Localization and identification of the multiple endocrine neoplasia type 1 disease gene.

abstract：:Endocrinopathies are significant consequences of the treatment of childhood cancers. The risk of developing these adverse events is related to the underlying disease and its treatment with cytotoxic agents and radiation therapy. This article reviews hypothalamic-pituitary, thyroid, and gonadal dysfunction, as well as ...

journal_title：Endocrinology and metabolism clinics of North America

authors： Cohen LE

更新日期：2005-09-01 00:00:00

abstract：:The biologic actions of the peptides of the gastrointestinal tract indicate that they exert their effects by interacting with, in many instances, more than one receptor type and receptors on several tissues. Gut hormone profiles in pathophysiologic situations have not demonstrated a significant role for them in diseas...

journal_title：Endocrinology and metabolism clinics of North America

authors： Brown JC

更新日期：1993-12-01 00:00:00

abstract：:The degree of hyperglycemia may be an important predictor of morbidity and mortality among patients with MI or stroke, and in those undergoing surgical procedures including coronary artery bypass. Hyperglycemia should be aggressively controlled from the time of hospital admission regardless of the patient's primary me...

journal_title：Endocrinology and metabolism clinics of North America

authors： Levetan CS,Magee MF

更新日期：2000-12-01 00:00:00

abstract：:Renal artery stenosis, particularly related to advancing atherosclerotic disease, is a common concern to internists seeing patients with worsening hypertension and deteriorating renal function. Understanding the hormonal and hemodynamic consequences of critical vascular lesions allows better selection of antihypertens...

journal_title：Endocrinology and metabolism clinics of North America

authors： Textor SC

更新日期：1994-06-01 00:00:00

abstract：:Pheochromocytomas cause the most dramatic life-threatening crises in all of endocrinology. Pheochromocytoma is an explosive clinical syndrome that may be characterized by either severe hypertension associated with cerebral, cardiac, and renal complications or hypotension, or even shock and sudden death. Other emergenc...

journal_title：Endocrinology and metabolism clinics of North America

authors： Bravo EL,Gifford RW Jr

更新日期：1993-06-01 00:00:00

abstract：:Surgical approaches to hepatic metastases occupy an important role in the management of patients with neuroendocrine neoplasms and may have curative or palliative intentions. Resection of hepatic disease with curative intent is the only modality offering potential cure for patients with liver metastases; however, only...

journal_title：Endocrinology and metabolism clinics of North America

authors： Frilling A,Clift AK

更新日期：2018-09-01 00:00:00

abstract：:Glucocorticoids are critical in the management of chronic, noninfectious, inflammatory diseases. Bone loss is a most devastating side effect of these powerful medications. Glucocorticoids produce bone loss by altering calcium metabolism, suppressing gonadal hormone production, and inhibiting bone formation. Now that t...

journal_title：Endocrinology and metabolism clinics of North America

authors： Lane NE,Lukert B

更新日期：1998-06-01 00:00:00

abstract：:Hypergonadotropic forms of amenorrhea in young women are many and varied, and the disorder is not nearly as uncommon as previously believed. It is likely that all physicians seeing women with amenorrhea will encounter this disorder. Careful evaluation is warranted to eliminate any associated autoimmune disorders. Beca...

journal_title：Endocrinology and metabolism clinics of North America

authors： Rebar RW,Cedars MI

更新日期：1992-03-01 00:00:00

abstract：:In the last 2 decades, diabetes technology has emerged as a branch of diabetes management thanks to the advent of continuous glucose monitoring (CGM) and increased availability of continuous subcutaneous insulin infusion systems, or insulin pumps. These tools have progressed from rudimentary instruments to sophisticat...

journal_title：Endocrinology and metabolism clinics of North America

authors： Kravarusic J,Aleppo G

更新日期：2020-03-01 00:00:00

abstract：:With modern growth hormone (GH) replacement algorithms, children with a diagnosis of growth hormone deficiency achieve at the end of pediatric GH treatment an adult height that is on the average in the normal range. Recent experience with GH replacement in young adults with childhood-onset growth hormone deficiency, h...

