LPA in neural cell development.


:Lysophosphatidic acid (LPA) elicits diverse cellular responses through cell surface LPA receptors in nervous system-derived cells and cell lines. The developing nervous system is one of the major loci for LPA receptor expression. Recent studies have also revealed that metabolic pathways of LPA are present in the nervous system. A growing body of literature suggests a crucial role for LPA in neuronal development processes, including neurogenesis, neuronal migration, neuritogenesis, and myelination.


J Cell Biochem


Fukushima N




Has Abstract


2004-08-01 00:00:00












  • Multiple interactions of the transcription factor YY1 with human histone H4 gene regulatory elements.

    abstract::Multiple regulatory elements and intricate protein-DNA interactions mediate the transcription of the human histone H4 genes in a cell growth-dependent manner. Upon analysis of the regulatory elements of the FO108 histone H4 gene, we identified several potential YY1 binding sites. In this study, we have analyzed the ab...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Last TJ,van Wijnen AJ,Birnbaum MJ,Stein GS,Stein JL

    更新日期:1999-03-15 00:00:00

  • Mitochondrial impairment following neonatal overfeeding: A comparison between normal and ischemic-reperfused hearts.

    abstract::Overweight and obesity are established factors underpin several metabolic impairments, including the cardiovascular. Although the diversity of factors involved in overweight/obesity-induced cardiovascular diseases, mitochondria has been highlighted due to its role in cardiac metabolism. As obesity can be originated in...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: de Moura Freitas C,Nascimento LCPD,Braz GRF,Andrade-Silva SC,Lima-Junior NC,de Araujo Silva T,Fernandes MP,Ferreira DJS,Lagranha CJ

    更新日期:2018-10-28 00:00:00

  • DNA methylation in embryonic stem cells.

    abstract::Embryonic stem cells (ESCs) are pluripotent, self-renewing cells. These cells can be used in applications such as cell therapy, drug development, disease modeling, and the study of cellular differentiation. Investigating the interplay of epigenetics, genetics, and gene expression in control of pluripotence and differe...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Altun G,Loring JF,Laurent LC

    更新日期:2010-01-01 00:00:00

  • Pyrazinamide drug resistance in RpsA mutant (∆438A) of Mycobacterium tuberculosis: Dynamics of essential motions and free-energy landscape analysis.

    abstract::Pyrazinamide is an essential first-line antitubercular drug which plays pivotal role in tuberculosis treatment. It is a prodrug that requires amide hydrolysis by mycobacterial pyrazinamidase enzyme for conversion into pyrazinoic acid (POA). POA is known to target ribosomal protein S1 (RpsA), aspartate decarboxylase (P...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Singh A,Somvanshi P,Grover A

    更新日期:2018-11-02 00:00:00

  • Transcriptional regulation of collagenase-3 by interleukin-1 alpha in osteoblasts.

    abstract::Interleukin-1 (IL-1)alpha is an autocrine/paracrine agent of the skeletal tissue and it regulates bone remodeling. Collagenase-3 or matrix metalloproteinase (MMP)-13 is expressed in osteoblasts and its expression is modulated by several cytokines including IL-1alpha. Because the molecular mechanism of increased synthe...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Varghese S,Canalis E

    更新日期:2003-12-01 00:00:00

  • Nuclear factor 1 is a component of the nuclear matrix.

    abstract::Chicken histone H5 is an H1-like linker histone that is expressed only in nucleated erythrocytes. The histone H5 promoter has binding sites for Sp1 (a high affinity site) and UPE-binding protein, while the 3' erythroid-specific enhancer has binding sites for Sp1 (one moderate and three weak affinity), GATA-1, and NF1....

