Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.

Abstract:

BACKGROUND:Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation. OBJECTIVES:The purpose of this study was to investigate possible causal associations between dietary-derived circulating antioxidants and primary CHD risk using 2-sample Mendelian randomization (MR). METHODS:Single-nucleotide polymorphisms for circulating antioxidants (vitamins E and C, retinol, β-carotene, and lycopene), assessed as absolute levels and metabolites, were retrieved from the published data and were used as genetic instrumental variables. Summary statistics for gene-CHD associations were obtained from 3 databases: the CARDIoGRAMplusC4D consortium (60,801 cases; 123,504 control subjects), UK Biobank (25,306 cases; 462,011 control subjects), and FinnGen study (7,123 cases; 89,376 control subjects). For each exposure, MR analyses were performed per outcome database and were subsequently meta-analyzed. RESULTS:Among an analytic sample of 768,121 individuals (93,230 cases), genetically predicted circulating antioxidants were not causally associated with CHD risk. For absolute antioxidants, the odds ratio for CHD ranged between 0.94 (95% confidence interval [CI]: 0.63 to 1.41) for retinol and 1.03 (95% CI: 0.97 to 1.10) for β-carotene per unit increase in ln-transformed antioxidant values. For metabolites, the odds ratio ranged between 0.93 (95% CI: 0.82 to 1.06) for γ-tocopherol and 1.01 (95% CI: 0.95 to 1.08) for ascorbate per 10-fold increase in metabolite levels. CONCLUSIONS:Evidence from our study did not support a protective effect of genetic predisposition to high dietary-derived antioxidant levels on CHD risk. Therefore, it is unlikely that taking antioxidants to increase blood antioxidants levels will have a clinical benefit for the prevention of primary CHD.

journal_name

J Am Coll Cardiol

authors

Luo J,le Cessie S,van Heemst D,Noordam R

doi

10.1016/j.jacc.2020.10.048

subject

Has Abstract

pub_date

2021-01-05 00:00:00

pages

45-54

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(20)37793-7

journal_volume

77

pub_type

杂志文章
  • Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women: JACC State-of-the-Art Review.

    abstract::Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality for women in the United States and worldwide. There has been no American College of Cardiology (ACC)/American Heart Association guideline update specifically for the prevention of CVD in women since 2011. Since then, the body of sex-spec...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2020.03.060

    authors: Cho L,Davis M,Elgendy I,Epps K,Lindley KJ,Mehta PK,Michos ED,Minissian M,Pepine C,Vaccarino V,Volgman AS,ACC CVD Womens Committee Members.

    更新日期:2020-05-26 00:00:00

  • The Evolution of β-Blockers in Coronary Artery Disease and Heart Failure (Part 1/5).

    abstract::As new treatments continue to improve clinical outcomes in coronary artery disease (CAD) and heart failure, it is necessary to characterize the appropriate use of β-adrenergic receptor blockers (β-blockers) in the contemporary management of these conditions. This review examines the current evidence supporting β-block...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2019.04.067

    authors: Joseph P,Swedberg K,Leong DP,Yusuf S

    更新日期:2019-08-06 00:00:00

  • Value of the electrocardiogram in localizing the occlusion site in the left anterior descending coronary artery in acute anterior myocardial infarction.

    abstract:OBJECTIVES:The study assessed the value of the electrocardiogram (ECG) as predictor of the left anterior descending coronary artery (LAD) occlusion site in relation to the first septal perforator (S1) and/or the first diagonal branch (D1) in patients with acute anterior myocardial infarction (AMI). BACKGROUND:In anter...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(99)00197-7

    authors: Engelen DJ,Gorgels AP,Cheriex EC,De Muinck ED,Ophuis AJ,Dassen WR,Vainer J,van Ommen VG,Wellens HJ

    更新日期:1999-08-01 00:00:00

  • C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A substudy. Thrombolysis in Myocardial Infarction.

