abstract：:Vitamin D and calcium supplements are commonly used, often together, to optimize bone health. Multiple observational studies have linked low serum 25-hydroxyvitamin D concentrations with increased cardiovascular risk. However, subsequent randomized controlled trials (RCTs) failed to demonstrate cardiovascular benefit ...

journal_title：Journal of the American College of Cardiology

authors： Michos ED,Cainzos-Achirica M,Heravi AS,Appel LJ

更新日期：2021-02-02 00:00:00

abstract：BACKGROUND:Tricuspid regurgitation (TR) is a prevalent disease with limited treatment options. OBJECTIVES:This is the first 30-day report of the U.S. single-arm, multicenter, prospective CLASP TR early feasibility study of the PASCAL transcatheter valve repair system in the treatment of TR. METHODS:Patients with symp...

journal_title：Journal of the American College of Cardiology

authors： Kodali S,Hahn RT,Eleid MF,Kipperman R,Smith R,Lim DS,Gray WA,Narang A,Pislaru SV,Koulogiannis K,Grayburn P,Fowler D,Hawthorne K,Dahou A,Deo SH,Vandrangi P,Deuschl F,Mack MJ,Leon MB,Feldman T,Davidson CJ,CLASP TR

更新日期：2021-02-02 00:00:00

abstract：OBJECTIVES:This study sought to evaluate the ability of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab to reduce the risk of complex coronary atherosclerosis requiring revascularization. BACKGROUND:PCSK9 inhibitors induce plaque regression and reduce the risk of coronary revascularizati...

journal_title：Journal of the American College of Cardiology

authors： Oyama K,Furtado RHM,Fagundes A Jr,Zelniker TA,Tang M,Kuder J,Murphy SA,Hamer A,Wang H,Keech AC,Giugliano RP,Sabatine MS,Bergmark BA

更新日期：2021-01-26 00:00:00

abstract：BACKGROUND:Short-term exposure to ambient air pollution has been linked to occurrence of myocardial infarction (MI); however, only a limited number of studies investigated its association with death from MI, and the results remain inconsistent. OBJECTIVES:This study sought to investigate the association of short-term ...

journal_title：Journal of the American College of Cardiology

authors： Liu Y,Pan J,Fan C,Xu R,Wang Y,Xu C,Xie S,Zhang H,Cui X,Peng Z,Shi C,Zhang Y,Sun H,Zhou Y,Zhang L

更新日期：2021-01-26 00:00:00

abstract：BACKGROUND:Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation. OBJECTIVES:The purpose of this study ...

journal_title：Journal of the American College of Cardiology

authors： Luo J,le Cessie S,van Heemst D,Noordam R

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:The risk of sudden cardiac death (SCD) is high early after myocardial infarction (MI). Current knowledge and guidelines mainly rely on results from older clinical trials and registry studies. Left ventricular ejection fraction (LVEF) alone has not been proven a reliable predictor of SCD. OBJECTIVES:This stu...

journal_title：Journal of the American College of Cardiology

authors： Faxén J,Jernberg T,Hollenberg J,Gadler F,Herlitz J,Szummer K

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:Microvascular dysfunction plays an important role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). However, no mechanistic link between systemic microvasculature and congestion, a central feature of the syndrome, has yet been investigated. OBJECTIVES:This study aimed to investi...

journal_title：Journal of the American College of Cardiology

authors： Rossitto G,Mary S,McAllister C,Neves KB,Haddow L,Rocchiccioli JP,Lang NN,Murphy CL,Touyz RM,Petrie MC,Delles C

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Pulmonary vascular disease, pulmonary endothelial dysfunction, liver fibrosis, renal disease, and exercise intolerance are common in adults with Fontan physiology. Although the pathophysiologic mechanisms linking these phenomena have been studied, certain aspects are not well understood. OBJECTIVES:This stu...

journal_title：Journal of the American College of Cardiology

authors： Egbe AC,Miranda WR,Anderson JH,Borlaug BA

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND:Pulmonary hypertension worsens prognosis in patients with heart failure (HF) and secondary mitral regurgitation (SMR). OBJECTIVES:This study sought to determine whether baseline pulmonary hypertension influences outcomes of transcatheter mitral valve repair (TMVr) in patients with HF with SMR. METHODS:In t...

