Abstract：
OBJECTIVES:To show the effect of clinical, angio and demographic traits on late survival of Coronary Artery Surgery Study (CASS) patients following coronary artery bypass grafting (CABG) and introduce Hazard Function analysis to CASS survival data. METHODS:Patients were reached by mail survey with 94% response. By National Death Index, vital status was obtained in 99.7% (n = 8221) with a mean follow up of 15 years. Cox proportional hazard and Blackstone Hazard Function regressions were used to assess effects of preoperative traits. RESULTS:Ninety percent of patients were alive at 5, 74% at 10 and 56% at 15 years. Of those age 65 and age 75 at operation, 74% and 59% were living at 10 years and 54% and 33% at 15 years (now age 90), survival exceeding the matched U.S. population. Hazard Function falls rapidly after CABG to 9 to 12 months, then rises, doubling by 15 years. Young patients, below age 35, had lower late survival. The time-segmented Cox model (divided at time suggested by the Hazard Function) identified traits showing predictive power early, throughout and late. Female sex, small body surface, ischemic symptoms and emergency status affected survival early. Heavier weight, infarct(s), diuretics, diabetes, smoking, left main and LAD stenosis and use of vein grafts only increased hazard late only. CONCLUSIONS:There are still lessons from the CASS database. CABG in the elderly is supported by the survival pattern of our patients age 75 at operation. Time-segmented Cox analysis and Hazard Function analysis separate baseline variables into those that predict early mortality and those that predict long survival.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Myers WO,Blackstone EH,Davis K,Foster ED,Kaiser GCdoi
10.1016/s0735-1097(98)00563-4subject
Has Abstractpub_date
1999-02-01 00:00:00pages
488-98issue
2eissn
0735-1097issn
1558-3597pii
S0735109798005634journal_volume
33pub_type
临床试验,杂志文章,多中心研究abstract：BACKGROUND:Exercise has been proposed as a trigger for arrhythmogenic right ventricular cardiomyopathy (ARVC) phenotype manifestation; however, research is hampered by the limited availability of animal models in which disease-associated mutations can be tested. OBJECTIVES:This study evaluated the impact of exercise o...
journal_title：Journal of the American College of Cardiology
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doi：10.1016/j.jacc.2015.01.045
更新日期：2015-04-14 00:00:00
abstract：:The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Trial randomized 368 patients with symptoms and signs of acute myocardial infarction of less than 6 h duration to either conventional care or 1.5 million units of intravenous streptokinase. The mean time to randomization was 209 min and 52...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1988-04-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/0735-1097(95)00124-i
更新日期：1995-07-01 00:00:00
abstract：:Resistance of coronary occlusive thrombus to thrombolytic therapy, found in some patients with acute myocardial infarction, may be due to the presence of platelet-rich coronary clot. Reperfusion therapy in such patients may require the development and evaluation of alternative strategies in animal models. Therefore, p...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(90)90327-l
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2004.02.042
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abstract：:The prevalence of atrial fibrillation (AF) in end-stage renal failure is high, with an increased risk of stroke among these patients with AF compared with the AF population without severe renal impairment. Many trials have shown the net clinical benefit of oral anticoagulation therapy for primary and secondary prevent...
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pub_type： 杂志文章,评审
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journal_title：Journal of the American College of Cardiology
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doi：10.1016/j.jacc.2005.11.083
更新日期：2006-05-16 00:00:00
abstract：OBJECTIVES:This study was designed to characterize the nature and time course of carboxy-terminal lysine cleavages from the tissue isoform of MB creatine kinase (CK) in vivo. BACKGROUND:Rapid conversion of the tissue isoform of MM CK to two additional circulating isoforms with one or both carboxy-terminal lysines clea...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
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journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章
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更新日期：1993-10-01 00:00:00
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journal_title：Journal of the American College of Cardiology
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更新日期：2013-12-03 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(98)00625-1
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(95)00250-8
更新日期：1995-09-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0735-1097(94)90099-x
更新日期：1994-11-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
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更新日期：1984-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0735-1097(86)80381-3
更新日期：1986-11-01 00:00:00
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journal_title：Journal of the American College of Cardiology
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journal_title：Journal of the American College of Cardiology
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journal_title：Journal of the American College of Cardiology
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journal_title：Journal of the American College of Cardiology
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更新日期：2002-08-21 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2016-08-30 00:00:00
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journal_title：Journal of the American College of Cardiology
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更新日期：2015-09-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2015.05.020
更新日期：2015-07-21 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-08-20 00:00:00
abstract：OBJECTIVES:We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI). BACKGROUND:Renal insufficiency and renal failure (RF) have been associated with increased cardiovascula...
journal_title：Journal of the American College of Cardiology
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更新日期：2003-07-02 00:00:00
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journal_title：Journal of the American College of Cardiology
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doi：10.1016/j.jacc.2006.06.048
更新日期：2006-10-03 00:00:00
