Ulnar neuropathy. Incidence, outcome, and risk factors in sedated or anesthetized patients.


BACKGROUND:Ulnar neuropathy is well-recognized as a potential complication of procedures performed on anesthetized patients. However, reported outcomes and risk factors for this problem are based on small series and anecdotes. METHODS:We retrospectively reviewed the perioperative courses of 1,129,692 consecutive patients who underwent diagnostic and noncardiac surgical procedures with concurrent anesthetic management at the Mayo Clinic from 1957 through 1991 (inclusive). The medical diagnoses of patients who had these procedures were scanned for 26 diagnoses associated with neuropathy. Persistent neuropathy of an ulnar nerve was defined as a sensory or motor deficit of greater than 3 months' duration. Risk factors anecdotally associated with persistent neuropathy were analyzed by comparing patients with an ulnar neuropathy with control subjects in a 1:3 case-control study. RESULTS:Persistent ulnar neuropathies were identified in 414 patients, a rate of 1 per 2,729 patients. Of these, 38 (9%) patients had bilateral neuropathies. Approximately equal numbers of the neuropathies included sensory loss only or mixed sensory and motor loss. Initial symptoms form most neuropathies were noted more than 24 h after the procedure. Factors associated with persistent ulnar neuropathy included male gender and a duration of hospitalization of more than 14 days (P < 0.01). Neuropathy was more likely to develop in very thin and obese patients than in patients with average body habitus. Neither the type of anesthetic technique nor the patient position was found to be associated with this neuropathy. Of the 382 patients who survived the 1st postoperative yr, 53% regained complete motor function and sensation and were asymptomatic. Of those with neuropathies persisting for more than 1 yr, most had moderate or greater disability from pain or weakness. CONCLUSIONS:These data suggest that perioperative ulnar neuropathies are associated with factors other than general anesthesia and intraoperative positioning. Men at the extremes of body habitus who have prolonged hospitalizations are particularly susceptible to development of ulnar neuropathies.






Warner MA,Warner ME,Martin JT


Has Abstract


1994-12-01 00:00:00












  • Opioid-volatile anesthetic synergy: a response surface model with remifentanil and sevoflurane as prototypes.

    abstract:BACKGROUND:Combining a hypnotic and an analgesic to produce sedation, analgesia, and surgical immobility required for clinical anesthesia is more common than administration of a volatile anesthetic alone. The aim of this study was to apply response surface methods to characterize the interactions between remifentanil a...


    pub_type: 杂志文章,随机对照试验


    authors: Manyam SC,Gupta DK,Johnson KB,White JL,Pace NL,Westenskow DR,Egan TD

    更新日期:2006-08-01 00:00:00

  • Liposome encapsulation prolongs alfentanil spinal analgesia and alters systemic redistribution in the rat.

    abstract::The effect of liposome encapsulation on the analgesia produced by intrathecally administered alfentanil was examined in the rat. In rats prepared with chronic intrathecal catheters, alfentanil in doses of 1-50 micrograms was administered intrathecally in either saline or in multilamellar liposomes (dipalmitoylphosphat...


    pub_type: 杂志文章


    authors: Bernards CM,Luger TJ,Malmberg AB,Hill HF,Yaksh TL

    更新日期:1992-09-01 00:00:00

  • Ventilatory response to CO2 following intravenous and epidural lidocaine.

    abstract::The authors determined the effects of intravenous infusion and epidural administration of lidocaine on the control of ventilation in two groups of eight healthy unpremedicated subjects. In the intravenous group, an injection of 1.5 mg/kg lidocaine was followed by an infusion at a rate of 60 micrograms X kg-1 X min-1 f...


    pub_type: 杂志文章


    authors: Labaille T,Clergue F,Samii K,Ecoffey C,Berdeaux A

    更新日期:1985-08-01 00:00:00

  • A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery.

    abstract:BACKGROUND:Vasospasm of arterial grafts represents an unpredictable complication of coronary artery surgery and may compromise myocardial revascularization, and treatment is based on empirical therapy with nitroglycerin. Because of the potential for tolerance to nitroglycerin to occur, the authors studied different vas...


    pub_type: 杂志文章


    authors: Huraux C,Makita T,Montes F,Szlam F,Levy JH

    更新日期:1998-06-01 00:00:00

  • Anesthetic interactions of midazolam and fentanyl: is there acute tolerance to the opioid?

    abstract::The anesthetic effects and interactions of midazolam and fentanyl were determined in terms of their reduction of enflurane MAC in dogs, and the effects of their specific antagonists were also investigated. Control enflurane MAC was determined by the tail clamp method in 18 mongrel dogs. Each animal then received an iv...


