abstract：AIM:To investigate the link between the hypoglycemia (registrated accurately by the professional Continuous Glucose Monitoring CGM; severe hypoglycemia at home) and the hetero-/homozygote carriage of single nucleotide polymorphisms (SNP) of cytochrome systems geneCYP2C9(rs1799853CYP2C9*2 иrs1057910CYP2C9*3) at the pati...

journal_title：Terapevticheskii arkhiv

authors： Chernikova NA,Kamynina LL,Ametov AS,Sychev DA,Grishina EA,Ryzhikova KA

更新日期：2020-11-24 00:00:00

abstract：AIM:The aim of our study was to assess the prevalence of contrast-induced acute kidney injury (CI-AKI) in patients with stable coronary artery disease (CAD) receiving optimal medical treatment with indications to coronary angiography and intraarterial administration of contrast agents. MATERIALS AND METHODS:1023 patie...

journal_title：Terapevticheskii arkhiv

authors： Mironova OI,Staroverov II,Sivakova OA,Fomin VV

更新日期：2020-10-14 00:00:00

abstract：:Among the many causes of the inflammatory process in the esophagus, infectious diseases are becoming increasingly important due to their steady growth. Previously esophageal infections have traditionally been associated with immunodeficiency syndromes, but now in clinical practice, these disorders are becoming increas...

journal_title：Terapevticheskii arkhiv

authors： Trukhmanov AS,Makushina AA,Storonova OA,Ivashkina NY

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:In 819% of patients with atrial fibrillation (AF) with anticoagulant therapy (ACT), hemorrhagic complications occur, including due to excess doses of AC. At the same time, ACT is necessary for patients with AF, since anticoagulants effectively reduces the risk of ischemic stroke. To make a decision on the ap...

journal_title：Terapevticheskii arkhiv

authors： Chernov AA,Kleymenova EB,Sychev DA,Yashina LP,Nigmatkulova MD,Otdelenov VA,Payushchik SA

更新日期：2020-09-03 00:00:00

abstract：:Therapy with tyrosine kinase inhibitors (TKI) allows to achieve a deep molecular response in 6070% of patients with chronic myeloid leukemia (CML). According to the current guidelines CML patients receive a long-term treatment with TKI in standard dose. The frequently observed adverse effects (AE) of TKI therapy are m...

journal_title：Terapevticheskii arkhiv

authors： Gurianova MA,Chelysheva EY,Shukhov OA,Turkina AG

更新日期：2020-09-01 00:00:00

abstract：:Treatment programs for patients with acquired aplastic anemia include two main therapeutic options: allogeneic bone marrow transplantation and combined immunosuppressive therapy (IST). However, combined IST remains the method of choice for most adult AA patients. This study included 120 AA patients who received IST at...

journal_title：Terapevticheskii arkhiv

authors： Mikhaylova EA,Fidarova ZT,Abramova AV,Luchkin AV,Troitskaya VV,Dvirnyk VN,Galtseva IV,Kliasova GA,Kovrigina AM,Kulikov SM,Chabaeva YА,Parovichnikova EN,Savchenko VG,Obukhova TN

更新日期：2020-09-01 00:00:00

abstract：:Osteoarthritis is a common pathology, which indicates the great medical and social significance of this disease. The article discusses the issues of pathogenesis, risk factors and diagnosis of professional and professionally caused osteoarthritis: the age of onset of the disease, the specifics of work, the localizatio...

journal_title：Terapevticheskii arkhiv

authors： Strizhakov LA,Guliaev SV,Babanov SA,Moiseev SV

更新日期：2020-07-09 00:00:00

abstract：AIM:Determine whether bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry can be used as predictor of increased risk of death in hemodialysis patients. MATERIALS AND METHODS:A prospective study was performed of 516 patients with chronic kidney disease treated with hemodialysis (men 265, women 251, ...

journal_title：Terapevticheskii arkhiv

authors： Mazurenko SO,Nakatis YA,Enkin AA,Staroselsky KG,Vasiliev AN,Mazurenko OG,Soin PV,Ermolaeva LG,Ivanov IG

更新日期：2020-07-09 00:00:00

abstract：:Takayasu arteritis (TA) is a systemic vasculitis with predominatly lesions of aorta and its large branches. In some cases pulmonary arteries (PA) are involved in the pathological inflammatory process and lead to the formation of pulmonary hypertension and significantly worse the prognosis. Timely development of lesion...

journal_title：Terapevticheskii arkhiv

authors： Маrtynuk TV,Aleevskaya AM,Gramovich VV,Danilov NM,Korobkova IZ,Matchin UG,Solodovnikova LV,Beketova TV

更新日期：2020-06-05 00:00:00

abstract：:Uncontrolled hypercoagulation and inflammation (thromboinflammation), which are both independent and closely related and amplifying each other pathological processes, form the basis for pathogenesis of a wide range of diseases and complications, including immuno-inflammatory (autoimmune) rheumatic diseases, with the d...

