Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis.

abstract：:A novel class of targeted chemotherapeutic agents based on cytotoxic compounds linked to LHRH analogs was tested in a long term superfusion system in order to determine their effects on different types of rat pituitary cells. The compounds investigated included two cytotoxic LHRH agonists, T-98 ([D-Lys6]LHRH coupled t...

journal_title：Endocrinology

authors： Rékási Z,Szöke B,Nagy A,Groot K,Rékási ES,Schally AV

更新日期：1993-05-01 00:00:00

abstract：:Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...

journal_title：Endocrinology

authors： Frolova A,Flessner L,Chi M,Kim ST,Foyouzi-Yousefi N,Moley KH

更新日期：2009-03-01 00:00:00

abstract：:There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. ...

journal_title：Endocrinology

authors： França LR,Suescun MO,Miranda JR,Giovambattista A,Perello M,Spinedi E,Calandra RS

更新日期：2006-03-01 00:00:00

abstract：:GnRH neurons active in the preovulatory LH surge have been identified in several species using the early intermediate gene product, Fos, but the GnRH neurons active during episodic LH secretion remain unknown. In this study, we have used Fos and Fos-related antigens (FRA) to determine whether a subset of GnRH neurons ...

journal_title：Endocrinology

authors： Boukhliq R,Goodman RL,Berriman SJ,Adrian B,Lehman MN

更新日期：1999-12-01 00:00:00

abstract：:The guinea pig is unusual in that its postnatal growth appears to be independent of GH even though its pituitary gland produces a GH molecule. The effects of fasting on the GH secretory pattern and the GH responses to insulin, GH-releasing factor (GRF), and somatostatin (SS) during fasting have now been studied by aut...

journal_title：Endocrinology

authors： Fairhall KM,Gabrielsson BG,Robinson IC

更新日期：1990-08-01 00:00:00

abstract：:We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. 7alpha-Hydroxypregnenolone stimulates locomotor activity of male newts. Locomotor activity of male newts increases during the breeding period as in o...

journal_title：Endocrinology

authors： Haraguchi S,Koyama T,Hasunuma I,Vaudry H,Tsutsui K

更新日期：2010-05-01 00:00:00

abstract：:We have investigated, in young and aged rats, tuberoinfundibular dopaminergic (TIDA) and nigrostriatal neurons of the brain, and the role of the testes and anterior pituitary (AP) on 1) the in situ activity of tyrosine hydroxylase (TH), 2) translation of TH mRNA, as reflected by the mass of TH, and 3) transcription of...

journal_title：Endocrinology

authors： Aguila-Mansilla N,Kedzierski W,Porter JC

更新日期：1991-08-01 00:00:00

abstract：:In the ewe, photoperiod modulates LH and PRL secretion as well as median eminence (ME) dopaminergic activity. The studies reported here were designed to characterize the functional significance of this photoperiodic modulation of ME dopaminergic neuron activity in relation to the regulation of LH and PRL secretion. Th...

journal_title：Endocrinology

authors： Viguié C,Thibault J,Thiéry JC,Tillet Y,Malpaux B

更新日期：1997-01-01 00:00:00

abstract：:While uterine stromal cells (USC) appear to modify the function of uterine epithelial cells (UEC) under certain conditions in vivo, relatively little is known about the effect of epithelial cells on stromal cell differentiation and function. To determine if UEC modulate USC function in vitro, highly enriched (> 95%) c...

journal_title：Endocrinology

authors： Wegner CC,Carson DD

更新日期：1992-12-01 00:00:00

abstract：:Reproductive function is dependent on the interaction between GnRH and its cognate receptor found on gonadotrope cells of the anterior pituitary gland. GnRH activation of the GnRH receptor (GnRHR) is a potent stimulus for increased expression of multiple genes including the gene encoding the GnRHR itself. Thus, homolo...

journal_title：Endocrinology

authors： Ellsworth BS,White BR,Burns AT,Cherrington BD,Otis AM,Clay CM

更新日期：2003-03-01 00:00:00

abstract：:Owing to the prevalence of depression during childbearing, mothers can be prescribed multiple antidepressants; however, little is known about the risk and consequences to the offspring or subsequent generations. Fluoxetine (FLX) is usually the first-line of pharmacological treatment for affective disorders in pregnant...

