Abstract:
:NONMEM is an extremely powerful tool for nonlinear mixed-effect modelling and simulation of pharmacokinetic and pharmacodynamic data. However, it is a console-based application whose output does not lend itself to rapid interpretation or efficient management. NONMEMory has been created to be a comprehensive project manager for NONMEM, providing detailed summary, comparison and overview of the runs comprising a given project, including the display of output data, simple post-run processing, fast diagnostic plots and run output management, complementary to other available modelling aids. Analysis time ought not to be spent on trivial tasks, and NONMEMory's role is to eliminate these as far as possible by increasing the efficiency of the modelling process. NONMEMory is freely available from http://www.uct.ac.za/depts/pha/nonmemory.php.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Wilkins JJdoi
10.1016/j.cmpb.2005.02.003subject
Has Abstractpub_date
2005-06-01 00:00:00pages
259-67issue
3eissn
0169-2607issn
1872-7565pii
S0169-2607(05)00058-1journal_volume
78pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVE:Type 2 diabetes mellitus (T2DM) complications seriously affect the quality of life and could not be cured completely. Actions should be taken for prevention and self-management. Analysis of warning factors is beneficial for patients, on which some previous studies focused. They generally used t...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105302
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Dataset imbalance is an important problem in neuroimaging. Imbalanced datasets would cause the performance degradation of a classifier by utilizing imbalanced learning, which tends to overfocus on the majority class. In this paper, we consider an imbalanced neuroimaging classification problem, ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105676
更新日期:2020-11-01 00:00:00
abstract::Rapid and accurate discrimination of single units from extracellular recordings is a fundamental process for the analysis and interpretation of electrophysiological recordings. We present an algorithm that performs detection, characterization, discrimination, and analysis of action potentials from extracellular record...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2004.07.001
更新日期:2004-12-01 00:00:00
abstract::The successful implementation of PACS (or IMACS) depends on the integration of image and image related data handling systems in an overall hospital information system (HIS) and other departmental information systems (DIS), one of which is radiology information system (RIS). With respect to standardization in the medic...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(94)90181-3
更新日期:1994-05-01 00:00:00
abstract::The cumulative incidence function is commonly reported in studies with competing risks. The aim of this paper is to compute the treatment-specific cumulative incidence functions, adjusting for potentially imbalanced prognostic factors among treatment groups. The underlying regression model considered in this study is ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2010.07.005
更新日期:2011-01-01 00:00:00
abstract::The continuing education is a challenge for health care professionals, considering the growing amount and variable quality of information in this field. In this context, we developed a method allowing clinicians to have a centralised access to the best current medical evidence supporting medical decision-making. Relev...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(02)00055-x
更新日期:2003-05-01 00:00:00
abstract::A computer program for a microcomputer (HP 86) is presented to discriminate between different models and to design new experiments for model discrimination. By a non-linear fitting algorithm a set of experimental data is fitted with different models suggested by the user. The parameters characterizing each model are e...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(86)90022-2
更新日期:1986-04-01 00:00:00
abstract::We discuss how vocal disorders can be post-corrected via a simple nonlinear noise reduction scheme. This work is motivated by the need of a better understanding of voice dysfunctions. This would entail a 2-fold advantage for affected patients: Physicians can perform better surgical interventions and on the other hand ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(01)00161-4
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Drug-target interaction prediction plays an intrinsic role in the drug discovery process. Prediction of novel drugs and targets helps in identifying optimal drug therapies for various stringent diseases. Computational prediction of drug-target interactions can help to identify potential drug-ta...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2018.08.011
更新日期:2018-10-01 00:00:00
abstract::Magnetic resonance angiography (MRA) offers a non-invasive approach to the acquisition of anatomically accurate human arterial structure. Combining the latest computational fluid dynamics (CFD) techniques with clinical data from MRA, the detailed haemodynamics information in the human circulation system can be obtaine...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(98)00008-x
更新日期:1998-06-01 00:00:00
abstract::The aim of DILEMMA is to provide tools for the development of decision support systems for use in general medical practice, hospital-based cancer care, and shared care of cancer and cardiology patients. In primary care, the project intends to provide aids to clinical performance in prescribing, referral and the use of...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(94)90011-6
更新日期:1994-10-01 00:00:00
abstract::Research in muscle physiology has progressed in both the volume and complexity of data examined. Dependence on manual methods to analyze and condense this amount of information can present a narrow bottleneck to the efficient completion of a study, and can compromise the reliability of the results. We designed a gener...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(89)90161-2
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:The purpose of the study was to probe into the changes in life expectancy associated with schooling years found by the Organization for Economic Co-operation and Development (OECD). METHODS:The study was based on the OECD database from the period 2000 to 2006. The data of thirty countries were constructed t...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2013.11.016
更新日期:2014-03-01 00:00:00
abstract::Tools for calculating Gaussian parametric statistics are widely available in hand-held calculators and program packages for desktop as well as mainframe computers. The standard deviation calculated from non-Gaussian data may, however, be meaningless or even absurd. Furthermore, the standard error of the mean is freque...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(88)90046-6
