Blood transfusions recruit the microcirculation during cardiac surgery.


BACKGROUND:Perioperative red blood cell transfusions are commonly used in patients undergoing cardiac surgery to correct anemia caused by blood loss and hemodilution associated with cardiopulmonary bypass circulation. The aim of this investigation was to test the hypothesis that blood transfusion has beneficial effects on sublingual microcirculatory density, perfusion, and oxygenation. To this end, sidestream dark field (SDF) imaging and spectrophotometry were applied sublingually before and after blood transfusion during cardiac surgery. STUDY DESIGN AND METHODS:Twenty-four adult patients undergoing on-pump cardiac surgery, including coronary artery bypass grafting, cardiac-valve surgery, or a combination of these two procedures, were included consecutively in this prospective, observational study. Sublingual microcirculatory density and perfusion were assessed using SDF imaging in 12 patients (Group A). Sublingual reflectance spectrophotometry was applied in 12 patients (Group B) to monitor microcirculatory oxygenation and hemoglobin (Hb) concentration. RESULTS:Blood transfusion caused an increase in systemic Hb concentration (p < 0.01) and hematocrit (p < 0.01). At the microcirculatory level, blood transfusion resulted in increased microcirculatory density (from 10.5 ± 1.2 to 12.9 ± 1.2 mm capillary/mm(2) tissue, p < 0.01) as shown using SDF imaging. In concert with the SDF measurements, spectrophotometry showed that microcirculatory Hb content increased from 61.4 ± 5.9 to 70.0 ± 4.7 AU (p < 0.01) and that microcirculatory Hb oxygen saturation increased from 65.6 ± 8.3% to 68.6 ± 8.4% (p = 0.06). CONCLUSION:In this study we have shown that blood transfusion: 1) improves the systemic circulation and oxygen-carrying capacity, 2) improves sublingual microcirculatory density but not perfusion velocity, and 3) improves microcirculatory oxygen saturation.






Yuruk K,Almac E,Bezemer R,Goedhart P,de Mol B,Ince C




Has Abstract


2011-05-01 00:00:00












  • Dimethyl sulfoxide: effects on function of fresh platelets and on the viability of platelets in storage.

    abstract::Dimethyl sulfoxide (DMSO) is used as a cryoprotective agent when platelets are frozen. We examined the effect of DMSO (0.1 to 10%) on platelet aggregation, release, and prostaglandin synthesis (as indicated by malondialdehyde formation) in response to thrombin, collagen, arachidonic acid and calcium ionophore. Inhibit...


    pub_type: 杂志文章


    authors: Fratantoni JC,Poindexter BJ

    更新日期:1983-03-01 00:00:00

  • A novel approach to pathogen reduction in platelet concentrates using short-wave ultraviolet light.

    abstract:BACKGROUND:Transfusion of platelet concentrates (PCs) is the basic treatment for severe platelet disorders. PCs carry the risk of pathogen transmission, especially bacteria. Pathogen reduction (PR) by addition of photochemical reagents and irradiation with visible or ultraviolet (UV) light can significantly reduce this...


    pub_type: 杂志文章


    authors: Mohr H,Steil L,Gravemann U,Thiele T,Hammer E,Greinacher A,Müller TH,Völker U

    更新日期:2009-12-01 00:00:00

  • Plateletpheresis does not cause long-standing platelet-derived growth factor release into the donor blood.

    abstract:BACKGROUND:Recently, long-standing elevations of soluble growth factors released from platelets (PLTs) after contact with artificial surfaces during dialysis were described. They could be jointly responsible for the high frequency of death from cardiovascular diseases in dialysis patients. There are no comparable data ...


    pub_type: 杂志文章


    authors: Zimmermann R,Loew D,Weisbach V,Strasser E,Ringwald J,Zingsem J,Eckstein R

    更新日期:2005-03-01 00:00:00

  • Filtration of methylene blue-photooxidized plasma: influence on coagulation and cellular contamination.

    abstract:BACKGROUND:Virus inactivation of plasma can be achieved by photodynamic methods in the presence of phenothiazine dyes such as methylene blue (MB). Subsequent filtration may increase the efficacy of virus inactivation and reduce adverse effects of WBC contamination and MB. STUDY DESIGN AND METHODS:This study examined t...


    pub_type: 杂志文章


    authors: Riggert J,Humpe A,Legler TJ,Wolf C,Simson G,Köhler M

    更新日期:2001-01-01 00:00:00

  • Evidence of acute primary occult hepatitis B virus infection in an Italian repeat blood donor.

    abstract:BACKGROUND:Preliminary evidence of cases of acute occult hepatitis B virus (HBV) infection (OBI) has been recently reported in the literature. Furthermore, OBI definition has been the object of an international consensus conference. STUDY DESIGN AND METHODS:A case of acute primary OBI was identified and followed up in...


