threshold depolarization increased steadily until the very end of their discharge period...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1975.38.5.1172
更新日期:1975-09-01 00:00:00
abstract::Leopard frog saccular hair cells exhibit an electrical resonance in response to a depolarizing stimulus that has been proposed to contribute to the tuning properties of the frog sacculus by acting as an electrical band-pass filter. With the whole cell patch-clamp technique, we have investigated the effect of temperatu...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.1998.79.1.312
更新日期:1998-01-01 00:00:00
abstract::We investigated behavior, physiology, sensitivity to exogenous application of ecdysone, and nerve terminal structure for differences between the reduced ecdysone genotype, ecd(1)/ecd(1), and wild-type control ecd(1)/TM6B animals during the early and late third instars when raised at 25 degrees C. The ecd(1) mutants we...
journal_title:Journal of neurophysiology
pub_type: 杂志文章
doi:10.1152/jn.2001.85.1.98
更新日期:2001-01-01 00:00:00