Neuroendocrine tumors: current recommendations for diagnosis and surgical management.

Abstract:

:Neuroendocrine tumors (NETs) are rare neoplasms found in diverse locations within the body. These tumors are commonly classified by the primary tumor's location, further subclassified by their differentiation, and finally segregated by their ability to hypersecrete peptides or amines. A number of groups have summarized their recommendations for diagnosis and therapy; however, the rarity of these lesions makes prospective randomized multiinstitutional trials difficult. Thus, these "consensus statements" often remain opinion-based. The authors have collaboratively developed a consensus on the current diagnostic work-up necessary for patients with NETs to help clinicians with this confusing field and followed this with some of the more advanced surgical techniques and considerations that are currently only available in specialty centers to show the evolving management of NETs.

authors

Joseph S,Wang YZ,Boudreaux JP,Anthony LB,Campeau R,Raines D,O'Dorisio T,Go VL,Vinik AI,Cundiff J,Woltering EA

doi

10.1016/j.ecl.2010.08.004

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

205-31, x

issue

1

eissn

0889-8529

issn

1558-4410

pii

S0889-8529(10)00064-2

journal_volume

40

pub_type

杂志文章,评审
  • Thyrotoxicosis and thyroid storm.

    abstract::Thyroid storm represents the extreme manifestation of thyrotoxicosis as a true endocrine emergency. Although Grave's disease is the most common underlying disorder in thyroid storm, there is usually a precipitating event or condition that transform the patient into life-threatening thyrotoxicosis. Treatment of thyroid...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2006.09.008

    authors: Nayak B,Burman K

    更新日期:2006-12-01 00:00:00

  • Glucocorticoids and osteoporosis.

    abstract::In summary, patients who will remain on glucocorticoids for more than a few weeks are clearly at risk for osteoporosis. A list of therapeutic strategies is provided in Table 2. While our therapy remains inadequate at this time, newer agents are on the horizon. In the near future, it may be possible to recommend specif...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Adler RA,Rosen CJ

    更新日期:1994-09-01 00:00:00

  • Diagnosis and management of polyendocrinopathy syndromes.

    abstract::The autoimmune polyendocrinopathy syndromes are variable in presentation and can be challenging to diagnose and manage. Diagnosis of the type 1 autoimmune polyendocrinopathy syndrome can be difficult at an early age when often only one manifestation is present, and it may take years for others to appear. Increased awa...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2009.01.007

    authors: Owen CJ,Cheetham TD

    更新日期:2009-06-01 00:00:00

  • Dermatologic Conditions in Transgender Populations.

    abstract::Transgender persons receiving gender-affirming hormone therapy and procedures may face specific skin conditions. Skin diseases in transgender patients often are underdiagnosed and underrecognized despite their important impact on quality of life and mental health. This article discusses pathophysiology, diagnosis, and...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2019.01.005

    authors: Yeung H,Kahn B,Ly BC,Tangpricha V

    更新日期:2019-06-01 00:00:00

  • Adrenocortical Carcinoma with Hypercortisolism.

    abstract::Adrenocortical carcinoma (ACC) is a rare and aggressive tumor. ACC may be associated with different syndromes of hormone excess, most frequently Cushing's syndrome with or without hypersecretion of androgens. Recent data suggest that cortisol excess is a negative prognostic factor in advanced and localized ACC. Surger...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2018.02.003

    authors: Puglisi S,Perotti P,Pia A,Reimondo G,Terzolo M

    更新日期:2018-06-01 00:00:00

  • Exercise in the treatment of obesity.

    abstract::Exercise is an important component of behavioral weight control interventions, and exercise may be most effective for weight control when combined with modifications to energy intake. Clinicians should initially encourage overweight and obese adults to adopt at least 150 minutes of moderate-intensity exercise per week...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(03)00075-6

    authors: Jakicic JM

    更新日期:2003-12-01 00:00:00

  • Radiotherapy for pituitary adenomas.

    abstract::This article describes the technical aspects and the clinical results of conventional radiotherapy and modern stereotactic radiotherapy for pituitary adenomas. Systematic review of the published literature provides a factual basis for the comparison and the selection of appropriate radiation technique in patients who ...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2007.10.005

    authors: Brada M,Jankowska P

    更新日期:2008-03-01 00:00:00

  • Post-transplantation osteoporosis.

    abstract::Osteoporosis is prevalent in transplant recipients and is related to pre- and post-transplantation factors. Low bone density and fractures may antedate transplantation, related to traditional risk factors for osteoporosis, effects of chronic illness, and end-stage organ failure and its therapy, on the skeleton. Bone l...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2007.07.008

    authors: Stein E,Ebeling P,Shane E

    更新日期:2007-12-01 00:00:00

  • Long-term health care outcomes in diabetes. Economic and political implications.

