Role of acetate during platelet storage in a synthetic medium.

abstract：:The US Food and Drug Administration (FDA) held a workshop on red blood cell (RBC) product regulatory science on October 6 and 7, 2016, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. The workshop was supported by the National Heart, Lung, and Blood Institute, N...

journal_title：Transfusion

authors： Vostal JG,Buehler PW,Gelderman MP,Alayash AI,Doctor A,Zimring JC,Glynn SA,Hess JR,Klein H,Acker JP,Spinella PC,D'Alessandro A,Palsson B,Raife TJ,Busch MP,McMahon TJ,Intaglietta M,Swartz HM,Dubick MA,Cardin S,Patel

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Commercially available additive solutions (ASs) require 30% to 35% plasma for optimal storage of platelets (PLTs). PLTs suspended in M-sol, a bicarbonate-based experimental platelet additive solution (PAS), maintain in vitro PLT properties during storage with low levels of plasma (< or =5%). STUDY DESIGN AN...

journal_title：Transfusion

authors： Wagner SJ,Skripchenko A,Myrup A,Thompson-Montgomery D,Awatefe H,Moroff G

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Endothelial cells (ECs) play a pivotal role in the allogeneic immune response upon transplantation. Semaphorin 3A (Sema3A) was implicated in the modulation of EC growth, but its effects on immunogenicity were not previously investigated. STUDY DESIGN AND METHODS:ECs were transduced with a lentiviral vector ...

journal_title：Transfusion

authors： Schlahsa L,Zhang H,Battermann A,Verboom M,Immenschuh S,Eiz-Vesper B,Stripecke R,Engelmann K,Blasczyk R,Figueiredo C

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Blood transfusion has been cited as one of the five most overutilized therapeutic procedures in the United States. We assessed the impact of clinical decision support at computerized physician order entry and education on red blood cell (RBC) transfusions and clinical patient outcomes at our institution. ST...

journal_title：Transfusion

authors： Goodnough LT,Maggio P,Hadhazy E,Shieh L,Hernandez-Boussard T,Khari P,Shah N

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:At Canadian Blood Services, platelet concentrate (PC) shelf life was extended to 7 days with a large-volume, delayed-sampling bacterial screening algorithm. We present the development study and postimplementation results. STUDY DESIGN AND METHODS:In the development study, PCs inoculated with five bacteria (...

journal_title：Transfusion

authors： Ramirez-Arcos S,Evans S,McIntyre T,Pang C,Yi QL,DiFranco C,Goldman M

更新日期：2020-12-01 00:00:00

abstract：:The quantity of anti-IgG bound at equilibrium to cell-bound anti-D failed to increase with enzymatic modification of intact red blood cells. This contrasts with results obtained by immunoelectronmicroscopy with unsealed red blood cell ghosts. Ghosts derived from enzyme-modified, anti-D-sensitized intact red blood cell...

journal_title：Transfusion

authors： Rearden A,Masouredis SP

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:Besides ABO and RH, the KEL blood group system, including the two antithetical antigens KEL1 and KEL2, is the most important owing to the frequent appearance of anti-KEL alloantibodies and their considerable clinical significance. So far, only limited information was available on KEL variant alleles determin...

journal_title：Transfusion

authors： Körmöczi GF,Wagner T,Jungbauer C,Vadon M,Ahrens N,Moll W,Mühlbacher A,Ozgül-Gülce S,Kleinrath T,Kilga-Nogler S,Schönitzer D,Gassner C

更新日期：2007-04-01 00:00:00

abstract：:Blood from humans collected into heparin or citrate was inoculated with toxoplasma organisms. After storage at 4 C up to 28 days, samples were injected into the ear veins of rabbits. The test rabbits developed toxoplasmosis. Similar results were obtained by transfusing rabbits with blood obtained from rabbits subcutan...

journal_title：Transfusion

authors： Räisänen S

更新日期：1978-05-01 00:00:00

abstract：:The studies reported in this monograph were performed between 1972 and 2002 when it was possible to study healthy male and female baboons. A colony of baboons was maintained for 30 years without any adverse events observed in these baboons in the numerous studies that were performed. These protocols were reviewed and ...