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sun JM,Chen HY,Davie JR

    更新日期:1994-06-01 00:00:00

  • miR-200a mediates protection of thymosin β-4 in cardiac microvascular endothelial cells as a novel mechanism under hypoxia-reoxygenation injury.

    abstract::Thymosin β-4 (Tβ4) is a ubiquitous protein, which has been suggested to regulate multiple cell signal pathways and a variety of cellular functions. However, the role Tβ4 plays in the cardiac microvascular endothelial cells (CMECs) under myocardial ischemia/reperfusion injury is currently unknown. Here we investigated ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Li Y,Zhu X,Liu X,Du A,Yu B

    更新日期:2019-11-01 00:00:00

  • MicroRNA-1296-5p suppresses the proliferation, migration, and invasion of human osteosarcoma cells by targeting NOTCH2.

    abstract::Osteosarcoma (OS) is a highly aggressive bone tumor with a poor prognosis. MicroRNAs are revealed to exerts essential roles in the carcinogenesis and tumor invasion of OS. But, the function of miR-1296-5p and its related mechanism in OS progression have not yet been studied. This study discovered the levels of miR-129...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang L,Hu K,Chao Y,Wang X

    更新日期:2020-02-01 00:00:00

  • Src protein and tyrosine-phosphorylated protein profiles in marrow stroma during osteogenic stimulation.

    abstract::Src protein is essential for the regulation of bone turnover primarily via bone resorption because it is required in osteoclast differentiation and function. We followed temporal changes of Src protein abundance in marrow stromal cells induced to mineralize by dexamethasone (DEX), growth in cold temperature, or both. ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Klein BY,Levitzki R,Ben-Bassat H

    更新日期:1998-06-01 00:00:00

  • Characterization of female germ-like cells derived from mouse embryonic stem cells through expression of GFP under the control of Figla promoter.

    abstract::Previous studies have demonstrated that germ cells can be derived from mouse embryonic stem cells (ESCs). However, there is still no efficient system, which can visualize the stage of germ cell specification in vitro, and further to identify and enrich germ cells derived from ESCs. Figla (factor in the germline, alpha...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hu Y,Sun J,Wang J,Wang L,Bai Y,Yu M,Lian Z,Zhang S,Hua J

    更新日期:2012-04-01 00:00:00

  • Chromatin modification of the human imprinted NDN (necdin) gene detected by in vivo footprinting.

    abstract::Allele-specific transcription is a characteristic feature of imprinted genes. Many imprinted genes are also transcribed in a tissue- or cell type-specific manner. Overlapping epigenetic signals must, therefore, modulate allele-specific and tissue-specific expression at imprinted loci. In addition, long-range interacti...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hanel ML,Lau JC,Paradis I,Drouin R,Wevrick R

    更新日期:2005-04-01 00:00:00

  • Upregulated microRNA-485 suppresses apoptosis of renal tubular epithelial cells in mice with lupus nephritis via regulating the TGF-β-MAPK signaling pathway by inhibiting RhoA expression.

    abstract::Lupus nephritis (LN) is a common and severe complication of systemic lupus erythematosus. Without intervention, LN may cause acute kidney injury and end-stage renal disease. This study aims to determine whether microRNA-485 (miR-485) affects renal tubular epithelial cells (RTECs) in LN mice via the TGF-β-MAPK signalin...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Tian Y,Han YX,Guo HF,Jin HT,Sun C,Qi X,Ma LY,Bo SW

    更新日期:2018-11-01 00:00:00

  • Immune cells as anti-cancer therapeutic targets and tools.

    abstract::Chronic inflammation is a contributing factor to overall cancer risk as well as cancer promotion and progression; however, pathways regulating onset of cancer-promoting inflammatory responses are still poorly understood. Clinical data suggest that deficient anti-tumor cell-mediated immunity, in combination with enhanc...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Johansson M,Tan T,de Visser KE,Coussens LM

    更新日期:2007-07-01 00:00:00

  • Extracellular-regulated kinase-mitogen-activated protein kinase cascade: unsolved issues.

    abstract::This review point out several aspects regarding the mitogen-activated protein kinase (MAPK)/extracellular-regulated kinase (Erk) network, which are still pending issues in the understanding how this pathway integrate information to drive cell fates. Focusing on the role of Erk during cell cycle, it has to be underline...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Bodart JF

    更新日期:2010-04-01 00:00:00

  • Immunological comparison of desmosomal components from several bovine tissues.