journal_title：Journal of the American College of Cardiology

authors： Ben-Yehuda O,Shahim B,Chen S,Liu M,Redfors B,Hahn RT,Asch FM,Weissman NJ,Medvedofsky D,Puri R,Kapadia S,Sannino A,Grayburn P,Kar S,Lim S,Lindenfeld J,Abraham WT,Mack MJ,Stone GW

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Although oral P2Y12 inhibitors are key in the management of patients with non-ST-segment elevation acute coronary syndrome, the optimal timing of their administration is not well defined. OBJECTIVES:The purpose of this study was to compare downstream and upstream oral P2Y12 inhibitors administration strateg...

journal_title：Journal of the American College of Cardiology

authors： Tarantini G,Mojoli M,Varbella F,Caporale R,Rigattieri S,Andò G,Cirillo P,Pierini S,Santarelli A,Sganzerla P,Cacciavillani L,Babuin L,De Cesare N,Limbruno U,Massoni A,Rognoni A,Pavan D,Belloni F,Cernetti C,Favero L,

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:The prevalence of obstructive coronary artery disease (CAD) in symptomatic patients referred for diagnostic testing has declined, warranting optimization of individualized diagnostic strategies. OBJECTIVES:This study sought to present a simple, clinically applicable tool enabling estimation of the likelihoo...

journal_title：Journal of the American College of Cardiology

authors： Winther S,Schmidt SE,Mayrhofer T,Bøtker HE,Hoffmann U,Douglas PS,Wijns W,Bax J,Nissen L,Lynggaard V,Christiansen JJ,Saraste A,Bøttcher M,Knuuti J

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:The underlying etiology of ischemic stroke remains unknown in up to 30% of patients. OBJECTIVES:This study explored the causal role of complicated (American Heart Association-lesion type VI) nonstenosing carotid artery plaques (CAPs) in cryptogenic stroke (CS). METHODS:CAPIAS (Carotid Plaque Imaging in Acu...

journal_title：Journal of the American College of Cardiology

authors： Kopczak A,Schindler A,Bayer-Karpinska A,Koch ML,Sepp D,Zeller J,Strecker C,Hempel JM,Yuan C,Malik R,Wollenweber FA,Boeckh-Behrens T,Cyran CC,Helck A,Harloff A,Ziemann U,Poli S,Poppert H,Dichgans M,Saam T

更新日期：2020-11-10 00:00:00

abstract：:Intermediate-risk (submassive) pulmonary embolism (PE) describes normotensive patients with evidence of right ventricular compromise, whereas high-risk (massive) PE comprises those who have experienced hemodynamic decompensation with hypotension, cardiogenic shock, or cardiac arrest. Together, these 2 syndromes repres...

journal_title：Journal of the American College of Cardiology

authors： Piazza G

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Myocardial injury is frequent among patients hospitalized with coronavirus disease-2019 (COVID-19) and is associated with a poor prognosis. However, the mechanisms of myocardial injury remain unclear and prior studies have not reported cardiovascular imaging data. OBJECTIVES:This study sought to characteriz...

journal_title：Journal of the American College of Cardiology

authors： Giustino G,Croft LB,Stefanini GG,Bragato R,Silbiger JJ,Vicenzi M,Danilov T,Kukar N,Shaban N,Kini A,Camaj A,Bienstock SW,Rashed ER,Rahman K,Oates CP,Buckley S,Elbaum LS,Arkonac D,Fiter R,Singh R,Li E,Razuk V,Ro

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Currently, there is a paucity of information on surgical explantation after transcatheter aortic valve replacement (TAVR). OBJECTIVES:The purpose of this study was to examine the incidence, patient characteristics, predictors, and outcomes of surgical explantation after TAVR using a population-based, nation...

journal_title：Journal of the American College of Cardiology

authors： Hirji SA,Percy ED,McGurk S,Malarczyk A,Harloff MT,Yazdchi F,Sabe AA,Bapat VN,Tang GHL,Bhatt DL,Thourani VH,Leon MB,O'Gara P,Shah PB,Kaneko T

更新日期：2020-10-20 00:00:00

abstract：:Viral respiratory infections are risk factors for cardiovascular disease (CVD). Underlying CVD is also associated with an increased risk of complications following viral respiratory infections, including increased morbidity, mortality, and health care utilization. Globally, these phenomena are observed with seasonal i...

journal_title：Journal of the American College of Cardiology

authors： Behrouzi B,Araujo Campoverde MV,Liang K,Talbot HK,Bogoch II,McGeer A,Fröbert O,Loeb M,Vardeny O,Solomon SD,Udell JA

