[Characteristics of erythropoiesis regulation in population living at high altitude].

Abstract:

AIM:To study characteristics of iron deficiency anemia (IDA) in native population of high altitude territories. MATERIAL AND METHODS:1300 women living in Tien-Shan areas were examined for serum and erythrocytic ferritins (SF and EF), general iron-binding capacity of the serum, transferrin saturation with iron, transferrin, soluble transferrin receptor (TR), erythropoietin (EP), Hb, erythrocytes, erythrocytic indices. RESULTS:Regulation of erythropoiesis in women living at high altitude is specific, i.e. disagreement between complete depletion of iron (by SF and EF) and normal level of Hb, erythrocytes, EP and TR. CONCLUSION:It is suggested that in population living at high altitudes (3000 m above the sea level and higher) long-term adaptation to hypoxia gave rise to an original mechanism of erythropoiesis regulation when all coming iron participates in hemoglobin synthesis without iron deposition. Under hypoxic hypoxia regulation of erythropoiesis is directed to prevention of tissue hypoxia.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Makeshova AB,Levina AA,Mamukova IuI,Raimzhanov AR

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

95-7

issue

11

eissn

0040-3660

issn

2309-5342

journal_volume

76

pub_type

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