Abstract:
:ODMixed is a computer program to obtain optimal designs for linear mixed models of longitudinal studies. These designs account for heterogeneous correlated errors and for data with dropout. Designs are compared by using relative efficiencies, e.g., between a D-optimal design for homogeneous data and another for heterogeneous data or between a D-optimal design for complete data against another that optimizes designs when data is missing at random. Two examples are worked out to illustrate how researchers could use this computer program to profit of optimal design theory at the planning stage of longitudinal studies.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Ortega S,Tan FE,Berger MPdoi
10.1016/j.cmpb.2010.04.004subject
Has Abstractpub_date
2011-01-01 00:00:00pages
62-71issue
1eissn
0169-2607issn
1872-7565pii
S0169-2607(10)00089-1journal_volume
101pub_type
杂志文章abstract:UNLABELLED:This paper presents two new ideas. The first one is to apply the Viola integral waveform method to analyze the heart sounds recorded by an electric stethoscope, and the multi-scale moment analysis is proposed to locate each cycle of heart sounds. A fast algorithm for calculating characteristic waveform (CW) ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2009.09.008
更新日期:2010-05-01 00:00:00
abstract::A PC-based real-time quality control (QC) system for multitest analyzers has been developed as a prototype. The system is built with use of a relational database management system (DBMS). Control values from the various analytical channels are stored and administrated with use of the DBMS. The control values collected...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(91)90042-r
更新日期:1991-02-01 00:00:00
abstract::We have developed a new system to produce target movements for our particular purposes using a microcomputer and 9-bit digital-to-analog converter. A continuously changing sinusoidal wave was produced to examine the relationship between the frequencies of target movements and smooth pursuit. A random sinusoidal wave w...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(86)90057-x
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Virtual simulations recreate scenarios where student nurses can practice procedures in a safe and supervised manner and with no risk to the patient. Virtual scenarios include digital characters that reproduce human actions. Generally, these characters are modeled as males and restricted roles a...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2018.05.019
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Fraction of Inspired Oxygen is one of the arbitrary set ventilator parameters which has critical influence on the concentration of blood oxygen. Normally mechanical ventilators providing respiratory assistance are tuned manually to supply required inspired oxygen to keep the oxygen saturation a...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.04.014
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Retinal diseases are becoming a major health problem in recent years. Their early detection and ensuing treatment are essential to prevent visual damage, as the number of people affected by diabetes is expected to grow exponentially. Retinal diseases progress slowly, without any discernible sym...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105877
更新日期:2020-11-28 00:00:00
abstract::An iterative algorithm is given to correct for the zeroth and first order phase errors in NMR spectroscopy. A FORTRAN computer program is listed and two sample runs exemplified. No a priori knowledge of the existing phase errors is required. The parameters are optimised iteratively under the assumption that when the s...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(88)90078-8
更新日期:1988-01-01 00:00:00
abstract::Cardiac MR image-based predictive models integrating statistical atlases of heart anatomy and fiber orientations can aid in better diagnosis of cardiovascular disease, a major cause of death worldwide. Such atlases have been built from diffusion tensor (DT) images and can be used in anisotropic models for personalized...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2019.105200
更新日期:2020-04-01 00:00:00
abstract::This paper presents a dialogue computer program, DIABLOG, for the education of diabetic patients with insulin therapy. Through mathematical modelling of glucose-insulin dynamics this program is able to simulate glucose and insulin profiles of a 24 h period and display them graphically as curves. The subjects could var...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(90)90114-o
更新日期:1990-07-01 00:00:00
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journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2007.04.003
更新日期:2007-07-01 00:00:00
abstract::Workplace description is an operation indispensable for the identification of professional risks and, in fulfillment of that objective, can best be accomplished by listing the constituent tasks associated with each job. This article presents a software in Visual-Basic to be run on a portable micro-computer, which faci...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(97)01777-x
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Analysis of glomeruli geometry is important in histopathological evaluation of renal microscopic images. Due to the shape and size disparity of even glomeruli of same kidney, automatic detection of these renal objects is not an easy task. Although manual measurements are time consuming and at t...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.08.011
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Accurate segmentation of optic disc and cup from monocular color fundus images plays a significant role in the screening and diagnosis of glaucoma. Though optic cup is characterized by the drop in depth from the disc boundary, most existing methods segment the two structures separately and rely...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.06.004
更新日期:2017-08-01 00:00:00
abstract::Gaze is a natural input for a Human Computer Interface (HCI) for disabled people, who have of course an acute need for a communication system. An efficient eye tracking procedure is presented providing a non-invasive method for real time detection of a subject eyes in a sequence of frames captured by low cost equipmen...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2009.03.010