    pub_type: 杂志文章


    authors: Manzini P,Abate ML,Valpreda C,Milanesi P,Curti F,Rizzetto M,Smedile A

    更新日期:2009-04-01 00:00:00

  • The in vitro evaluation of modifications in CPD-adenine anticoagulated-preserved blood at various hematocrits.

    abstract::Erythrocytes stored in the new CPD-adenine anticoagulant (CPDA-1) barely met the 70 per cent 24-hour postinfusion 51Cr recoveries on day 35 when stored at hematocrit greater than or equal to 75 per cent. CPDA-1 differs from CPD in that it has 1.25 times the glucose concentration plus 17.3 mg adenine/63 ml. In an effor...


    pub_type: 杂志文章


    authors: Moore GL,Ledford ME,Peck CC

    更新日期:1980-07-01 00:00:00

  • A whole genome approach for discovering the genetic basis of blood group antigens: independent confirmation for P1 and Xga.

    abstract:BACKGROUND:Although P1 and Xga are known to be associated with the A4GALT and XG genes, respectively, the genetic basis of antigen expression has been elusive. Recent reports link both P1 and Xga expression with nucleotide changes in the promotor regions and with antigen-negative phenotypes due to disruption of transcr...


    pub_type: 杂志文章


    authors: Lane WJ,Aguad M,Smeland-Wagman R,Vege S,Mah HH,Joseph A,Blout CL,Nguyen TT,Lebo MS,Sidhu M,Lomas-Francis C,Kaufman RM,Green RC,Westhoff CM,MedSeq Project.

    更新日期:2019-03-01 00:00:00

  • Red blood cell use outside the operating theater: a prospective observational study with modeling of potential blood conservation during severe blood shortages.

    abstract:BACKGROUND:National guidance recommends planning for future blood shortages, but few studies have evaluated how reduced demand could be achieved acutely. STUDY DESIGN AND METHODS:A trained observer collected data concerning red blood cell (RBC) transfusion events outside the operating theater during 68 hours of blood ...


    pub_type: 杂志文章


    authors: Joseph BG,Hendry C,Walsh TS

    更新日期:2009-10-01 00:00:00

  • Electronic enhancements to blood ordering reduce component waste.

    abstract:BACKGROUND:The effect on component wastage after enhancing the clinician's ability to order blood products in the computerized physician order entry (CPOE) system was investigated in a multihospital network. METHODS:A novel field was added to the CPOE of eight hospitals within a health care system allowing the physici...


    pub_type: 杂志文章


    authors: Yazer MH,Deandrade DS,Triulzi DJ,Wisniewski MK,Waters JH

    更新日期:2016-03-01 00:00:00

  • Heterogeneity of the phenotype Jk(a-b-) found in Japanese.

    abstract::Fourteen Jk(a-b-) persons were detected by testing 638,460 Osaka blood donors with an automated 2 M urea technique. Two of these 14 Jk(a-b-) samples were quite different from the hitherto reported Jk(a-b-) phenotype, and a family study showed that the mode of the inheritance was dominant. The red cell membranes of the...


    pub_type: 杂志文章


    authors: Okubo Y,Yamaguchi H,Nagao N,Tomita T,Seno T,Tanaka M

    更新日期:1986-05-01 00:00:00

  • First results of a ferritin-based blood donor deferral policy in the Netherlands.

    abstract:BACKGROUND:Whole blood donors are at risk of becoming iron deficient. To monitor iron stores, Sanquin implemented a new deferral policy based on ferritin levels, in addition to the traditional hemoglobin measurements. METHODS:Ferritin levels are determined in every fifth donation, as well as in all first-time donors. ...


    pub_type: 杂志文章


    authors: Vinkenoog M,van den Hurk K,van Kraaij M,van Leeuwen M,Janssen MP

    更新日期:2020-08-01 00:00:00

  • Obtaining an accepted Investigational New Drug application to operate an umbilical cord blood bank.

    abstract:BACKGROUND:The residual blood left in the placenta, previously considered a biologic waste, contains sufficient hematopoietic stem and progenitor cells to consistently engraft at least a small recipient. Over the past several years, more than 500 HLA-matched, related and unrelated, allogeneic cord blood transplants hav...


    pub_type: 杂志文章


    authors: Reems JA,Fujita D,Tyler T,Moldwin R,Smith SD

    更新日期:1999-04-01 00:00:00

  • Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation.

    abstract:BACKGROUND:Clinical outcomes in transfused patients may be affected by the duration of blood storage, possibly due to red blood cell (RBC)-mediated disruption of nitric oxide (NO) signaling, a key regulator of vascular tone and blood flow. STUDY DESIGN AND METHODS:AS-1 RBC units stored up to 42 days were sampled at se...


