Abstract:
BACKGROUND:Tapentadol (Nucynta) is indicated for the treatment of moderate to severe pain in adults. Tapentadol's mechanism of action consists of acting as an agonist on the μ-opioid receptor and by inhibiting the reuptake of norepinephrine. There are no published reports on the toxicity of tapentadol in pediatric patients. The goals of this study are to describe the incidence, medical outcomes, clinical effects, and treatment secondary to tapentadol exposure. METHODS:This retrospective observational study used data from the National Poison Data System. Inclusion criteria were exposure to tapentadol from November 1, 2008 to December 31, 2013; age 0 to 17 years; single ingestion; and followed to a known outcome. RESULTS:There were 104 patients who met the inclusion criteria. Eighty patients were aged ≤ 6, 2-year-olds the most common age group (60.6%). There were 52 male and 52 female patients. Of the 104 patients, 93 had unintentional exposures. No deaths were reported. Sixty-two of the patients had no effect, 34 had minor effects, 6 had moderate and 2 had major effects. Thirty patients reported drowsiness and lethargy. Other effects reported included nausea, vomiting, miosis, tachycardia, respiratory depression, dizziness/vertigo, coma, dyspnea, pallor, vomiting, edema, hives/welts, slurred speech, pruritus, and hallucinations/delusions. Fifty-three patients were reported to have no medical intervention. CONCLUSIONS:This is the first study examining the toxic effects of tapentadol in a pediatric population. Although a majority of the patients in this review developed no effect from their exposure, two had life-threatening events. The most common effects reported were opioidlike.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Borys D,Stanton M,Gummin D,Drott Tdoi
10.1542/peds.2014-2096subject
Has Abstractpub_date
2015-02-01 00:00:00pages
e392-6issue
2eissn
0031-4005issn
1098-4275pii
peds.2014-2096journal_volume
135pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Extracorporeal membrane oxygenation (ECMO) is a life-saving therapy for neonates with intractable respiratory failure, but the long-term pulmonary outcome is unknown. Our aim was to investigate the long-term pulmonary sequelae of these children. STUDY DESIGN:We studied 50 children at 11.1 +/- 1.1 years (mean...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2003-1080-L
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To evaluate a secondary liver iron overload and its fate in children who are treated conventionally for acute lymphoblastic leukemia and to assess whether serum soluble transferrin receptor (sTfR) is useful in detecting iron load. METHODS:Liver siderosis was estimated histologically from liver biopsy specime...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.111.1.91
更新日期:2003-01-01 00:00:00
abstract::We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone. The child responded to narcotic reversal. Pediatric physicians should be aware of this possible complication. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3243
更新日期:2010-07-01 00:00:00
abstract::Thirty-nine newborn infants with severe persistent pulmonary hypertension and respiratory failure who met criteria for 85% likelihood of dying were enrolled in a randomized trial in which extracorporeal membrane oxygenation (ECMO) therapy was compared with conventional medical therapy (CMT). In phase I, 4 of 10 babies...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:This report is an update of the US Preventive Services Task Force (USPSTF) 2006 recommendation on screening for speech and language delay in preschool-aged children. METHODS:The USPSTF reviewed the evidence on screening for speech and language delay and disorders in children aged 5 years or younger, includi...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2015-1711
更新日期:2015-08-01 00:00:00
abstract::Three Laotian refugee children with chronic pulmonary complaints and findings were found to have pulmonary paragonimiasis during a one-year period in Chicago. These patients ranged from 8 to 11 years of age and the diagnosis was delayed five to six months in two children because of the unfamiliarity of American physic...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVES:The goals were (1) to examine the influence of continuity of care on delivery of lead, anemia, and tuberculosis screening in a cohort of Medicaid-enrolled children, (2) to determine whether well-child care continuity had a greater effect than continuity for all ambulatory visits, and (3) to investigate which...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1497
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:Hepatitis B vaccine is recommended for all infants, and the series may be started during the delivery admission. For infants who are born either to women who are positive for hepatitis B surface antigen (HBsAg) or to women whose HBsAg status is unknown, vaccination should be started within 12 hours of birth t...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.111.6.e645
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of a cognitive-behavioral group intervention for children with chronic illnesses and to test the effect of an added parent component. METHODS:Children (n = 194) and their parents participated in a multicenter randomized clinical trial comparing a child-only intervention and a pare...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2012-2222
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:There has been a gradual decrease in the proportion of children covered by private health insurance in Colorado and the United States with a commensurate increase in those with public insurance or having no insurance which may impact access to care and outcomes. OBJECTIVE:The purpose of this work was to det...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0162
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:In this study we sought to evaluate the efficacy of motivational interviewing (MI) compared with structured brief advice (SBA) for adolescent smoking behavior change. METHODS:Participants (N=355) were randomly assigned to 5 sessions of either MI or SBA. The primary outcomes were attempts to reduce and to qui...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2010-2174
更新日期:2011-07-01 00:00:00
abstract::Inhaled corticosteroids have become an important therapeutic option in the treatment of childhood asthma. The preparations currently available for pediatric use (beclomethasone dipropionate and triamcinolone acetonide) do not, in general, cause significant hypothalamic-pituitary-adrenal axis suppression and physical s...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:In 2010, 9120 cases of pertussis were reported in California, more than any year since 1947. Although this resurgence has been widely attributed to waning immunity of the acellular vaccine, the role of vaccine refusal has not been explored in the published literature. Many factors likely contributed to the o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0878
