Comparison of enflurane, halothane, and isoflurane for diagnostic and therapeutic procedures in children with malignancies.

abstract：BACKGROUND:Sugammadex (Org 25969) forms a complex with steroidal neuromuscular blocking agents, thereby reversing neuromuscular block. This study investigated the dose-response relation, safety, and pharmacokinetics of sugammadex to reverse rocuronium-induced block. METHODS:Twenty-seven male surgical patients aged 18-...

journal_title：Anesthesiology

authors： Sorgenfrei IF,Norrild K,Larsen PB,Stensballe J,Ostergaard D,Prins ME,Viby-Mogensen J

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:A decrease in radial artery blood pressure relative to central arterial blood pressure is commonly associated with the rewarming phase of cardiopulmonary bypass. Decreased hand vascular resistance has been suggested as a possible mechanism. Although decreased blood viscosity due to hemodilution may contribut...

journal_title：Anesthesiology

authors： Hynson JM,Sessler DI,Moayeri A,Katz JA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Isoflurane induces cell death in neurons undergoing synaptogenesis via increased production of pro-brain-derived neurotrophic factor (proBDNF) and activation of postsynaptic p75 neurotrophin receptor (p75). Astrocytes express p75, but their role in neuronal p75-mediated cell death remains unclear. The author...

journal_title：Anesthesiology

authors： Stary CM,Sun X,Giffard RG

更新日期：2015-10-01 00:00:00

abstract：:No significant change in pseudocholinesterase levels was observed in random specimens of whole blood stored for as long as 30 days. Levels in plasma anticoagulated with heparin or ethylenediaminetetraacetic acid declined only slightly. Therefore, massive transfusions do not contraindicate succinylcholine administratio...

journal_title：Anesthesiology

authors： Lanks KW,Sklar GS

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:Load-dependent impairment of left ventricular (LV) function was observed after leg elevation in a subgroup of coronary surgery patients. The present study investigated underlying mechanisms by comparing hemodynamic effects of an increase in LV systolic pressures with leg elevation to effects of a similar inc...

journal_title：Anesthesiology

authors： De Hert SG,Gillebert TC,Ten Broecke PW,Moulijn AC

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:In patients with acute respiratory distress syndrome (ARDS), the ventilatory approach is based on tidal volume (VT) of 10-15 ml/kg and positive end-expiratory pressure (PEEP). To avoid further pulmonary injury, decreasing VT and allowing PaCO2 to increase (permissive hypercapnia) has been suggested. Effects ...

journal_title：Anesthesiology

authors： Ranieri VM,Mascia L,Fiore T,Bruno F,Brienza A,Giuliani R

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Densities in dependent lung regions worsen oxygenation in patients with acute respiratory distress syndrome. Identification of these densities requires examination using computed tomography (CT). In this study, the authors evaluated the use of transesophageal echocardiography (TEE) to estimate densities in t...

journal_title：Anesthesiology

authors： Tsubo T,Sakai I,Suzuki A,Okawa H,Ishihara H,Matsuki A

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Rapid elimination of nitrous oxide from the lungs at the end of inhalational anesthesia dilutes alveolar oxygen, producing "diffusion hypoxia." A similar dilutional effect on accompanying volatile anesthetic agent has not been evaluated and may impact the speed of emergence. METHODS:Twenty patients undergoi...

journal_title：Anesthesiology

authors： Peyton PJ,Chao I,Weinberg L,Robinson GJ,Thompson BR

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Obesity is an important risk factor for surgical site infections. The incidence of surgical wound infections is directly related to tissue perfusion and oxygenation. Fat tissue mass expands without a concomitant increase in blood flow per cell, which might result in a relative hypoperfusion with decreased ti...

journal_title：Anesthesiology

authors： Kabon B,Nagele A,Reddy D,Eagon C,Fleshman JW,Sessler DI,Kurz A

更新日期：2004-02-01 00:00:00

abstract：:Arteriolar diameters and tissue oxygen tensions were measured in the cremaster muscles of 68 hemorrhaged rats which were anesthetized with either intramuscular ketamine, 125 mg/kg, plus 30 mg/kg supplements as needed, or enflurane, 2.2% inspired. Animals breathed room air, or room air plus enflurane, throughout the ex...