journal_title：Endocrinology

authors： Vera-Chang MN,Moon TW,Trudeau VL

更新日期：2019-09-01 00:00:00

abstract：:Using a primary culture of neonatal rat heart, we investigated the properties of iodothyronine 5'-deiodinating activity in the heart. 125I- release from [125I] reverse T3 incubated with cell homogenates depended on the concentrations of protein and dithiothreitol, pH, incubation time, and temperature of the incubation...

journal_title：Endocrinology

authors： Mori Y,Nishikawa M,Toyoda N,Yonemoto T,Matsubara H,Inada M

更新日期：1991-06-01 00:00:00

abstract：:We previously reported that dexamethasone (DEX) induces dose-dependent biphasic effects on steady state somatostatin (SS) messenger RNA (mRNA) levels in normal rat islet and islet SS-producing tumor cells (1027B2), characterized by stimulation at low doses and marked inhibition at high doses. The stimulatory effect is...

journal_title：Endocrinology

authors： Liu JL,Patel YC

更新日期：1995-06-01 00:00:00

abstract：:The binding properties of the gamma-emitting 125I-labeled 11 beta-methoxy analog of 16 alpha-iodoestradiol, 11 beta-methoxy-16 alpha-iodoestradiol (MIE2), were characterized for its use in vivo as a ligand for the measurement and localization of estrogen-binding sites. In binding displacement studies, MIE2 bound to ra...

journal_title：Endocrinology

authors： Brown TJ,MacLusky NJ,Toran-Allerand CD,Zielinski JE,Hochberg RB

更新日期：1989-05-01 00:00:00

abstract：:To test the hypothesis that vitamin D-dependent calcium-binding protein (CaBP) and active calcium (Ca) transport in the small intestine of vitamin D-replete lactating rats are regulated by dietary Ca intake, pregnant rats were given a high Ca (1.6% Ca and 1.4% phosphorus) or low Ca (0.1% Ca and 0.4% phosphorus) diet s...

journal_title：Endocrinology

authors： Bruns ME,Boass A,Toverud SU

更新日期：1987-07-01 00:00:00

abstract：:In the adrenal gland, neuroendocrine cells that synthesize catecholamines and epithelial cells that produce steroid hormones are united beneath a common organ capsule to function as a single stress-responsive organ. The functional anatomy of the steroid hormone-producing adrenal cortex and the catecholamine-producing ...

journal_title：Endocrinology

authors： Sun N,Wu Y,Nanba K,Sbiera S,Kircher S,Kunzke T,Aichler M,Berezowska S,Reibetanz J,Rainey WE,Fassnacht M,Walch A,Kroiss M

更新日期：2018-03-01 00:00:00

abstract：:Oxyntomodulin is derived from proglucagon processing in the intestine and the central nervous system. To date, no role in the central nervous system has been demonstrated. We report here that oxyntomodulin inhibits refeeding when injected intracerebroventricularly and into the hypothalamic paraventricular nucleus of 2...

journal_title：Endocrinology

authors： Dakin CL,Gunn I,Small CJ,Edwards CM,Hay DL,Smith DM,Ghatei MA,Bloom SR

更新日期：2001-10-01 00:00:00

abstract：:The disappearance of 125-I-ACTH from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. The mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. The higher fetal than mate...

journal_title：Endocrinology

authors： Jones CT,Luther E,Ritchie JW,Worthington D

更新日期：1975-01-01 00:00:00

abstract：:The estrogen receptor-alpha (ERalpha) pituitary-specific variant, TERP-1, is regulated dramatically by physiological status. We examined hormonal regulation of the TERP-1 promoter in transient transfection assays in GH3 somatolactotrope cells. We found that 17beta-estradiol (E2), genistein, androgen, pituitary adenyla...

journal_title：Endocrinology

authors： Bryant WM,Gibson MA,Shupnik MA

更新日期：2006-01-01 00:00:00

abstract：:Primary astroglial cells produce insulin-like growth factor (IGF)-binding proteins (IGFBPs), which modulate the biological activity of IGFs on the developing astroglia. Alterations in the synthesis of astroglial IGFBPs by hormones and growth factors may, therefore, influence the paracrine regulatory actions of IGFs. T...