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Maintaining adequate organ blood flow is the target of vasopressor treatment, but the impact of these measures on cerebral perfusion has not yet been evaluated systematically in a randomized, blinded, clinical trial. OBJECTIVES:To explore the effects on brain hemodynamics of 2 different inotropic agents use...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.2004-1396
更新日期:2005-06-01 00:00:00
abstract::: media-1vid110.1542/5799875103001PEDS-VA_2017-3616Video Abstract OBJECTIVES: Noncigarette tobacco products may confer a risk of marijuana use similar to combustible cigarettes. We examined whether adolescent electronic cigarette (e-cigarette), hookah, or combustible cigarette use is associated with initiating and cur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-3616
更新日期:2018-09-01 00:00:00
abstract::Three infants with infant botulism are presented to illustrate how atypical, early, and severe features may obscure or delay diagnosis. Two boys aged 6 weeks and 20 days, respectively, presented with rapid deterioration after brief periods of poor feeding, one with an apparent life-threatening event at home and the ot...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0297
更新日期:2005-09-01 00:00:00
abstract::The influence of sociodemographic factors on the incidence and duration of breast-feeding was evaluated in 668 black and 511 white women delivering their first child in the metropolitan Washington, DC, area. Breast-feeding rates were 84% among white and 49% among black women. Maternal educational level was strongly as...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::A review of hospital admissions of patients with status asthmaticus at the Childrens Hospital of Los Angeles showed a marked increase in admissions in recent years. Asthma mortality did not increase. Patients tended to be young, boys, and black as compared with patients admitted to a general hospital. Interviews with ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Diagnostic imaging procedures (DIPs) producing radiation exposure in children have been associated with increased cancer risk. To develop effective clinical practice interventions that reduce pediatric radiation exposure, a longitudinal assessment of DIP ordering practices in the current clinic...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1228
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Safety concerns for fluoroquinolones exist from animal studies demonstrating cartilage injury in weight-bearing joints, dependent on dose and duration of therapy. For children treated with levofloxacin or comparator in randomized, prospective, comparative studies for acute otitis media and community-acquired...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.2013-3636
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Value in Inpatient Pediatrics Network sponsored the Improving Care in Community Acquired Pneumonia collaborative with the goal of increasing evidence-based management of children hospitalized with community acquired pneumonia (CAP). Project aims included: increasing use of narrow-spectrum ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2016-1411
更新日期:2017-03-01 00:00:00
abstract::Herpes simplex virus 1 and 2 infections affect up to 50 million people in the United States, with a natural history of recurrent viral shedding with or without recurrence of symptoms. Although many patients remain asymptomatic or with mild symptoms, a spectrum of rare but significant nervous system complications have ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-2631
更新日期:2019-07-01 00:00:00
abstract::A considerable portion of pediatric deaths represent disease with risk of recurrence in subsequent family members. Procedures to obtain samples of body fluids and tissues suitable for diagnosis of mendelian and chromosomal disorders are described. These procedures, the "perimortem protocol," are used in studying child...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract::Kwashiorkor, with typical edema and skin rash is occasionally seen in affluent countries as a result of severe protein restriction. Treatment is with a lactose-free formula after rehydration and sometimes after a period of parenteral alimentation. Complications of therapy included: diarrhea, congestive heart failure, ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract:OBJECTIVE:Posterior fossa hemorrhages may be underdiagnosed in surviving neonates, with cerebellar hemorrhage discovered in 10% to 25% of autopsy specimens from very low birth weight infants. Posterior fossa lesions have been difficult to visualize by the traditional ultrasonography approach through the anterior fontan...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.6.e62
更新日期:1998-12-01 00:00:00
abstract::Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication of initiation of highly active antiretroviral therapy in HIV-infected patients. As the immune system recovers, an inappropriate inflammatory response often occurs that causes significant disease. It is most commonly seen in patients na...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-1246
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:The prevalence and identification of hypertriglyceridemia in youths will likely will increase in the future as a consequence of childhood obesity and increased screening for dyslipidemias. We sought to review our clinical experience with hypertriglyceridemia, evaluate factors associated with increased trigly...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-0367
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the relationship among the size of the lateral ventricles, head-circumference measure, and brain volumes. In addition, the association between ventricular dilatation and various brain lesions was defined. PATIENTS AND METHODS:A total of 257 preterm very low birth weight (...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-3264
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare the incidence of nephrotoxicity, defined as doubling of baseline serum creatinine concentration, in newborn infants with peak vancomycin serum concentrations =40 microg/mL at steady state to infants with peak vancomycin serum concentrations >40 microg/mL. A secondary...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.4.e48
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The pediatric inpatient discharge medication process is complicated, and caregivers have difficulty managing instructions. Authors of few studies evaluate systematic processes for ensuring quality in these care transitions. We aimed to improve caregiver medication management and understanding ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-2711
更新日期:2021-02-01 00:00:00