    abstract:OBJECTIVES:We evaluated C-reactive protein (CRP) alone and in conjunction with a rapid qualitative assay for cardiac-specific troponin T (cTnT) for predicting 14-day mortality in patients with unstable angina or non-Q wave myocardial infarction (NQMI). BACKGROUND:Elevated CRP has been found to correlate with higher ri...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0735-1097(98)00136-3

    authors: Morrow DA,Rifai N,Antman EM,Weiner DL,McCabe CH,Cannon CP,Braunwald E

    更新日期:1998-06-01 00:00:00

  • Intracellular calcium transients in human working myocardium as detected with aequorin.

    abstract::The calcium transients associated with contraction in human working myocardium were recorded by use of the bioluminescent protein, aequorin, a substance that emits light when it combines with calcium ion (Ca++). Small amounts of aequorin were microinjected into superficial cells of human atrial and ventricular muscle ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80028-5

    authors: Morgan JP,Chesebro JH,Pluth JR,Puga FJ,Schaff HV

    更新日期:1984-02-01 00:00:00

  • Ventricular function and infarct size: the Western Washington Intravenous Streptokinase in Myocardial Infarction Trial.

    abstract::The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Trial randomized 368 patients with symptoms and signs of acute myocardial infarction of less than 6 h duration to either conventional care or 1.5 million units of intravenous streptokinase. The mean time to randomization was 209 min and 52...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0735-1097(88)90197-0

    authors: Ritchie JL,Cerqueira M,Maynard C,Davis K,Kennedy JW

    更新日期:1988-04-01 00:00:00

  • Induction of silent myocardial ischemia with mental stress testing: relation to the triggers of ischemia during daily life activities and to ischemic functional severity.

    abstract:OBJECTIVES:This study examined the relations among the triggers of ischemia during the activities of daily life, mental stress-induced ischemia in the laboratory and functional severity of ischemia on exercise testing. BACKGROUND:Myocardial ischemia is readily induced with exercise testing, but most episodes of ischem...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)90169-4

    authors: Gottdiener JS,Krantz DS,Howell RH,Hecht GM,Klein J,Falconer JJ,Rozanski A

    更新日期:1994-12-01 00:00:00

  • Influence of treatment modality on angiographic outcome after coronary stenting in diabetic patients: a controlled study.

    abstract:OBJECTIVES:This retrospective study was designed to determine the six-month angiographic outcome after stenting of native coronary arteries in insulin-treated (ITDM) and non-ITDM patients with diabetes mellitus (DM) and compare the results with those in non-DM patients. BACKGROUND:The influence of the treatment modali...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(00)00574-x

    authors: Schofer J,Schlüter M,Rau T,Hammer F,Haag N,Mathey DG

    更新日期:2000-05-01 00:00:00

  • Predictive value of wavelet correlation functions of signal-averaged electrocardiogram in patients after anterior versus inferior myocardial infarction.

    abstract:OBJECTIVES:This study sought to evaluate the prognostic value of wavelet correlation functions of the signal-averaged electrocardiogram (ECG) for arrhythmic events in patients after myocardial infarction. BACKGROUND:Wavelet transform of the signal-averaged ECG has been shown to be a nonstationary analysis technique de...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/0735-1097(96)80739-X

    authors: Reinhardt L,Mäkijärvi M,Fetsch T,Montonen J,Sierra G,Martínez-Rubio A,Katila T,Borggrefe M,Breithardt G

    更新日期:1996-01-01 00:00:00

  • Antithrombotic therapy in patients with valvular heart disease and prosthetic heart valves.

    abstract::Indications and the type of antithrombotic therapy for the prevention of thromboembolism in patients with valvular heart disease, mechanical prosthetic heart valves and bioprosthetic heart valves are discussed. The evidence for these clinical recommendations is described and graded into five levels. The indications fo...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0735-1097(86)80006-7

    authors: Chesebro JH,Adams PC,Fuster V

    更新日期:1986-12-01 00:00:00

  • Rapid electrical stimulation of contraction modulates gap junction protein in neonatal rat cultured cardiomyocytes: involvement of mitogen-activated protein kinases and effects of angiotensin II-receptor antagonist.

