当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.

Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.

Abstract：

BACKGROUND:Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation. OBJECTIVES:The purpose of this study was to investigate possible causal associations between dietary-derived circulating antioxidants and primary CHD risk using 2-sample Mendelian randomization (MR). METHODS:Single-nucleotide polymorphisms for circulating antioxidants (vitamins E and C, retinol, β-carotene, and lycopene), assessed as absolute levels and metabolites, were retrieved from the published data and were used as genetic instrumental variables. Summary statistics for gene-CHD associations were obtained from 3 databases: the CARDIoGRAMplusC4D consortium (60,801 cases; 123,504 control subjects), UK Biobank (25,306 cases; 462,011 control subjects), and FinnGen study (7,123 cases; 89,376 control subjects). For each exposure, MR analyses were performed per outcome database and were subsequently meta-analyzed. RESULTS:Among an analytic sample of 768,121 individuals (93,230 cases), genetically predicted circulating antioxidants were not causally associated with CHD risk. For absolute antioxidants, the odds ratio for CHD ranged between 0.94 (95% confidence interval [CI]: 0.63 to 1.41) for retinol and 1.03 (95% CI: 0.97 to 1.10) for β-carotene per unit increase in ln-transformed antioxidant values. For metabolites, the odds ratio ranged between 0.93 (95% CI: 0.82 to 1.06) for γ-tocopherol and 1.01 (95% CI: 0.95 to 1.08) for ascorbate per 10-fold increase in metabolite levels. CONCLUSIONS:Evidence from our study did not support a protective effect of genetic predisposition to high dietary-derived antioxidant levels on CHD risk. Therefore, it is unlikely that taking antioxidants to increase blood antioxidants levels will have a clinical benefit for the prevention of primary CHD.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Luo J,le Cessie S,van Heemst D,Noordam R

doi

10.1016/j.jacc.2020.10.048

subject

Has Abstract

pub_date

2021-01-05 00:00:00

pages

45-54

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(20)37793-7

journal_volume

77

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Long-Term Outcomes of Anticoagulation for Bioprosthetic Valve Thrombosis.

    abstract：BACKGROUND:Early in the prevention and treatment of bioprosthetic valve thrombosis (BPVT), anticoagulation is effective, but the long-term outcome after BPVT is unknown. OBJECTIVES:The goal of this study was to assess the long-term outcomes of patients with BPVT treated with anticoagulation. METHODS:This analysis was...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2019.12.037

    authors： Petrescu I,Egbe AC,Ionescu F,Nkomo VT,Greason KL,Pislaru C,Pellikka PA,Connolly HM,Pislaru SV

    更新日期：2020-03-03 00:00:00

  • Determinants of prognosis in symptomatic ventricular tachycardia or ventricular fibrillation late after myocardial infarction. The Dutch Ventricular Tachycardia Study Group of the Interuniversity Cardiology Institute of The Netherlands.

    abstract：:In a multicenter study, 390 patients with sustained symptomatic ventricular tachycardia or ventricular fibrillation late after acute myocardial infarction were prospectively followed up to assess determinants of mortality and recurrence of arrhythmic events. Patients were given standard antiarrhythmic treatment, which...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/0735-1097(90)90336-n

    authors： Willems AR,Tijssen JG,van Capelle FJ,Kingma JH,Hauer RN,Vermeulen FE,Brugada P,van Hoogenhuyze DC,Janse MJ

    更新日期：1990-09-01 00:00:00

  • Incidence of asymptomatic intracranial embolic events after pulmonary vein isolation: comparison of different atrial fibrillation ablation technologies in a multicenter study.

    abstract：OBJECTIVES:We compared the safety of different devices by screening for subclinical intracranial embolic events after pulmonary vein isolation with either conventional irrigated radiofrequency (RF) or cryoballoon or multielectrode phased RF pulmonary vein ablation catheter (PVAC). BACKGROUND:New devices specifically d...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2011.04.010

    authors： Herrera Siklódy C,Deneke T,Hocini M,Lehrmann H,Shin DI,Miyazaki S,Henschke S,Fluegel P,Schiebeling-Römer J,Bansmann PM,Bourdias T,Dousset V,Haïssaguerre M,Arentz T

    更新日期：2011-08-09 00:00:00

  • Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

    abstract：BACKGROUND:Renin-angiotensin system activation is a feature of many cardiovascular conditions. Activity of myocardial reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2 or Nox2) is enhanced by angiotensin II (Ang II) and contributes to increased hypertrophy, fibrosis, and adverse remodeling....

