当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Ventricular function and infarct size: the Western Washington Intravenous Streptokinase in Myocardial Infarction Trial.

Ventricular function and infarct size: the Western Washington Intravenous Streptokinase in Myocardial Infarction Trial.

Abstract：

:The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Trial randomized 368 patients with symptoms and signs of acute myocardial infarction of less than 6 h duration to either conventional care or 1.5 million units of intravenous streptokinase. The mean time to randomization was 209 min and 52% of patients were randomized within 3 h of symptom onset. Quantitative, tomographic thallium-201 infarct size and radionuclide ejection fraction were measured at 8.2 +/- 7.5 weeks in 207 survivors who lived within a 100 mile radius of a centralized laboratory. Overall, infarct size as a percent of the left ventricle was 19 +/- 13% for control subjects and 15 +/- 13% for treatment patients (p = 0.03). For anterior infarction in patients entered within 3 h of symptom onset, infarct size was 28 +/- 13% in the control group versus 19 +/- 15% for the treatment group (p = 0.09). Left ventricular ejection fraction was 47 +/- 15% in the control versus 51 +/- 15% in the treatment group (p = 0.08). For anterior infarction of less than 3 h duration, the ejection fraction was 38 +/- 16% in the control versus 48 +/- 20% in the treatment group (p = 0.13). By statistical analysis incorporating the nonsurvivors, p values for all of these variables were less than or equal to 0.08. There was no benefit for patients with inferior infarction or for anterior infarction of greater than 3 h duration. It is concluded that intravenous streptokinase, when given within 3 h of symptom onset to patients with anterior infarction, reduces infarct size and improves ventricular function.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Ritchie JL,Cerqueira M,Maynard C,Davis K,Kennedy JW

doi

10.1016/0735-1097(88)90197-0

subject

Has Abstract

pub_date

1988-04-01 00:00:00

pages

689-97

issue

4

eissn

0735-1097

issn

1558-3597

pii

0735-1097(88)90197-0

journal_volume

11

pub_type

临床试验,杂志文章,随机对照试验

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Effects of amiodarone and its active metabolite desethylamiodarone on the ventricular defibrillation threshold.

    abstract：OBJECTIVES:We evaluated whether the reported difference in the ventricular defibrillation threshold (DFT) between short-term intravenous and oral amiodarone is due to the effect of amiodarone's active metabolite desethylamiodarone (DEA). BACKGROUND:Amiodarone is frequently used in patients with implantable cardioverte...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(98)00160-0

    authors： Zhou L,Chen BP,Kluger J,Fan C,Chow MS

    更新日期：1998-06-01 00:00:00

  • Once daily therapy with isosorbide-5-mononitrate causes endothelial dysfunction in humans: evidence of a free-radical-mediated mechanism.

    abstract：OBJECTIVES:The aim of the study was to determine if isosorbide-5-mononitrate (IS-5-MN) 120 mg, taken once daily for 7 days, is associated with evidence of endothelial dysfunction and whether this effect is determined by increased free radical production. BACKGROUND:Tolerance to nitroglycerin is associated with increas...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jacc.2006.10.074

    authors： Thomas GR,DiFabio JM,Gori T,Parker JD

    更新日期：2007-03-27 00:00:00

  • Identification of large families in early repolarization syndrome.

    abstract：OBJECTIVES:The aim of this study was to identify families affected by early repolarization syndrome (ERS) and to determine the mode of transmission of the disease. BACKGROUND:Early repolarization (ER) has recently been linked to idiopathic ventricular fibrillation. Familial inheritance of the disease has been suggeste...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2012.09.040

    authors： Gourraud JB,Le Scouarnec S,Sacher F,Chatel S,Derval N,Portero V,Chavernac P,Sandoval JE,Mabo P,Redon R,Schott JJ,Le Marec H,Haïssaguerre M,Probst V

    更新日期：2013-01-15 00:00:00

  • Bethesda Conference #36 and the European Society of Cardiology Consensus Recommendations revisited a comparison of U.S. and European criteria for eligibility and disqualification of competitive athletes with cardiovascular abnormalities.