journal_title：Transfusion

authors： Valeri CR,Ragno G

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Hemolytic disease of the fetus and newborn (HDFN) is a severe disease, resulting from maternal red cell (RBC) alloantibodies directed against fetal RBCs. The effect of a first-trimester antibody screening program on the timely detection of HDFN caused by antibodies other than anti-D was evaluated. STUDY DES...

journal_title：Transfusion

authors： Koelewijn JM,Vrijkotte TG,van der Schoot CE,Bonsel GJ,de Haas M

更新日期：2008-05-01 00:00:00

abstract：:The initial uptake of adenine from plasma by human red blood cells was measured at 0, 10, and 20 C. Initial uptake is completed in several minutes as distribution equilibrium is reached; however, total uptake requires several weeks at 4 C. Adenine inside the red blood cell was shown to egress to the plasma if the equi...

journal_title：Transfusion

authors： Moore GL,Ledford ME

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Perioperative red blood cell transfusions are commonly used in patients undergoing cardiac surgery to correct anemia caused by blood loss and hemodilution associated with cardiopulmonary bypass circulation. The aim of this investigation was to test the hypothesis that blood transfusion has beneficial effects...

journal_title：Transfusion

authors： Yuruk K,Almac E,Bezemer R,Goedhart P,de Mol B,Ince C

更新日期：2011-05-01 00:00:00

abstract：:Controversy exists about the suitability of blood from autologous donors for homologous use. We compared the infectious disease test results of 426 autologous donors, designated by donor history as suitable for homologous use, to those of 86,138 volunteer donations collected over the same 5 month period. Although dono...

journal_title：Transfusion

authors： Grossman BJ,Stewart NC,Grindon AJ

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:There is controversy regarding the application of transfusion triggers in cardiac surgery. The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting pa...

journal_title：Transfusion

authors： Bracey AW,Radovancevic R,Riggs SA,Houston S,Cozart H,Vaughn WK,Radovancevic B,McAllister HA Jr,Cooley DA

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Storage age of red blood cells (RBCs) has been reported to be associated with increased mortality and morbidity. During storage, RBCs undergo changes in biochemical and functional properties. Stored RBCs may also contain white blood cells (WBCs), activated platelets (PLTs), cytokines, immunoglobulin, and oth...

journal_title：Transfusion

authors： Sowemimo-Coker SO

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Transfusion-associated microchimerism (TA-MC), the persistence of significant levels of donor white blood cells (WBCs) in blood recipients for prolonged periods, has been demonstrated after nonleukoreduced and leukoreduced transfusion to patients with severe traumatic injury. Development of TA-MC has not bee...

journal_title：Transfusion

authors： Sanchez R,Lee TH,Wen L,Montalvo L,Schechterly C,Colvin C,Alter HJ,Luban NL,Busch MP

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:It is important to compare the incidence of bacterial contamination of components collected from the peripheral blood or bone marrow (BM), as well as of components processed with or without cell selection or depletion, and to evaluate the sequelae of such contamination. STUDY DESIGN AND METHODS:Bacterial co...

journal_title：Transfusion

authors： Webb IJ,Coral FS,Andersen JW,Elias AD,Finberg RW,Nadler LM,Ritz J,Anderson KC

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:In this study whether metabolic suppression can be used to preserve platelet (PLT) function during prolonged storage was investigated. STUDY DESIGN AND METHODS:Washed human PLTs were incubated without glucose and with antimycin A to block energy generation. Metabolic suppressed PLTs (MSPs) were stored for 7...

journal_title：Transfusion

authors： Badlou BA,Ijseldijk MJ,Smid WM,Akkerman JW

更新日期：2005-02-01 00:00:00

abstract：:The present study describes the use of a new polyacrolein microsphere (acrobead) protein A column. This method enables immunomodulation by the perfusion of whole blood. The efficacy of the column and its adverse effects following perfusion of blood of patients with immune thrombocytopenic purpura (ITP) or malignancies...

journal_title：Transfusion

authors： Dvilansky A,Aharon M,Riesenfeld G,Nathan I

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:The testing of cord blood (CB) progenitor and stem cell units for transplantation suitability involves enumeration of total nucleated cells before freezing. CD34+ cell counts may also be a means of determining suitability. Studies have been conducted to evaluate how specific storage conditions influence cell...

journal_title：Transfusion

authors： Kurtz J,Seetharaman S,Greco N,Moroff G

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Life-threatening situations requiring blood transfusion under extreme conditions or in remote and austere locations, such as the battlefield or in traffic accidents, would benefit from reliable blood typing practices that are easily understood by a nonscientist or nonlaboratory technician and provide quick r...