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2015.05.020

    authors： Zhang M,Prosser BL,Bamboye MA,Gondim ANS,Santos CX,Martin D,Ghigo A,Perino A,Brewer AC,Ward CW,Hirsch E,Lederer WJ,Shah AM

    更新日期：2015-07-21 00:00:00

  • The early repolarization pattern in the general population: clinical correlates and heritability.

    abstract：OBJECTIVES:This study sought to describe the clinical correlates and heritability of the early repolarization pattern (ERP) in 2 large, population-based cohorts. BACKGROUND:There is growing recognition that ERP is associated with adverse outcomes. METHODS:Participants of the Framingham Heart Study (FHS) (N = 3,995) a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2011.04.003

    authors： Noseworthy PA,Tikkanen JT,Porthan K,Oikarinen L,Pietilä A,Harald K,Peloso GM,Merchant FM,Jula A,Väänänen H,Hwang SJ,O'Donnell CJ,Salomaa V,Newton-Cheh C,Huikuri HV

    更新日期：2011-05-31 00:00:00

  • Long-term outcomes of older diabetic patients after percutaneous coronary stenting in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.

    abstract：OBJECTIVES:The purpose of this study was to characterize long-term outcomes of percutaneous coronary intervention (PCI) in elderly diabetic patients in routine practice. BACKGROUND:Although drug-eluting stent (DES) implantation in diabetic patients is common practice, pivotal randomized trials enrolled <2,500 diabetic...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2012.08.993

    authors： Hillegass WB,Patel MR,Klein LW,Gurm HS,Brennan JM,Anstrom KJ,Dai D,Eisenstein EL,Peterson ED,Messenger JC,Douglas PS

    更新日期：2012-12-04 00:00:00

  • Exercise echocardiographic detection of coronary artery disease in women.

    abstract：:The utility of exercise echocardiography for the diagnosis of coronary artery disease has been demonstrated in populations consisting largely of men with a high prevalence of disease. To determine the diagnostic value of exercise echocardiography in women, 57 women who presented with chest pain were studied with coron...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(89)90378-1

    authors： Sawada SG,Ryan T,Fineberg NS,Armstrong WF,Judson WE,McHenry PL,Feigenbaum H

    更新日期：1989-11-15 00:00:00

  • The ligament of Marshall: a structural analysis in human hearts with implications for atrial arrhythmias.

    abstract：OBJECTIVES:We sought to study the anatomy of human ligament of Marshall (LOM). BACKGROUND:Although the LOM has been implicated in the genesis of focal atrial tachyarrhythmias, its gross anatomic and microscopic features in humans hearts have not been completely defined. METHODS:We studied seven postmortem human heart...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)00819-6

    authors： Kim DT,Lai AC,Hwang C,Fan LT,Karagueuzian HS,Chen PS,Fishbein MC

    更新日期：2000-10-01 00:00:00

  • Doppler echocardiographic profile and indexes in the evaluation of aortic coarctation in patients before and after stenting.

    abstract：OBJECTIVES:We sought to assess the effect of successful stenting on the Doppler profile of aortic coarctation and to identify echocardiographic indexes that could be used for follow-up of such patients. BACKGROUND:Doppler echocardiography demonstrates characteristic flow patterns in significant aortic coarctation. ME...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.05.076

    authors： Tan JL,Babu-Narayan SV,Henein MY,Mullen M,Li W

    更新日期：2005-09-20 00:00:00

  • Tricuspid regurgitation: noninvasive techniques for determining causes and severity.

