Abstract:
OBJECTIVE:Hypoxemia, often assessed via pulse oximetry, is associated with neurocognitive deficits in children. The best way to qualify hypoxemia, or which level of hypoxemia already affects cognition, is unknown. METHODS:We assessed the association of pulse oximetry-derived variables that qualify hypoxemia with impaired academic performance in mathematics in a population-based cross-section of 995 primary school children who underwent overnight home recordings of motion-resistant new-generation pulse oximeter saturation (SpO2). Impaired academic performance in mathematics was based on the last school report and defined as grade 4 to 6 on a 6-point scale (ie, approximately the lowest quintile grades). RESULTS:Of 10 variables under study, only the nadir of the SpO2 values was significantly associated with impaired performance. Categories of this variable representing mild (ie, 91%-93% SpO2; odds ratio: 1.65; 95% confidence interval: 1.06-2.56) and moderate hypoxemia (ie, < or =90% SpO2 ; odds ratio: 2.28; 95% confidence interval: 1.30-4.01) both were associated with impaired performance in mathematics. CONCLUSIONS:We suggest using the nadir of the SpO2 values in an overnight study to qualify hypoxemia in future studies. This variable may predict neurocognitive deficits in school children. Mild hypoxemia, as yet widely considered benign, may already affect cognition in childhood. SpO2
journal_name
Pediatricsjournal_title
Pediatricsauthors
Urschitz MS,Wolff J,Sokollik C,Eggebrecht E,Urschitz-Duprat PM,Schlaud M,Poets CFdoi
10.1542/peds.2004-1256subject
Has Abstractpub_date
2005-02-01 00:00:00pages
e204-9issue
2eissn
0031-4005issn
1098-4275pii
peds.2004-1256journal_volume
115pub_type
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