    pub_type: 杂志文章


    authors: Schwieger IM,Hall RI,Szlam F,Hug CC Jr

    更新日期:1989-04-01 00:00:00

  • Isoflurane depresses membrane currents associated with contraction in myocytes isolated from guinea-pig ventricle.

    abstract::The influence of isoflurane on membrane currents, action potentials, and contraction was investigated in single cells isolated from guinea-pig ventricle. Isoflurane (1.65-4.45%) reduced the action potential duration at 20% and 90% repolarization times. When step depolarizations were applied under voltage-clamp conditi...


    pub_type: 杂志文章


    authors: Terrar DA,Victory JG

    更新日期:1988-11-01 00:00:00

  • Effects of pre- and postischemic administration of thiopental on transmitter amino acid release and histologic outcome in gerbils.

    abstract:BACKGROUND:The mechanism by which barbiturates protect neurons against ischemia is unclear, particularly when they are given after ischemia or reperfusion begins. Because an excess release of excitatory neurotransmitters causes postsynaptic membrane depolarization, which triggers neuronal damage in ischemia, the effect...


    pub_type: 杂志文章


    authors: Amakawa K,Adachi N,Liu K,Ikemune K,Fujitani T,Arai T

    更新日期:1996-12-01 00:00:00

  • Relationship between oxygen uptake and mixed venous oxygen saturation in the immediate postoperative period.

    abstract:BACKGROUND:During muscular exercise, a negative correlation has been demonstrated between the value of mixed venous oxygen saturation (SvO2) and the level of muscular work, expressed at each level as the ratio of oxygen uptake (VO2) to each subject's maximal oxygen uptake (VO2max). Because the immediate postoperative p...


    pub_type: 杂志文章


    authors: Viale JP,Annat G,Lehot JJ,Quard S,Quintin L,Parlow J,Durand PG,Zabot JM,Villard J,Estanove S

    更新日期:1994-02-01 00:00:00

  • Neuroprotective effect of epidural electrical stimulation against ischemic spinal cord injury in rats: electrical preconditioning.

    abstract:BACKGROUND:Electroconvulsion therapy is likely to serve as an effective preconditioning stimulus for inducing tolerance to ischemic brain injury. The current study examines whether electrical stimuli on the spinal cord is also capable of inducing tolerance to ischemic spinal cord injury by transient aortic occlusion. ...


    pub_type: 杂志文章


    authors: Kakinohana M,Harada H,Mishima Y,Kano T,Sugahara K

    更新日期:2005-07-01 00:00:00

  • Minute ventilation and oxygen consumption during labor with epidural analgesia.

    abstract::Oxygen consumption (VO2) and minute ventilation (VE) were measured between and during uterine contractions in the first stage of labor before and after lumbar epidural analgesia (LEA) in 11 women who served as their own controls. VO2 and VE between contractions were essentially unchanged by LEA to a T10 or higher sens...


    pub_type: 杂志文章


    authors: Hägerdal M,Morgan CW,Sumner AE,Gutsche BB

    更新日期:1983-11-01 00:00:00

  • Noninvasive Tracking of Anesthesia Neurotoxicity in the Developing Rodent Brain.

    abstract:BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We...


    pub_type: 杂志文章


    authors: Makaryus R,Lee H,Robinson J,Enikolopov G,Benveniste H

    更新日期:2018-07-01 00:00:00

  • Long-term pain and activity during recovery from major thoracotomy using thoracic epidural analgesia.

    abstract:BACKGROUND:Pain following thoracotomy can persist for years with an undetermined impact on quality of life. Factors hypothesized to modulate this painful experience include analgesic regimen, gender, and type of incision. METHODS:A total of 157 generally healthy patients of both genders scheduled for segmentectomy, lo...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ochroch EA,Gottschalk A,Augostides J,Carson KA,Kent L,Malayaman N,Kaiser LR,Aukburg SJ

    更新日期:2002-11-01 00:00:00

  • Resting metabolic rate of the critically ill patient: measured versus predicted.

    abstract::Critically ill patients requiring mechanical ventilation are particularly susceptible to malnutrition. A knowledge of the energy requirements of these patients is essential in designing nutritional regimens. This study examines 45 resting energy-expenditure measurements performed in a group (n = 40) of postoperative, ...


    pub_type: 杂志文章


    authors: Weissman C,Kemper M,Askanazi J,Hyman AI,Kinney JM

    更新日期:1986-06-01 00:00:00

  • Reducing myoclonus after etomidate.

