New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome.

Abstract:

:The 3243A>G mutation in mitochondrial DNA (mtDNA) is a genetic variant that is associated with a high risk of developing diabetes during life. Enhanced aging of pancreatic beta-cells, a reduced capacity of these cells to synthesize large amounts of insulin,and a resetting of the ATP/ADP-regulated K-channel seem to be the pathogenic factors involved.

authors

Maassen JA,Jahangir Tafrechi RS,Janssen GM,Raap AK,Lemkes HH,'t Hart LM

doi

10.1016/j.ecl.2006.02.014

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

385-96, x-xi

issue

2

eissn

0889-8529

issn

1558-4410

pii

S0889-8529(06)00015-6

journal_volume

35

pub_type

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