    abstract：:Aspiration to reduce the risks of athletic field deaths prompted the American Heart Association and European Society of Cardiology (ESC) to establish consensus guidelines for eligibility/disqualification decisions in competitive athletes with cardiovascular abnormalities. Since 2005, the Bethesda Conference #36 and th...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2008.08.055

    authors： Pelliccia A,Zipes DP,Maron BJ

    更新日期：2008-12-09 00:00:00

  • Hybrid thoracoscopic surgical and transvenous catheter ablation of atrial fibrillation.

    abstract：OBJECTIVES:The purpose of this study was to evaluate the feasibility, safety, and clinical outcomes up to 1 year in patients undergoing combined simultaneous thoracoscopic surgical and transvenous catheter atrial fibrillation (AF) ablation. BACKGROUND:The combination of the transvenous endocardial approach with the th...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2011.12.055

    authors： Pison L,La Meir M,van Opstal J,Blaauw Y,Maessen J,Crijns HJ

    更新日期：2012-07-03 00:00:00

  • Associations among androgens, estrogens, and natriuretic peptides in young women: observations from the Dallas Heart Study.

    abstract：OBJECTIVES:We sought to determine if natriuretic peptides are associated with estrogen and androgen status in a population study of young women without known cardiac disease. BACKGROUND:Circulating concentrations of plasma B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are higher in women than in m...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2006.10.040

    authors： Chang AY,Abdullah SM,Jain T,Stanek HG,Das SR,McGuire DK,Auchus RJ,de Lemos JA

    更新日期：2007-01-02 00:00:00

  • Restenosis after coronary angioplasty: the paradox of increased lumen diameter and restenosis.

    abstract：:Restenosis after coronary angioplasty is the single complication that most limits this revascularization procedure in clinical practice. The process is largely unpredictable and the lesion-related factors predisposing to restenosis are poorly understood, with little consensus in published reports. In this study using ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(92)90475-3

    authors： Beatt KJ,Serruys PW,Luijten HE,Rensing BJ,Suryapranata H,de Feyter P,van den Brand M,Laarman GJ,Roelandt J

    更新日期：1992-02-01 00:00:00

  • Comparison of the effects of nitroprusside and nifedipine on diastolic properties in patients with hypertrophic cardiomyopathy: altered left ventricular loading or improved muscle inactivation?

    abstract：:The calcium channel blocking agent, nifedipine, has been shown to improve indexes of left ventricular relaxation, diastolic filling and compliance in patients with hypertrophic cardiomyopathy. The mechanism of action of nifedipine on diastolic properties in patients with hypertrophic cardiomyopathy is unclear and coul...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80235-6

    authors： Paulus WJ,Lorell BH,Craig WE,Wynne J,Murgo JP,Grossman W

    更新日期：1983-11-01 00:00:00

  • Intrinsic sympathomimetic activity and the effects of beta-adrenergic blocking drugs on vulnerability to ventricular fibrillation.

    abstract：:Beta-adrenergic blocking agents differ considerably in their effects on myocardial excitable properties. The possibility that intrinsic sympathomimetic activity might contribute to such differences has not been adequately explored. This study examined the influence of intrinsic sympathomimetic activity on the electrop...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80047-3

    authors： Raeder EA,Verrier RL,Lown B

    更新日期：1983-06-01 00:00:00

  • External Aortic Root Support to Prevent Aortic Dilatation in Patients With Marfan Syndrome.

    abstract：BACKGROUND:Personalized external aortic root support (PEARS) was introduced in 2004 for prevention of aortic root dilatation in Marfan patients. The individual's aortic root is replicated by 3-dimensional printing. A polymer mesh sleeve is manufactured, which is implanted with the aim to support and stabilize the aorti...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2018.06.053

    authors： Izgi C,Newsome S,Alpendurada F,Nyktari E,Boutsikou M,Pepper J,Treasure T,Mohiaddin R