    abstract:BACKGROUND:The authors hypothesized that myoclonus after etomidate is dose-related, could be suppressed when small doses of etomidate were administered before induction, and is unassociated with seizure-like activity on electroencephalogram (EEG). METHODS:Three studies were performed. In the first study, 36 men were r...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Doenicke AW,Roizen MF,Kugler J,Kroll H,Foss J,Ostwald P

    更新日期:1999-01-01 00:00:00

  • Reference Values for Noninvasive Blood Pressure in Children during Anesthesia: A Multicentered Retrospective Observational Cohort Study.

    abstract:BACKGROUND:Although noninvasive blood pressure (NIBP) monitoring during anesthesia is a standard of care, reference ranges for blood pressure in anesthetized children are not available. We developed sex- and age-specific reference ranges for NIBP in children during anesthesia and surgery. METHODS:In this retrospective...


    pub_type: 杂志文章,多中心研究


    authors: de Graaff JC,Pasma W,van Buuren S,Duijghuisen JJ,Nafiu OO,Kheterpal S,van Klei WA

    更新日期:2016-11-01 00:00:00

  • Drug actions at mammalian motor nerve endings: the suppression of neostigmine-induced fasciculations by vecuronium and isoflurane.

    abstract::The occurrence of fasciculations following administration of agents is a well-known pharmacologic phenomenon. Using the cat soleus nerve-muscle preparation, intravenous neostigmine doses between 20-200 micrograms/kg evoked fasciculations in a dose-related manner. The data demonstrate that the fasciculations were the r...


    pub_type: 杂志文章


    authors: Baker T,Stanec A

    更新日期:1987-12-01 00:00:00

  • The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction.

    abstract::The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0.2 microgram) has been compared in an in vitro perfused and ventilated rat lung preparation in the presence and absence of agents known to block the lipoxygenase (BW755C) and/or the cyclooxygenase (...


    pub_type: 杂志文章


    authors: Marshall C,Kim SD,Marshall BE

    更新日期:1987-04-01 00:00:00

  • Intracranial pressure during hypotension and subsequent vasopressor therapy in anesthetized cats.

    abstract::The effects of vasopressor therapy on intracranial pressure (ICP) during hypotension were evaluated in 45 adult cats anesthetized with pentobarbital and hyperventilated via an endotracheal tube with nitrous oxide, 70 per cent, and oxygen, 30 per cent, to maintain Paco2 25 plus or minus 5 torr. Hypotension was induced ...


    pub_type: 杂志文章


    authors: Stullken EH Jr,Sokoll MD

    更新日期:1975-04-01 00:00:00

  • Pulmonary vasoregulation by arginine vasopressin in conscious, halothane-anesthetized, and pentobarbital-anesthetized dogs with increased vasomotor tone.

    abstract:BACKGROUND:Arginine vasopressin (AVP) is an important "stress" hormone that is known to play a key role in cardiovascular homeostasis of the systemic circulation. In contrast, the effects of AVP on the pulmonary circulation have not been extensively investigated, and the extent to which general anesthesia alters the pu...


    pub_type: 杂志文章


    authors: Trempy GA,Nyhan DP,Murray PA

    更新日期:1994-09-01 00:00:00

  • Concentration-effect relation of succinylcholine chloride during propofol anesthesia.

    abstract:BACKGROUND:The pharmacokinetics and pharmacodynamics of succinylcholine were studied simultaneously in anesthetized patients to understand why the drug has a rapid onset and short duration of action. A quantitative model describing the concentration-effect relation of succinylcholine was proposed. The correlation betwe...


    pub_type: 杂志文章


    authors: Roy JJ,Donati F,Boismenu D,Varin F

    更新日期:2002-11-01 00:00:00

  • The effects of diazepam on cerebral blood flow and oxygen consumption in rats and its synergistic interaction with nitrous oxide.

    abstract::The effects of diazepam on cerebral blood flow (CBF) and cerebral oxygen uptake (CMRO2) was studied using a 133xenon modification of the Kety-Schmidt (1948) technique in paralyzed, artifically ventilated rats with and without simultaneous administration of 70 per cent nitrous oxide. Diazepam was given iv in doses that...


    pub_type: 杂志文章


    authors: Carlsson C,Hgerdal M,Kaasik AE,Siesjö BK

    更新日期:1976-09-01 00:00:00

  • Heparinase I (neutralase) reversal of systemic anticoagulation.

    abstract:BACKGROUND:Protamine causes multiple adverse reactions. Heparinase I, a specific enzyme that inactivates heparin, is a possible alternative to protamine. In this study, the authors examined the efficacy of heparinase I to reverse heparin-induced anticoagulation in vitro and compared heparinase I to protamine as an anta...


