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hs-CRP is strongly associated with coronary heart disease (CHD): A data mining approach using decision tree algorithm.

Abstract：

BACKGROUND AND AIMS:Coronary heart disease (CHD) is an important public health problem globally. Algorithms incorporating the assessment of clinical biomarkers together with several established traditional risk factors can help clinicians to predict CHD and support clinical decision making with respect to interventions. Decision tree (DT) is a data mining model for extracting hidden knowledge from large databases. We aimed to establish a predictive model for coronary heart disease using a decision tree algorithm. METHODS:Here we used a dataset of 2346 individuals including 1159 healthy participants and 1187 participant who had undergone coronary angiography (405 participants with negative angiography and 782 participants with positive angiography). We entered 10 variables of a total 12 variables into the DT algorithm (including age, sex, FBG, TG, hs-CRP, TC, HDL, LDL, SBP and DBP). RESULTS:Our model could identify the associated risk factors of CHD with sensitivity, specificity, accuracy of 96%, 87%, 94% and respectively. Serum hs-CRP levels was at top of the tree in our model, following by FBG, gender and age. CONCLUSION:Our model appears to be an accurate, specific and sensitive model for identifying the presence of CHD, but will require validation in prospective studies.

journal_name

Comput Methods Programs Biomed

journal_title

Computer methods and programs in biomedicine

authors

Tayefi M,Tajfard M,Saffar S,Hanachi P,Amirabadizadeh AR,Esmaeily H,Taghipour A,Ferns GA,Moohebati M,Ghayour-Mobarhan M

doi

10.1016/j.cmpb.2017.02.001

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

105-109

eissn

0169-2607

issn

1872-7565

pii

S0169-2607(16)31190-7

journal_volume

141

pub_type

杂志文章

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