Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.

abstract：:In this issue of Cancer Research, Xia and colleagues show that MYC-induced metabolic reprograming results in dependency on the serine-glycine-one-carbon (SGOC) metabolic pathway in neuroblastoma. This occurs through MYCN and ATF4 activation of the SGOC biosynthetic pathway in MYCN-amplified cells. Furthermore, inhibit...

journal_title：Cancer research

authors： Garcia AR,Arsenian-Henriksson M

更新日期：2019-08-01 00:00:00

abstract：:DRAIC is a 1.7 kb spliced long noncoding RNA downregulated in castration-resistant advanced prostate cancer. Decreased DRAIC expression predicts poor patient outcome in prostate and seven other cancers, while increased DRAIC represses growth of xenografted tumors. Here, we show that cancers with decreased DRAIC expres...

journal_title：Cancer research

authors： Saha S,Kiran M,Kuscu C,Chatrath A,Wotton D,Mayo MW,Dutta A

更新日期：2020-03-01 00:00:00

abstract：:Cancer vaccines may have applications in the therapy and prevention of mammary carcinoma. To investigate such applications, we constructed a recombinant adenoviral vaccine expressing a kinase-inactive mutant form of human HER2 and introduced this into BALB/c wild-type (WT) or HER2 transgenic mice. Here, we report cont...

journal_title：Cancer research

authors： Triulzi C,Vertuani S,Curcio C,Antognoli A,Seibt J,Akusjärvi G,Wei WZ,Cavallo F,Kiessling R

更新日期：2010-10-01 00:00:00

abstract：:Earlier studies suggested that TSP50 is a testis-specific gene that encodes a protein, which is homologous to serine proteases but differs in that threonine replaces serine in its catalytic triad. Most importantly, it was abnormally reactivated in many breast cancer biopsies tested. While further investigating its bio...

journal_title：Cancer research

authors： Xu H,Shan J,Jurukovski V,Yuan L,Li J,Tian K

更新日期：2007-02-01 00:00:00

abstract：:High amounts of nitric oxide (NO) produced by activated macrophages or NO donors are required to induce cytotoxicity and apoptosis in pathogens and tumor cells. High concentrations of NO may lead to nonspecific toxicity thereby limiting the use of NO donors in the treatment of cancer. In this study, we tested the poss...

journal_title：Cancer research

authors： Pervin S,Singh R,Gau CL,Edamatsu H,Tamanoi F,Chaudhuri G

更新日期：2001-06-15 00:00:00

abstract：:Multiple copies of N-myc proto-oncogene are only rarely detected in localized neuroblastomas (NBs), and the prognostic relevance of amplification in this subset of patients is not clear. We analyzed a series of 850 children with NB admitted to a Pediatric Oncology Group NB Biology Study and identified six patients wit...

journal_title：Cancer research

authors： Cohn SL,Look AT,Joshi VV,Holbrook T,Salwen H,Chagnovich D,Chesler L,Rowe ST,Valentine MB,Komuro H

更新日期：1995-02-15 00:00:00

abstract：:Oncogene activation and loss of tumor suppressor genes are known to play a role in tumor initiation as well as its progression. The potential roles of these genes in perturbation of genome stability has become a major interest. To better understand the relationship between expression of an oncogene and genetic instabi...

journal_title：Cancer research

authors： Wani MA,Xu X,Stambrook PJ

更新日期：1994-05-01 00:00:00

abstract：:For patients with solid tumors, the tolerance of surrounding tissues often limits the dose of radiation that can be delivered. Thus, agents that preferentially increase the cytotoxic effects of radiation toward tumor cells would significantly alter the therapeutic ratio and improve patient survival. Using a high-throu...

journal_title：Cancer research

authors： Lally BE,Geiger GA,Kridel S,Arcury-Quandt AE,Robbins ME,Kock ND,Wheeler K,Peddi P,Georgakilas A,Kao GD,Koumenis C

更新日期：2007-09-15 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (sum of which is denoted as total NNAL) are metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNK and NNAL can induce lung cancer in laboratory animals but human data are limited. The association between prediagnostic levels o...

journal_title：Cancer research

authors： Yuan JM,Koh WP,Murphy SE,Fan Y,Wang R,Carmella SG,Han S,Wickham K,Gao YT,Yu MC,Hecht SS

更新日期：2009-04-01 00:00:00

abstract：:Metastasis requires cytoskeletal remodeling for migration, adhesion, and extravasation of metastatic cells. Although protein kinase C (PKC) is involved in tumor promotion/progression and cytoskeletal remodeling, its role in metastasis has not been defined. PKCdelta levels are increased in highly metastatic 13762NF mam...