journal_title：Anesthesiology

authors： Longnecker DE,Ross DC,Silver IA

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Blood conservation techniques are being increasingly used because of the increased cost and lack of availability of allogeneic blood. Cell salvage offers great blood savings opportunities but is thought to be contraindicated in a number of areas (e.g., blood contaminated with bacteria). Several outcome studi...

journal_title：Anesthesiology

authors： Waters JH,Tuohy MJ,Hobson DF,Procop G

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Factor VII is the most affected clotting factor during the early phase of warfarin therapy. An international normalized ratio (INR) of more than 1.4 is considered unsafe for epidural catheter placement or removal, according to the American Society of Regional Anesthesia and Pain Medicine. The authors tested ...

journal_title：Anesthesiology

authors： Benzon HT,Avram MJ,Benzon HA,Kirby-Nolan M,Nader A

更新日期：2010-02-01 00:00:00

abstract：:To study the effect of halothane on the coronary circulation, the circumflex diastolic coronary vascular resistance was measured in the working heart and total mean coronary resistance (TCR) in the isolated nonworking heart of the dog during administration of 100 per cent oxygen and during administration of 2--3 per c...

journal_title：Anesthesiology

authors： Domenech RJ,Macho P,Valdes J,Penna M

更新日期：1977-04-01 00:00:00

abstract：:Volatile anesthetics inhibit phagocytic cell function, yet little is known about their effects on target tissues or on the target tissue response to stimulated phagocytes. Experiments were performed to determine how exposure to halothane and isoflurane changes rat pulmonary artery endothelial cell (RPAEC) viability in...

journal_title：Anesthesiology

authors： Shayevitz JR,Varani J,Ward PA,Knight PR

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Sweating, vasoconstriction, and shivering have been observed during general anesthesia. Among these, vasoconstriction is especially important because-once triggered-it minimizes further hypothermia. Surprisingly, the core-temperature plateau associated with vasoconstriction appears to preserve core temperatu...

journal_title：Anesthesiology

authors： Plattner O,Semsroth M,Sessler DI,Papousek A,Klasen C,Wagner O

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Protamine causes multiple adverse reactions. Heparinase I, a specific enzyme that inactivates heparin, is a possible alternative to protamine. In this study, the authors examined the efficacy of heparinase I to reverse heparin-induced anticoagulation in vitro and compared heparinase I to protamine as an anta...

journal_title：Anesthesiology

authors： Michelsen LG,Kikura M,Levy JH,Lee MK,Lee KC,Zimmermann JJ,Szlam F

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Because tactile evaluation is the most common form of clinical neuromuscular monitoring, this study examines the relative efficacy of antagonizing residual block at different levels of recovery of the tactile train-of-four (TOF) response. METHODS:Anesthesia was induced in 64 adults with 2-5 microg/kg fentan...

journal_title：Anesthesiology

authors： Kirkegaard H,Heier T,Caldwell JE

更新日期：2002-01-01 00:00:00

abstract：:The effects of local infiltration anesthesia, brachial plexus blockade, isoflurane, or halothane anesthesia on blood flow through the brachial artery and through a newly created forearm arteriovenous fistula (AVF) were compared in 36 patients with endstage renal failure. Brachial artery blood flow was measured at two ...

journal_title：Anesthesiology

authors： Mouquet C,Bitker MO,Bailliart O,Rottembourg J,Clergue F,Montejo LS,Martineaud JP,Viars P

更新日期：1989-06-01 00:00:00

abstract：:A carcinogen bioassay of enflurane was performed in Swiss/ICR mice. Two groups of weanling mice, each of 125 males and 125 females, were exposed to eigher a maximum tolerated dose of enflurane, 3000 ppm (0.3 per cent v/v) or compressed air for 4 hs per day, 5 days per week. After 52 weeks exposure, 25 males and 25 fem...

journal_title：Anesthesiology

authors： Baden JM,Egbert B,Mazze RI

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Isoflurane induces cell apoptosis by an unknown mechanism. The authors hypothesized that isoflurane activates inositol 1,4,5-trisphosphate (IP3) receptors on the endoplasmic reticulum (ER) membrane, causing excessive calcium release, triggering apoptosis. METHODS:The authors determined isoflurane-induced cy...