    abstract:OBJECTIVES:The aim of this study was to investigate the effects of rapid electrical stimulation (RES) of contraction on the expression of connexin (Cx)43 gap junction in neonatal rat cultured ventricular myocytes and the consequent changes of conduction properties. BACKGROUND:The expression and distribution of gap jun...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2004.05.054

    authors: Inoue N,Ohkusa T,Nao T,Lee JK,Matsumoto T,Hisamatsu Y,Satoh T,Yano M,Yasui K,Kodama I,Matsuzaki M

    更新日期:2004-08-18 00:00:00

  • Magnetic resonance imaging of arrhythmogenic right ventricular dysplasia: sensitivity, specificity, and observer variability of fat detection versus functional analysis of the right ventricle.

    abstract:OBJECTIVES:The purpose of this study was to determine interobserver agreement for interpretation of magnetic resonance imaging (MRI) examinations of arrhythmogenic right ventricular dysplasia (ARVD) and to determine sensitivity and specificity of fat detection versus functional parameters measured by MRI. BACKGROUND:T...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2006.07.051

    authors: Tandri H,Castillo E,Ferrari VA,Nasir K,Dalal D,Bomma C,Calkins H,Bluemke DA

    更新日期:2006-12-05 00:00:00

  • Tracking dynamic conduction recovery across the cavotricuspid isthmus.

    abstract:OBJECTIVES:We sought to assess the dynamic temporal course of conduction recovery during and after radiofrequency (RF) catheter ablation of the cavotricuspid isthmus. BACKGROUND:Although cavotricuspid isthmus block is accepted as the best end point of ablation for typical flutter, conduction recovery is thought to und...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(00)00600-8

    authors: Shah DC,Takahashi A,Jaïs P,Hocini M,Peng JT,Clementy J,Haïssaguerre M

    更新日期:2000-05-01 00:00:00

  • The prevalence and outcomes of transradial percutaneous coronary intervention for ST-segment elevation myocardial infarction: analysis from the National Cardiovascular Data Registry (2007 to 2011).

    abstract:OBJECTIVES:The purpose of this study was to examine use and describe outcomes of radial access for percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Transradial PCI (TRI) is associated with reduced risk of bleeding and vascular complications, as co...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2012.10.032

    authors: Baklanov DV,Kaltenbach LA,Marso SP,Subherwal SS,Feldman DN,Garratt KN,Curtis JP,Messenger JC,Rao SV

    更新日期:2013-01-29 00:00:00

  • Reversible atrioventricular block associated with closure of atrial septal defects using the Amplatzer device.

    abstract:OBJECTIVES:We sought to determine the incidence, nature, and predisposing factors of atrioventricular block (AVB) associated with closure of atrial septal defects (ASDs) using the Amplatzer septal occluder (ASO). BACKGROUND:In our institution, 162 patients underwent ASD closure using ASO between December 1997 and Dece...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2003.12.042

    authors: Suda K,Raboisson MJ,Piette E,Dahdah NS,Miró J

    更新日期:2004-05-05 00:00:00

  • Infarct artery perfusion and changes in left ventricular volume in the month after acute myocardial infarction.

    abstract::The relation between perfusion of the infarct-related artery and changes in left ventricular volume and function during the month after a first myocardial infarction was examined in 40 patients who did not receive thrombolytic therapy. Infarct artery perfusion was documented at predischarge coronary angiography, and l...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(87)80298-x

    authors: Jeremy RW,Hackworthy RA,Bautovich G,Hutton BF,Harris PJ

    更新日期:1987-05-01 00:00:00

  • Flecainide acetate for resistant arrhythmias in the young: efficacy and pharmacokinetics.

