Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.


BACKGROUND:Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation. OBJECTIVES:The purpose of this study was to investigate possible causal associations between dietary-derived circulating antioxidants and primary CHD risk using 2-sample Mendelian randomization (MR). METHODS:Single-nucleotide polymorphisms for circulating antioxidants (vitamins E and C, retinol, β-carotene, and lycopene), assessed as absolute levels and metabolites, were retrieved from the published data and were used as genetic instrumental variables. Summary statistics for gene-CHD associations were obtained from 3 databases: the CARDIoGRAMplusC4D consortium (60,801 cases; 123,504 control subjects), UK Biobank (25,306 cases; 462,011 control subjects), and FinnGen study (7,123 cases; 89,376 control subjects). For each exposure, MR analyses were performed per outcome database and were subsequently meta-analyzed. RESULTS:Among an analytic sample of 768,121 individuals (93,230 cases), genetically predicted circulating antioxidants were not causally associated with CHD risk. For absolute antioxidants, the odds ratio for CHD ranged between 0.94 (95% confidence interval [CI]: 0.63 to 1.41) for retinol and 1.03 (95% CI: 0.97 to 1.10) for β-carotene per unit increase in ln-transformed antioxidant values. For metabolites, the odds ratio ranged between 0.93 (95% CI: 0.82 to 1.06) for γ-tocopherol and 1.01 (95% CI: 0.95 to 1.08) for ascorbate per 10-fold increase in metabolite levels. CONCLUSIONS:Evidence from our study did not support a protective effect of genetic predisposition to high dietary-derived antioxidant levels on CHD risk. Therefore, it is unlikely that taking antioxidants to increase blood antioxidants levels will have a clinical benefit for the prevention of primary CHD.


J Am Coll Cardiol


Luo J,le Cessie S,van Heemst D,Noordam R




Has Abstract


2021-01-05 00:00:00














  • Left atrial appendage thrombus is not uncommon in patients with acute atrial fibrillation and a recent embolic event: a transesophageal echocardiographic study.

    abstract:OBJECTIVES:The objective of this study was to determine the frequency of left atrial thrombus in patients with acute atrial fibrillation. BACKGROUND:It is commonly assumed but unproved that left atrial thrombus in patients with atrial fibrillation begins to form after the onset of atrial fibrillation and that it requi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Stoddard MF,Dawkins PR,Prince CR,Ammash NM

    更新日期:1995-02-01 00:00:00

  • Angina and persistent exercise thallium defects: independent risk factors in elective vascular surgery.

    abstract:OBJECTIVES:In this study, we assessed the utility of exercise thallium-201 scintigraphy and other clinical factors in predicting perioperative cardiac complications in patients undergoing elective vascular surgery. BACKGROUND:The risk of cardiac complications among such patients is very high. METHODS:The study group ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: McFalls EO,Doliszny KM,Grund F,Chute E,Chesler E

    更新日期:1993-05-01 00:00:00

  • Coronary angioplasty in young adults: initial results and late outcome.

    abstract::The initial and late outcome of coronary angioplasty was studied in 148 patients less than 40 years of age (mean 36.4 +/- 3). Angioplasty was performed on a single vessel in 70% of patients and on multiple vessels in 30%; it was performed on a totally occluded vessel in 20%. Angioplasty was successful in 90.5% of pati...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章


    authors: Webb JG,Myler RK,Shaw RE,Anwar A,Stertzer SH

    更新日期:1990-12-01 00:00:00

  • Level of Blood Pressure Control and Cardiovascular Events: SPRINT Criteria Versus the 2014 Hypertension Recommendations.

    abstract:BACKGROUND:Blood pressure (BP) targets from the SPRINT (Systolic Blood Pressure Intervention Trial) differ from targets of the 2014 hypertension (HTN) recommendations of the Eighth Joint National Committee. OBJECTIVES:The goal of this study was to estimate the proportion of hypertensive adults with who would meet BP g...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Ko MJ,Jo AJ,Park CM,Kim HJ,Kim YJ,Park DW

    更新日期:2016-06-21 00:00:00

  • Nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy: one-year follow-up.

    abstract:OBJECTIVE:The objective of this study is to evaluate the one-year outcome of the first 50 patients who underwent nonsurgical septal reduction for symptomatic hypertrophic obstructive cardiomyopathy at our institution. BACKGROUND:Left ventricular outflow tract obstruction is an important determinant of clinical symptom...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章


    authors: Lakkis NM,Nagueh SF,Dunn JK,Killip D,Spencer WH 3rd

    更新日期:2000-09-01 00:00:00

  • Bileaflet, tilting disc and porcine aortic valve substitutes: in vivo hydrodynamic characteristics.