journal_title：Transfusion

authors： Clavier B,Pouget T,Sailliol A

更新日期：2018-02-01 00:00:00

abstract：:A microplate system for performing ABO and Rh(D) blood group determinations with a Kemble Kemtek 1000SP liquid handling processor, an Anthos 2001 microplate reader, an IBM Personal System 2 microcomputer, and Sanguin Forma software is described. The performance of this Kemble/Anthos/IBM/Sanguin microplate system for A...

journal_title：Transfusion

authors： Chung A,Birch P,Ilagan K

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:The AABB Clinical Transfusion Medicine Committee (CTMC) compiles an annual synopsis of the published literature covering important developments in the field of transfusion medicine (TM) for the board of director's review. This synopsis is now made available as a manuscript published in TRANSFUSION. STUDY DE...

journal_title：Transfusion

authors： Pagano MB,Allen ES,Chou ST,Dunbar NM,Gniadek T,Goel R,Harm SK,Hopkins CK,Jacobson J,Lokhandwala PM,Metcalf RA,Raval JS,Schwartz J,Shan H,Spinella PC,Storch E,Cohn CS

更新日期：2020-07-01 00:00:00

abstract：:Clinical and serological data on 1435 Italian thalassemia major patients were collected during a cooperative study involving 19 centers in 10 regions. The main findings were as follows: 18 percent of the patients were under 6 years of age, 63 percent between 6 and 15, and 19 percent over 15. Forty-one percent had unde...

journal_title：Transfusion

authors： Sirchia G,Zanella A,Parravicini A,Morelati F,Rebulla P,Masera G

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The mechanism of action of anti-D in ameliorating immune thrombocytopenia (ITP) remains unclear. The monoclonal antibody (MoAb) Ter119, which targets murine red blood cells (RBCs), has been shown to mimic the effect of anti-D in improving antibody-mediated murine ITP. The mechanism of Ter119-mediated ITP ame...

journal_title：Transfusion

authors： Yu X,Menard M,Seabright G,Crispin M,Lazarus AH

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Uncommonly, antibodies that appear to exhibit antigenic specificity on red blood cell (RBC) panels fail to maintain specificity following alloadsorption (i.e., they mimic antigenic specificity). Understanding both the pitfalls and the proper pathways to establish the diagnosis and to interpret the clinical s...

journal_title：Transfusion

authors： Dwyre DM,Clapper A,Heintz M,Elbert C,Strauss RG

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Absolute counts of CD4+ T-lymphocytes are used in the management of patients with human immunodeficiency virus infection. Low absolute counts of CD3+CD4+ cells have also been observed in healthy people--a phenomenon called idiopathic CD4 lymphocytopenia. It is common practice for normal ranges for lymphocyte...

journal_title：Transfusion

authors： Bryant JA,Wylie BR,Yuan FF,Ribeiro A,Thomson AR,Cooley MA,Fletcher A

更新日期：1996-06-01 00:00:00

abstract：:The In(Lu) gene, which inhibits the expression of Lutheran blood group antigens by red cells (RBCs), also down-regulates the expression of an 80-kD glycoprotein, In(Lu)-related p80, by both RBCs and a subset of white cells. This study examined the expression of multiple-RBC p80 epitopes by autosomal and X-linked reces...

journal_title：Transfusion

authors： Telen MJ,Green AM

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Preliminary evidence of cases of acute occult hepatitis B virus (HBV) infection (OBI) has been recently reported in the literature. Furthermore, OBI definition has been the object of an international consensus conference. STUDY DESIGN AND METHODS:A case of acute primary OBI was identified and followed up in...

journal_title：Transfusion

authors： Manzini P,Abate ML,Valpreda C,Milanesi P,Curti F,Rizzetto M,Smedile A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Jra is a high-frequency antigen seen in all populations, but the clinical significance of Jra antibodies is incompletely understood. Two cases are reported in which patients with anti-Jra received incompatible transfusions. CASE REPORTS:A 69-year-old Japanese man had anti-K and anti-Jra. Despite multiple tr...

journal_title：Transfusion

authors： Kwon MY,Su L,Arndt PA,Garratty G,Blackall DP

更新日期：2004-02-01 00:00:00