更新日期:1988-03-01 00:00:00
abstract::An iterative algorithm is given to correct for the zeroth and first order phase errors in NMR spectroscopy. A FORTRAN computer program is listed and two sample runs exemplified. No a priori knowledge of the existing phase errors is required. The parameters are optimised iteratively under the assumption that when the s...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(88)90078-8
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Deployment of Body Area Networks (BAN) in hospitals can enable real time data collection and analysis for patient health. Such networks have a two-tier structure: the primary layer consists of nodes that are installed on hospital facilities, while the second tier contains sensors on patient bod...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105411
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Ever since its discovery, calcium imaging has proven its worth in discovering new insights into the mechanisms of cellular communication. Yet, the analysis of the data generated by calcium imaging experiments demands a large amount of time from researchers. Tools enabling automated and semi-aut...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.104991
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:The present investigation is concerned with hybrid mediated blood flow model through atherosclerotic bifurcated artery with slip effects by considering the properties of compliant walls. DESIGN/APPROACH:In human body, the circulatory system is made up of a network of blood vessels that include the bifurcatio...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.07.008
更新日期:2019-10-01 00:00:00
abstract::The Diabetes Advisory System (DIAS) is a model of human glucose metabolism which predicts hourly blood glucose concentrations and provides advice on insulin dose. Its ability to provide appropriate advice was assessed in 20 well-controlled IDDM patients (mean (SD) age 38 (11), duration 17 (9) years; HbA1 8.8 (0.9)%, r...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(98)00022-4
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Early-phase virtual screening of candidate drug molecules plays a key role in pharmaceutical industry from data mining and machine learning to prevent adverse effects of the drugs. Computational classification methods can distinguish approved drugs from withdrawn ones. We focused on 6 data set...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.02.004
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:In cardiac medical imaging, the extraction and segmentation of the part of interest is the key to the diagnosis of heart disease. Due to irregular diastole and contraction, magnetic resonance imaging (MRI) images have poorly defined boundaries, and traditional segmentation algorithms have poor performance. In...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105755
更新日期:2020-12-01 00:00:00
abstract::We have developed a reference management system, MacRefer, using HyperTalk on Macintosh personal computers. Using this program, one can automatically acquire data from databases created by EndNote Plus and from OVID- or Medlar-formatted records downloaded via an online use of Medline. The MacRefer's capability of form...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(96)01731-2
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Dizziness is a major consequence of imbalance and vestibular dysfunction. Compared to surgery and drug treatments, balance training is non-invasive and more desired. However, training exercises are usually tedious and the assessment tool is insufficient to diagnose patient's severity rapidly. ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2014.04.014
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To increase the success rate of invasive mechanical ventilation weaning in critically ill patients using Machine Learning models capable of accurately predicting the outcome of programmed extubations. METHODS:The study population was adult patients admitted to the Intensive Care Unit. Target e...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105869
更新日期:2020-11-24 00:00:00
abstract:BACKGROUND:The augmentation of cooling or heating in a mechanical and industrial process may create a saving in energy, decrease process time, protract the working existence of hardware and raise thermal rating. A few procedures are even influenced subjectively by the action of increased heat transport. The advancement...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105017
更新日期:2019-10-01 00:00:00
abstract::Finite element (FE) analysis is a valuable tool in musculoskeletal research. The demands associated with mesh development, however, often prove daunting. In an effort to facilitate anatomic FE model development we have developed an open-source software toolkit (IA-FEMesh). IA-FEMesh employs a multiblock meshing scheme...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2008.12.003
更新日期:2009-04-01 00:00:00
abstract::Tight glycemic control (TGC) has shown benefits in ICU patients, but been difficult to achieve consistently due to inter- and intra- patient variability that requires more adaptive, patient-specific solutions. STAR (Stochastic TARgeted) is a flexible model-based TGC framework accounting for patient variability with a ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2011.07.003
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Deep learning enables tremendous progress in medical image analysis. One driving force of this progress are open-source frameworks like TensorFlow and PyTorch. However, these frameworks rarely address issues specific to the domain of medical image analysis, such as 3-D data handling and distanc...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105796
更新日期:2021-01-01 00:00:00
abstract::A hypertext-based system called IntroStat has been developed to introduce fundamental methods of biomedical statistics. The system has been developed on a Macintosh II using HyperCard. It is written mainly in Hypertalk, a scripting language of HyperCard. Being an electronic textbook of probability and statistics, the ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(95)01623-2
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Heart rate variability (HRV) has increasingly been linked to medical phenomena and several HRV metrics have been found to be good indicators of patient health. This has enabled generalised treatment plans to be developed in order to respond to subtle personal differences that are reflected in ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105127
更新日期:2020-03-01 00:00:00