journal_title：Anesthesiology

authors： Wei H,Liang G,Yang H,Wang Q,Hawkins B,Madesh M,Wang S,Eckenhoff RG

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The effects of anesthetics on ischemia-induced ventricular arrhythmias remain poorly studied. This study investigated the effects of propofol and sevoflurane on the survival rate and morbidity as a result of ventricular arrhythmias, and defined a possible mechanism for the arrhythmogenic properties of anesth...

journal_title：Anesthesiology

authors： Hirata N,Kanaya N,Kamada N,Kimura S,Namiki A

更新日期：2009-01-01 00:00:00

abstract：:Positive pressure ventilation can affect hemodynamic stability by neuroreflex-mediated activity. Inhalational anesthesia is known to attenuate the arterial baroreflex function; however, little information is known about the effect of volatile anesthetics on the lung inflation reflex. The influence of isoflurane on sta...

journal_title：Anesthesiology

authors： Cheng EY,Kay J,Hoka S,Bosnjak ZJ,Coon RL,Kampine JP

更新日期：1992-06-01 00:00:00

abstract：:In a recent editorial, Kapur described perioperative nausea and vomiting as "the big 'little problem' following ambulatory surgery."257 Although the actual morbidity associated with nausea is relatively low in health outpatients, it should not be considered an unavoidable part of the perioperative experience. The avai...

journal_title：Anesthesiology

authors： Watcha MF,White PF

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Valdecoxib and its intravenous prodrug parecoxib are reported to increase thromboembolic risk after coronary artery bypass grafting. The authors conducted a randomized trial to examine their safety and analgesic efficacy in patients recovering from major noncardiac surgical procedures. METHODS:The trial was...

journal_title：Anesthesiology

authors： Nussmeier NA,Whelton AA,Brown MT,Joshi GP,Langford RM,Singla NK,Boye ME,Verburg KM

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The mechanism of the protective actions of volatile anesthetics in ischemic myocardium has not been clearly elucidated. The role of myocardial adenosine triphosphate-regulated potassium (KATP) channels in isoflurane-induced enhancement of recovery of regional contractile function after multiple brief occlusi...

journal_title：Anesthesiology

authors： Kersten JR,Schmeling TJ,Hettrick DA,Pagel PS,Gross GJ,Warltier DC

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:There is an increasing interest in the use of dexmedetomidine for anesthesia and sedation. Here, we used the mouse organotypic hippocampal slice culture to investigate whether dexmedetomidine exhibits postconditioning properties against oxygen and glucose deprivation (OGD). The role of the focal adhesion and...

journal_title：Anesthesiology

authors： Dahmani S,Rouelle D,Gressens P,Mantz J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:In spinal anesthesia, often a large interindividual variability in analgesic response is observed after administration of a certain fixed dose of anesthetic to a patient population. To improve therapeutic outcome it is important to characterize the variability in response by means of a population model (e.g....

journal_title：Anesthesiology

authors： Schnider TW,Minto CF,Bruckert H,Mandema JW

更新日期：1996-09-01 00:00:00

abstract：:The effects of morphine, halothane, and their various combinations on the purposeful movement (PM) response and the heart rate (HR) increase caused by noxious stimulation were studied in 250 rat experiments. Doses that block the PM and HR responses for the single agent and for combinations were determined with a probi...

journal_title：Anesthesiology

authors： Kissin I,Kerr CR,Smith LR

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Whether coronary steal is induced by inhaled anesthetic agents remains controversial in part because multiple factors determine collateral blood flow. METHODS:We used an established model to determine how halothane, isoflurane, and desflurane affect the hemodynamic determinants of coronary collateral blood ...

journal_title：Anesthesiology

authors： Mignella R,Buffington CW

更新日期：1995-10-01 00:00:00

abstract：:Using magnetic resonance spectroscopy, the authors tested whether cerebral concentrations of inhaled anesthetics do not increase proportionately at inspired concentrations exceeding 3% 1) because anesthetics bind to and saturate specific sites in the brain or 2) because anesthetic-induced depression of ventilation lim...

journal_title：Anesthesiology

authors： Lockhart SH,Cohen Y,Yasuda N,Kim F,Litt L,Eger EI 2nd,Chang LH,James T

更新日期：1990-09-01 00:00:00