    更新日期：2018-09-04 00:00:00

  • Does lowering pulmonary arterial pressure eliminate severe functional tricuspid regurgitation? Insights from pulmonary thromboendarterectomy.

    abstract：OBJECTIVES:Because pulmonary thromboendarterectomy (PTE) can result in an immediate reduction in pulmonary artery (PA) pressure, we sought to evaluate the effect of PTE on severe tricuspid regurgitation (TR) without tricuspid annuloplasty. BACKGROUND:Few data exist regarding the frequency and magnitude of functional T...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2003.12.058

    authors： Sadeghi HM,Kimura BJ,Raisinghani A,Blanchard DG,Mahmud E,Fedullo PF,Jamieson SW,DeMaria AN

    更新日期：2004-07-07 00:00:00

  • Statins, low-density lipoprotein cholesterol, and risk of cancer.

    abstract：OBJECTIVES:We sought to assess whether statin-mediated reductions in low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of cancer. BACKGROUND:We recently reported an inverse association between on-treatment LDL-C levels and incident cancer in statin-treated patients enrolled in large ran...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jacc.2008.06.037

    authors： Alsheikh-Ali AA,Trikalinos TA,Kent DM,Karas RH

    更新日期：2008-09-30 00:00:00

  • Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial.

    abstract：OBJECTIVES:The purpose of this study is to evaluate the efficacy and safety of ticagrelor and clopidogrel in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery (CABG), as a post-randomization strategy. BACKGROUND:Ticagrelor is a novel, reversibly binding, oral, direct-acting P2Y(12)-...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2010.10.029

    authors： Held C,Asenblad N,Bassand JP,Becker RC,Cannon CP,Claeys MJ,Harrington RA,Horrow J,Husted S,James SK,Mahaffey KW,Nicolau JC,Scirica BM,Storey RF,Vintila M,Ycas J,Wallentin L

    更新日期：2011-02-08 00:00:00

  • Clinical Outcomes in Adolescents and Adults After the Fontan Procedure.

    abstract：BACKGROUND:Long-term outcomes of Fontan patients who survive to age ≥16 years have not been well characterized. The Australian and New Zealand Fontan Registry (ANZFR) provides a unique opportunity to understand survival and complication rates in Fontan patients who transition to adult congenital heart disease centers. ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2017.12.054

    authors： Dennis M,Zannino D,du Plessis K,Bullock A,Disney PJS,Radford DJ,Hornung T,Grigg L,Cordina R,d'Udekem Y,Celermajer DS

    更新日期：2018-03-06 00:00:00

  • Gadobutrol-Enhanced Cardiac Magnetic Resonance Imaging for Detection of Coronary Artery Disease.

    abstract：BACKGROUND:Gadolinium-based contrast agents were not approved in the United States for detecting coronary artery disease (CAD) prior to the current studies. OBJECTIVES:The purpose of this study was to determine the sensitivity and specificity of gadobutrol for detection of CAD by assessing myocardial perfusion and lat...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2020.07.060

    authors： Arai AE,Schulz-Menger J,Berman D,Mahrholdt H,Han Y,Bandettini WP,Gutberlet M,Abraham A,Woodard PK,Selvanayagam JB,McCann GP,Hamilton-Craig C,Schoepf UJ,San Tan R,Kramer CM,Friedrich MG,Haverstock D,Liu Z,Brueggenwerth

    更新日期：2020-09-29 00:00:00

  • Effectiveness of implantable defibrillators for preventing arrhythmic events and death: a meta-analysis.

    abstract：OBJECTIVES:The aim of this study was to compare the effectiveness of the implantable cardioverter defibrillator (ICD) and medical strategies for prevention of arrhythmic events and death. BACKGROUND:The ICD is a potential strategy to reduce mortality in patients at risk of sudden death. METHODS:The MEDLINE, EMBASE, a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/s0735-1097(03)00253-5

    authors： Lee DS,Green LD,Liu PP,Dorian P,Newman DM,Grant FC,Tu JV,Alter DA

    更新日期：2003-05-07 00:00:00

  • Predicting the Unpredictable: Drug-Induced QT Prolongation and Torsades de Pointes.