    abstract::Drug efficacy and pharmacokinetics were assessed in 63 patients, aged 5 days to 30 years (mean 8 years), who received flecainide acetate for control of resistant arrhythmias. Doses of flecainide ranged from 59 to 225 mg/m2 body surface area per day (mean 141) in divided doses every 8 to 12 h and serum trough levels ra...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(89)90070-3

    authors: Perry JC,McQuinn RL,Smith RT Jr,Gothing C,Fredell P,Garson A Jr

    更新日期:1989-07-01 00:00:00

  • Coexistent pulmonary and portal hypertension: morphologic and clinical features.

    abstract::Patients with portal hypertension of varying etiology may develop pulmonary artery hypertension. In the present autopsy study, pulmonary and hepatic tissue was studied in 12 patients in whom pulmonary and portal hypertension coexisted. Plexogenic pulmonary arteriopathy was present in 10 patients, 7 of whom had coexist...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(87)80123-7

    authors: Edwards BS,Weir EK,Edwards WD,Ludwig J,Dykoski RK,Edwards JE

    更新日期:1987-12-01 00:00:00

  • Determinants of the spontaneous ectopic activity in repetitive monomorphic idiopathic ventricular tachycardia.

    abstract::Twenty-four hour ambulatory electrocardiographic tape recordings of 30 patients (16 men and 14 women, mean age 42 +/- 17 years) with repetitive monomorphic idiopathic ventricular tachycardia were analyzed using a new computerized system designed to study 15 RR cycles and mean heart rate of the 3 minutes preceding any ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(86)80139-5

    authors: Zimmermann M,Maisonblanche P,Cauchemez B,Leclercq JF,Coumel P

    更新日期:1986-06-01 00:00:00

  • Prognostic implications of atrial fibrillation in patients undergoing myocardial perfusion single-photon emission computed tomography.

    abstract:OBJECTIVES:The aim of this research was to determine whether presence of atrial fibrillation (AF) provides incremental prognostic information relative to myocardial perfusion single-photon emission computed tomography (MPS) with respect to risk of cardiac death (CD). BACKGROUND:The prognostic significance of AF in pat...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2004.05.076

    authors: Abidov A,Hachamovitch R,Rozanski A,Hayes SW,Santos MM,Sciammarella MG,Cohen I,Gerlach J,Friedman JD,Germano G,Berman DS

    更新日期:2004-09-01 00:00:00

  • Transesophageal Doppler color flow mapping assessment of atrial septal defect.

    abstract::Transesophageal Doppler color flow imaging was performed in 19 adult patients (mean age 35 years) with an atrial septal defect demonstrated by cardiac catheterization or at surgery, or both. The transesophageal study correctly identified and classified 19 of 19 shunts in contrast to 16 of 18 shunts identified by the t...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(10)80355-9

    authors: Mehta RH,Helmcke F,Nanda NC,Hsiung M,Pacifico AD,Hsu TL

    更新日期:1990-10-01 00:00:00

  • Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.

    abstract:OBJECTIVES:The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. BACKGROUND:It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coron...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jacc.2012.01.078

    authors: Helgadottir A,Gretarsdottir S,Thorleifsson G,Holm H,Patel RS,Gudnason T,Jones GT,van Rij AM,Eapen DJ,Baas AF,Tregouet DA,Morange PE,Emmerich J,Lindblad B,Gottsäter A,Kiemeny LA,Lindholt JS,Sakalihasan N,Ferrell RE,C

    更新日期:2012-08-21 00:00:00

  • Effect of chronic supraventricular tachycardia on left ventricular function and structure in newborn pigs.

    abstract:OBJECTIVES:The purpose of this study was to examine the effects of supraventricular pacing tachycardia on left ventricular function and myocardial structure in newborn, immature pigs and to determine whether immature pigs respond to supraventricular tachycardia differently from adults. BACKGROUND:Previous studies have...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(92)90462-v

    authors: Tanaka R,Spinale FG,Crawford FA,Zile MR

    更新日期:1992-12-01 00:00:00

  • Persistent transient myocardial ischemia despite beta-adrenergic blockade predicts a higher risk of adverse cardiac events in patients with coronary artery disease.