    abstract::The St. Jude valve is a new bileaflet disc cardiac valve prosthesis designed to avoid some of the hemodynamic drawbacks of other prostheses. The in vivo flow characteristics of the St. Jude aortic valve (42 patients) were studied and compared with those of three other commonly used aortic prostheses. Björk-Shiley (12 ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Gray RJ,Chaux A,Matloff JM,DeRobertis M,Raymond M,Stewart M,Yoganathan A

    更新日期:1984-02-01 00:00:00

  • Failed direct coronary angioplasty for acute myocardial infarction: in-hospital outcome and predictors of death.

    abstract:OBJECTIVES:The purpose of this study was to compare the mechanisms, predictors and outcome of patients with failed direct coronary angioplasty of the infarct-related artery with those in patients with successful direct angioplasty. BACKGROUND:Direct coronary angioplasty of the infarct-related artery, without anteceden...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Bedotto JB,Kahn JK,Rutherford BD,McConahay DR,Giorgi LV,Johnson WL,O'Keefe JH,Shimshak TM,Ligon RW,Hartzler GO

    更新日期:1993-09-01 00:00:00

  • The prevalence of coronary artery calcium among diabetic individuals without known coronary artery disease.

    abstract:OBJECTIVES:We sought to examine the age and gender distribution of coronary artery calcium (CAC) by diabetes status in a large cohort of asymptomatic individuals. BACKGROUND:Among individuals with diabetes, coronary artery disease (CAD) is a major cause of morbidity and mortality. Electron-beam tomography (EBT) quanti...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Hoff JA,Quinn L,Sevrukov A,Lipton RB,Daviglus M,Garside DB,Ajmere NK,Gandhi S,Kondos GT

    更新日期:2003-03-19 00:00:00

  • Reliability of retrograde atrial activation patterns during ventricular pacing for localizing accessory pathways.

    abstract::Definitive localization of accessory pathways is based on atrial activation patterns during orthodromic supraventricular tachycardia when retrograde conduction occurs exclusively through the accessory pathway. In some patients, supraventricular tachycardia cannot be induced or is deleterious. To determine whether acce...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Crossen KJ,Lindsay BD,Cain ME

    更新日期:1987-06-01 00:00:00

  • Balloon dilation of the aortic valve: studies in normal lambs and in children with aortic stenosis.

    abstract::To evaluate the risks of and optimal method for valve dilation in aortic stenosis, balloons of different sizes were used to dilate the normal aortic root in 16 lambs and then stenotic valves in 15 children. In the lambs, inflated balloon to aortic anulus diameter ratios ranged from 0.9 to 1.5. These hearts were examin...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Helgason H,Keane JF,Fellows KE,Kulik TJ,Lock JE

    更新日期:1987-04-01 00:00:00

  • Data for cardiovascular modeling.

    abstract::Data are required for a meaningful approach to quality and cost-conscious cardiovascular care. How to identify the types of data available and their sources, advantages and limitations to their use, issues involved in combining data from different sources for decision modeling and some possible solutions are discussed...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Muhlbaier LH,Pryor DB

    更新日期:1989-09-01 00:00:00

  • Lipoprotein-associated phospholipase A2 is an independent predictor of incident coronary heart disease in an apparently healthy older population: the Rancho Bernardo Study.

    abstract:OBJECTIVES:Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels predict incident coronary heart disease (CHD) in adults without known CHD, independent of heart disease risk factors. We examined whether the independent association was apparent in older adults. BACKGROUND:Serum levels of Lp-PLA2, an enzyme that hydr...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Daniels LB,Laughlin GA,Sarno MJ,Bettencourt R,Wolfert RL,Barrett-Connor E

    更新日期:2008-03-04 00:00:00

  • Sustained release of erythropoietin using biodegradable gelatin hydrogel microspheres persistently improves lower leg ischemia.

    abstract:OBJECTIVES:We hypothesized that erythropoietin (EPO)-immersed gelatin hydrogel microspheres (GHM) injected into ischemic legs might continuously release a small amount of EPO to locally stimulate angiogenesis without unfavorable systemic effects. BACKGROUND:EPO is a potent angiogenic factor, but its use for relieving ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Li L,Okada H,Takemura G,Esaki M,Kobayashi H,Kanamori H,Kawamura I,Maruyama R,Fujiwara T,Fujiwara H,Tabata Y,Minatoguchi S

    更新日期:2009-06-23 00:00:00

  • Gender-related differences in the central arterial pressure waveform.

    abstract:OBJECTIVES:This study investigated the effect of age and gender on central arterial hemodynamic variables derived from noninvasive tonometric carotid pressure waveforms. BACKGROUND:Women have a greater age-related increase in left ventricular (LV) mass than do men and are more likely to experience symptomatic heart fa...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Hayward CS,Kelly RP

    更新日期:1997-12-01 00:00:00

  • Management of pulmonary arterial hypertension.

