Abstract：
:The GALEN project is developing language independent concept representation systems as the foundations for the next generation of multilingual coding systems. It aims to support the flexibility required to cope with the diversity amongst medical applications, while ensuring the coherence necessary for integration and re-use of terminologies. GALEN is developing a fully compositional and generative formal system for modelling concepts: the GALEN Representation and Integration Language (GRAIL) Kernel. Its goal is to overcome many of the problems with traditional coding and classification systems, in particular the combinatorial explosion of terms in enumerative systems and the generation of nonsensical terms in partially compositional systems. It will also provide a clean separation between the concept model and linguistic mechanisms which interpret that model (i.e., the words in a specific language, syntax, alternative phrasings, etc.) in order to allow the development of multilingual systems. GRAIL aims to be formally sound and produce models that are verifiable and contain no contradictions or ambiguities, with realistic human effort. A Coding Reference (CORE) Model of medical terminology covering is being developed which aims to represent the core concepts in for example pathology, anatomy and therapeutics, that have widespread applicability in medical applications. It should also provide the basis for specialist extensions according to the formal principles of GRAIL. The main results of GALEN will be delivered as a Terminology Server (TeS) which encapsulates and coordinates the functionality of the concept module, multilingual module, and code conversion module, and also provides a uniform applications programming interface and network services for use by external applications.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Rector AL,Nowlan WAdoi
10.1016/0169-2607(94)90020-5subject
Has Abstractpub_date
1994-10-01 00:00:00pages
75-8issue
1-2eissn
0169-2607issn
1872-7565pii
0169-2607(94)90020-5journal_volume
45pub_type
杂志文章abstract：:In the case of an unexpected high frequency of serious adverse events (SAE), statistical methods are needed to help in the decision making process as to continuation of accrual to the trial. This paper describes an R package, named SAE that implements a method recently developed by defining stopping rules after each o...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.05.005
更新日期：2011-11-01 00:00:00
abstract：:Glaucoma is a destructive eye disease that causes blindness in individuals displaying little or no symptoms. There is no cure as yet though there are treatments that can arrest its effects or slow its development. The earlier the disease is detected, the more likely the treatment will be successful; however early dete...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.01.002
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Fraction of Inspired Oxygen is one of the arbitrary set ventilator parameters which has critical influence on the concentration of blood oxygen. Normally mechanical ventilators providing respiratory assistance are tuned manually to supply required inspired oxygen to keep the oxygen saturation a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.04.014
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Diabetic disease is typically composed because of higher than normal blood sugar levels. Instead the production of insulin may be regarded insufficient. It has been noted in recent days that the percentage of diabetes-affected patients have grown to a larger extent throughout the world. Evident...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105659
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:With ongoing interest in CNT nanofluids and materials in biotechnology, energy and environment, microelectronics, composite materials etc., the current investigation is carried out to analyze the effects of variable viscosity and thermal conductivity of CNT nanofluids flow driven by cilia indu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.08.001
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In oral and maxillofacial surgery, conventional radiographic cephalometry is one of the standard auxiliary tools for diagnosis and surgical planning. While contemporary computer-assisted cephalometric systems and methodologies support cephalometric analysis, they tend neither to be practical no...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.03.014
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:The traditional biomedical image retrieval methods as well as content-based image retrieval (CBIR) methods originally designed for non-biomedical images either only consider using pixel and low-level features to describe an image or use deep features to describe images but still leave a lot of...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.02.003
更新日期：2018-05-01 00:00:00
abstract：:An automated system is described that screens requests for laboratory investigations from GPs and delivers feedback with respect to the adequacy of the requests. The system has to replace and extend the current system in which feedback is provided on a manual basis each half year, based on the tests requested during a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(96)01742-n
更新日期：1996-07-01 00:00:00
abstract：:The long-term variability of the fetal heart rate (FHR) provides valuable information on the fetal health status. The routine clinical FHR measurements are usually carried out by the means of ultrasound cardiography. Although the frequent FHR monitoring is recommendable, the high quality ultrasound devices are so expe...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(02)00111-6
更新日期：2003-07-01 00:00:00
abstract：:An interactive computer program written in BASIC with the objective of assisting the identification of species of common gastrointestinal parasites of humans is presented. The computer program acquires observational information needed for the identification of a parasite from the user. The user selects a description f...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(88)90037-5
更新日期：1988-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Deep learning enables tremendous progress in medical image analysis. One driving force of this progress are open-source frameworks like TensorFlow and PyTorch. However, these frameworks rarely address issues specific to the domain of medical image analysis, such as 3-D data handling and distanc...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105796
更新日期：2021-01-01 00:00:00
abstract：:This corrigendum corrects the dimensions of partial differential equations in the paper [1], where these mistakes are occurred during typing processes. But the results in [1] does not affect the scientific and mathematical validity of the paper. ...
