Abstract：
:This paper describes a framework, called QCMF (Qualitative Compartmental Modeling Framework), which assists the user in formulating models of a pathophysiological system and in analyzing their behaviors through the simulation of the effects of a variety of pathogenetic mechanisms and therapeutical treatments. QCMF has adopted the compartmental theory as modeling ontology: a system is represented as a finite set of interacting compartments. The user enters, through an iconic language and menus, the compartmental structure of a pathophysiological system and the definition of the kinds of functional relationships describing the interactions between compartments. Then, QCMF automatically generates a behavior model of the system. Such a model consists of a set of ordinary differential equations, which are qualitatively expressed, and is directly coded into the language which is interpreted by the simulation algorithm. The system behavior can be obtained by simulating the model starting from an initial state which describes the perturbations acting on the system. The code defining the initial state is automatically built by QCMF as well. Finally, explanations of the predicted behavior are also automatically generated.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Ironi L,Stefanelli Mdoi
10.1016/0169-2607(94)90096-5subject
Has Abstractpub_date
1994-04-01 00:00:00pages
233-54issue
4eissn
0169-2607issn
1872-7565pii
0169-2607(94)90096-5journal_volume
42pub_type
杂志文章abstract：:A minimal model of the cardio-vascular system (CVS) with ventricular interaction and inertial effects that accurately captures the physiological trends of a variety of disease states has been developed. However, the physiologically accurate open on pressure, close on flow valve law is computationally heavy to implemen...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.06.003
更新日期：2005-10-01 00:00:00
abstract：:A hypertext-based system called IntroStat has been developed to introduce fundamental methods of biomedical statistics. The system has been developed on a Macintosh II using HyperCard. It is written mainly in Hypertalk, a scripting language of HyperCard. Being an electronic textbook of probability and statistics, the ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(95)01623-2
更新日期：1995-04-01 00:00:00
abstract：:This paper compares bibliographic retrieval using current MeSH (Medical Subject Headings) to bibliographic retrieval using explicitly coded semantic relationships between index terms. In a previous study, ten lists of abstracts, each list containing 20-40 papers discussing a specific pair of terms, were analyzed to id...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(88)90084-3
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Empirical antimicrobial prescription strategies have been proposed to counteract the selection of resistant pathogenic strains. The respective merits of such strategies have been debated. Rather than comparing a finite number of policies, we take an optimization approach and propose a solution...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105767
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Detection and classification of pulmonary nodules are critical tasks in medical image analysis. The Lung Image Database Consortium (LIDC) database is a widely used resource for small pulmonary nodule classification research. This dataset is comprised of nodule characteristic evaluations and CT...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.10.009
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Accurate segmentation of optic disc and cup from monocular color fundus images plays a significant role in the screening and diagnosis of glaucoma. Though optic cup is characterized by the drop in depth from the disc boundary, most existing methods segment the two structures separately and rely...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.06.004
更新日期：2017-08-01 00:00:00
abstract：:Accurate and fast approaches for automatic ECG data classification are vital for clinical diagnosis of heart disease. To this end, we propose a novel multistage algorithm that combines various procedures for dimensionality reduction, consensus clustering of randomized samples and fast supervised classification algorit...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.08.002
更新日期：2013-12-01 00:00:00
abstract：:Software which provides an interface to the features of the Sound Blaster Pro card for the IBM PC using MS-DOS is described. The library may be called from a Turbo Pascal version 6 program. It permits tones of specified frequency (500 Hz-8 kHz in increments of 500Hz) and aversive noise to be turned on and off by a con...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)01588-7
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:This contribution presents a rapid computational framework to mechanically simulate the insertion of a slender medical instrument in a tubular structure such as an artery, the cochlea or another slender instrument. METHODS:Beams are employed to rapidly simulate the mechanical behaviour of the ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105527
更新日期：2020-11-01 00:00:00
abstract：:This paper is concerned with the challenge of enabling the use of confidential or private data for research and policy analysis, while protecting confidentiality and privacy by reducing the risk of disclosure of sensitive information. Traditional solutions to the problem of reducing disclosure risk include releasing d...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.04.001
更新日期：2008-09-01 00:00:00
abstract：:Organisational changes take place at three different levels: at the department, in the hospital and in the county. Important changes locally are the easy and fast access to better images, a rise in production and a possible reduction in patient stay. The radiological services to the community improve, reading can be d...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00132-8
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Social Network Analysis is an attractive approach to model and analyze complex networks. In recent years, several bioinformatics related networks have been modeled and analyzed thoroughly using social network analysis. The objective of this study is to build a social network analysis based cla...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.06.015
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:This paper presents an improved scheme able to perform accurate segmentation and classification of cancer nuclei in immunohistochemical (IHC) breast tissue images in order to provide quantitative evaluation of estrogen or progesterone (ER/PR) receptor status that will assist pathologists in can...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.08.005
更新日期：2018-10-01 00:00:00
abstract：:We propose a specially optimized computer program for the user-independent calculation of the correlation dimension D and the largest Lyapunov exponent L of heart rate dynamics on the basis of only 1024 electrocardiographically recorded RR intervals (heartbeat intervals). The validity of our program was established by...