    pub_type: 杂志文章


    authors: Michelsen LG,Kikura M,Levy JH,Lee MK,Lee KC,Zimmermann JJ,Szlam F

    更新日期:1996-08-01 00:00:00

  • Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits.

    abstract:BACKGROUND:Acid instillation leads to direct lung and to secondary systemic organ injury, probably via activated macrophages and neutrophils. This study investigated the effects of neutrophil elastase on organ injury after unilateral lung acid instillation by administrating a specific neutrophil elastase inhibitor, ONO...


    pub_type: 杂志文章


    authors: Kaneko K,Kudoh I,Hattori S,Yamada H,Ohara M,Wiener-Kronish J,Okumura F

    更新日期:1997-09-01 00:00:00

  • Anterior shift of the dominant EEG rhytham during anesthesia in the Java monkey: correlation with anesthetic potency.

    abstract::EEG amplitude dominance in awake man is posterior. During EEG monitoring in patients, the authors observed the abrupt appearance of anterior amplitude dominance during induction of anesthesia with halothane, enflurane, or thiopental. This EEG change is coincident with loss of eyelid reflex and loss of ability to respo...


    pub_type: 杂志文章


    authors: Tinker JH,Sharbrough FW,Michenfelder JD

    更新日期:1977-04-01 00:00:00

  • Protection from local anesthetic-induced convulsions by gamma-aminobutyric acid.

    abstract::The effects of gamma-aminobutyric acid (GABA) on the induction of convulsions by local anesthetics were investigated in mice and rats. Intraventricular administration of 0.8-1.6 mg GABA protected rats against convulsions induced by procaine, lidocaine, cocaine, and tetracaine in a dose-related manner. Intraperitoneal ...


    pub_type: 杂志文章


    authors: Ikeda M,Dohi T,Tsujimoto A

    更新日期:1982-05-01 00:00:00

  • The influence of lactic acid on the serum protein binding of bupivacaine: species differences.

    abstract::Various animal models have been used for studies of bupivacaine cardiovascular toxicity. These studies are difficult to relate to the clinical situation, since the disposition of bupivacaine in the various species is unknown. The serum protein binding of bupivacaine, therefore, was determined in human, sheep, monkey, ...


    pub_type: 杂志文章


    authors: Coyle DE,Denson DD,Thompson GA,Myers JA,Arthur GR,Bridenbaugh PO

    更新日期:1984-08-01 00:00:00

  • Local cerebral glucose uptake in awake and halothane-anesthetized primates.

    abstract::Local glucose consumption within specific brain structures in awake and halothane-anesthetized primates was studied using a quantitative autoradiographic technique for glucose (14C-deoxyglucose). In both awake and anesthetized animals, significant heterogeneity (one-way analysis of variance) in uptake of glucose was f...


    pub_type: 杂志文章


    authors: Shapiro HM,Greenberg JH,Reivich M,Ashmead G,Sokoloff L

    更新日期:1978-02-01 00:00:00

  • Developmental effects of neonatal isoflurane and sevoflurane exposure in rats.

    abstract:BACKGROUND:The general anesthetics, isoflurane and sevoflurane, cause developmental abnormalities in neonatal animal models via incompletely understood mechanisms. Despite many common molecular targets, isoflurane and sevoflurane exhibit substantial differences in their actions. The authors sought to determine whether ...


    pub_type: 杂志文章


    authors: Seubert CN,Zhu W,Pavlinec C,Gravenstein N,Martynyuk AE

    更新日期:2013-08-01 00:00:00

  • Effect of spinal morphine after long-term potentiation of wide dynamic range neurones in the rat.

    abstract:BACKGROUND:Studies have shown that long-term increase in the excitability of single wide dynamic range neurones in the spinal dorsal horn of rats may be induced after tetanic stimulation to the sciatic nerve. This sensory event is possibly an in vivo counterpart of long-term potentiation, described in the brain. This s...


    pub_type: 杂志文章


    authors: Rygh LJ,Green M,Athauda N,Tjølsen A,Dickenson AH

    更新日期:2000-01-01 00:00:00

  • Consumption of vitamin B12 during sodium nitroprusside administration in humans.

    abstract::In view of evidence suggesting possible participation of cobalamin in cyanide metabolism, the effects of sodium nitroprusside (SNP) infusion on blood cyanide and plasma thiocyanate levels and serum vitamin B12 levels were examined in ten patients undergoing major orthopedic procedures. Whole blood cyanide concentratio...


    pub_type: 杂志文章


    authors: Fahmy NR

    更新日期:1981-04-01 00:00:00