    abstract::A panel of monoclonal antibodies and conventional antisera directed against desmosomal proteins from bovine muzzle epidermis was used to identify immunologically related proteins from two other bovine stratified squamous epithelia, cornea and esophagus. Desmosome-enriched tissue fractions were prepared from epidermis,...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Giudice GJ,Cohen SM,Patel NH,Steinberg MS

    更新日期:1984-01-01 00:00:00

  • The effect of combined pulsed wave low-level laser therapy and mesenchymal stem cell-conditioned medium on the healing of an infected wound with methicillin-resistant Staphylococcal aureus in diabetic rats.

    abstract::This study aims to investigate the combined effects of Pulsed wave low-level laser therapy (PW LLLT) and human bone marrow mesenchymal stem cell-conditioned medium (hBM-MSC-CM) on the microbial flora and tensiometrical properties of an infected wound model with methicillin-resistant staphylococcal aureus (MRSA) in an ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Kouhkheil R,Fridoni M,Piryaei A,Taheri S,Chirani AS,Anarkooli IJ,Nejatbakhsh R,Shafikhani S,Schuger LA,Reddy VB,Ghoreishi SK,Jalalifirouzkouhi R,Chien S,Bayat M

    更新日期:2018-07-01 00:00:00

  • Activation of PKR/eIF2α signaling cascade is associated with dihydrotestosterone-induced cell cycle arrest and apoptosis in human liver cells.

    abstract::Androgen receptor (AR) signaling plays an important role in the development and progression of several liver diseases, including hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD). Dihydrotestosterone (DHT) is the active metabolite of the major circulating androgen, testosterone. In this stud...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Dai R,Yan D,Li J,Chen S,Liu Y,Chen R,Duan C,Wei M,Li H,He T

    更新日期:2012-05-01 00:00:00

  • Genistein blocks breast cancer cells in the G(2)M phase of the cell cycle.

    abstract::Genistein, a natural isoflavone phytoestrogen present in soybeans, caused a dose-dependent growth inhibition of the two hormone-sensitive cell lines T47D and ZR75.1 and of the two hormone-independent cell lines MDAMB-231 and BT20. Flow cytometric analysis of cells treated for 4 days with 15 and 30 microM genistein sho...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Cappelletti V,Fioravanti L,Miodini P,Di Fronzo G

    更新日期:2000-09-14 00:00:00

  • Physiological functions of Wilms' tumor 1-associating protein and its role in tumourigenesis.

    abstract::The Wilms' tumor-associated gene WT1 encodes a tumor suppressor gene, which is implicated in renal differentiation and development of adult urogenital system. Wilms' tumor 1-associating protein (WTAP) is initially identified as a nuclear protein that specifically interacts with WT1 in both in vitro and in vivo assays....

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Xie W,Wei L,Guo J,Guo H,Song X,Sheng X

    更新日期:2019-02-12 00:00:00

  • The cellular prion protein: a new partner of the lectin CBP70 in the nucleus of NB4 human promyelocytic leukemia cells.

    abstract::Prion diseases are characterized by the presence of an abnormal isoform of the cellular prion protein (PrPc) whose physiological role still remains elusive. To better understand the function of PrPc, it is important to identify the different subcellular localization(s) of the protein and the different partners with wh...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Rybner C,Finel-Szermanski S,Felin M,Sahraoui T,Rousseau C,Fournier JG,Sève AP,Botti J

    更新日期:2002-01-01 00:00:00

  • Stem cell-based cell therapy for neuroprotection in stroke: A review.

    abstract::Neurological disorders, such as stroke, are triggered by a loss of neurons and glial cells. Ischemic stroke remains a substantial problem for industrialized countries. Over the previous few decades our understanding about the pathophysiology of stroke has enhanced, nevertheless, more awareness is required to advance t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Rikhtegar R,Yousefi M,Dolati S,Kasmaei HD,Charsouei S,Nouri M,Shakouri SK

    更新日期:2019-06-01 00:00:00

  • Interaction between miRNAs and signaling cascades of Wnt pathway in chronic lymphocytic leukemia.

    abstract::Chronic lymphocytic leukemia (CLL), a severe problem all over the world and represents around 25% of all total leukemia cases, is generating the need for novel targets against CLL. Wnt signaling cascade regulates cell proliferation, differentiation, and cell death processes. Thus, any alteration of the Wnt signaling p...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Bhattacharya M,Sharma AR,Sharma G,Patra BC,Lee SS,Chakraborty C