journal_title：Cancer research

authors： Kiley SC,Clark KJ,Goodnough M,Welch DR,Jaken S

更新日期：1999-07-01 00:00:00

abstract：:Formalin-fixed, paraffin-embedded tissues from 108 cases of invasive carcinoma of the uterine cervix, consisting of 40 cases of adenocarcinoma, 44 cases of adenosquamous carcinoma, and, as a control, 24 cases of squamous cell carcinoma were examined for the presence of human papillomavirus (HPV) DNA by in situ hybridi...

journal_title：Cancer research

authors： Tase T,Okagaki T,Clark BA,Manias DA,Ostrow RS,Twiggs LB,Faras AJ

更新日期：1988-02-15 00:00:00

abstract：:Despite the initial efficacy of androgen deprivation therapy, most patients with advanced prostate cancer eventually progress to hormone-refractory prostate cancer, for which there is no curative therapy. Previous studies from our laboratory and others have shown the antiproliferative and proapoptotic effects of 3,3'-...

journal_title：Cancer research

authors： Bhuiyan MM,Li Y,Banerjee S,Ahmed F,Wang Z,Ali S,Sarkar FH

更新日期：2006-10-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is considered an early onset subtype of breast cancer that carries with it a poorer prognosis in young rather than older women for reasons that remain poorly understood. Hematopoiesis in the bone marrow becomes altered with age and may therefore affect the composition of tumor-infi...

journal_title：Cancer research

authors： Marsh T,Wong I,Sceneay J,Barakat A,Qin Y,Sjödin A,Alspach E,Nilsson B,Stewart SA,McAllister SS

更新日期：2016-05-15 00:00:00

abstract：:Transfection of C3H/10T1/2 cells with either a c-myc or an activated c-Ha-ras gene decreased the cellular dependence for serum-derived factors to proliferate in monolayer. The c-myc-transfected cells did, however, require a high plasma concentration for significant growth, while the ras transfectants grew extremely we...

journal_title：Cancer research

authors： Leof EB,Lyons RM,Cunningham MR,O'Sullivan D

更新日期：1989-05-01 00:00:00

abstract：:Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes in human cancer. We treated two immortalized glioma cell lines, T98 and U87, and 10 patient-derived primary glioma cell lines with trichostatin A (TSA), a histone d...

journal_title：Cancer research

authors： Foltz G,Ryu GY,Yoon JG,Nelson T,Fahey J,Frakes A,Lee H,Field L,Zander K,Sibenaller Z,Ryken TC,Vibhakar R,Hood L,Madan A

更新日期：2006-07-01 00:00:00

abstract：:Concanavalin A (Con A) binding of fixed malignant and nonmalignant C3H/He mouse mammary epithelia in monolayer cultures was examined with markers and labels of various sizes. In Con A-mediated hemadsorption, high epithelial cell densities resulted in the adsorbance of more guinea pig red blood cells per culture dish b...

journal_title：Cancer research

authors： Mitani H,Murakami A,Tanaka H

更新日期：1984-02-01 00:00:00

abstract：:Epidermal growth factor receptor vIII (EGFRvIII) is a tumor-specific, ligand-independent, constitutively active variant of the EGFR. Its expression has been detected in gliomas and various other human malignancies. To more fully characterize the function and potential biological role of EGFRvIII in regulating cell pro...

journal_title：Cancer research

authors： Tang CK,Gong XQ,Moscatello DK,Wong AJ,Lippman ME

更新日期：2000-06-01 00:00:00

abstract：:SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, and lineage commitment in various tissues including the intestinal epithelium. Here, we present functional and cl...

journal_title：Cancer research

authors： Matheu A,Collado M,Wise C,Manterola L,Cekaite L,Tye AJ,Canamero M,Bujanda L,Schedl A,Cheah KS,Skotheim RI,Lothe RA,López de Munain A,Briscoe J,Serrano M,Lovell-Badge R

更新日期：2012-03-01 00:00:00

abstract：:Transgenic mice have been previously established that express v-rasHa or v-fos exclusively in the epidermis by means of a targeting vector based on the human keratin 1 gene (HK1). Epidermal expression of v-rasHa (HK1.ras) or v-fos (HK1.fos) resulted in hyperplasia, hyperkeratosis, and later, in benign tumors. To asses...

journal_title：Cancer research

authors： Greenhalgh DA,Quintanilla MI,Orengo CC,Barber JL,Eckhardt JN,Rothnagel JA,Roop DR

更新日期：1993-11-01 00:00:00

abstract：:Proliferating mammalian stem and cancer cells express telomerase [telomerase reverse transcriptase (TERT)] in an effort to extend chromosomal G-overhangs and maintain telomere ends. Telomerase-expressing cells also have higher levels of the single-stranded DNA-binding protein SSB1, which has a critical role in DNA dou...

journal_title：Cancer research

authors： Pandita RK,Chow TT,Udayakumar D,Bain AL,Cubeddu L,Hunt CR,Shi W,Horikoshi N,Zhao Y,Wright WE,Khanna KK,Shay JW,Pandita TK

