Epigenetics of ovarian cancer: from the lab to the clinic.

Abstract:

OBJECTIVE:Ovarian cancer remains the most lethal gynaecological cancer. Various molecular changes have been identified and have shown promise for their diagnostic, prognostic and curative capacity but still need further validation. Among different mechanisms, the present article reviews the importance of epigenetic changes in ovarian cancer. METHODS:Recent literature relevant to epigenetics of ovarian cancer has been reviewed. RESULTS:Greater insight into the epigenetic phenomena DNA methylation, histone modification and posttranscriptional gene downregulation by microRNAs is provided. In addition, the contribution of epigenetic control of gene expression to ovarian oncology is analysed and its potential in the clinic is considered. CONCLUSIONS:Although the epigenetics of ovarian cancer is still in its beginnings, it holds promising potential in early stage ovarian cancer detection, evaluation of prognosis/drug resistance and targeted cancer treatment.

journal_name

Gynecol Oncol

journal_title

Gynecologic oncology

authors

Asadollahi R,Hyde CA,Zhong XY

doi

10.1016/j.ygyno.2010.03.015

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

81-7

issue

1

eissn

0090-8258

issn

1095-6859

pii

S0090-8258(10)00265-9

journal_volume

118

pub_type

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