Abstract：
:This paper is concerned with the challenge of enabling the use of confidential or private data for research and policy analysis, while protecting confidentiality and privacy by reducing the risk of disclosure of sensitive information. Traditional solutions to the problem of reducing disclosure risk include releasing de-identified data and modifying data before release. In this paper we discuss the alternative approach of using a remote analysis server which does not enable any data release, but instead is designed to deliver useful results of user-specified statistical analyses with a low risk of disclosure. The techniques described in this paper enable a user to conduct a wide range of methods in exploratory data analysis, regression and survival analysis, while at the same time reducing the risk that the user can read or infer any individual record attribute value. We illustrate our methods with examples from biostatistics using publicly available data. We have implemented our techniques into a software demonstrator called Privacy-Preserving Analytics (PPA), via a web-based interface to the R software. We believe that PPA may provide an effective balance between the competing goals of providing useful information and reducing disclosure risk in some situations.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Sparks R,Carter C,Donnelly JB,O'Keefe CM,Duncan J,Keighley T,McAullay Ddoi
10.1016/j.cmpb.2008.04.001subject
Has Abstractpub_date
2008-09-01 00:00:00pages
208-22issue
3eissn
0169-2607issn
1872-7565pii
S0169-2607(08)00093-Xjournal_volume
91pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Respiratory gating training is a common technique to increase patient proprioception, with the goal of (e.g.) minimizing the effects of organ motion during radiotherapy. In this work, we devise a system based on autoencoders for classification of regular, apnea and unconstrained breathing patte...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105675
更新日期：2020-10-01 00:00:00
abstract：:In muscle cells, force development is controlled by Ca2+ ions, which are rapidly released from the sarcoplasmic reticulum (SR) during sarcolemmal depolarization. In addition to this synchronized spatially homogeneous calcium signal, localized quantal Ca2+ release events (sparks) have been recorded using laser scanning...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.06.004
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The detection of optic nerve head (ONH) in retinal fundus images plays a key role in identifying Diabetic Retinopathy (DR) as well as other abnormal conditions in eye examinations. This paper presents a method and its associated software towards the development of an Android smartphone app base...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.05.004
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The use of objective detection techniques applied to the auditory steady-state responses (ASSRs) for the assessment of auditory thresholds has been investigated over the years. The idea consists in setting up the audiometric profile without subjective inference from patients and evaluators. The...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.01.031
更新日期：2018-06-01 00:00:00
abstract：:Endoscopy is used for inspection of the inner surface of organs such as the colon. During endoscopic inspection of the colon or colonoscopy, a tiny video camera generates a video signal, which is displayed on a monitor for interpretation in real-time by physicians. In practice, these images are not typically captured,...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.04.003
更新日期：2012-11-01 00:00:00
abstract：:This paper presents the control system design of a rehabilitation and training robot for the upper limbs. Based on a hierarchical structure, this control system allows the execution of sequence of switching control laws (position, force, impedance and force/impedance) corresponding to the required training configurati...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.07.006
更新日期：2008-02-01 00:00:00
abstract：:The aim of the present study was to design, implement and evaluate a software system for discriminating between metastatic and primary brain tumors (gliomas and meningiomas) on MRI, employing textural features from routinely taken T1 post-contrast images. The proposed classifier is a modified probabilistic neural netw...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.10.007
更新日期：2008-01-01 00:00:00
abstract：:Cloud computing and the Internet of Things are the two hot points in the Internet application field. The application of the two new technologies is in hot discussion and research, but quite less on the field of medical monitoring and managing application. Thus, in this paper, we study and analyze the application of cl...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.03.024
更新日期：2016-07-01 00:00:00
abstract：:An outline of the Hokkaido University PACS (HU-PACS) and 10 months experience of its clinical use are reported. It is concluded that HU-PACS is a useful clinical tool, even though some points still remain to be improved. ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(91)90049-y
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND AND AIMS:Coronary heart disease (CHD) is an important public health problem globally. Algorithms incorporating the assessment of clinical biomarkers together with several established traditional risk factors can help clinicians to predict CHD and support clinical decision making with respect to interventions...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.02.001
更新日期：2017-04-01 00:00:00
abstract：:The GALEN project is developing language independent concept representation systems as the foundations for the next generation of multilingual coding systems. It aims to support the flexibility required to cope with the diversity amongst medical applications, while ensuring the coherence necessary for integration and ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90020-5
更新日期：1994-10-01 00:00:00
abstract：:In recent years, mild cognitive impairment (MCI) has attracted significant attention as an indicator of high risk for Alzheimer's disease (AD), and the diagnosis of MCI can alert patient to carry out appropriate strategies to prevent AD. To avoid subjectivity in diagnosis, we propose an ontology driven decision suppor...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.12.023
更新日期：2014-03-01 00:00:00
abstract：:The use of well characterized laboratory animals in biomedical research is of importance for quality securing and reproducibility of animal experiments. Therefore, breeders should not only have in mind the reproduction of their animal stocks, but they should also be interested to achieve an optimal resemblance of the ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(92)90076-j