更新日期：2015-03-01 00:00:00

abstract：:The involvement of immune response in the resistance of chemically induced stomach cancer was studied in a resistant rat strain (Buffalo) and a sensitive rat strain (ACI). Groups of 10 male Buffalo and ACI rats, 6 weeks of age, were given drinking water with or without N-methyl-N'-nitro-N-nitrosoguanidine (MNNG; 100 m...

journal_title：Cancer research

authors： Oka M,Furihata C,Kitoh K,Yamamoto M,Tatematsu M,Ichinose M,Miki K,Ito T,Sakaki Y,Reske K

更新日期：1998-09-15 00:00:00

abstract：:We describe two flow cytometric assays performed on populations of cells which have been stained with various fluorescent tracer molecules by the scrape-loading technique. One assay uses a simple one-color analysis on a flow cytometer by quantitating the fluorescence intensity of scrape-loaded lucifer yellow CH (LY) i...

journal_title：Cancer research

authors： Kavanagh TJ,Martin GM,el-Fouly MH,Trosko JE,Chang CC,Rabinovitch PS

更新日期：1987-11-15 00:00:00

abstract：:The radiation response of autochthonous tumors induced by s.c. injection of 3-methylcholanthrene in ICR/JCL mice was studied. The tumors were mostly fibrosarcomas and grew with an average volume-doubling time of 2.6 days, independently of the time tumor appearance or dose of the chemical used. The tumors were locally ...

journal_title：Cancer research

authors： Tanooka H,Hoshino H,Tanaka K,Nagase M

更新日期：1980-07-01 00:00:00

abstract：:We have previously reported that abdominal irradiation prior to i.v. injection of syngeneic tumor cells reduced metastases in lung. Our report described an investigation of the significance of intestinal organisms in the radiation effect. We found that eliminating intestinal organisms with antibiotics totally abolishe...

journal_title：Cancer research

authors： Matsumoto T,Ando K,Koike S

更新日期：1988-06-01 00:00:00

abstract：:High speed (200 ms temporal resolution) functional computed tomography was used to demonstrate tumor vascular heterogeneity with 0.05 microliter spatial resolution. Vascular topologies were investigated in 2 human small cell lung cancer lines implanted either s.c. or as a tissue isolated preparation in immunocompromis...

journal_title：Cancer research

authors： Hamberg LM,Kristjansen PE,Hunter GJ,Wolf GL,Jain RK

更新日期：1994-12-01 00:00:00

abstract：:To elucidate the role of cyclin E in cell growth and tumorigenesis in mammary epithelial cells, we have used retrovirus-mediated transduction to generate derivatives of the nontransformed HC11 mouse mammary epithelial cell line that stably express a human cyclin E cDNA (HU4). These derivatives expressed two distinct f...

journal_title：Cancer research

authors： Sgambato A,Han EK,Zhou P,Schieren I,Weinstein IB

更新日期：1996-03-15 00:00:00

abstract：:Using the phage lambdaLIZ-based transgenic in vivo mutagenesis assay, mean mutant rates were determined in the spleen of mice exposed to sustained oxidative stress and were found to be increased approximately 3-fold in plasmacytoma-susceptible BALB/c and C.D2-Idh1-Pep3 mice, but not in plasmacytoma-resistant DBA/2N mi...

journal_title：Cancer research

authors： Felix K,Kelliher K,Bornkamm GW,Janz S

更新日期：1998-04-15 00:00:00

abstract：:C19ORF5 is a sequence homologue of microtubule-associated proteins MAP1A/MAP1B of unknown function, except for its association with mitochondria-associated proteins and the paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A. Here, we show that when overexpressed in mammalian cells the recomb...

journal_title：Cancer research

authors： Liu L,Vo A,Liu G,McKeehan WL

更新日期：2005-05-15 00:00:00

abstract：:In an attempt to identify phytochemicals contributing to the well-documented preventive effect of plant-based diets on cancer incidence and mortality, we have previously shown that certain flavonoids inhibit in vitro angiogenesis. Here, we show that the flavonoid luteolin inhibited tumor growth and angiogenesis in a m...

journal_title：Cancer research

authors： Bagli E,Stefaniotou M,Morbidelli L,Ziche M,Psillas K,Murphy C,Fotsis T

更新日期：2004-11-01 00:00:00

abstract：:Human peripheral blood lymphocytes (PBL), obtained from patients with a variety of cancers, were incubated in vitro with phytohemagglutinin, concanavalin A, and crude or lectin-free T-cell growth factors. The lectin-activated PBL of nine patients were capable of lysing fresh autologous tumor during a 4-hr 51Cr release...

journal_title：Cancer research

authors： Mazumder A,Grimm EA,Zhang HZ,Rosenberg SA

更新日期：1982-03-01 00:00:00