journal_title：Terapevticheskii arkhiv

authors： Nasonov EL,Reshetnyak TM,Alekberova ZS

更新日期：2020-06-05 00:00:00

abstract：:New methods and treatment plans for patients with chronic coronary artery disease after endovascular interventions are currently introduced into clinical practice. It allows reducing hospital stay down to 24 hour, with discharge the next morning. This approach is called overnight stay. Using a similar strategy increas...

journal_title：Terapevticheskii arkhiv

authors： Basinkevich AB,Matchin YG,Ageev FT

更新日期：2020-05-19 00:00:00

abstract：:Low patient compliance due to the development of adverse events in the form of antibiotic-associated diarrhea (AAD) is considered as the main reason for the failure of the eradication of optimized anti-Helicobacter therapy regimens. A key mechanism for the development of AAD is to reduce the number and species diversi...

journal_title：Terapevticheskii arkhiv

authors： Butorova LI,Ardatskaya MD,Osadchuk MA,Kadnikova NG,Lukianova EI,Plavnik RG,Sayutina EV,Topchiy TB,Tuayeva EM

更新日期：2020-05-19 00:00:00

abstract：:Cough variant asthma (CVA) was first described by W. Corrao. CVA was described as the isolated chronic cough as the only presenting symptom responsive to bronchodilator therapy.This phenotype of asthma is present with airway hyperresponsiveness, eosinophilic inflammation airways and bronchodilator responsive coughing ...

journal_title：Terapevticheskii arkhiv

authors： Uryasjev MO,Ponomareva IV,Bhar M,Glotov SI

更新日期：2020-04-27 00:00:00

abstract：AIM:To evaluate 24-hour dynamics of the arterial stiffness main indicators in patients with bronchial asthma of various severity and control. MATERIALS AND METHODS:The study included 119 patients with bronchial asthma, who formed main groups: the first group 48 patients with mild and moderate asthma, the second 71 pat...

journal_title：Terapevticheskii arkhiv

authors： Karoli NA,Zarmanbetova OT,Rebrov AP

更新日期：2020-04-27 00:00:00

abstract：AIM:To determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome. MATERIALS AND METHODS:312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27.2%) patients had no ...

journal_title：Terapevticheskii arkhiv

authors： Kozlova IV,Bykova AP,Osadchuk MA

更新日期：2020-04-27 00:00:00

abstract：AIM:The goal is to evaluate the effectiveness of pancreatic enzyme replacement therapy (PERT) using microencapsulated pancreatin preparations for the correction of nutritional status in patients with chronic pancreatitis (CP) and associated exocrine pancreatic insufficiency (EPI). MATERIALS AND METHODS:The study inclu...

journal_title：Terapevticheskii arkhiv

authors： Bideeva TV,Maev IV,Kucheryavyy YA,Andreev DN,Shah YS,Lobanova EG,Zaborovskiy AV,Levchenko AI

更新日期：2020-01-15 00:00:00

abstract：:In the review article are provided the approaches to the therapy for improvement of prognosis in patients with peripheral and multifocal atherosclerosis which are available now; some limitations and a real situation are designated for the antithrombotic therapy in this category of patients. According to the clinical t...

journal_title：Terapevticheskii arkhiv

authors： Barbarash OL,Kashtalap VV

更新日期：2019-12-15 00:00:00

abstract：:The purpose of study was to analyze own clinical experience and assess the effectiveness in treatment of severe very poorly controlled allergic asthma patients with omalizumab. The effectiveness of biologic treatment with omalizumab was analyzed in 10 patients with severe very poorly controlled allergic asthma. It has...

journal_title：Terapevticheskii arkhiv

authors： Skorokhodkina OV,Valeeva AR,Luntsov AV,Pozdnyak VA

更新日期：2019-12-15 00:00:00

abstract：AIM:to determine the perspectives for the use of drugs with combined antiviral, anti - inflammatory and immunomodulatory activity on the basis of medical studies of existing antiviral drugs for the treatment of influenza and acute respiratory viral infections in Russia. MATERIALS AND METHODS:A brief review of the anti...

journal_title：Terapevticheskii arkhiv

authors： Pshenichnaya NY,Bulgakova VA,Volchkova EV,Kareva EN,Selkova EP,Gorodin VN

更新日期：2019-11-15 00:00:00

abstract：AIM:The article presents data on the evaluation of the clinical efficacy of using a conjugated pneumococcal vaccine in patients with COPD in combination with 2-type diabetes during a 3-year follow - up period. MATERIALS AND METHODS:The study included 309 patients with an isolated course of COPD and in combination with...

journal_title：Terapevticheskii arkhiv

authors： Ignatova GL,Blinova EV,Antonov VN,Grebneva IV

更新日期：2019-11-15 00:00:00

abstract：:Thyroid cancer is the most common malignant tumor of the endocrine system. An increase in the incidence of thyroid cancer has been noted over the past decade, mainly due to papillary cancer. The influence of environmental factors, increased availability of medical care, including sensitive diagnostic tests, such as ul...