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Gadolinium-based contrast agents were not approved in the United States for detecting coronary artery disease (CAD) prior to the current studies. OBJECTIVES:The purpose of this study was to determine the sensitivity and specificity of gadobutrol for detection of CAD by assessing myocardial perfusion and lat...

journal_title：Journal of the American College of Cardiology

authors： Arai AE,Schulz-Menger J,Berman D,Mahrholdt H,Han Y,Bandettini WP,Gutberlet M,Abraham A,Woodard PK,Selvanayagam JB,McCann GP,Hamilton-Craig C,Schoepf UJ,San Tan R,Kramer CM,Friedrich MG,Haverstock D,Liu Z,Brueggenwerth

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:The recommended doses for direct oral anticoagulants (DOACs) to prevent stroke and systemic embolism (SE) in patients with atrial fibrillation (AF) are described in specific regulatory authority approvals. OBJECTIVES:The impact of DOAC dosing, according to the recommended guidance on all-cause mortality, st...

journal_title：Journal of the American College of Cardiology

authors： Camm AJ,Cools F,Virdone S,Bassand JP,Fitzmaurice DA,Arthur Fox KA,Goldhaber SZ,Goto S,Haas S,Mantovani LG,Kayani G,Grierson Turpie AG,Antoon Verheugt FW,Kakkar AK,GARFIELD-AF Investigators.

更新日期：2020-09-22 00:00:00

abstract：BACKGROUND:Paroxysmal and permanent atrial fibrillation (AF) are common in heart failure with preserved ejection fraction (HFpEF). OBJECTIVES:This study sought to determine the implications of left atrial (LA) myopathy and dysrhythmia across the spectrum of AF burden in HFpEF. METHODS:Consecutive patients with HFpEF ...

journal_title：Journal of the American College of Cardiology

authors： Reddy YNV,Obokata M,Verbrugge FH,Lin G,Borlaug BA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Limited data are available regarding the risk for adverse clinical events with concomitant nonsteroidal anti-inflammatory drug (NSAID) treatment after myocardial infarction (MI). OBJECTIVES:The aim of this study was to investigate the risk for cardiovascular and bleeding events according to groups of antith...

journal_title：Journal of the American College of Cardiology

authors： Kang DO,An H,Park GU,Yum Y,Park EJ,Park Y,Jang WY,Kim W,Choi JY,Roh SY,Na JO,Kim JW,Kim EJ,Rha SW,Park CG,Seo HS,Choi CU

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:Bacterial growth in cultures of resected heart valves of patients with infective endocarditis (IE) is influenced by pre-operative antibiotic treatment (preop-AT). OBJECTIVES:This study sought to evaluate the time dependency of valve culture results (positive valve culture [PVC] vs. negative valve culture) o...

journal_title：Journal of the American College of Cardiology

authors： Gisler V,Dürr S,Irincheeva I,Limacher A,Droz S,Carrel T,Englberger L,Sendi P

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:This study demonstrated the safety and effectiveness of baroreflex activation therapy (BAT) in patients with heart failure with reduced ejection fraction (HFrEF). OBJECTIVES:The BeAT-HF (Baroreflex Activation Therapy for Heart Failure) trial was a multicenter, prospective, randomized, controlled trial; subj...

journal_title：Journal of the American College of Cardiology

authors： Zile MR,Lindenfeld J,Weaver FA,Zannad F,Galle E,Rogers T,Abraham WT

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:Reliable methods for predicting myocardial infarction in patients with established coronary artery disease are lacking. Coronary 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) provides an assessment of atherosclerosis activity. OBJECTIVES:This study assessed whether 18F-NaF PET predicts my...

journal_title：Journal of the American College of Cardiology

authors： Kwiecinski J,Tzolos E,Adamson PD,Cadet S,Moss AJ,Joshi N,Williams MC,van Beek EJR,Dey D,Berman DS,Newby DE,Slomka PJ,Dweck MR

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Graft patency is one of the major determinants of long-term outcome following coronary artery bypass graft surgery (CABG). Biomarkers, if indicative of the underlying pathophysiological mechanisms, would suggest strategies to limit graft failure. The prognostic value of microvesicles (MVs) for midterm graft ...

journal_title：Journal of the American College of Cardiology

authors： Camera M,Brambilla M,Canzano P,Cavallotti L,Parolari A,Tedesco CC,Zara C,Rossetti L,Tremoli E

更新日期：2020-06-09 00:00:00

abstract：:Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality for women in the United States and worldwide. There has been no American College of Cardiology (ACC)/American Heart Association guideline update specifically for the prevention of CVD in women since 2011. Since then, the body of sex-spec...

journal_title：Journal of the American College of Cardiology

authors： Cho L,Davis M,Elgendy I,Epps K,Lindley KJ,Mehta PK,Michos ED,Minissian M,Pepine C,Vaccarino V,Volgman AS,ACC CVD Womens Committee Members.