    abstract：:Drug-induced long QT syndrome (diLQTS) and congenital LQTS (cLQTS) share many features, and both syndromes can result in life-threatening torsades de pointes (TdP). Our understanding of their mechanistic and genetic similarities has led to their improved clinical management. However, our inability to prevent diLQTS ha...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2015.12.063

    authors： Schwartz PJ,Woosley RL

    更新日期：2016-04-05 00:00:00

  • The clinical course of multifocal atrial tachycardia in infants and children.

    abstract：OBJECTIVES:This study outlines the clinical course, treatment and the late outcome of infants and children with multifocal atrial tachycardia (MAT). BACKGROUND:Multifocal atrial tachycardia is defined by three distinct P-waveforms, irregular P-P intervals, isoelectric baseline between P-waves and rapid rate on an elec...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0735-1097(01)01390-0

    authors： Bradley DJ,Fischbach PS,Law IH,Serwer GA,Dick M 2nd

    更新日期：2001-08-01 00:00:00

  • A high ankle brachial index is associated with greater left ventricular mass MESA (Multi-Ethnic Study of Atherosclerosis).

    abstract：OBJECTIVES:This study sought to determine the association of high ankle brachial index (ABI) measurements with left ventricular (LV) mass, and to compare its strength with that of low ABI with LV mass. BACKGROUND:Arterial stiffness leads to LV mass through nonatherosclerotic pathways in mice. In humans, a high ABI ind...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2009.11.010

    authors： Ix JH,Katz R,Peralta CA,de Boer IH,Allison MA,Bluemke DA,Siscovick DS,Lima JA,Criqui MH

    更新日期：2010-01-26 00:00:00

  • A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence.

    abstract：OBJECTIVES:This study aimed to identify the genetic defect in a family with idiopathic ventricular fibrillation (IVF) manifesting in childhood and adolescence. BACKGROUND:Although sudden cardiac death in the young is rare, it frequently presents as the first clinical manifestation of an underlying inherited arrhythmia...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2013.07.091

    authors： Marsman RF,Barc J,Beekman L,Alders M,Dooijes D,van den Wijngaard A,Ratbi I,Sefiani A,Bhuiyan ZA,Wilde AA,Bezzina CR

    更新日期：2014-01-28 00:00:00

  • Three-year clinical follow-up after Palmaz-Schatz stenting.

    abstract：OBJECTIVES:Our goals were to examine late clinical outcome in a cohort of patients who electively received Palmaz-Schatz intracoronary stents, to identify specific predictors of outcome and to determine the time course of the development of ischemic cardiac events after stenting. BACKGROUND:Short-term results of Palma...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00574-9

    authors： Klugherz BD,DeAngelo DL,Kim BK,Herrmann HC,Hirshfeld JW,Kolansky DM

    更新日期：1996-04-01 00:00:00

  • Role of atrial electrophysiology and autonomic nervous system in patients with supraventricular tachycardia and paroxysmal atrial fibrillation.

    abstract：OBJECTIVES:The purposes of this study were to evaluate the atrial electrophysiology and autonomic nervous system in patients who had paroxysmal supraventricular tachycardia (PSVT) associated with paroxysmal atrial fibrillation (PAF). BACKGROUND:PAF frequently appeared in patients with PSVT. However, the critical deter...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(98)00305-2

    authors： Chen YJ,Chen SA,Tai CT,Wen ZC,Feng AN,Ding YA,Chang MS

    更新日期：1998-09-01 00:00:00

  • Disparity of reperfusion arrhythmias after reversible myocardial ischemia in open chest and conscious dogs.

    abstract：:Myocardial reperfusion after brief, reversible ischemia is frequently associated with malignant arrhythmias in experimental animals. These observations have been extrapolated to humans despite being restricted to anesthetized, open chest preparations. No data are available regarding the incidence of reperfusion arrhyt...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(86)80222-4

    authors： Bolli R,Myers ML,Zhu WX,Roberts R

    更新日期：1986-05-01 00:00:00

  • Ongoing clinical trials of angiotensin-converting enzyme inhibitors for treatment of coronary artery disease in patients with preserved left ventricular function.

