Abstract:
:In adults, GHD is a clinical syndrome that occurs in patients with pituitary or hypothalamic disease. It may be asymptomatic or present with relatively nonspecific constitutional symptoms. Most patients have abnormal body composition, consisting of increased fat mass and decreased lean mass. Life expectancy is significantly decreased in hypopituitary patients with GHD, with cardiovascular disease a common cause of death. Treatment with growth hormone reverses abnormalities in body composition and may reduce cardiovascular risk factors; however, the long-term treatment outcomes regarding mortality, the incidence of cardiovascular disease, bone fractures, tumor development, and recurrence are not known. Longer prospective clinical studies are needed. The major manufacturers of growth hormone have initiated postmarketing surveillance databases to monitor the safety of growth hormone treatment.
journal_name
Endocrinol Metab Clin North Amjournal_title
Endocrinology and metabolism clinics of North Americaauthors
Stavrou S,Kleinberg DLdoi
10.1016/s0889-8529(05)70201-2subject
Has Abstractpub_date
2001-09-01 00:00:00pages
545-63issue
3eissn
0889-8529issn
1558-4410pii
S0889-8529(05)70201-2journal_volume
30pub_type
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journal_title:Endocrinology and metabolism clinics of North America
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journal_title:Endocrinology and metabolism clinics of North America
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journal_title:Endocrinology and metabolism clinics of North America
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journal_title:Endocrinology and metabolism clinics of North America
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journal_title:Endocrinology and metabolism clinics of North America
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journal_title:Endocrinology and metabolism clinics of North America
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journal_title:Endocrinology and metabolism clinics of North America
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journal_title:Endocrinology and metabolism clinics of North America
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