更新日期：2020-05-26 00:00:00

abstract：BACKGROUND:P2Y12 inhibitor monotherapy with ticagrelor after a brief period of dual antiplatelet therapy can reduce bleeding without increasing ischemic harm after percutaneous coronary intervention (PCI). The impact of this approach among patients with diabetes mellitus (DM) remains unknown. OBJECTIVES:The purpose of...

journal_title：Journal of the American College of Cardiology

authors： Angiolillo DJ,Baber U,Sartori S,Briguori C,Dangas G,Cohen DJ,Mehta SR,Gibson CM,Chandiramani R,Huber K,Kornowski R,Weisz G,Kunadian V,Oldroyd KG,Ya-Ling H,Kaul U,Witzenbichler B,Dudek D,Sardella G,Escaned J,Sharma

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Cholesterol reduction with proprotein convertase subtilisin-kexin type 9 inhibitors reduces ischemic events; however, the cost-effectiveness in statin-treated patients with recent acute coronary syndrome remains uncertain. OBJECTIVES:This study sought to determine whether further cholesterol reduction with ...

journal_title：Journal of the American College of Cardiology

authors： Bhatt DL,Briggs AH,Reed SD,Annemans L,Szarek M,Bittner VA,Diaz R,Goodman SG,Harrington RA,Higuchi K,Joulain F,Jukema JW,Li QH,Mahaffey KW,Sanchez RJ,Roe MT,Lopes RD,White HD,Zeiher AM,Schwartz GG,Gabriel Steg P,

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:Elevated triglyceride-rich lipoprotein (TRL) and small-dense low-density lipoprotein (sdLDL) particles are hallmarks of atherogenic dyslipidemia, and their cholesterol content is hypothesized to drive atherosclerotic risk. Prospective epidemiological data pertaining to cholesterol content of TRLs and sdLDL i...

journal_title：Journal of the American College of Cardiology

authors： Duran EK,Aday AW,Cook NR,Buring JE,Ridker PM,Pradhan AD

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:The respective impacts of transvalvular flow, gradient, sex, and their interactions on mortality in patients with severe aortic stenosis undergoing surgical aortic valve replacement (AVR) are unknown. OBJECTIVES:This study sought to compare the impact of pre-operative flow-gradient patterns on mortality aft...

journal_title：Journal of the American College of Cardiology

authors： Guzzetti E,Poulin A,Annabi MS,Zhang B,Kalavrouziotis D,Couture C,Dagenais F,Pibarot P,Clavel MA

更新日期：2020-04-28 00:00:00

abstract：:It has long been observed that heart failure (HF) is associated with measures of systemic inflammation. In recent years, there have been significant advancements in our understanding of how inflammation contributes to the pathogenesis and progression of HF. However, although numerous studies have validated the associa...

journal_title：Journal of the American College of Cardiology

authors： Murphy SP,Kakkar R,McCarthy CP,Januzzi JL Jr

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Early pathogenesis of diabetic cardiomyopathy (DMCM) may involve lipotoxicity of cardiomyocytes in the context of hyperglycemia. There are many preclinical studies of DMCM pathogenesis, but the human evidence is still poorly understood. OBJECTIVES:By using a nondiabetic mellitus (non-DM) heart transplanted ...

journal_title：Journal of the American College of Cardiology

authors： Marfella R,Amarelli C,Cacciatore F,Balestrieri ML,Mansueto G,D'Onofrio N,Esposito S,Mattucci I,Salerno G,De Feo M,D'Amico M,Golino P,Maiello C,Paolisso G,Napoli C

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:Although cardiomyopathy has emerged as a leading cause of death in Duchenne muscular dystrophy (DMD), limited studies and therapies have emerged for dystrophic heart failure. OBJECTIVES:The purpose of this study was to model DMD cardiomyopathy using DMD patient-specific human induced pluripotent stem cell (...

