Abstract：
:Methods for evaluating a single diagnostic test with reference to the disease prevalence in a given population include sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Patient disease status and, ultimately, the treatment course is determined by the outcome of these diagnostics. The advantage of ordering a single diagnostic test, or series of diagnostic tests is a concern of physicians. How much information is gained from using the results of two diagnostic tests, each designed to detect the same disease? Combining tests may be the optimal methodology for determining the disease status of the patient. We propose a systematic strategy for optimizing (minimizing alpha and/or beta errors) the combination of two diagnostic tests. This strategy is then illustrated by the use of data from Doppler ultrasound and ocular pneumoplethysmography in detecting carotid artery disease.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Borowiak D,Reed JF 3rddoi
10.1016/0169-2607(91)90119-esubject
Has Abstractpub_date
1991-07-01 00:00:00pages
171-5issue
3eissn
0169-2607issn
1872-7565pii
0169-2607(91)90119-Ejournal_volume
35pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Changes in mechano-electrochemical properties of articular cartilage play an essential role in the majority of cartilage diseases. Despite of this importance, the specific effect of each parameter into tissue behavior remains still obscure. Parametric computational modeling of cartilage can pro...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2015.09.018
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Hypokinetic dysarthria (HD) is a frequent speech disorder associated with idiopathic Parkinson's disease (PD). It affects all dimensions of speech production. One of the most common features of HD is dysprosody that is characterized by alterations of rhythm and speech rate, flat speech melody, ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2015.12.011
更新日期：2016-04-01 00:00:00
abstract：:A novel methodology of electrophoretic gel image analysis has been proposed that is based on two-dimensional image processing methods instead of previously used one-dimensional Gaussian deconvolution. The crucial problem of the analysis of imperfect gels, that consists in band detection, is solved using the algorithms...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.09.007
更新日期：2005-03-01 00:00:00
abstract：:The Department of Radiology of the Shinshu University Hospital is presently in the process of developing a new type of mini-PACS with a hybrid architecture consisting of a video and a digital image archiving network. The video block consists of a server station with a video write-once optical disk (LD) and three works...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(91)90058-2
更新日期：1991-10-01 00:00:00
abstract：:A microcomputer program in BASIC for predicting percentage of occurrence of electroshock-induced convulsion in mice was designed. A formula published by the author to express the mathematical relationship among the drug dose, the time, and the biological response was used in this program. Analysis of the actual, and t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(89)90177-6
更新日期：1989-01-01 00:00:00
abstract：:This work is aimed at developing an innovative simulation environment supporting and improving the design of standard joint implants (JPD integrated design environment (JIDE)). The conceptual workflow starts from the design of a new implant, by using conventional CAD programmes and completes with the generation of a r...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2001.12.001
更新日期：2004-09-01 00:00:00
abstract：:The paper presents a computer-based assessment for facioscapulohumeral dystrophy (FSHD) diagnosis through characterisation of the fat and oedema percentages in the muscle region. A novel multi-slice method for the muscle-region segmentation in the T1-weighted magnetic resonance images is proposed using principles of t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2015.03.006
更新日期：2015-06-01 00:00:00
abstract：:The analysis of human motion from video has been the object of interest for many application areas, these including surveillance, control, biomedical analysis, video annotation etc. This paper addresses the advances within this topic in relation to epilepsy, a domain where human motion is with no doubt one of the most...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章,评审
doi：10.1016/j.cmpb.2012.08.005
更新日期：2012-12-01 00:00:00
abstract：:A first software (JHS) for the elaboration of job histories oriented toward risks was designed and results published In an article "A software for the elaboration of Job Histories". This article presents a second software (JES), based on the use of a job-exposure matrix designed for one company. The matrix is essentia...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(92)90056-d
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Glioblastoma multiforme (GBM) is the most frequent primary brain tumor in adults and Temozolomide (TMZ) is an effective chemotherapeutic agent for its treatment. In Silico models of GBM growth provide an appropriate foundation for analysis and comparison of different regimens. We propose a mathematical frame...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105443
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Segmentation is a crucial step in multiple biomechanics and orthopedics applications. The time-intensiveness and expertise requirements of medical image segmentation present a significant bottleneck for corresponding workflows. The current study develops and evaluates convolutional neural netwo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105328
更新日期：2020-06-01 00:00:00
abstract：:ENZEDUC 1.0 is a software package developed in Microsoft QuickBASIC v7.1 for computation of hyperbolic enzyme kinetics. The educational focus of the package is laboratory practical teaching. The program can manage a maximum of 18 substrate concentration values and 72 reaction rate values for each substrate concentrati...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(96)01716-6
更新日期：1996-03-01 00:00:00
abstract：:Sleep-related breathing disorders are common in adults and they have a significant impact on vigilance and quality of life. Previous studies have shown the validity of the static-charge-sensitive bed (SCSB) in monitoring breathing abnormalities during sleep. A whole nights sleep study produces a signal with considerab...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(99)00043-7
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The application of medical knowledge strongly affects the performance of intelligent diagnosis, and method of learning the weights of medical knowledge plays a substantial role in probabilistic graphical models (PGMs). The purpose of this study is to investigate a discriminative weight-learning...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.01.005