journal_title：Computer methods and programs in biomedicine
pub_type： 信件
doi：10.1016/j.cmpb.2019.105251
更新日期：2020-04-01 00:00:00
abstract：:A novel approach for the heartbeat and respiration detection based on optical interferometer and wavelet transform is proposed in this paper. Optical interferometer is a sensitive device that detects physical elongation of optical fibre due to external perturbations. Mechanical activity of cardiac muscle and respirati...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.03.003
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Objective Structured Clinical Examination (OSCE) has been used in many areas of healthcare training over the years. However, it constantly needs to be upgraded and enhanced due to technological and teaching changes. We aim at implementing an integrative OSCE method which employs informatics via...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.11.006
更新日期：2018-05-01 00:00:00
abstract：:This study employs the concept of applying constant-phase models to input respiratory impedance data obtained with the non-invasive Forced Oscillation Technique (FOT) lung function test. Changes in respiratory mechanics from healthy and chronic obstructive pulmonary disease (COPD) diagnosed patients are observed with ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.06.006
更新日期：2010-01-01 00:00:00
abstract：:NONMEM is an extremely powerful tool for nonlinear mixed-effect modelling and simulation of pharmacokinetic and pharmacodynamic data. However, it is a console-based application whose output does not lend itself to rapid interpretation or efficient management. NONMEMory has been created to be a comprehensive project ma...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.02.003
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:The application of entropy optimization has consistently incorporated in traditional and industrial fields. The system is permanently sustainable, usually a final ideal structure may not exist in general, as common evolution shows trends in a long time. The measurement of the entropy generation related to he...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105262
更新日期：2020-05-01 00:00:00
abstract：:The feasibility of computer translation of scientific and medical documents is controversial. This report describes a minicomputer-based translation system (TRANSOFT) that employs word order rearrangement followed by word-for-word translation and resolution of ambiguities based on context. This translation system was ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(86)90091-x
更新日期：1986-03-01 00:00:00
abstract：:Optimal sampling schedule (OSS) is of great interest in biomedical experiment design, as it can improve the physiological parameter estimation precision and significantly reduce the samples required. A number of well designed algorithms and software packages have been developed, which deal with the instantaneous measu...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(00)00114-0
更新日期：2001-04-01 00:00:00
abstract：:A computer program for a microcomputer (HP 86) is presented to discriminate between different models and to design new experiments for model discrimination. By a non-linear fitting algorithm a set of experimental data is fitted with different models suggested by the user. The parameters characterizing each model are e...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(86)90022-2
更新日期：1986-04-01 00:00:00
abstract：:Cloud computing and the Internet of Things are the two hot points in the Internet application field. The application of the two new technologies is in hot discussion and research, but quite less on the field of medical monitoring and managing application. Thus, in this paper, we study and analyze the application of cl...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.03.024
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Signal segmentation and spike detection are two important biomedical signal processing applications. Often, non-stationary signals must be segmented into piece-wise stationary epochs or spikes need to be found among a background of noise before being further analyzed. Permutation entropy (PE) h...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.02.008
更新日期：2016-05-01 00:00:00
abstract：:The purpose of this study was to evaluate the clinical efficacy of 3D reconstruction of the tracheobronchial system using spiral CT. A total of 25 patients with tracheobronchial abnormalities, stenosis (n = 21) and fistula with esophagus (n = 4), underwent a single breathhold spiral CT (5 mm collision, 5 mm)/s increme...
journal_title：Computer methods and programs in biomedicine
pub_type： 临床试验,杂志文章
doi：10.1016/s0169-2607(98)00053-4
更新日期：1998-08-01 00:00:00
abstract：:Cosmetic doctor utilizes the position, size and shapes of female's breast to judge whether the breast is under steady-state condition after breast implant plastic surgery. Since, doctor evaluates the breast condition with the subjective discrimination (such as vision, sense of touch) without using the objective physic...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2007.11.013
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In the last decade, Ultrasound-Guided Regional Anesthesia (UGRA) gained importance in surgical procedures and pain management, due to its ability to perform target delivery of local anesthetics under direct sonographic visualization. However, practicing UGRA can be challenging, since it require...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.03.013
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Breast cancer is the most common cancer affecting females worldwide. Breast cancer survivability prediction is challenging and a complex research task. Existing approaches engage statistical methods or supervised machine learning to assess/predict the survival prospects of patients. OBJECTIVE:The main objec...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.12.011
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In clinical examinations and brain-computer interface (BCI) research, a short electroencephalogram (EEG) measurement time is ideal. The use of event-related potentials (ERPs) relies on both estimation accuracy and processing time. We tested a particle filter that uses a large number of particle...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2015.11.006
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Early-phase virtual screening of candidate drug molecules plays a key role in pharmaceutical industry from data mining and machine learning to prevent adverse effects of the drugs. Computational classification methods can distinguish approved drugs from withdrawn ones. We focused on 6 data set...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2017.02.004
更新日期：2017-04-01 00:00:00
abstract：PURPOSE:This study was performed to evaluate the usefulness of virtual magnetic resonance microscopy (VMRM) for the diagnosis of cerebral aneurysms. MATERIALS AND METHODS:We reviewed 11 patients with unruptured aneurysms confirmed by angiography or surgical therapy. We evaluated the ability of VMRM to represent aneury...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00142-0
更新日期：2001-07-01 00:00:00
abstract：:This paper is concerned with the investigation on the fatigue failure of implant fixation by numerical approaches. A computer algorithm based on finite element analysis and continuum damage mechanics was proposed to quantify the fatigue damage rate of cement mantle under physiological conditions. In examining the inte...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2004.05.004
更新日期：2004-11-01 00:00:00