    abstract::With building pressure for cost-containment of medical expenditures, the medical community is finding it increasingly necessary to justify its procedures and systems of care. The analysis of health care outcomes has been extensively applied to diabetes care as a means of determining the process by which optimal outcom...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(05)70262-0

    authors: Ratner RE

    更新日期:1997-09-01 00:00:00

  • Regulation of peripheral metabolism by substrate partitioning in the brain.

    abstract::All organisms must adapt to changing nutrient availability, with nutrient surplus promoting glucose metabolism and nutrient deficit promoting alternative fuels (in mammals, mainly free fatty acids). A major function of glucose-sensing neurons in the hypothalamus is to regulate blood glucose. When these neurons sense g...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2012.11.007

    authors: Moreno C,Yang L,Dacks P,Isoda F,Poplawski M,Mobbs CV

    更新日期:2013-03-01 00:00:00

  • New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome.

    abstract::The 3243A>G mutation in mitochondrial DNA (mtDNA) is a genetic variant that is associated with a high risk of developing diabetes during life. Enhanced aging of pancreatic beta-cells, a reduced capacity of these cells to synthesize large amounts of insulin,and a resetting of the ATP/ADP-regulated K-channel seem to be ...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2006.02.014

    authors: Maassen JA,Jahangir Tafrechi RS,Janssen GM,Raap AK,Lemkes HH,'t Hart LM

    更新日期:2006-06-01 00:00:00

  • Lipid management in patients who have HIV and are receiving HIV therapy.

    abstract::Dyslipidemia now is recognized as a significant potential adverse event in HIV-infected patients who are receiving antiretroviral therapy. HIV-infected persons who have hyperlipidemia should be managed similarly to those without HIV infection in accordance with the National Cholesterol Education Program. Providers mus...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2008.11.009

    authors: Aberg JA

    更新日期:2009-03-01 00:00:00

  • Body composition and childhood obesity.

    abstract::Underwater weighing has been the gold standard for the measurement of body composition in humans; however, the two formulas widely used, the Siri and Bronze, were developed using young adult white males. The development of newer techniques in the past 20 years has greatly expanded the accuracy and ease of measuring bo...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(05)70359-5

    authors: Harsha DW,Bray GA

    更新日期:1996-12-01 00:00:00

  • Disorders of gonadal differentiation and congenital adrenal hyperplasia.

    abstract::Ambiguity of the external genitalia may be based on disordered steroid biosynthesis or may arise from fundamental genetic and chromosomal abnormalities that produce failure of gonadogenesis. This article first discusses congenital adrenal hyperplasia and then considers the diverse abnormalities that cause disordered g...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: New MI,Josso N

    更新日期:1988-06-01 00:00:00

  • The science and therapy of glucocorticoid-induced bone loss.

    abstract::Glucocorticoids are critical in the management of chronic, noninfectious, inflammatory diseases. Bone loss is a most devastating side effect of these powerful medications. Glucocorticoids produce bone loss by altering calcium metabolism, suppressing gonadal hormone production, and inhibiting bone formation. Now that t...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(05)70017-7

    authors: Lane NE,Lukert B

    更新日期:1998-06-01 00:00:00

  • The dyslipidemia of diabetes mellitus: giving triglycerides and high-density lipoprotein cholesterol a higher priority?

    abstract::CVD is the primary cause of morbidity and mortality in patients who have diabetes mellitus. Most such patients have at least one lipid abnormality. Managing these complex lipid disorders is a crucial component of comprehensive diabetes mellitus care and limits the risk for cardiovascular morbidity and mortality. With ...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2004.11.004

    authors: Kendall DM

    更新日期:2005-03-01 00:00:00

  • Hospital management of diabetes.

    abstract::The degree of hyperglycemia may be an important predictor of morbidity and mortality among patients with MI or stroke, and in those undergoing surgical procedures including coronary artery bypass. Hyperglycemia should be aggressively controlled from the time of hospital admission regardless of the patient's primary me...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(05)70162-6

    authors: Levetan CS,Magee MF

    更新日期:2000-12-01 00:00:00

  • Prolactin and neuroleptic drugs.

    abstract::Serum prolactin is reliably elevated by the antipsychotic drugs. Prolactin levels have been followed in psychotic patients during the use of these drugs as an indicator of underlying pathophysiology or as a reflection of drug activity. Considerable research is underway to elucidate further the potential clinical and r...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Green AI,Brown WA

    更新日期:1988-03-01 00:00:00

  • Glucocorticoid withdrawal schemes in chronic medical disorders. A systematic review.

    abstract::This systematic review highlights the uncertainty about the safety and efficacy of glucocorticoid withdrawal in many chronic diseases, elucidating the need for further research in this area. The problem of glucocorticoid withdrawal seems to be good example for wide variation in physicians' approaches to weaning patien...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(02)00008-7

    authors: Richter B,Neises G,Clar C

    更新日期:2002-09-01 00:00:00

  • Selective estrogen receptors modulators in the prevention and treatment of postmenopausal osteoporosis.