journal_title：Endocrinology

authors： Bradshaw SL,Han VK

更新日期：1993-10-01 00:00:00

abstract：:GH promotes not only longitudinal growth in children but is active throughout life in protein, fat, and carbohydrate metabolism. The multiple actions of GH start when GH binds to the cell surface-expressed GH receptor. Effectiveness of the hormone depends both on its presence in the circulation and the availability of...

journal_title：Endocrinology

authors： van Kerkhof P,Smeets M,Strous GJ

更新日期：2002-04-01 00:00:00

abstract：:We tested the hypothesis that depressed duodenal calcium absorption in the streptozotocin diabetic rat is the consequence of diabetes rather than nephrotoxicity of the diabetogenic agent causing abnormal renal vitamin D metabolism. We treated streptozotocin diabetic rats with insulin and compared their duodenal calciu...

journal_title：Endocrinology

authors： Schneider LE,Nowosielski LM,Schedl HP

更新日期：1977-01-01 00:00:00

abstract：:Mutations in the GnRH receptor gene (GNRHR) can result in hypogonadotropic hypogonadism in humans. Unlike most mammals, mice lack a second form of GnRH (GnRH2) and a type 2 GnRH receptor. To determine whether the GnRH receptor is critical at all stages of reproduction and whether this receptor has additional physiolog...

journal_title：Endocrinology

authors： Wu S,Wilson MD,Busby ER,Isaac ER,Sherwood NM

更新日期：2010-03-01 00:00:00

abstract：:Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...

journal_title：Endocrinology

authors： Hashimoto K,Ishida E,Miura A,Ozawa A,Shibusawa N,Satoh T,Okada S,Yamada M,Mori M

更新日期：2013-01-01 00:00:00

abstract：:Arginine vasopressin (AVP) stimulates the secretion of ACTH from pituitary corticotropes. We investigated the action of AVP in single corticotropes of male rats. Corticotropes were identified with the reverse hemolytic plaque assay using antibodies against ACTH. Using the whole-cell recording technique in conjunction ...

journal_title：Endocrinology

authors： Tse A,Lee AK

更新日期：1998-05-01 00:00:00

abstract：:Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating d...

journal_title：Endocrinology

authors： Warden SJ,Robling AG,Sanders MS,Bliziotes MM,Turner CH

更新日期：2005-02-01 00:00:00

abstract：:Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confounding effects from a potential developmental defect arising from global deletion ...

journal_title：Endocrinology

authors： Herrera GGB,Lierz SL,Harris EA,Donoghue LJ,Hewitt SC,Rodriguez KF,Jefferson WN,Lydon JP,DeMayo FJ,Williams CJ,Korach KS,Winuthayanon W

更新日期：2020-02-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) was studied for its effect on renin release by rat renal cortical slices. ANF (rat) alone (10(-9)-10(-6) M) had no effect on basal renin release, but significantly (P less than 0.001) potentiated angiotensin II (AII) inhibition of renin secretion in doses as low as 10(-9) M. ANF also po...

journal_title：Endocrinology

authors： Antonipillai I,Vogelsang J,Horton R

更新日期：1986-07-01 00:00:00

abstract：:Studies were undertaken to evaluate the effects of chronic morphine exposure on the negative and positive feedback effects of estradiol (E2) on LH and FSH secretion in ovariectomized rats. Two days of E2 exposure reduced at 1000 h and stimulated at 1600 h the serum LH concentration at each dose tested. Chronic exposur...

journal_title：Endocrinology

authors： Gabriel SM,Berglund LA,Simpkins JW

更新日期：1987-05-01 00:00:00

abstract：:Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites are dependent on the activity o...

journal_title：Endocrinology

authors： Pooley JR,Flynn BP,Grøntved L,Baek S,Guertin MJ,Kershaw YM,Birnie MT,Pellatt A,Rivers CA,Schiltz RL,Hager GL,Lightman SL,Conway-Campbell BL

更新日期：2017-05-01 00:00:00