Abstract:
:Adrenocortical carcinoma (ACC) is a rare and aggressive tumor. ACC may be associated with different syndromes of hormone excess, most frequently Cushing's syndrome with or without hypersecretion of androgens. Recent data suggest that cortisol excess is a negative prognostic factor in advanced and localized ACC. Surgery with radical intent, when feasible, is the most effective treatment for ACC with hypercortisolism. Mitotane is the medical treatment of choice, both postoperatively and in inoperable or metastatic cases. Because of its slow onset of action, combination with other antisecretory agents (ie, metyrapone) is helpful to achieve more rapid and effective control of hypercortisolism.
journal_name
Endocrinol Metab Clin North Amjournal_title
Endocrinology and metabolism clinics of North Americaauthors
Puglisi S,Perotti P,Pia A,Reimondo G,Terzolo Mdoi
10.1016/j.ecl.2018.02.003subject
Has Abstractpub_date
2018-06-01 00:00:00pages
395-407issue
2eissn
0889-8529issn
1558-4410pii
S0889-8529(18)30011-2journal_volume
47pub_type
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