更新日期：2018-03-01 00:00:00
abstract：:In muscle cells, force development is controlled by Ca2+ ions, which are rapidly released from the sarcoplasmic reticulum (SR) during sarcolemmal depolarization. In addition to this synchronized spatially homogeneous calcium signal, localized quantal Ca2+ release events (sparks) have been recorded using laser scanning...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.06.004
更新日期：2005-01-01 00:00:00
abstract：:This study presents the development of a hybrid system consisting of an ensemble of Extended Kalman Filter (EKF) based Multi Layer Perceptron Network (MLPN) and a one-pass learning Fuzzy Inference System using Look-up Table Scheme for the recognition of electrocardiogram (ECG) signals. This system can distinguish vari...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2006.03.003
更新日期：2006-05-01 00:00:00
abstract：:The microcomputer program presented here allows the simulation of linear compartmental physiological models whose structure is known. The method used is the 4th order Runge-Kutta method. Implemented on the Apple IIe, this program is fully interactive and presents the possibility of changing model parameters or initial...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(87)90066-6
更新日期：1987-02-01 00:00:00
abstract：:The importance of computer aided decision making is continuously increasing. In the ICU, medical decision support services gather and process medical data of patients and present results and suggestions to the medical staff. The medical decision support services can monitor for example blood pressure, creatinine level...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.05.003
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Skin cancer is the commonest form of cancer in the worldwide population. Non-invasive and non-contact imaging modalities are being used for the screening of melanoma and other cutaneous malignancies to endorse early detection and prevention of the disease. Traditionally it has been a problem fo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.06.018
更新日期：2019-09-01 00:00:00
abstract：:Measurement systems used in the collection and processing of laboratory data must be calibrated periodically to obtain accurate results. Because calibration factors can change over time or may be reset to optimize measurements for specific tests, care must be taken to assure that calibration factors and data are align...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(91)90014-k
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Attention deficit hyperactivity disorder (ADHD) is often presented with conduct disorder (CD). There is currently no objective laboratory test or diagnostic method to discern between ADHD and CD, and diagnosis is further made difficult as ADHD is a common neuro-developmental disorder often pre...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2021.105941
更新日期：2021-01-14 00:00:00
abstract：:Electroencephalogram (EEG) has established itself as an important means of identifying and analyzing epileptic seizure activity in humans. In most cases, identification of the epileptic EEG signal is done manually by skilled professionals, who are small in number. In this paper, we try to automate the detection proces...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.02.005
更新日期：2008-08-01 00:00:00
abstract：:This paper presents a new method for the construction of three-dimensional (3D) probabilistic facial averages and demonstrates the potential for applications in clinical craniofacial research and patient assessment. Averages are constructed from a database of registered laser-range scans and photographic images using ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00072-9
更新日期：2000-08-01 00:00:00
abstract：:Many computer studies and models have been developed in order to simulate cell biochemical pathways. The difficulty of integrating all the biochemical reactions that occur in a cell in a single model is the main reason for the poor results in the prediction and simulation of cell behaviour under different chemical and...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.06.004
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Retinal pathology diseases such as glaucoma, obesity, diabetes, hypertension etc. have deadliest impact on life of human being today. Retinal blood vessels consist of various significant information which are helpful in detection and treatment of these diseases. Therefore, it is essential to se...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105490
更新日期：2020-10-01 00:00:00
abstract：:NONMEM is an extremely powerful tool for nonlinear mixed-effect modelling and simulation of pharmacokinetic and pharmacodynamic data. However, it is a console-based application whose output does not lend itself to rapid interpretation or efficient management. NONMEMory has been created to be a comprehensive project ma...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.02.003
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The anatomical structure detection in retinal images is an open problem. However, most of the works in the related literature are oriented to the detection of each structure individually or assume the previous detection of a structure which is used as a reference. The objective of this paper is...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.06.022
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Automatic osteosarcoma tumor segmentation on computed tomography (CT) images is a challenging problem, as tumors have large spatial and structural variabilities. In this study, an automatic tumor segmentation method, which was based on a fully convolutional networks with multiple supervised sid...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.02.013
更新日期：2017-05-01 00:00:00
abstract：:Rapid and accurate discrimination of single units from extracellular recordings is a fundamental process for the analysis and interpretation of electrophysiological recordings. We present an algorithm that performs detection, characterization, discrimination, and analysis of action potentials from extracellular record...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.07.001
更新日期：2004-12-01 00:00:00
abstract：:A physician's problem-solving performance improves with experience. The performance of most medical expert systems does not. The author has developed a diagnosis program for coronary disease that improves its performance by remembering and learning from cases that it has already solved. The program diagnoses commonly-...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(89)90070-9
更新日期：1989-10-01 00:00:00