journal_title：Endocrinology and metabolism clinics of North America

authors： Attanasio AF,Shalet SM

更新日期：2007-03-01 00:00:00

abstract：:Thyroid cancer is the most common endocrine malignancy. Its incidence and mortality rates have increased for patients with advanced-stage papillary thyroid cancer. The characterization of the molecular pathways essential in thyroid cancer initiation and progression has made huge progress, underlining the role of intra...

journal_title：Endocrinology and metabolism clinics of North America

authors： Valvo V,Nucera C

更新日期：2019-03-01 00:00:00

abstract：:Combined clinical and laboratory investigations of MEN-1 have resulted in an increased understanding of this disorder, which may be inherited as an autosomal dominant condition. Defining the features of each disease manifestation in MEN-1 has improved patient management and treatment and has facilitated a screening pr...

journal_title：Endocrinology and metabolism clinics of North America

authors： Thakker RV

更新日期：2000-09-01 00:00:00

abstract：:A series of investigations have emphasized the heterogeneous nature of the clinical condition known as PCOS and have delineated several factors that may contribute to the hyperandrogenemia and anovulation in this condition. Currently, it remains unclear whether intrinsic abnormalities of ovarian steroidogenesis, the e...

journal_title：Endocrinology and metabolism clinics of North America

authors： Marshall JC,Eagleson CA

更新日期：1999-06-01 00:00:00

abstract：:The notion that Graves' ophthalmopathy is an autoimmune disease has been based primarily on the clinical associations between it and Graves' hyperthyroidism, and on the frequently beneficial response of the disease to immunosuppressive therapy. Recent advances in molecular biology have led to new insights into the pat...

journal_title：Endocrinology and metabolism clinics of North America

authors： Bahn RS

更新日期：2000-06-01 00:00:00

abstract：:Trabecular bone score (TBS) is a novel method that assesses skeletal texture from spine dual-energy X-ray absorptiometry (DXA) images. TBS improves fracture-risk prediction beyond that provided by DXA bone mineral density (BMD) and clinical risk factors, and can be incorporated to the Word Health Organization Fracture...

journal_title：Endocrinology and metabolism clinics of North America

authors： Silva BC,Leslie WD

更新日期：2017-03-01 00:00:00

abstract：:Identifying patients with a high risk of fracture and monitoring a patient's therapeutic response are important. Current methods to evaluate the risk of fracture include the measurement of bone mineral density as well as other risk factors, including those associated with the risk of falling. Several considerations ar...

journal_title：Endocrinology and metabolism clinics of North America

authors： Sowers M

更新日期：1997-03-01 00:00:00

abstract：:Lifestyle modification is the cornerstone treatment of type 2 diabetes in the obese patient, and is highly effective at promoting glucose regulation. However, many individuals struggle over time to maintain optimal glycemic control and/or body weight with lifestyle modification. Therefore, additional therapeutic appro...

journal_title：Endocrinology and metabolism clinics of North America

authors： Malin SK,Kashyap SR

更新日期：2016-09-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare and aggressive tumor. ACC may be associated with different syndromes of hormone excess, most frequently Cushing's syndrome with or without hypersecretion of androgens. Recent data suggest that cortisol excess is a negative prognostic factor in advanced and localized ACC. Surger...

journal_title：Endocrinology and metabolism clinics of North America

authors： Puglisi S,Perotti P,Pia A,Reimondo G,Terzolo M

更新日期：2018-06-01 00:00:00

abstract：:In this article we present factors that determine whether one can trust the results of studies that describe the properties of diagnostic tests. We review the ways in which the results of such studies could be presented to the readers and consider factors that determine the value of such reports in one's own clinical ...

journal_title：Endocrinology and metabolism clinics of North America

authors： Jaeschke R,Guyatt GH,Montori VM

更新日期：2002-09-01 00:00:00

abstract：:The liver is key to glucose homeostasis. Any disruption of its metabolism, structural integrity, or intracellular dynamics may alter the liver's ability to maintain normal glucose homeostasis. When such disruption affects hepatic glucose output, hypoglycemia may eventuate. Multiple drugs including alcohol may alter th...