    pub_type: 杂志文章


    authors: Alexander JT,El-Ali AM,Newman JL,Karatela S,Predmore BL,Lefer DJ,Sutliff RL,Roback JD

    更新日期:2013-11-01 00:00:00

  • Associated factors of umbilical cord blood collection quality.

    abstract::After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be gr...


    pub_type: 杂志文章,评审


    authors: Faivre L,Couzin C,Boucher H,Domet T,Desproges A,Sibony O,Bechard M,Vanneaux V,Larghero J,Cras A

    更新日期:2018-02-01 00:00:00

  • The symbolic roots of blood donation.

    abstract:BACKGROUND:Throughout history, blood has been embedded with powerful and paradoxical connotations. In the last decades, a more rational conception based on scientific knowledge has emerged, portraying blood as a "disenchanted" and utilitarian object, hence more apt for donation between strangers. This study aims to exa...


    pub_type: 杂志文章


    authors: Charbonneau J,Tran NY

    更新日期:2013-12-01 00:00:00

  • A statistical model for estimating donor postdonation platelet counts after plateletpheresis.

    abstract:BACKGROUND:To avoid the need, in serial apheresis donors, either to delay plateletpheresis until a predonation platelet count is completed or to obtain a postdonation count after each procedure, a statistical model has been developed to predict the postdonation platelet count from the donor predonation platelet count, ...


    pub_type: 杂志文章


    authors: Cabezudo I,Winegarden DK,Randels MJ,Strauss RG

    更新日期:1994-01-01 00:00:00

  • Another potential source of error in Rh-hr typing.

    abstract::Three cases are presented in which the presence of sodium caprylate dependent albumin auto-agglutinins in the patients' sera resulted in erroneous Rh-hr phenotyping of their erythrocytes. In the initial testing, the albumin control was negative in each case. Since one of the cases was an Rh0(D) negative individual who...


    pub_type: 杂志文章


    authors: Reid ME,Ellisor SS,Frank BA

    更新日期:1975-09-01 00:00:00

  • Potassium load in CPD-preserved whole blood and two types of packed red blood cells.

    abstract::The potassium load of transfused blood must be minimized. We have compared the total plasma potassium content of units of CPD-preserved stored whole blood (SWB), stored packed cells (SPC), and packed cells prepared from stored whole blood (WB-PC). Plasma potassium concentrations, unit weights, and hematocrits of 20 un...


    pub_type: 杂志文章


    authors: Michael JM,Dorner I,Bruns D,Ladenson JH,Sherman LA

    更新日期:1975-03-01 00:00:00

  • Selective protection of RBCs against photodynamic damage by the band 3 ligand dipyridamole.

    abstract:BACKGROUND:All studied photosensitizers for virus inactivation impair RBCs. To reduce damage to the RBCs without affecting virucidal activity, selective protection of the RBCs is necessary. The ability of the band 3 ligand, dipyridamole, to react with singlet oxygen and to increase the selectivity of photosterilization...


    pub_type: 杂志文章


    authors: vanSteveninck J,Trannoy LL,Besselink GA,Dubbelman TM,Brand A,de Korte D,Verhoeven AJ,Lagerberg JW

    更新日期:2000-11-01 00:00:00

  • Postdonation iron replacement for maintaining iron stores in female whole blood donors in routine donor practice: results of two feasibility studies in Australia.

    abstract:BACKGROUND:Iron deficiency represents a risk to donor health and the blood supply. Efficacy trials indicate that postdonation iron replacement improves iron stores but they do not account for complexities of implementation in the routine collection context. We therefore conducted two prospective feasibility studies in ...


    pub_type: 杂志文章


    authors: Pasricha SR,Marks DC,Salvin H,Brama T,Keller AJ,Pink J,Speedy J

    更新日期:2017-08-01 00:00:00

  • Unexpected red blood cell antibody distributions in Chinese people by a systematic literature review.

    abstract:BACKGROUND:Unexpected antibodies are frequently associated with hemolytic disease of the fetus and newborn (HDFN) and hemolytic transfusion reactions (HTRs), and screening for those unexpected antibodies is critical for the safety and effectiveness of transfusion. Different populations differ in the prevalence of signi...


    pub_type: 杂志文章,评审


    authors: Chen C,Tan J,Wang L,Han B,Sun W,Zhao L,Huang C,Tan B,Qin L

    更新日期:2016-04-01 00:00:00

  • Further studies on the dependence of some examples of anti-M and anti-N on the presence of red-cell-borne sialic acid.

    abstract::Previous studies have shown that some examples of anti-M and anti-N fail to agglutinate neuraminidase-treated (NeuNAc-depleted) red cells. This investigation extends those observations and shows that the antibodies fail to bind to such treated red cells. These observations may mean that NeuNAc residues act to orient t...