    abstract::Pulmonary hypertension (PH) is common and may result from a number of disorders, including left heart disease, lung disease, and chronic thromboembolic disease. Pulmonary arterial hypertension (PAH) is an uncommon disease characterized by progressive remodeling of the distal pulmonary arteries, resulting in elevated p...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审


    authors: McLaughlin VV,Shah SJ,Souza R,Humbert M

    更新日期:2015-05-12 00:00:00

  • Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure.

    abstract:OBJECTIVES:The aim of this study was to investigate the role of peripheral presynaptic alpha-2 adrenergic receptors in modulating norepinephrine (NE) release in congestive heart failure (CHF). BACKGROUND:Activation of the sympathetic nervous system is a hallmark of CHF. Clonidine, an imidazoline and adrenergic agonist...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Aggarwal A,Esler MD,Socratous F,Kaye DM

    更新日期:2001-04-01 00:00:00

  • Multicenter low energy transvenous atrial defibrillation (XAD) trial results in different subsets of atrial fibrillation.

    abstract:OBJECTIVES:This prospective, multicenter trial was aimed at defining efficacy and safety of low energy shocks during atrial fibrillation in a diverse cohort of patients. BACKGROUND:Experimental studies in sheep and preliminary data in humans have suggested that low energy internal shocks delivered between right atrial...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Lévy S,Ricard P,Lau CP,Lok NS,Camm AJ,Murgatroyd FD,Jordaens LJ,Kappenberger LJ,Brugada P,Ripley KL

    更新日期:1997-03-15 00:00:00

  • Pathophysiology and prognostic significance of Holter-detected ST segment depression after myocardial infarction. The Tissue Plasminogen Activator: Toronto (TPAT) Study Group.

    abstract:OBJECTIVES:We performed Holter monitoring on days 4 and 7 after acute myocardial infarction in 109 patients to assess whether ST segment shift would identify those with more severe coronary artery disease, left ventricular dysfunction and unfavorable prognosis. BACKGROUND:Silent myocardial ischemia is a frequent and p...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Langer A,Minkowitz J,Dorian P,Casella L,Harris L,Morgan CD,Armstrong PW

    更新日期:1992-11-15 00:00:00

  • PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses.

    abstract:OBJECTIVES:The aim of this study was to examine the effect of PCSK9 R46L on low-density lipoprotein cholesterol (LDL-C), risk of ischemic heart disease (IHD), and mortality. BACKGROUND:The 46L allele has been associated with reductions in LDL-C and risk of IHD, but results vary between studies. METHODS:We determined ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,meta分析,评审


    authors: Benn M,Nordestgaard BG,Grande P,Schnohr P,Tybjaerg-Hansen A

    更新日期:2010-06-22 00:00:00

  • A technique for the rapid diagnosis of atrial tachycardia in the electrophysiology laboratory.

    abstract:OBJECTIVE:The purpose of this study was to determine if the atrial response upon cessation of ventricular pacing associated with 1:1 ventriculoatrial conduction during paroxysmal supraventricular tachycardia is a useful diagnostic maneuver in the electrophysiology laboratory. BACKGROUND:Despite various maneuvers, it c...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Knight BP,Zivin A,Souza J,Flemming M,Pelosi F,Goyal R,Man C,Strickberger SA,Morady F

    更新日期:1999-03-01 00:00:00

  • Increased level of pericardial insulin-like growth factor-1 in patients with left ventricular dysfunction and advanced heart failure.

    abstract:OBJECTIVES:To test the hypothesis that the cardiac insulin-like growth factor-1 (IGF-1) system is up-regulated in the failing heart, we measured the pericardial (cardiac) and plasma (circulating) IGF-1 levels in coronary artery disease patients. BACKGROUND:Local IGF-1 systems are regulated differently from the systemi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Abe N,Matsunaga T,Kameda K,Tomita H,Fujiwara T,Ishizaka H,Hanada H,Fukui K,Fukuda I,Osanai T,Okumura K

    更新日期:2006-10-03 00:00:00

  • Sex-Specific Thresholds of High-Sensitivity Troponin in Patients With Suspected Acute Coronary Syndrome.

    abstract:BACKGROUND:Major disparities between women and men in the diagnosis, management, and outcomes of acute coronary syndrome are well recognized. OBJECTIVES:The aim of this study was to evaluate the impact of implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial in...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lee KK,Ferry AV,Anand A,Strachan FE,Chapman AR,Kimenai DM,Meex SJR,Berry C,Findlay I,Reid A,Cruickshank A,Gray A,Collinson PO,Apple FS,McAllister DA,Maguire D,Fox KAA,Newby DE,Tuck C,Keerie C,Weir CJ,Shah ASV,

    更新日期:2019-10-22 00:00:00

  • Symptomatic myocardial bridges: overview of ischemic mechanisms and current diagnostic and treatment strategies.