journal_title：Endocrinology and metabolism clinics of North America

authors： Arky RA

更新日期：1989-03-01 00:00:00

abstract：:Cardiovascular disease is a serious complication of diabetes mellitus. In the last 2 decades, great strides have been made in reducing microvascular complications in patients with diabetes through improving glycemic control. Decreasing rates of cardiovascular events have proved to be more difficult than simply intensi...

journal_title：Endocrinology and metabolism clinics of North America

authors： Szuszkiewicz-Garcia MM,Davidson JA

更新日期：2014-03-01 00:00:00

abstract：:Skin manifestations associated with diabetes mellitus are common and, with close scrutiny, can occur in most, if not all, patients. Little information is available on what common pathophysiologic thread is responsible for the skin manifestation and diabetes. Although controlled studies are lacking, a recognition of th...

journal_title：Endocrinology and metabolism clinics of North America

authors： Sibbald RG,Landolt SJ,Toth D

更新日期：1996-06-01 00:00:00

abstract：:Mediators of neuroendocrine and autonomic function seem to play important roles in the core symptoms of major depression. Although centrally directed corticotropin-releasing hormones and norepinephrine contribute to core symptoms such as alterations in anxiety, arousal, and mood, they also exert significant potentiall...

journal_title：Endocrinology and metabolism clinics of North America

authors： Gold PW,Gabry KE,Yasuda MR,Chrousos GP

更新日期：2002-03-01 00:00:00

abstract：:Normal aging is accompanied by many changes in the hormonal systems involved in control of sodium and water balance. These alterations, together with age-associated changes in renal function, diminish the capacity of the elderly person to withstand the challenges of illness, drugs, and physiologic stresses. Thus, the ...

journal_title：Endocrinology and metabolism clinics of North America

authors： Miller M

更新日期：1995-06-01 00:00:00

abstract：:Health care providers and patients have lots of choice to treat type 2 diabetes, but the blood glucose improvement is limited. The one therapy with unlimited potential (at least theoretically) is insulin. Many studies show that glucose control is achievable with insulin safely in most patients with type 2 diabetes. Ef...

journal_title：Endocrinology and metabolism clinics of North America

authors： Leahy JL

更新日期：2012-03-01 00:00:00

abstract：:This article summarizes the main principles for the appropriate use of laboratory testing in the diagnosis and management of thyroid disorders, as well as controversies that have arisen in association with some of these biochemical tests. To place a test in perspective, its sensitivity and accuracy should be taken int...

journal_title：Endocrinology and metabolism clinics of North America

authors： Esfandiari NH,Papaleontiou M

更新日期：2017-09-01 00:00:00

abstract：:Over the past 40 years, meal skipping and snacking in US adults have increased, and currently most eating occasions occur later in the day than previously. Whether these changes have played a causal role in the obesity epidemic is poorly understood. Observational studies are largely inconclusive due to methodological ...

journal_title：Endocrinology and metabolism clinics of North America

authors： McCrory MA,Shaw AC,Lee JA

更新日期：2016-09-01 00:00:00

abstract：:Diseases in other organs may impair the male reproductive system. Acute critical conditions such as severe trauma, surgery, myocardial infarction, burns, liver failure, intoxication, or starvation are associated with suppression of gonadotropin secretion and secondary hypogonadism. With chronic illnesses, a primary te...

journal_title：Endocrinology and metabolism clinics of North America

authors： Baker HW

更新日期：1998-12-01 00:00:00

abstract：:In adults, GHD is a clinical syndrome that occurs in patients with pituitary or hypothalamic disease. It may be asymptomatic or present with relatively nonspecific constitutional symptoms. Most patients have abnormal body composition, consisting of increased fat mass and decreased lean mass. Life expectancy is signifi...

journal_title：Endocrinology and metabolism clinics of North America

authors： Stavrou S,Kleinberg DL

更新日期：2001-09-01 00:00:00

abstract：:A small abut important subset of patients with differentiated thyroid cancer will die of disease. Our approach to therapy treats almost all patients similarly, with aggressive surgery and I-131 therapy. Meticulous follow-up should include multiple I-131 diagnostic scans using at least 5 to 10 mCi of I-131 with attenti...

journal_title：Endocrinology and metabolism clinics of North America

authors： Sweeney DC,Johnston GS

更新日期：1995-12-01 00:00:00