    abstract：:Tricuspid regurgitation is often not apparent on physical examination and several methods are now available to aid in this difficult assessment. Cardiac catheterization using right ventriculography, previously considered the diagnostic standard, has several limitations. Currently available noninvasive tools such as M-...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0735-1097(84)80294-6

    authors： DePace NL,Ross J,Iskandrian AS,Nestico PF,Kotler MN,Mintz GS,Segal BL,Hakki AH,Morganroth J

    更新日期：1984-06-01 00:00:00

  • Low-level exercise echocardiography detects contractile reserve and predicts reversible dysfunction after acute myocardial infarction: comparison with low-dose dobutamine echocardiography.

    abstract：OBJECTIVES:The aim of this study was to evaluate low-level exercise echocardiography (LLEE) in detecting contractile reserve and predicting functional improvement of akinetic myocardium early after acute myocardial infarction (AMI). BACKGROUND:Experimental and clinical studies have shown that low-dose dobutamine enhan...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0735-1097(99)00340-x

    authors： Hoffer EP,Dewé W,Celentano C,Piérard LA

    更新日期：1999-10-01 00:00:00

  • Implications of small reference vessel diameter in patients undergoing percutaneous coronary revascularization.

    abstract：OBJECTIVES:The purpose of this study was to determine whether small reference diameter of the culprit coronary artery influences the outcome of an attempted percutaneous revascularization procedure in the current era of interventional cardiology. BACKGROUND:Although the interventional strategy is largely determined by...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00181-3

    authors： Schunkert H,Harrell L,Palacios IF

    更新日期：1999-07-01 00:00:00

  • Angiotensin-Converting Enzyme Inhibition Early After Heart Transplantation.

    abstract：BACKGROUND:Cardiac allograft vasculopathy (CAV) remains a leading cause of mortality after heart transplantation (HT). Angiotensin-converting enzyme inhibitors (ACEIs) may retard the development of CAV but have not been well studied after HT. OBJECTIVES:This study tested the safety and efficacy of the ACEI ramipril on...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2017.03.598

    authors： Fearon WF,Okada K,Kobashigawa JA,Kobayashi Y,Luikart H,Sana S,Daun T,Chmura SA,Sinha S,Cohen G,Honda Y,Pham M,Lewis DB,Bernstein D,Yeung AC,Valantine HA,Khush K

    更新日期：2017-06-13 00:00:00

  • Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes.

    abstract：BACKGROUND:Subclinical inflammation mediated in part by interleukin (IL)-1β participates in peripheral insulin resistance and impaired pancreatic insulin secretion. OBJECTIVES:The authors tested the hypothesis that the IL-1β inhibitor canakinumab reduces incident diabetes. METHODS:The authors randomized 10,061 patien...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jacc.2018.03.002

    authors： Everett BM,Donath MY,Pradhan AD,Thuren T,Pais P,Nicolau JC,Glynn RJ,Libby P,Ridker PM

    更新日期：2018-05-29 00:00:00

  • Corrected QT variability in serial electrocardiograms in long QT syndrome: the importance of the maximum corrected QT for risk stratification.

    abstract：OBJECTIVES:We evaluated the incremental prognostic information provided by multiple corrected QT (QTc) measurements on serial electrocardiograms (ECGs) in patients with the inherited long QT syndrome (LQTS). BACKGROUND:A baseline QTc of > or =500 ms has been shown to be associated with increased risk of cardiac events...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2006.06.033

    authors： Goldenberg I,Mathew J,Moss AJ,McNitt S,Peterson DR,Zareba W,Benhorin J,Zhang L,Vincent GM,Andrews ML,Robinson JL,Morray B

    更新日期：2006-09-05 00:00:00

  • Products of myocardial ischemia and electrical instability of the heart.

    abstract：:Products of ischemic metabolism can make a major contribution to electrical instability of the heart. In particular, enhanced extracellular potassium slows conduction, thereby predisposing to reentrant circuits, especially when levels of cyclic adenosine monophosphate (AMP) increase in the early ischemic period. Other...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0735-1097(85)80549-0

    authors： Opie LH

    更新日期：1985-06-01 00:00:00

  • Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?

    abstract：OBJECTIVES:We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI). BACKGROUND:Renal insufficiency and renal failure (RF) have been associated with increased cardiovascula...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(03)00564-3

    authors： Zebrack JS,Anderson JL,Beddhu S,Horne BD,Bair TL,Cheung A,Muhlestein JB,Intermountain Heart Collaborative Study Group.