journal_title：Computer methods and programs in biomedicine
pub_type： 临床试验,杂志文章
doi：10.1016/0169-2607(95)01707-0
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The use of objective detection techniques applied to the auditory steady-state responses (ASSRs) for the assessment of auditory thresholds has been investigated over the years. The idea consists in setting up the audiometric profile without subjective inference from patients and evaluators. The...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.01.031
更新日期：2018-06-01 00:00:00
abstract：:When underlying distributions are unknown and sample sizes are small, permutation tests may have superior features to parametric tests, such as smaller type I error and more accurate probability values when testing the null hypothesis. However, permutation tests are not widely used in clinical trials because of their ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.03.010
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Diagnosis of Parkinson's with higher accuracy is always desirable to slow down the progression of the disease and improved quality of life. There are evidences of inherent neurological differences between male and females as well as between elderly and adults. However, the potential of such ge...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105305
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Diabetic disease is typically composed because of higher than normal blood sugar levels. Instead the production of insulin may be regarded insufficient. It has been noted in recent days that the percentage of diabetes-affected patients have grown to a larger extent throughout the world. Evident...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105659
更新日期：2020-11-01 00:00:00
abstract：:Properly representing the heterogeneous distribution of bone tissue material properties is a key step in constructing subject-specific finite element (FE) bone models from computed tomography (CT) data. Conventional methods represent heterogeneity by subjectively grouping bone of similar attenuation together. A new te...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.11.009
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Cerebrovascular diseases (CVDs) affect a large number of patients and often have devastating outcomes. The hallmarks of CVDs are the abnormalities formed on brain blood vessels, including protrusions, narrows, widening, and bifurcation of the blood vessels. CVDs are often diagnosed by digital s...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105159
更新日期：2020-03-01 00:00:00
abstract：:The optic nerve disease is an important disease that appears commonly in public. In this paper, we propose a hybrid diagnostic system based on discretization (quantization) method and classification algorithms including C4.5 decision tree classifier, artificial neural network (ANN), and least square support vector mac...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.04.009
更新日期：2008-09-01 00:00:00
abstract：:Telemedicine provides a new way of delivering medical services. The good quality of the picture is, however, essential for a proper and reliable teleconsultation, especially in the cases when visual information about the patient's physical condition is of great importance as in ophthalmology and dermatology. Therefore...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00120-6
更新日期：2001-05-01 00:00:00
abstract：:A medical application is a highly complex system that embraces many data types and a very large number of data processing functions and methods. The development of integrated software engineering environments has deeply changed the conception of applications and the profile of the application developers. In this paper...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In this study, a wireless blood pressure holter that can be used with smart mobile devices was developed. The developed blood pressure holter consists of two parts, which are a smart mobile device and a cuff. The smart mobile device is used as a recording, control and display device through a d...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.12.025
更新日期：2018-03-01 00:00:00
abstract：:Methods for evaluating a single diagnostic test with reference to the disease prevalence in a given population include sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Patient disease status and, ultimately, the treatment course is determined by the outcome of these diagnos...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(91)90119-e
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In this note we propose a nonlinear programming approach for simultaneous fitting of quantile regression models for two or more quantiles. The approach is straightforward, flexible and practical. We apply this approach to a dataset of lactic acid values from a screening dataset in childhood mal...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.10.019
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The presence of circulating tumor cells in the patient's blood is a clinical factor that indicates the initiation of metastasis. METHODS:In this paper, a microfluidic device is designed to separate, enumerate, and to diagnose cancer cells from the patient's blood sample. Here, we present a new...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105147
更新日期：2020-03-01 00:00:00
abstract：CONTEXT:People who have recently recovered from the threat of deteriorating coronavirus disease-2019 (COVID-19) have antibodies to the coronavirus circulating in their blood. Thus, the transfusion of these antibodies to deteriorating patients could theoretically help boost their immune system. Biologically, two challen...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105617
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Estimating patient specific annual risk of rupture of abdominal aortic aneurysm (AAA) is currently based only on population. More accurate knowledge based on patient specific data would allow surgical treatment of only those AAAs with significant risk of rupture. This would be beneficial for bo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105916
更新日期：2020-12-25 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Univariate feature selection is one of the simplest and most commonly used techniques to develop a multigene predictor for survival. Presently, there is no software tailored to perform univariate feature selection and predictor construction. METHODS:We develop the compound.Cox R package that i...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.10.020
更新日期：2019-01-01 00:00:00
