Abstract:
:The 3243A>G mutation in mitochondrial DNA (mtDNA) is a genetic variant that is associated with a high risk of developing diabetes during life. Enhanced aging of pancreatic beta-cells, a reduced capacity of these cells to synthesize large amounts of insulin,and a resetting of the ATP/ADP-regulated K-channel seem to be the pathogenic factors involved.
journal_name
Endocrinol Metab Clin North Amjournal_title
Endocrinology and metabolism clinics of North Americaauthors
Maassen JA,Jahangir Tafrechi RS,Janssen GM,Raap AK,Lemkes HH,'t Hart LMdoi
10.1016/j.ecl.2006.02.014subject
Has Abstractpub_date
2006-06-01 00:00:00pages
385-96, x-xiissue
2eissn
0889-8529issn
1558-4410pii
S0889-8529(06)00015-6journal_volume
35pub_type
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