Abstract:
:To determine the correlation between the partial pressures of anesthetics in venous and arterial blood (Pv and Pa), and to assess whether this correlation was better than that between the partial pressure of anesthetic in alveolar gas (PA) and Pa, isoflurane (n = 4) or halothane (n = 4) was administered to eight patients undergoing surgery, and Pv, PA, and Pa were measured. PA correlated with Pa better than did Pv (R = 0.960 vs. 0.878), and there was less variability in the data. Differences between Pv and Pa increased as the relative blood flow to the hand decreased [indicated by an increasing arterial-to-venous (a-v) O2 content difference]. The difference between PA and Pa was approximately 20% of the difference between inspired gas (PI) and Pa. The differences between PA and Pa appear to be due primarily to contamination of alveolar gas by physiologic dead space gas.
journal_name
Anesthesiologyjournal_title
Anesthesiologyauthors
Carpenter RL,Eger EI 2nddoi
10.1097/00000542-198904000-00014subject
Has Abstractpub_date
1989-04-01 00:00:00pages
630-5issue
4eissn
0003-3022issn
1528-1175journal_volume
70pub_type
杂志文章相关文献
ANESTHESIOLOGY文献大全abstract:BACKGROUND:The Neurologic and Adaptive Capacity Score (NACS) is a multi-item scale that was published in 1982 to measure the effects of intrapartum drugs on the neonate. Although this scoring system has been widely used in obstetric anesthesia research, studies confirming its reliability have not been published. The pu...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章
doi:10.1097/00000542-200106000-00007
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects of sevoflurane to future offspring. As germ cells are susceptible to reprogramming by environmental factors across the lifespan, the authors hy...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000002920
更新日期:2019-11-01 00:00:00
abstract::This study was performed to determine if direct arterial dilating actions of propofol contribute to the drug's hypotensive actions. The effects of propofol were compared with those of thiopental on isolated vascular ring preparations from rat thoracic aorta and pulmonary artery. Thoracic aortic ring responses were eva...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199211000-00019
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Conflicting opinions are present in the literature regarding the origin of the negative inotropic effect of propofol on the myocardium. This study aims to resolve these discrepancies by investigating the inotropic effects of propofol the L-type calcium channels and the sodium-calcium exchanger (NCX). METHOD...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200211000-00019
更新日期:2002-11-01 00:00:00
abstract::The pharmacokinetics, biodisposition, and neuromuscular blocking properties of 3-desacetylvecuronium were studied in 17 adult cats. Animals were divided into three groups: five cats with kidney failure induced by bilateral ligation of the renal pedicles, six cats with galactosamine-induced fulminant hepatitis, and six...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199106000-00013
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Dexmedetomidine is an alpha 2 agonist with potential utility in clinical anesthesia for both its sedative and sympatholytic properties. METHODS:The pharmacokinetics and hemodynamic changes that occurred in ten healthy male volunteers were determined after administration of dexmedetomidine 2 micrograms/kg by...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199305000-00002
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Pain behavior in response to skin incision is developmentally regulated, but little is known about the underlying neuronal mechanisms. The authors hypothesize that the spatial activation and intensity of dorsal horn neuron responses to skin incision differ in immature and adult spinal cord. METHODS:Single w...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181870a32
更新日期:2008-10-01 00:00:00
abstract::The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0.2 microgram) has been compared in an in vitro perfused and ventilated rat lung preparation in the presence and absence of agents known to block the lipoxygenase (BW755C) and/or the cyclooxygenase (...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198704000-00015
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:The medical, social, and economic effects of the teaching mission on delivery of care at an academic medical center (AMC) are not fully understood. When a free-standing private practice ambulatory clinic with no teaching mission was merged into an AMC, a natural experiment was created. The authors compared p...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e31824a88d0
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Initial anesthetic-induced hypothermia results largely from core-to-peripheral redistribution of heat. Nifedipine administration may minimize hypothermia by inducing vasodilation well before induction of anesthesia. Although vasodilation would redistribute heat to peripheral tissues, thermoregulatory respons...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00000542-199401000-00019
更新日期:1994-01-01 00:00:00
abstract::Neomycin and polymyxin B produce neuromuscular blocks with distinct features by different mechanisms of action. In eight anesthetized cats the authors studied their interaction by examining the neuromuscular block produced by an equipotent mixture. Values of onset, potency, dose-response relations, duration and revers...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-197903000-00010
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Conventional cardiopulmonary resuscitation (CPR) includes 80-100/min precordial compressions with intermittent positive pressure ventilation (IPPV) after every fifth compression. To prevent gastric insufflation, chest compressions are held during IPPV if the patient is not intubated. Elimination of IPPV woul...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199904000-00022
更新日期:1999-04-01 00:00:00
abstract::The hepatic effects of repeated anesthesia of phenobarbital-induced Fischer 344 rats with 1% halothane/14% oxygen were investigated, after anesthetics were administered at either 1-day or 5-day intervals. Urinary excretion of fluoride, a product of reductive halothane metabolism, was increased in the 24-h period follo...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198709000-00013
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:Anesthetics administered to immature brains may cause histopathological changes and long-term behavioral abnormalities. The association between perinatal exposure to anesthetics during Cesarean delivery (CD) and development of learning disabilities (LD) was determined in a population-based birth cohort. MET...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0b013e3181adf481
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:General anesthetics are thought to produce their hypnotic effects mainly by acting at ligand-gated ionic channels in the central nervous system (CNS). Although it is well established that volatile anesthetics significantly modify the activity of the acetylcholine nicotinic receptors of the neuromuscular junc...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199703000-00016
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Whether intraoperative use of hydroxyethyl starch impairs kidney function remains unknown. The authors thus tested the primary hypothesis that Hextend promotes renal injury in surgical patients. Secondarily, the authors evaluated the dose-outcome relationship, in-hospital and 90-day mortality, and whether th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000000375
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Inhalational anesthetics inhibit the nitric oxide-guanylyl cyclase signaling pathway, but the site of this inhibition is not yet clear. This study was designed to test the hypothesis that receptor activation or downstream signaling events leading to nitric oxide synthase activation are important sites for th...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199605000-00018
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Systemic magnesium has been used to minimize postoperative pain with conflicting results by clinical studies. It remains unknown whether the administration of perioperative systemic magnesium can minimize postoperative pain. The objective of the current investigation was to evaluate the effect of systemic ma...