    abstract::This review article focuses on the morphological and functional alterations that characterize patients with myocardial bridges (MB) as well as the currently available diagnostic and treatment strategies. Because of incomplete understanding of the pathophysiology of MB, their clinical significance has been the subject ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审


    authors: Bourassa MG,Butnaru A,Lespérance J,Tardif JC

    更新日期:2003-02-05 00:00:00

  • Level of adenosine diphosphate receptor P2Y12 blockade during percutaneous coronary intervention predicts the extent of endothelial injury, assessed by circulating endothelial cell measurement.

    abstract:OBJECTIVES:We aimed to investigate whether clopidogrel-induced inhibition of platelet reactivity could reduce the level of circulating endothelial cells (CEC), reflecting the endothelial injury induced by percutaneous coronary intervention (PCI). BACKGROUND:Clopidogrel loading dose before percutaneous coronary angiopl...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章


    authors: Bonello L,Harhouri K,Sabatier F,Camoin-Jau L,Arnaud L,Baumstarck-Barrau K,Ait-Mokhtar O,Roubille F,Piot C,Lesavre N,Paganelli F,Dignat-George F

    更新日期:2010-09-21 00:00:00

  • Intravascular stents in congenital heart disease: short- and long-term results from a large single-center experience.

    abstract:OBJECTIVES:This report describes the results of the Food and Drug Administration's phase 1 and 2 clinical trials of intravascular stents at Texas Children's Hospital. BACKGROUND:Since the late 1980s, intravascular stent implantation for the treatment of arterial and venous stenoses in congenital heart disease has been...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Shaffer KM,Mullins CE,Grifka RG,O'Laughlin MP,McMahon W,Ing FF,Nihill MR

    更新日期:1998-03-01 00:00:00

  • Diagnosis of spontaneous coronary artery dissection by optical coherence tomography.

    abstract:OBJECTIVES:This study sought to assess the diagnostic value of optical coherence tomography (OCT) in patients with suspected spontaneous coronary artery dissection (SCAD). BACKGROUND:SCAD is a rare but challenging clinical entity. METHODS:Following a prospective protocol, OCT was performed in 17 consecutive patients ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Alfonso F,Paulo M,Gonzalo N,Dutary J,Jimenez-Quevedo P,Lennie V,Escaned J,Bañuelos C,Hernandez R,Macaya C

    更新日期:2012-03-20 00:00:00

  • Electrocardiographic evolutionary changes and left ventricular remodeling after acute myocardial infarction: results of the GISSI-3 Echo substudy.

    abstract:OBJECTIVES:The aim of this study was to describe the electrocardiographic (ECG) evolutionary changes after an acute myocardial infarction (AMI) and to evaluate their correlation with left ventricular function and remodeling. BACKGROUND:The QRS complex changes after AMI have been correlated with infarct size and left v...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bosimini E,Giannuzzi P,Temporelli PL,Gentile F,Lucci D,Maggioni AP,Tavazzi L,Badano L,Stoian I,Piazza R,Heyman I,Levantesi G,Cervesato E,Geraci E,Nicolosi GL

    更新日期:2000-01-01 00:00:00

  • Sudden death in a pediatric cardiology population, 1958 to 1983: relation to prior arrhythmias.

    abstract::This review of sudden death in patients previously seen in a pediatric cardiology clinic attempts to identify factors that may have been predictive of sudden death. The denominator for these factors is unknown. For example, the number of patients with these possible risk factors who have well tolerated arrhythmias is ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Garson A Jr,McNamara DG

    更新日期:1985-06-01 00:00:00

  • Double outlet right ventricle associated with common atrioventricular canal: report of nine anatomic specimens.

    abstract::Double outlet right ventricle associated with complete atrioventricular (AV) canal is a rare malformation. Nine cases are reported. In this abnormality the anterior AV leaflet is undivided and free floating and the aortic and pulmonary orifices are in the same frontal plane. In four of the nine cases, the conus was bi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Toussaint M,Planche C,Graff WC,Royon M,Ribierre M

    更新日期:1986-08-01 00:00:00

  • Isolated systolic hypertension in young and middle-aged adults and 31-year risk for cardiovascular mortality: the Chicago Heart Association Detection Project in Industry study.

    abstract:BACKGROUND:Isolated systolic hypertension (ISH), defined as systolic blood pressure (SBP) ≥140 mm Hg and diastolic blood pressure (DBP) <90 mm Hg, in younger and middle-aged adults is increasing in prevalence. OBJECTIVE:The aim of this study was to assess the risk for cardiovascular disease (CVD) with ISH in younger a...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章


    authors: Yano Y,Stamler J,Garside DB,Daviglus ML,Franklin SS,Carnethon MR,Liu K,Greenland P,Lloyd-Jones DM

    更新日期:2015-02-03 00:00:00