Mucinous adenocarcinoma arising in rectovaginal fistulas associated with Crohn's disease.

Abstract:

BACKGROUND:Crohn's disease is a chronic inflammatory disorder characterized by focal, transmural inflammation of the intestine. Gynecologic involvement, including rectovaginal fistula formation, is frequent. Case #1. A 53-year-old female with a 30-year history of Crohn's disease and numerous perirectal fistulas developed a foul smelling, purulent drainage from her rectum and a mucopurulent, bloody discharge from her vagina. A lower vaginal lesion biopsy demonstrated a low-grade mucinous adenocarcinoma. Case #2. A 42-year-old female with a 15-year history of Crohn's disease developed drainage from her vagina. Physical examination revealed an enlarging mass involving the posterior wall of the vaginal vault that connected to the anus by a fistula tract. A biopsy revealed mucinous adenocarcinoma. CONCLUSIONS:Malignant transformation of persistent rectovaginal fistulas is a potential complication of Crohn's disease.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Moore-Maxwell CA,Robboy SJ

doi

10.1016/j.ygyno.2003.11.056

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

266-8

issue

1

eissn

0090-8258

issn

1095-6859

pii

S0090825803008497

journal_volume

93

pub_type

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