    更新日期：2003-07-02 00:00:00

  • Evaluation of QT interval duration and dispersion and proposed clinical criteria in diagnosis of long QT syndrome in patients with a genetically uniform type of LQT1.

    abstract：OBJECTIVES:This study investigated the ability of QT duration, QT dispersion (QTD) and clinical diagnostic criteria to correctly identify genetically documented LQT1 type long QT syndrome (LQTS) patients, and to separate symptomatic and asymptomatic LQT1 patients. BACKGROUND:Ventricular repolarization has played an es...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(98)00248-4

    authors： Swan H,Saarinen K,Kontula K,Toivonen L,Viitasalo M

    更新日期：1998-08-01 00:00:00

  • Non-high-density lipoprotein cholesterol versus apolipoprotein B in cardiovascular risk stratification: do the math.

    abstract：:With the emergence of new lipid risk markers and a growing cardiometabolic risk burden in the United States, there is a need to better integrate residual risk into cardiovascular disease (CVD) risk stratification. In anticipation of the Adult Treatment Panel IV (ATP IV) guidelines from the National Cholesterol Educati...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2011.05.009

    authors： Ramjee V,Sperling LS,Jacobson TA

    更新日期：2011-07-26 00:00:00

  • Surgical management of severe aortic outflow obstruction in lesions other than the hypoplastic left heart syndrome: use of a pulmonary artery to aorta anastomosis.

    abstract：:Between December 1985 and April 1990, 50 infants with a variety of congenital cardiac lesions other than the hypoplastic left heart syndrome underwent surgical relief of aortic outflow obstruction by creation of a pulmonary artery to aorta anastomosis. The patients were grouped anatomically by ventriculoarterial align...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90806-k

    authors： Rychik J,Murdison KA,Chin AJ,Norwood WI

    更新日期：1991-09-01 00:00:00

  • Effect of a single oral dose of milrinone on left ventricular diastolic performance in the failing human heart.

    abstract：:In 14 patients with severe congestive heart failure, left ventricular pressure (measured by tip manometer) and derived variables were measured before and every 10 minutes after administration of oral milrinone (10 mg) for 50 minutes along with measurements of coronary sinus blood flow and drug plasma levels. Arterial ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(87)80134-1

    authors： Piscione F,Jaski BE,Wenting GJ,Serruys PW

    更新日期：1987-12-01 00:00:00

  • Restenosis after percutaneous transluminal coronary angioplasty: pathologic observations in 20 patients.

    abstract：:Histopathologic examination was performed in 20 patients undergoing antemortem coronary angioplasty. Thirty-four lesions were dilated and the interval between coronary angioplasty and death ranged from several hours to 4 years. Intimal proliferation of smooth muscle cells, as a major cause of restenosis, was observed ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(10)80111-1

    authors： Nobuyoshi M,Kimura T,Ohishi H,Horiuchi H,Nosaka H,Hamasaki N,Yokoi H,Kim K

    更新日期：1991-02-01 00:00:00

  • Alzheimer's Disease and Vascular Aging: JACC Focus Seminar.

    abstract：:Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, age-related vascular changes accompany or even precede the development of Alzheimer's pathology, raising the possibilit...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2019.10.062

    authors： Cortes-Canteli M,Iadecola C

    更新日期：2020-03-03 00:00:00

  • Atrial emptying with orthotopic heart transplantation using bicaval and pulmonary venous anastomoses: a magnetic resonance imaging study.