    更新日期:2020-11-01 00:00:00

  • Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity.

    abstract::Previous work from this laboratory indicates a role for the complement component C5 in neuroprotection against excitotoxicity. In the present study, we tested the hypothesis that the C5-derived anaphylatoxin C5a protects against kainic acid (KA)-induced neurodegeneration and investigated the mechanism of C5a neuronal ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Osaka H,Mukherjee P,Aisen PS,Pasinetti GM

    更新日期:1999-06-01 00:00:00

  • Cloning and characterization of human syndecan-3.

    abstract::Syndecans are cell-surface heparan sulfate proteoglycans, which perform a variety of functions in the cell. Most important, they are co-receptors for growth factors and mediate cell-cell and cell-matrix interactions. Four syndecans (syndecan 1-4) have been described in different species. The aim of this work was the c...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Berndt C,Casaroli-Marano RP,Vilaró S,Reina M

    更新日期:2001-01-01 00:00:00

  • Catabolite repression in the gram-positive bacteria: generation of negative regulators of transcription.

    abstract::Operons subject to catabolite repression (CR) in the gram-positive bacteria appear to be transcriptionally regulated by negative acting catabolite repressors. Cis elements within the promoter regions of a few CR operons have been identified as the target sequences for these repressors. It has also been proposed that s...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Stewart GC

    更新日期:1993-01-01 00:00:00

  • Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism.

    abstract::Adult human mesenchymal stem cells (MSCs) hold promise for an increasing list of therapeutic uses due to their ease of isolation, expansion, and multi-lineage differentiation potential. To maximize the clinical potential of MSCs, the underlying mechanisms by which MSC functionality is controlled must be understood. We...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Pricola KL,Kuhn NZ,Haleem-Smith H,Song Y,Tuan RS

    更新日期:2009-10-15 00:00:00

  • Association of Hsp47, Grp78, and Grp94 with procollagen supports the successive or coupled action of molecular chaperones.

    abstract::Hsp47, Grp78, and Grp94 have been implicated with procollagen maturation events. In particular, Hsp47 has been shown to nascent procollagen alpha 1(I) chains in the course of synthesis and/or translocation into the endoplasmic reticulum (ER). Although, Hsp47 binding to gelatin and collagen has previously been suggeste...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ferreira LR,Norris K,Smith T,Hebert C,Sauk JJ

    更新日期:1994-12-01 00:00:00

  • Amyloid precursor protein expression is induced by tumor necrosis factor alpha in 3T3-L1 adipocytes.

    abstract::Amyloid precursor protein (APP) has been characterized as an adipocyte-secreted protein that might contribute to obesity-related insulin resistance, inflammation, and dementia. In the current study, regulation of APP by the proinflammatory and insulin resistance-inducing cytokine tumor necrosis factor (TNF) alpha was ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sommer G,Kralisch S,Lipfert J,Weise S,Krause K,Jessnitzer B,Lössner U,Blüher M,Stumvoll M,Fasshauer M

    更新日期:2009-12-15 00:00:00

  • Oxidative stress in cervical cancer pathogenesis and resistance to therapy.

    abstract::Cervical cancer (CC) is one of the most common cancers among females, and it is most notable in developing countries. The exact etiology of CC is poorly understood; but, smoking, oral contraceptives, immunosuppression, and infection with human papillomavirus (HPV) may increase the risk of CC. There is also an associat...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ebrahimi S,Soltani A,Hashemy SI

    更新日期:2018-11-13 00:00:00

  • Jun, Gal, Cd74, and C1qb as potential indicator for neuropathic pain.

    abstract::Neuropathic pain is a kind of pain caused by primary or secondary impairment or dysfunction of peripheral or central nervous system. Patients with neuropathic pain were often with poor clinical outcome. We screened the differentially expressed genes between sciatic nerve injury and dorsal root ganglion gene in the sha...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Yang JA,He JM,Lu JM,Jie LJ

    更新日期:2018-06-01 00:00:00