    abstract::Raloxifene, the first of the second-generation of SERMs to be widely available, represents a significant improvement over tamoxifen. It prevents postmenopausal bone loss and reduces the incidence of vertebral fractures and of new breast cancer cases in osteoporotic patients without stimulating the endometrium. The sug...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(02)00057-9

    authors: Fontana A,Delmas PD

    更新日期:2003-03-01 00:00:00

  • Surgical Approaches to the Management of Neuroendocrine Liver Metastases.

    abstract::Surgical approaches to hepatic metastases occupy an important role in the management of patients with neuroendocrine neoplasms and may have curative or palliative intentions. Resection of hepatic disease with curative intent is the only modality offering potential cure for patients with liver metastases; however, only...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2018.04.001

    authors: Frilling A,Clift AK

    更新日期:2018-09-01 00:00:00

  • Endocrine late effects of cancer treatment.

    abstract::Endocrinopathies are significant consequences of the treatment of childhood cancers. The risk of developing these adverse events is related to the underlying disease and its treatment with cytotoxic agents and radiation therapy. This article reviews hypothalamic-pituitary, thyroid, and gonadal dysfunction, as well as ...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2005.04.008

    authors: Cohen LE

    更新日期:2005-09-01 00:00:00

  • Utility of Continuous Glucose Monitoring in Type 1 and Type 2 Diabetes.

    abstract::A consensus conference of the American Association of Clinical Endocrinologists and American College of Endocrinology held in February 2016 advocated expanding the use of continuous glucose monitoring (CGM) in the management of diabetes. Based on the data described in this paper, CGM use is shown to improve glucose co...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2016.06.003

    authors: Toschi E,Wolpert H

    更新日期:2016-12-01 00:00:00

  • Neuroendocrine aspects of polycystic ovary syndrome.

    abstract::A series of investigations have emphasized the heterogeneous nature of the clinical condition known as PCOS and have delineated several factors that may contribute to the hyperandrogenemia and anovulation in this condition. Currently, it remains unclear whether intrinsic abnormalities of ovarian steroidogenesis, the e...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(05)70071-2

    authors: Marshall JC,Eagleson CA

    更新日期:1999-06-01 00:00:00

  • The vitamin D receptor: new paradigms for the regulation of gene expression by 1,25-dihydroxyvitamin D(3).

    abstract::The actions of the vitamin D hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) are mediated by the vitamin D receptor (VDR), a ligand-activated transcription factor that functions to control gene expression. After ligand activation, the VDR binds directly to specific sequences located near promoters and recruits a ...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2010.02.007

    authors: Pike JW,Meyer MB

    更新日期:2010-06-01 00:00:00

  • Genetics of Adrenocortical Development and Tumors.

    abstract::This article links the understanding of developmental physiology of the adrenal cortex to adrenocortical tumor formation. Many molecular mechanisms that lead to formation of adrenocortical tumors have been discovered via next-generation sequencing approaches. The most frequently mutated genes in adrenocortical tumors ...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2017.01.007

    authors: Lodish M

    更新日期:2017-06-01 00:00:00

  • Cystinuria and other noncalcareous calculi.

    abstract::Urinary stone disease is the only clinical presentation in patients with cystinuria. Two genes have been associated with type I (SLC3A1) and non-type I (SLC7A9) cystinuria and multiple mutations of these genes have been identified. The type I form is completely recessive while the non-type I form is incompletely reces...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(02)00054-3

    authors: Shekarriz B,Stoller ML

    更新日期:2002-12-01 00:00:00

  • Changing concepts in the diagnosis and management of thyroid nodules.

    abstract::Thyroid nodules are extremely common, affecting from 4% to 7% of the population. Fine-needle aspiration biopsy is the most accurate and cost-effective technique for nodule diagnosis. It is simple, safe, and should be the first test used in patient work-up. Routine thyroxine (T4) suppressive therapy is no longer recomm...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/s0889-8529(05)70282-6

    authors: Gharib H

    更新日期:1997-12-01 00:00:00

  • Insulin therapy in type 2 diabetes mellitus.

    abstract::Health care providers and patients have lots of choice to treat type 2 diabetes, but the blood glucose improvement is limited. The one therapy with unlimited potential (at least theoretically) is insulin. Many studies show that glucose control is achievable with insulin safely in most patients with type 2 diabetes. Ef...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecl.2012.03.004

    authors: Leahy JL

    更新日期:2012-03-01 00:00:00

  • Endocrine therapy for prostate cancer.

    abstract::Prostate cancer is the most frequent cancer in men. A discovery of major importance in the endocrinology of prostate cancer is that the testes contribute only 60% of total androgens in adult men; the remaining 40% are synthesized in peripheral tissues, including the normal and cancerous prostate, from inactive androge...

    journal_title:Endocrinology and metabolism clinics of North America

    pub_type: 杂志文章,评审

    doi:

    authors: Labrie F

    更新日期:1991-12-01 00:00:00