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To increase the success rate of invasive mechanical ventilation weaning in critically ill patients using Machine Learning models capable of accurately predicting the outcome of programmed extubations. METHODS:The study population was adult patients admitted to the Intensive Care Unit. Target e...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105869
更新日期:2020-11-24 00:00:00
abstract::In this study a novel approach based on 2D FIR filters is presented for denoising digital images. In this approach the filter coefficients of 2D FIR filters were optimized using the Artificial Bee Colony (ABC) algorithm. To obtain the best filter design, the filter coefficients were tested with different numbers (3×3,...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2013.05.009
更新日期:2013-09-01 00:00:00
abstract::Tokyo Hitachi Hospital, Hitachi Ltd., has used a hospital-wide PACS for over 1 year. The system runs a 100 Mb/s optical fiber network over the whole hospital including wards and outpatient clinic rooms, with 11 image workstations. The network links digital imaging modalities such as X-CT, MRI, computed radiography (CR...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(94)90190-2
更新日期:1994-05-01 00:00:00
abstract::This paper describes the open source framework MARVIN for rapid application development in the field of biomedical and clinical research. MARVIN applications consist of modules that can be plugged together in order to provide the functionality required for a specific experimental scenario. Application modules work on ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2008.04.007
更新日期:2008-08-01 00:00:00
abstract::A discrete model has been developed which reproduces the intercellular electrophysiological processes within a block of myocardial tissue. The behaviour of individual elements is introduced in the form of the digitised physiologic and premature action potentials which are comprehended as series of jumps between discre...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(91)90070-a
更新日期:1991-06-01 00:00:00
abstract:PURPOSE:This study was performed to evaluate the usefulness of virtual magnetic resonance microscopy (VMRM) for the diagnosis of cerebral aneurysms. MATERIALS AND METHODS:We reviewed 11 patients with unruptured aneurysms confirmed by angiography or surgical therapy. We evaluated the ability of VMRM to represent aneury...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/s0169-2607(01)00142-0
更新日期:2001-07-01 00:00:00
abstract::This paper summarizes the main topics of discussion at a workshop hosted by the Centre for Law Ethics and Risk in Telemedicine at the 2nd International Conference on Advances in the Delivery of Care, held at the Institute of Health Sciences, City University, London from Wednesday 24 to Friday 26 March 1999. The worksh...
journal_title:Computer methods and programs in biomedicine
pub_type:
doi:10.1016/s0169-2607(00)00142-5
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:A crucial factor for proper electrocardiogram (ECG) interpretation is the correct electrode placement in standard 12-lead ECG and extended 16-lead ECG for accurate diagnosis of acute myocardial infarctions. In the context of optimal patient care, we present and evaluate a new method for automat...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2016.06.003
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Retinal pathology diseases such as glaucoma, obesity, diabetes, hypertension etc. have deadliest impact on life of human being today. Retinal blood vessels consist of various significant information which are helpful in detection and treatment of these diseases. Therefore, it is essential to se...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2020.105490
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Social Network Analysis is an attractive approach to model and analyze complex networks. In recent years, several bioinformatics related networks have been modeled and analyzed thoroughly using social network analysis. The objective of this study is to build a social network analysis based cla...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2017.06.015
更新日期:2017-10-01 00:00:00
abstract::A parametric model for the ultrasound signals from blood and tissue is developed and a new imaging method, knowledge-based imaging, is defined. This method utilizes the likelihood ratio function to classify blood and tissue signals. The method separates blood and tissue signals by the difference in movement patterns i...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2009.03.012
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Stable isotope labeling by amino acids in cell culture (SILAC) is a practical and powerful approach for quantitative proteomic analysis. A key advantage of SILAC is the ability to simultaneously detect the isotopically labeled peptides in a single instrument run and so guarantee relative quanti...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2016.09.017
更新日期:2016-12-01 00:00:00
abstract::A dynamic simulation model for the epithelial cell structures of the intestine has been developed. The model is based on hypotheses found in the literature. It is shown that basic cell dynamics can be reproduced by simulation experiments. The simulation program is designed so that model output comparable with experime...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(85)90067-7
更新日期:1985-11-01 00:00:00
abstract::As health care costs have risen dramatically, the use of clinical data to analyze the quality of health care provided has increased. Central to this analysis is the means by which the clinical data itself is obtained. The reliability and validity of the data must be established in order to insure credible use of the d...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/0169-2607(93)90063-q
更新日期:1993-09-01 00:00:00
abstract::This article was motivated by the doctors' demand to make a technical support in pathologies of gastrointestinal tract research [10], which would be based on machine vision tools. Proposed solution should be less expensive alternative to already existing RF (radio frequency) methods. The objective of whole experiment ...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2015.12.009
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Anxiety is one of the major influences on the dropout of relapse and treatment of substance abuse treatment. Chemically dependent individuals need (CDI) to be aware of their emotional state in situations of risk during their treatment. Many patients do not agree with the diagnosis of the therap...
journal_title:Computer methods and programs in biomedicine
pub_type: 杂志文章
doi:10.1016/j.cmpb.2016.11.014
更新日期:2017-03-01 00:00:00