    pub_type: 杂志文章


    authors: Issitt PD,Wilkinson SL

    更新日期:1983-03-01 00:00:00

  • Coagulation parameters of CPD fresh-frozen plasma and CPD cryoprecipitate-poor plasma after storage at 4 degrees C for 28 days.

    abstract::A pilot study was performed on the storage of plasma and cryosupernatant plasma at 4 degrees C for up to 28 days. Eight bags, four of CPD fresh-frozen plasma (FFP) and four of CPD cryosupernatant plasma (CSP, plasma without cryoprecipitate), were sampled during storage for assays of pH; factors V, VIII, IX, and XI; fi...


    pub_type: 杂志文章


    authors: Smak Gregoor PJ,Harvey MS,Briët E,Brand A

    更新日期:1993-09-01 00:00:00

  • Use of a pneumatic tube system for delivery of blood bank products and specimens.

    abstract::This study evaluated the effect of pneumatic tube transport on blood bank specimens and products. No important differences were found between aliquots transported in the tube system and those stored in the laboratory as controls. ABO, Rh, antibody detection or identification, direct antiglobulin testing, and elution w...


    pub_type: 杂志文章


    authors: Tanley PC,Wallas CH,Abram MC,Richardson LD

    更新日期:1987-03-01 00:00:00

  • Continuous- and semicontinuous-flow blood centrifugation systems: therapeutic applications, with plasma-, platelet, lympha-, and eosinapheresis.

    abstract::Blood centrifugation, with a continuous-flow or semicontinuous-flow system, was used in the treatment of 17 patients with various hematologic disorders. Total plasma exchange (TPE) controlled symptoms of hyperviscosity and arrested bleeding in three patients. In two patients, TPE made is possible to perform urgent sur...


    pub_type: 杂志文章


    authors: Pineda AA,Brzica SM Jr,Taswell HF

    更新日期:1977-09-01 00:00:00

  • Toward extended phenotype matching: a new operational paradigm for the transfusion service.

    abstract:BACKGROUND:Conventional pretransfusion testing uses hemagglutination to ensure donor-recipient compatibility for ABO/D status and recipient alloantibodies. While screening large numbers of donor units for multiple antigens by hemagglutination is impractical, novel methods of DNA analysis permit the rapid determination ...


    pub_type: 杂志文章,多中心研究


    authors: Klapper E,Zhang Y,Figueroa P,Ness P,Stubbs J,Abumuhor I,Bailey J,Epperson L,Tauscher C,Enriquez E,Hashmi G,Seul M

    更新日期:2010-03-01 00:00:00

  • Analysis of apheresis content of progenitor cell collections from normal donors to whom granulocyte-colony-stimulating factor is administered.

    abstract:BACKGROUND:Allogeneic blood cell transplantation is a new alternative to bone marrow transplantation. Preliminary data suggest that granulocyte-colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cells from normal donors can provide rapid hematopoietic engraftment without significant increases in tr...


    pub_type: 杂志文章


    authors: Weinthal JA,Nemunaitis JJ,Aston S,Magsamen MJ,Rosenfeld CS

    更新日期:1996-11-01 00:00:00

  • Effects of Intercept pathogen reduction treatment on extended cold storage of apheresis platelets.

    abstract:BACKGROUND:Platelets pose the greatest transfusion-transmitted infectious risk among blood products. Refrigeration of platelets can mitigate bacterial contamination and extend platelet shelf life. Implementation of pathogen reduction technologies (PRTs) at blood banks has become increasingly popular to protect against ...


    pub_type: 杂志文章


    authors: Agey A,Reddoch-Cardenas K,McIntosh C,Sharma U,Cantu C,Cap A,Bynum J

    更新日期:2020-12-08 00:00:00

  • Cesarean section due to fetal distress increases the number of stem cells in umbilical cord blood.

    abstract:BACKGROUND:Umbilical cord blood (UCB) can be used as hematopoietic stem cell source for transplantation. The success of a transplantation is highly correlated with the number of total nucleated cells (TNCs) and CD34+ cells in the UCB. Certain obstetric factors increase the yield of stem cells in the UCB. It is necessar...


    pub_type: 杂志文章


    authors: Manegold G,Meyer-Monard S,Tichelli A,Pauli D,Holzgreve W,Troeger C

    更新日期:2008-05-01 00:00:00

  • Immune-mediated hemolysis associated with the administration of a radiographic contrast medium.

    abstract::A female patient developed serious hemolysis in association with the injection of a radiographic contrast medium (RCM). Serologic investigation of her serum suggested complement-mediated hemolysis, induced by an RCM-dependent IgM antibody in her serum. The antibody was of high titer and low avidity. The antibody showe...


    pub_type: 杂志文章


    authors: Nordhagen R,Vik H,Wolthuis K,Bøhn HP,Urdahl P,Michaelsen TE

    更新日期:1991-11-01 00:00:00