Epigenetics of ovarian cancer: from the lab to the clinic.


OBJECTIVE:Ovarian cancer remains the most lethal gynaecological cancer. Various molecular changes have been identified and have shown promise for their diagnostic, prognostic and curative capacity but still need further validation. Among different mechanisms, the present article reviews the importance of epigenetic changes in ovarian cancer. METHODS:Recent literature relevant to epigenetics of ovarian cancer has been reviewed. RESULTS:Greater insight into the epigenetic phenomena DNA methylation, histone modification and posttranscriptional gene downregulation by microRNAs is provided. In addition, the contribution of epigenetic control of gene expression to ovarian oncology is analysed and its potential in the clinic is considered. CONCLUSIONS:Although the epigenetics of ovarian cancer is still in its beginnings, it holds promising potential in early stage ovarian cancer detection, evaluation of prognosis/drug resistance and targeted cancer treatment.


Gynecol Oncol


Gynecologic oncology


Asadollahi R,Hyde CA,Zhong XY




Has Abstract


2010-07-01 00:00:00














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    更新日期:2017-02-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jennens R,Rischin D,Yuen K,Toner G,Millward M

    更新日期:2003-10-01 00:00:00

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