    abstract：OBJECTIVES:We hypothesized that orthotopic heart transplantation with bicaval and pulmonary venous anastomoses preserves atrial contractility. BACKGROUND:The standard biatrial anastomotic technique of orthotopic heart transplantation causes impaired function and enlargement of the atria. Cine magnetic resonance imagin...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(94)00465-3

    authors： Freimark D,Silverman JM,Aleksic I,Crues JV,Blanche C,Trento A,Admon D,Queral CA,Harasty DA,Czer LS

    更新日期：1995-03-15 00:00:00

  • Coronary echocardiography in 406 patients with d-loop transposition of the great arteries.

    abstract：OBJECTIVES:The reliability of two-dimensional echocardiography for determining the proximal coronary artery anatomy in d-loop transposition of the great arteries was investigated in 406 infants who underwent surgical repair at one institution. BACKGROUND:The origin and proximal course of the main coronary arteries can...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(94)90026-4

    authors： Pasquini L,Sanders SP,Parness IA,Wernovsky G,Mayer JE Jr,Van der Velde ME,Spevak PJ,Colan SD

    更新日期：1994-09-01 00:00:00

  • Direct coronary angioplasty in acute myocardial infarction: outcome in patients with single vessel disease.

    abstract：:Percutaneous transluminal coronary angioplasty was performed as primary therapy in 215 consecutive patients (aged 56 +/- 11 years, 75% male) with acute myocardial infarction and single vessel coronary artery disease. Wide patency of the infarct-related artery was restored in 212 patients (99%). Complications consisted...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(90)90621-u

    authors： Stone GW,Rutherford BD,McConahay DR,Johnson WL Jr,Giorgi LV,Ligon RW,Hartzler GO

    更新日期：1990-03-01 00:00:00

  • Cardiac complications in acquired immunodeficiency syndrome (AIDS): a review.

    abstract：:Acquired immunodeficiency syndrome (AIDS) has become an increasingly important health problem worldwide. This review focuses on its cardiac complications. The key elements in the clinical syndrome are the opportunistic infections and the cancer that occur as a by-product of the immunodeficiency process. However, as ea...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0735-1097(89)90277-5

    authors： Acierno LJ

    更新日期：1989-04-01 00:00:00

  • Effects of verapamil on experimental cardiomyopathy in the Bio 14.6 Syrian hamster.

    abstract：:The Bio 14.6 Syrian hamster provides a good model for experimental study of cardiomyopathy. Cardiac receptor binding sites (alpha-1-, beta- and calcium antagonists) were studied in early (21 days old) and late (70 days old) stages of cardiomyopathy. The effects of verapamil on histologic features and free radicals in ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(87)80356-x

    authors： Kobayashi A,Yamashita T,Kaneko M,Nishiyama T,Hayashi H,Yamazaki N

    更新日期：1987-11-01 00:00:00

  • Silent ischemia during coronary occlusion produced by balloon inflation: relation to regional myocardial dysfunction.

    abstract：:Thirty patients with stable exertional angina undergoing percutaneous transluminal coronary angioplasty of an isolated obstructive lesion of the proximal left anterior descending artery were prospectively evaluated to investigate the relation between angina induced by balloon inflation and the quantity and severity of...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(87)80189-4

    authors： Wohlgelernter D,Jaffe CC,Cabin HS,Yeatman LA Jr,Cleman M

    更新日期：1987-09-01 00:00:00

  • Mortality in Patients With Atrial Fibrillation Receiving Nonrecommended Doses of Direct Oral Anticoagulants.

    abstract：BACKGROUND:The recommended doses for direct oral anticoagulants (DOACs) to prevent stroke and systemic embolism (SE) in patients with atrial fibrillation (AF) are described in specific regulatory authority approvals. OBJECTIVES:The impact of DOAC dosing, according to the recommended guidance on all-cause mortality, st...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2020.07.045

    authors： Camm AJ,Cools F,Virdone S,Bassand JP,Fitzmaurice DA,Arthur Fox KA,Goldhaber SZ,Goto S,Haas S,Mantovani LG,Kayani G,Grierson Turpie AG,Antoon Verheugt FW,Kakkar AK,GARFIELD-AF Investigators.

    更新日期：2020-09-22 00:00:00