journal_title：Journal of the American College of Cardiology

authors： Kamdar F,Das S,Gong W,Klaassen Kamdar A,Meyers TA,Shah P,Ervasti JM,Townsend D,Kamp TJ,Wu JC,Garry MG,Zhang J,Garry DJ

更新日期：2020-03-17 00:00:00

abstract：:Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, age-related vascular changes accompany or even precede the development of Alzheimer's pathology, raising the possibilit...

journal_title：Journal of the American College of Cardiology

authors： Cortes-Canteli M,Iadecola C

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Early in the prevention and treatment of bioprosthetic valve thrombosis (BPVT), anticoagulation is effective, but the long-term outcome after BPVT is unknown. OBJECTIVES:The goal of this study was to assess the long-term outcomes of patients with BPVT treated with anticoagulation. METHODS:This analysis was...

journal_title：Journal of the American College of Cardiology

authors： Petrescu I,Egbe AC,Ionescu F,Nkomo VT,Greason KL,Pislaru C,Pellikka PA,Connolly HM,Pislaru SV

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy (HCM) is an uncommon but important cause of sudden cardiac death. OBJECTIVES:This study sought to develop an artificial intelligence approach for the detection of HCM based on 12-lead electrocardiography (ECG). METHODS:A convolutional neural network (CNN) was trained and validat...

journal_title：Journal of the American College of Cardiology

authors： Ko WY,Siontis KC,Attia ZI,Carter RE,Kapa S,Ommen SR,Demuth SJ,Ackerman MJ,Gersh BJ,Arruda-Olson AM,Geske JB,Asirvatham SJ,Lopez-Jimenez F,Nishimura RA,Friedman PA,Noseworthy PA

更新日期：2020-02-25 00:00:00

abstract：:The advance of therapies to reduce the stroke impact of asymptomatic carotid artery stenosis has proved difficult over the last decade. Disagreement concerning the underlying randomized control trials has limited entry into the care arena of endovascular therapies. Recently, advances in percutaneous therapies for caro...

journal_title：Journal of the American College of Cardiology

authors： Beckman JA,Ansel GM,Lyden SP,Das TS

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Enterococcal endocarditis (EE) is a growing entity in Western countries. However, quality data from large studies is lacking. OBJECTIVES:The purpose of this study was to describe the characteristics and analyze the prognostic factors of EE in the GAMES cohort. METHODS:This was a post hoc analysis of a pros...

journal_title：Journal of the American College of Cardiology

authors： Pericàs JM,Llopis J,Muñoz P,Gálvez-Acebal J,Kestler M,Valerio M,Hernández-Meneses M,Goenaga MÁ,Cobo-Belaustegui M,Montejo M,Ojeda-Burgos G,Sousa-Regueiro MD,de Alarcón A,Ramos-Martínez A,Miró JM,GAMES Investigators.

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Abnormal pulmonary arterial pressure (PAP) responses to exercise have been described in select individuals; however, clinical and prognostic implications of exercise pulmonary hypertension (exPH) among broader samples remains unclear. OBJECTIVES:This study sought to investigate the association of exPH with ...

journal_title：Journal of the American College of Cardiology

authors： Ho JE,Zern EK,Lau ES,Wooster L,Bailey CS,Cunningham T,Eisman AS,Hardin KM,Farrell R,Sbarbaro JA,Schoenike MW,Houstis NE,Baggish AL,Shah RV,Nayor M,Malhotra R,Lewis GD

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Heart transplant recipients are at high risk for mortality, with traditional risk scores performing modestly in predicting post-transplant survival, underscoring the importance of as yet unidentified factors in determining prognosis. In this analysis, the association between PM2.5 exposure levels and surviva...

journal_title：Journal of the American College of Cardiology

authors： Al-Kindi SG,Sarode A,Zullo M,Brook J,Burnett R,Oliveira GH,Huang W,Brook R,Rajagopalan S

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:There is widespread consumer concern that statin use may be associated with impaired memory and cognitive decline. OBJECTIVES:This study sought to examine the association between statin use and changes in memory and global cognition in the elderly population over 6 years and brain volumes over 2 years. Inte...

journal_title：Journal of the American College of Cardiology

authors： Samaras K,Makkar SR,Crawford JD,Kochan NA,Slavin MJ,Wen W,Trollor JN,Brodaty H,Sachdev PS

更新日期：2019-11-26 00:00:00