Abstract：
:Many computer studies and models have been developed in order to simulate cell biochemical pathways. The difficulty of integrating all the biochemical reactions that occur in a cell in a single model is the main reason for the poor results in the prediction and simulation of cell behaviour under different chemical and physical stimuli. In this paper we have translated biochemical reactions into differential equations for the development of modular model of metabolism of a hepatocyte cultured in static and standard conditions (in a plastic multiwell placed in an incubator at 37 degrees C with 5% of CO(2)). Using biochemical equations and energetic considerations a set of non-linear differential equations has been derived and implemented in Simulink. This set of equations mimics some of the principal metabolic pathways of biomolecules present in the culture medium. The software platform developed is subdivided into separate modules, each one describing a different metabolic pathway; they constitute a library which can be used for developing new modules and models to project, predict and validate cell behaviour in vitro.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
De Maria C,Grassini D,Vozzi F,Vinci B,Landi A,Ahluwalia A,Vozzi Gdoi
10.1016/j.cmpb.2008.06.004subject
Has Abstractpub_date
2008-10-01 00:00:00pages
121-34issue
1eissn
0169-2607issn
1872-7565pii
S0169-2607(08)00155-7journal_volume
92pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:In oral and maxillofacial surgery, conventional radiographic cephalometry is one of the standard auxiliary tools for diagnosis and surgical planning. While contemporary computer-assisted cephalometric systems and methodologies support cephalometric analysis, they tend neither to be practical no...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.03.014
更新日期：2016-07-01 00:00:00
abstract：:Methods for evaluating a single diagnostic test with reference to the disease prevalence in a given population include sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. Patient disease status and, ultimately, the treatment course is determined by the outcome of these diagnos...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(91)90119-e
更新日期：1991-07-01 00:00:00
abstract：:Cardiac MR image-based predictive models integrating statistical atlases of heart anatomy and fiber orientations can aid in better diagnosis of cardiovascular disease, a major cause of death worldwide. Such atlases have been built from diffusion tensor (DT) images and can be used in anisotropic models for personalized...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105200
更新日期：2020-04-01 00:00:00
abstract：:Computer-assisted preoperative planning are particularly sought for enhancing surgical implantation and improving clinical outcome of ankle joint replacement arthroplasty. A planning tool was designed to enhance the surgical implantation of a novel ligament-compatible three-component prosthesis. The tool includes a ge...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00150-x
更新日期：2002-03-01 00:00:00
abstract：:The primary aim of the Improved Monitoring for Brain Dysfunction during Intensive Care and Surgery (IBIS) project was to create a unique and comprehensively annotated data library (DL) of multiple physiological, including neurophysiological, signals. Data collection was undertaken in Kuopio, Finland and London, UK, an...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00107-3
更新日期：2000-11-01 00:00:00
abstract：:Influence diagrams have been widely used as knowledge bases in medical informatics and many applied domains. In conventional influence diagrams, the numerical models of uncertainty are probability distributions associated with chance nodes and value tables for value nodes. However, when incomplete knowledge or linguis...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.11.009
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:In recent decades, cancer has become one of the most fatal and destructive diseases which is threatening humans life. Accordingly, different types of cancer treatment are studied with the main aim to have the best treatment with minimum side effects. Anti-angiogenic is a molecular targeted the...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.03.004
更新日期：2019-05-01 00:00:00
abstract：INTRODUCTION:Coronary artery disease (CAD) is still one of the primary causes of death in the developed countries. Stress single-photon emission computed tomography is used to evaluate myocardial perfusion and ventricular function in patients with suspected or known CAD. This study sought to test data mining and machin...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105343
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Detection and classification of pulmonary nodules are critical tasks in medical image analysis. The Lung Image Database Consortium (LIDC) database is a widely used resource for small pulmonary nodule classification research. This dataset is comprised of nodule characteristic evaluations and CT...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.10.009
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:The breast dense tissue percentage on digital mammograms is one of the most commonly used markers for breast cancer risk estimation. Geometric features of dense tissue over the breast and the presence of texture structures contained in sliding windows that scan the mammograms may improve the predictive abili...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.05.022
更新日期：2019-08-01 00:00:00
abstract：:ODMixed is a computer program to obtain optimal designs for linear mixed models of longitudinal studies. These designs account for heterogeneous correlated errors and for data with dropout. Designs are compared by using relative efficiencies, e.g., between a D-optimal design for homogeneous data and another for hetero...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.04.004
更新日期：2011-01-01 00:00:00
abstract：:A linear time invariant model is applied to functional fMRI blood flow data. Based on traditional time series analysis, this model assumes that the fMRI stochastic output sequence can be determined by a constant plus a linear filter (hemodynamic response function) of several fixed deterministic inputs and an error ter...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.12.003
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Frozen-thawed embryo transfer (FET) is now widely used for the treatment of infertility. For many couples and clinicians, concerns over the probability and how to increase the chance of a successful birth are very common. Currently, there is not a single model to predict the live birth outcomes...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105780
更新日期：2021-01-01 00:00:00
abstract：:This paper describes the results of a controlled multicenter study on the effect of the computer assistance in the intensive insulin therapy. The patient collective consisted of 50 diabetics, randomly divided in two groups with 25 patients per group. The Multiple Subcutaneous Injection (MSI) group was treated with the...