更新日期：1992-06-01 00:00:00
abstract：:Analysis of longitudinal data is one of the most challenging tasks in statistical modeling. In the analysis, it is often necessary to take into account nonlinear response to a set of parameters of interest and correlation between measurements taken from the same individual. In addition, between- and within-subject var...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(97)00066-7
更新日期：1998-03-01 00:00:00
abstract：:A linear time invariant model is applied to functional fMRI blood flow data. Based on traditional time series analysis, this model assumes that the fMRI stochastic output sequence can be determined by a constant plus a linear filter (hemodynamic response function) of several fixed deterministic inputs and an error ter...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.12.003
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Functional magnetic resonance imaging (fMRI) studies of the human brain are appearing in increasing numbers, providing interesting information about this complex system. Unique information about healthy and diseased brains is inferred using many types of experiments and analyses. In order to ob...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.07.015
更新日期：2016-10-01 00:00:00
abstract：:Role of hepatic insulin degradation in modulating insulin delivery to peripheral circulation, in insulin-resistant hypertensive patients, is not yet fully understood. This issue was investigated here by a novel application to hypertension of a previously proposed minimal modelling of insulin and C-peptide data, using ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.08.007
更新日期：2010-02-01 00:00:00
abstract：:Cosmetic doctor utilizes the position, size and shapes of female's breast to judge whether the breast is under steady-state condition after breast implant plastic surgery. Since, doctor evaluates the breast condition with the subjective discrimination (such as vision, sense of touch) without using the objective physic...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.11.013
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Analysis of glomeruli geometry is important in histopathological evaluation of renal microscopic images. Due to the shape and size disparity of even glomeruli of same kidney, automatic detection of these renal objects is not an easy task. Although manual measurements are time consuming and at t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.08.011
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Changes in mechano-electrochemical properties of articular cartilage play an essential role in the majority of cartilage diseases. Despite of this importance, the specific effect of each parameter into tissue behavior remains still obscure. Parametric computational modeling of cartilage can pro...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2015.09.018
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE AND BACKGROUND:This article featuring the peristaltic transport of viscous material with variable properties (i.e. temperature dependent viscosity and thermal conductivity) through curved configuration. Fluid saturating through porous channel walls of uniform space. Entropy generation consideration here is to...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105045
更新日期：2020-04-01 00:00:00
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journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105356
更新日期：2020-07-01 00:00:00
abstract：:The discovery of the radioimmunoassay for the measurement of insulin concentration stimulated several clever studies which showed, both in vitro and in vivo, the peculiar biphasic pattern of the beta-cell response to glucose stimulation. Physiologists took the challenge to describe with mathematical models those data,...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90059-0
更新日期：1994-01-01 00:00:00
abstract：:In this paper we discuss the SIMID tool for simulation of the spread of infectious disease, enabling spatio-temporal visualization of the dynamics of influenza outbreaks. SIMID is based on modern random network methodology and implemented within the R and GIS frameworks. The key advantage of SIMID is that it allows no...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.01.007
更新日期：2013-06-01 00:00:00
abstract：:The mixture cure model is a special type of survival models and it assumes that the studied population is a mixture of susceptible individuals who may experience the event of interest, and cure/non-susceptible individuals who will never experience the event. For such data, standard survival models are usually not appr...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.08.013
更新日期：2012-12-01 00:00:00
abstract：:This paper briefly reviews work undertaken within the DTI-sponsored MORSE project. The Clinical Biochemistry Department of the West Middlesex University Hospital, one of the five project partners, provides clinical and laboratory services to a wide range of users. The Laboratory Information Management System used with...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(94)90146-5
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Rotator cuff muscle tear is one of the most frequent reason of operations in orthopedic surgery. There are several clinical indicators such as Goutallier grade and occupation ratio in the diagnosis and surgery of these diseases, but subjective intervention of the diagnosis is an obstacle in acc...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105063
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Accurate and fast vessel segmentation from liver slices remain challenging and important tasks for clinicians. The algorithms from the literature are slow and less accurate. We propose fast parallel gradient based seeded region growing for vessel segmentation. Seeded region growing is tedious w...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105430
更新日期：2020-08-01 00:00:00
abstract：:A program in Turbo Pascal for robust analysis of variance is presented. A typical data file, the Pascal program listing and the corresponding output are given. ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(90)90074-j
更新日期：1990-12-01 00:00:00
abstract：:The long-term variability of the fetal heart rate (FHR) provides valuable information on the fetal health status. The routine clinical FHR measurements are usually carried out by the means of ultrasound cardiography. Although the frequent FHR monitoring is recommendable, the high quality ultrasound devices are so expe...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(02)00111-6
更新日期：2003-07-01 00:00:00