    abstract：:At present there is considerable activity in the area of prevention of atherosclerosis-related events using angiotensin-converting enzyme inhibitors. Large trials have demonstrated significant reduction in cardiovascular morbidity and mortality with long-term use of angiotensin-converting enzyme inhibitors in patients...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0735-1097(95)00605-2

    authors： Pepine CJ

    更新日期：1996-04-01 00:00:00

  • Accurate preoperative diagnosis of pericardial constriction using cine computed tomography.

    abstract：OBJECTIVES:The purpose of this study was to determine the accuracy of cine computed tomography in the diagnosis of constrictive pericarditis. BACKGROUND:Constrictive pericarditis is characterized by abnormalities of both cardiac structure and function. Accurate diagnosis requires detection of both a thickened pericard...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(93)90199-b

    authors： Oren RM,Grover-McKay M,Stanford W,Weiss RM

    更新日期：1993-09-01 00:00:00

  • Accuracy of plasma B-type natriuretic peptide to diagnose significant cardiovascular disease in children: the Better Not Pout Children! Study.

    abstract：OBJECTIVES:The purpose of this study was to assess the ability of plasma B-type natriuretic peptide (BNP) to diagnose significant cardiovascular disease (CVD) in the pediatric population. BACKGROUND:BNP has been shown to be reliable in detecting ventricular dysfunction and heart failure in adults. Timely and accurate ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2009.06.020

    authors： Law YM,Hoyer AW,Reller MD,Silberbach M

    更新日期：2009-10-06 00:00:00

  • Treatment of underlying atrial fibrillation: paced rhythm obscures recognition.

    abstract：OBJECTIVES:The purpose of this study was to evaluate the rate of recognition of atrial fibrillation (AF), use of warfarin and prevalence of cerebrovascular accident (CVA) in paced versus unpaced patients during admission to a tertiary care teaching hospital. BACKGROUND:The presence of AF underlying a continuously pace...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)00794-4

    authors： Patel AM,Westveer DC,Man KC,Stewart JR,Frumin HI

    更新日期：2000-09-01 00:00:00

  • The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study.

    abstract：OBJECTIVES:This study sought to evaluate the associations between different measures of obesity and prevalent atherosclerosis in a large population-based cohort. BACKGROUND:Although obesity is associated with cardiovascular mortality, it is unclear whether this relationship is mediated by increased atherosclerotic bur...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.04.066

    authors： See R,Abdullah SM,McGuire DK,Khera A,Patel MJ,Lindsey JB,Grundy SM,de Lemos JA

    更新日期：2007-08-21 00:00:00

  • A decrease in diastolic blood pressure combined with an increase in systolic blood pressure is associated with a higher cardiovascular mortality in men.

    abstract：OBJECTIVES:The study evaluated the risk of cardiovascular mortality according to combined spontaneous (non-treatment-related) changes in both systolic and diastolic blood pressure (BP). BACKGROUND:Long-term longitudinal changes in blood pressure may be a more accurate determinant of cardiovascular risk since changes i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00586-0

    authors： Benetos A,Zureik M,Morcet J,Thomas F,Bean K,Safar M,Ducimetière P,Guize L

    更新日期：2000-03-01 00:00:00

  • Ultrastructural findings in endomyocardial biopsy of patients with Kearns-Sayre syndrome.

    abstract：:Kearns-Sayre syndrome is clinically defined by progressive external ophthalmoplegia, atypical retinitis pigmentosa and the potential occurrence of complete atrioventricular (AV) block. Right septal endomyocardial biopsy specimens from nine patients (four men and five women with a mean [+/- SD] [corrected] age of 36.3 ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(88)80020-2

    authors： Schwartzkopff B,Frenzel H,Breithardt G,Deckert M,Lösse B,Toyka KV,Borggrefe M,Hort W

    更新日期：1988-12-01 00:00:00