    abstract:OBJECTIVES:We evaluated the prevalence and prognostic significance of transient myocardial ischemia despite beta-adrenergic blockade in patients with coronary artery disease. BACKGROUND:Persistence of transient ischemia despite therapy may correspond to a subset of high risk patients with coronary disease. The impact ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0735-1097(96)00050-2

    authors: Madjlessi-Simon T,Mary-Krause M,Fillette F,Lechat P,Jaillon P

    更新日期:1996-06-01 00:00:00

  • Clinical outcomes of catheter substrate ablation for high-risk patients with atrial fibrillation.

    abstract:OBJECTIVES:The purpose of this study was to determine the long-term clinical outcomes of catheter ablation of atrial fibrillation (AF) substrate for high-risk patients with AF. BACKGROUND:The benefits of catheter ablation for high-risk AF patients with respect to mortality and stroke reductions remain unclear. METHOD...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2007.10.044

    authors: Nademanee K,Schwab MC,Kosar EM,Karwecki M,Moran MD,Visessook N,Michael AD,Ngarmukos T

    更新日期:2008-02-26 00:00:00

  • Noninvasive measurement of the rest and exercise peak systolic pressure/end-systolic volume ratio: a sensitive two-dimensional echocardiographic indicator of left ventricular function.

    abstract::Thirty-five patients with previous myocardial infarction and 25 normal subjects underwent subcostal view two-dimensional echocardiography at rest and at peak up-right bicycle exercise. The purpose was to assess changes in left ventricular volume with maximal upright bicycle exercise and to compare the utility of the p...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80094-7

    authors: Ginzton LE,Laks MM,Brizendine M,Conant R,Mena I

    更新日期:1984-09-01 00:00:00

  • Application of metabolomics to cardiovascular biomarker and pathway discovery.

    abstract::Emerging technologies based on mass spectrometry and nuclear magnetic resonance enable the monitoring of hundreds of metabolites from tissues or body fluids, that is, "metabolomics." Because metabolites change rapidly in response to physiologic perturbations, they represent proximal reporters of disease phenotypes. Th...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2008.03.043

    authors: Lewis GD,Asnani A,Gerszten RE

    更新日期:2008-07-08 00:00:00

  • Acute endocarditis in drug addicts: surgical treatment for multiple valve infection.

    abstract::In 72 drug abusers surgically treated for acute infective endocarditis, 14 patients (19%) required surgical procedures on two valves. The predominant infecting organisms were Staphylococcus aureus and Pseudomonas aeruginosa (29%). In contrast to single valve infection, congestive heart failure was the most common oper...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80393-9

    authors: Silverman NA,Levitsky S,Mammana R

    更新日期:1984-10-01 00:00:00

  • Electroanatomic mapping of arrhythmogenic right ventricular dysplasia.

    abstract:OBJECTIVES:We tested the hypothesis that spatial association of low-amplitude intracardiac electrograms can identify the presence, location and extent of dysplastic regions in arrhythmogenic right ventricular dysplasia (ARVD). BACKGROUND:Arrhythmogenic right ventricular dysplasia is a right ventricular (RV) cardiomyop...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(01)01625-4

    authors: Boulos M,Lashevsky I,Reisner S,Gepstein L

    更新日期:2001-12-01 00:00:00

  • Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study.

    abstract:UNLABELLED:The relationship between renal insufficiency and amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels remains unclear. We examined this relationship in the context of patients who presented to the emergency department of an urban tertiary care medical center with dyspnea. Even in the presence of r...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2005.08.051

    authors: Anwaruddin S,Lloyd-Jones DM,Baggish A,Chen A,Krauser D,Tung R,Chae C,Januzzi JL Jr

    更新日期:2006-01-03 00:00:00