journal_title:Anesthesiology
pub_type: 杂志文章,meta分析,评审
doi:10.1097/ALN.0b013e318297630d
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Cardiac preconditioning, including that induced by halogenated anesthetics, is an innate protective mechanism against ischemia-reperfusion injury. The adenosine triphosphate-sensitive potassium (K(ATP)) channels are considered essential in preconditioning mechanism. However, it is unclear whether K(ATP) chan...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200607000-00018
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:The study evaluated the efficacy of recombinant human antithrombin (rhAT) for restoring heparin responsiveness in heparin resistant patients undergoing cardiac surgery. METHODS:This was a multicenter, randomized, double-blind, placebo-controlled study in heparin-resistant patients undergoing cardiac surgery...
journal_title:Anesthesiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00000542-200502000-00007
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Our objective was to elucidate the direct effects of fentanyl and morphine on cardiac excitation-contraction coupling using individual, field-stimulated rat ventricular myocytes. METHODS:Freshly isolated myocytes were loaded with fura-2 and field stimulated (0.3 Hz) at 28 degrees C. Amplitude and timing of ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199812000-00033
更新日期:1998-12-01 00:00:00
abstract::The effect of decreased cerebral perfusion pressure (CPP) on regional cerebral blood flow (CBF) with radiolabeled microspheres in dogs receiving either 1.4% or 2.8% isoflurane following anesthesia induction with thiopental (12 mg/kg, iv bolus) was studied. Mean arterial blood pressure (MABP), cerebrospinal fluid press...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-198810000-00008
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:Rocuronium, like other steroidal nondepolarizing muscle relaxants, may in part be eliminated by the liver. To determine the influence of liver disease on its neuromuscular blocking effect, we studied the pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis. METHODS:Eighteen patient...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199406000-00011
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:The mechanism by which barbiturates protect neurons against ischemia is unclear, particularly when they are given after ischemia or reperfusion begins. Because an excess release of excitatory neurotransmitters causes postsynaptic membrane depolarization, which triggers neuronal damage in ischemia, the effect...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199612000-00024
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Clonidine produces analgesia after spinal injection by activating alpha2-adrenergic receptors. Recently, clonidine has been demonstrated to increase spinal release of norepinephrine (NE) in vivo, in contrast to that anticipated by classic presynaptic autoinhibition. The purpose of the current study was to de...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200007000-00027
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function. The authors therefore tested the hypothesis that perioperative lidocaine infusion facilitates acute rehabilitation protocol in patients undergoing laparoscopic colectomy. METHODS:Forty patients scheduled ...
journal_title:Anesthesiology
pub_type: 杂志文章,随机对照试验
doi:10.1097/00000542-200701000-00007
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The objective of the survey was to assess the status of acute pain management in U.S. hospitals and attitudes of adults in the U.S. toward postoperative pain management, information that has not been previously available. METHODS:Two telephone questionnaire surveys were conducted U.S. hospital participants,...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199511000-00023
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Although halothane reduces digitalis toxicity, other anesthetics, notably cyclopropane, increase toxicity. This study determined the effects of isoflurane on digitalis toxicity in isolated cardiac tissue and compared these effects with those of halothane. METHODS:Standard microelectrode techniques were used...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-199412000-00026
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Despite improvements in neonatal heart surgery, neurologic complications continue to occur from low-flow cardiopulmonary bypass (LF-CPB) and deep hypothermic circulatory arrest (DHCA). Desflurane confers neuroprotection against ischemia at normothermia and for DHCA. This study compared neurologic outcome of ...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/00000542-200212000-00026
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Dexmedetomidine is only approved for use in humans as an intravenous medication. An oral formulation may broaden the use and benefits of dexmedetomidine to numerous care settings. The authors hypothesized that oral dexmedetomidine (300 mcg to 700 mcg) would result in plasma concentrations consistent with sed...
journal_title:Anesthesiology
pub_type: 杂志文章
doi:10.1097/ALN.0000000000003568
更新日期:2020-12-01 00:00:00