journal_title：Computer methods and programs in biomedicine
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0169-2607(02)00034-2
更新日期：2002-08-01 00:00:00
abstract：:Renal dysfunction is a major problem in the management of critically ill patients. Monitoring of renal parameters over time is a prerequisite for detection of any significant deterioration of kidney function. Thus, we developed a knowledge-base for the dynamic monitoring of renal function of critically ill patients. A...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(99)00044-9
更新日期：2000-05-01 00:00:00
abstract：:Hexosaminidase, polyamines and lipid-bound sialic acid are a few tumour-associated markers which are significantly elevated both in urine and serum of patients with haematopoietic malignancy, in direct correlation to dedifferentiation. Our computer database incorporates these parameters and predicts the clinical respo...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(90)90032-5
更新日期：1990-01-01 00:00:00
abstract：:This paper explains the automated image-processing steps for the quantification of microvascular growth formation in the rat thoracic aortic ring model, an ex vivo model using excised rings of rat aorta embedded in a collagen matrix which produce outgrowths of microvessels. This model of angiogenesis is useful to stud...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2003.11.001
更新日期：2004-07-01 00:00:00
abstract：:Blood vessels in ophthalmoscope images play an important role in diagnosis of some serious pathologies on retinal images. Hence, accurate extraction of vessels is becoming a main topic of this research area. Matched filter (MF) implementation for blood vessel detection is one of the methods giving more accurate result...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.04.005
更新日期：2009-11-01 00:00:00
abstract：:This paper briefly reviews work undertaken within the DTI-sponsored MORSE project. The Clinical Biochemistry Department of the West Middlesex University Hospital, one of the five project partners, provides clinical and laboratory services to a wide range of users. The Laboratory Information Management System used with...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90146-5
更新日期：1994-07-01 00:00:00
abstract：:This work is aimed at developing an innovative simulation environment supporting and improving the design of standard joint implants (JPD integrated design environment (JIDE)). The conceptual workflow starts from the design of a new implant, by using conventional CAD programmes and completes with the generation of a r...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2001.12.001
更新日期：2004-09-01 00:00:00
abstract：:Selecting appropriate ventilator settings decreases the risk of ventilator-induced lung injury. A decision support system (DSS) has been developed based on physiological models, which can advise on setting of tidal volume (Vt), respiratory frequency (f) and fraction of inspired oxygen (FiO2). The aim of this study is ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2008.07.001
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Ever since its discovery, calcium imaging has proven its worth in discovering new insights into the mechanisms of cellular communication. Yet, the analysis of the data generated by calcium imaging experiments demands a large amount of time from researchers. Tools enabling automated and semi-aut...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.104991
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Retinal pathology diseases such as glaucoma, obesity, diabetes, hypertension etc. have deadliest impact on life of human being today. Retinal blood vessels consist of various significant information which are helpful in detection and treatment of these diseases. Therefore, it is essential to se...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105490
更新日期：2020-10-01 00:00:00
abstract：:Interventricular septum thickness in end-diastole (IVSd) is one of the key parameters in cardiology. This paper presents a fast algorithm, suitable for pocket-sized ultrasound devices, for measurement of IVSd using 2D B-mode parasternal long axis images. The algorithm is based on a deformable model of the septum and t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.02.011
更新日期：2012-11-01 00:00:00
abstract：:Quesenberry and Hurst (1964), Goodman (1965) and Fitzpatrick and Scott (1987) proposed simultaneous construction of confidence intervals for multinomial proportions, however. statistical computing packages do not generally give one the option of specifying the type of construction to be used. We have written a SAS mac...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(97)01809-9
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Complementary and alternative medicine techniques have shown their potential for the treatment and diagnosis of chronical diseases like diabetes, arthritis etc. On the same time digital image processing techniques for disease diagnosis is reliable and fastest growing field in biomedical. Propos...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.01.004
更新日期：2018-04-01 00:00:00
abstract：:A program, AQ, has been developed to perform analog-to-digital (A/D) conversions on IBM PC products using the Data Translation DT2801-A or DT2801 boards. This program provides support for all of the triggered and continuous A/D modes of these boards. Additional subroutines for management of data files and display of a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(86)90067-2
更新日期：1986-12-01 00:00:00
abstract：:An interactive computer program written in BASIC with the objective of assisting the identification of species of common gastrointestinal parasites of humans is presented. The computer program acquires observational information needed for the identification of a parasite from the user. The user selects a description f...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(88)90037-5
更新日期：1988-03-01 00:00:00
abstract：:Control of blood glucose concentration for patients in intensive care units (ICUs) has been demonstrated to be beneficial in reducing mortality and the incidence of serious complications, for both diabetic and non-diabetic patients. However, the high degree of variability and uncertainty characterizing the physiologic...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.01.011
更新日期：2013-02-01 00:00:00
abstract：:A novel approach for the heartbeat and respiration detection based on optical interferometer and wavelet transform is proposed in this paper. Optical interferometer is a sensitive device that detects physical elongation of optical fibre due to external perturbations. Mechanical activity of cardiac muscle and respirati...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.03.003
更新日期：2013-07-01 00:00:00
