Abstract:
:The efficacy and safety of oral nadolol in supraventricular tachycardia were evaluated prospectively in 27 children (median age 5.5 years). Fifteen patients had an unsuccessful trial of digoxin therapy. Intravenous nadolol was given to seven patients during electrophysiologic study; five of these had an excellent response and two had a partial response (25% decrease in tachycardia rate). Six of these patients had a similar response to oral nadolol. Twelve patients received both propranolol and nadolol. Among six patients, intravenous propranolol was successful in four and unsuccessful in two; all six had a similar response to oral nadolol. With oral propranolol, tachycardia was well controlled in four patients and persistent in two; five of five patients had a similar response to oral nadolol. Twenty-six patients were treated with oral nadolol; the arrhythmia was well controlled in 23, 2 had recurrent tachycardia and 1 patient had tachycardia at a 25% slower rate. The effective dose of nadolol ranged between 0.5 and 2.5 mg/kg body weight once daily (median dose 1 mg/kg per day). During follow-up (3 to 36 months), compliance and tolerance were excellent; excluding 2 patients with reactive airway disease who developed wheezing, only 3 (12%) of 24 had side effects necessitating a change in drug therapy. Once a day nadolol is a safe and effective agent in the management of supraventricular tachycardia in children. Its long-term efficacy can be predicted by the short-term response to intravenous nadolol or propranolol during programmed electrophysiologic study.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Mehta AV,Chidambaram Bdoi
10.1016/s0735-1097(10)80283-9subject
Has Abstractpub_date
1992-03-01 00:00:00pages
630-5issue
3eissn
0735-1097issn
1558-3597pii
S0735-1097(10)80283-9journal_volume
19pub_type
临床试验,杂志文章abstract:OBJECTIVES:In this study, our goal was to determine if human resistin plays a role in regulating the uptake of atherogenic low-density lipoproteins in human hepatocytes. BACKGROUND:Serum levels of resistin, an adipose tissue-derived adipokine, are increased in human obesity and are positively correlated with atheroscl...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/j.jacc.2011.11.064
更新日期:2012-05-08 00:00:00
abstract:BACKGROUND:Coronary computed tomography angiography (CTA) is increasingly being used for evaluation of coronary artery disease (CAD). As a result of the widely reported potential of carcinogenic risk from x-ray based examinations, many strategies have been developed for dose reduction with CTA. OBJECTIVES:The purpose ...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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更新日期:2014-08-26 00:00:00
abstract::The current study determined the effectiveness of nicardipine, a 1,4-dihydropyridine calcium antagonist, in preserving reperfused myocardium in a cat model of temporary coronary occlusion and ascertained if replenishment of myocardial phosphate stores during reperfusion as defined by phosphorus-31 nuclear magnetic res...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/0735-1097(90)90328-m
更新日期:1990-12-01 00:00:00
abstract::Progress in tissue characterization of myocardium with ultrasound suggests that quantitative recognition of ischemic or scarred tissue will be achieved. Despite the increasing recognition and importance of cardiomyopathy, its diagnosis generally requires invasive procedures such as cardiac catheterization and biopsy. ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(84)80323-x
更新日期:1984-07-01 00:00:00
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doi:10.1016/S0735-1097(96)00315-4
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVES:We examined the association between diastolic function and left atrial volume indexed to body surface area (LAVi) in a population-based study. BACKGROUND:Atrial enlargement has been suggested as a marker of the severity and duration of diastolic dysfunction (DD). However, the association between DD and atri...
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更新日期:2005-01-04 00:00:00
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doi:10.1016/j.jacc.2007.03.036
更新日期:2007-07-24 00:00:00
abstract::Electrophysiologic and histologic studies were performed on Langendorff-perfused human hearts from patients who underwent heart transplantation because of extensive infarction. In nine hearts, 15 sustained ventricular tachycardias could be induced by programmed stimulation. In all hearts, mapping of epicardial and end...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(90)92832-m
更新日期:1990-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2011-02-08 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(88)90181-7
更新日期:1988-01-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(88)90290-2
更新日期:1988-06-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(90)90370-5
更新日期:1990-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2015-08-04 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jacc.2015.04.071
更新日期:2015-07-14 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0735-1097(96)00438-x
更新日期:1997-01-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(98)00627-5
更新日期:1999-03-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(89)90268-4
更新日期:1989-04-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究
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更新日期:2000-10-01 00:00:00
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更新日期:2002-11-06 00:00:00
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doi:10.1016/s0735-1097(00)00819-6
更新日期:2000-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0735-1097(85)80250-3
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journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章
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更新日期:1990-12-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2007-01-02 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1999-02-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1987-11-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(95)80002-x
更新日期:1995-08-01 00:00:00
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更新日期:2021-01-05 00:00:00
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更新日期:1995-06-01 00:00:00
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更新日期:1994-11-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0735-1097(84)80155-2
更新日期:1984-12-01 00:00:00