journal_title：Terapevticheskii arkhiv

authors： Rogova MO,Novosad SV,Martirosian NS,Trukhina LV,Petunina NA

更新日期：2019-10-15 00:00:00

abstract：PURPOSE OF THE STUDY:The study of the influenza and ARVI clinical performance, the development of patients with diabetes mellitus, evaluation of the effectiveness and safety application of antiviral therapy, carried out in the framework of routine clinical practice. MATERIALS AND METHODS:126 patients aged from 22 to 8...

journal_title：Terapevticheskii arkhiv

authors： Sitnikov IG,Fazylov VK,Silina EV

更新日期：2019-10-15 00:00:00

abstract：AIM:We aimed to assess autoantibodies to M2-cholinoceptors (M2-CR) in patients with paroxysmal lone atrial fibrillation (AF) and in patients with AF and arterial hypertension (AH). MATERIALS AND METHODS:100 patients with lone AF and 84 patients with AF and AH were included. Patients underwent clinical blood and urinal...

journal_title：Terapevticheskii arkhiv

authors： Mironova ES,Mironova NA,Sharf TV,Efremov EE,Azmuko AA,Molokoedov AS,Zykov KA,Golitsyn SP

更新日期：2019-09-15 00:00:00

abstract：:The aim of study was to evaluate the morphological and immunohystochemical characteristics of aspirated thrombi in patients with ST-elevation myocardial infarction undergoing precutaneous coronary intervention to find the possible platelet activation and inflammatory cell involvement in coronary thrombi. MATERIALS AN...

journal_title：Terapevticheskii arkhiv

authors： Sisakian HS,Mkhitaryan AG,Sahakyan VG,Kocharyan AS,Asatryan BA

更新日期：2019-09-15 00:00:00

abstract：:Deciphering immunopathogenesis, expanding the scope of diagnostics and developing new methods for treating human autoimmune diseases are among the priority areas of XXI century medicine. Particularly widely autoimmune pathology is presented in immunoinflammatory rheumatic diseases (IIRD), such as rheumatoid arthritis,...

journal_title：Terapevticheskii arkhiv

authors： Nasonov EL

更新日期：2019-08-15 00:00:00

abstract：AIM:To evaluate the clinical and economic feasibility of pharmacogenetic testing (PGT) for dabigataran etexilate administration in the treatment of atrial fibrillation (AF) without valve in comparison with tactics without pharmacogenetic testing. MATERIALS AND METHODS:The pharmacoeconomic model was done using generali...

journal_title：Terapevticheskii arkhiv

authors： Abdullaev SP,Mirzaev KB,Sychev DA

更新日期：2019-08-15 00:00:00

abstract：AIM:To study the epidemiology of multiple myeloma in the city of Moscow and compare the results obtained with data from similar studies in other countries. MATERIALS AND METHODS:The study is based on information from a database of case histories of 3942 patients suffering from symptomatic MM, residents of the city of ...

journal_title：Terapevticheskii arkhiv

authors： Vinogradova OY,Ptushkin VV,Chernikov MV,Kochkareva YB,Zherebtsova VA

更新日期：2019-07-15 00:00:00

abstract：:The paper describes the results of 15 consecutive Russian clinical trials in the treatment of different types of acute leukemias, conducted by Russian cooperative group within the last 27-years and included more than 25 hundred patients. It was shown that the 5-years overall survival in AML younger than 60 years patie...

journal_title：Terapevticheskii arkhiv

authors： Parovichnikova EN,Savchenko VG

更新日期：2019-07-15 00:00:00

abstract：AIM:To study the safety and clinical efficacy of an outpatient coronary angiography in various groups of patients according to a 6-year experience of the laboratory of endovascular diagnostic and treatment methods in the outpatient setting of the NMRC of Cardiology. MATERIALS AND METHODS:2166 patients which underwent ...

journal_title：Terapevticheskii arkhiv

authors： Danilushkin YV,Matchin YG,Shamrina NS,Bubnov DS,Atanesyan RV,Mitroshkin MG,Basinkevich AB,Ageev FT

更新日期：2019-05-16 00:00:00

abstract：:In the article, we report the causes of pulmonary hemorrhage (PH) according to the literature data and own experience, with an emphasis on patients suffering from rheumatic diseases. Methods of diagnosis and modern approaches to the treatment of PH are analyzed. :В представленной статье на основе данных литературы и ...

journal_title：Terapevticheskii arkhiv

authors： Kraeva VV,Beketova TV

更新日期：2019-05-15 00:00:00

abstract：:Success in a treatment of rheumatoid arthritis (RA), associated with a development of new medications and improving treatment strategies, allows to achieve remission in many patients. Despite this a lot of theoretical and clinical issues remain, including a definition of the term "remission", its characteristics and t...

journal_title：Terapevticheskii arkhiv

authors： Nasonov EL,Lila AM

更新日期：2019-05-15 00:00:00

abstract：:Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Liver is frequently involved in the pathological process. Wide range of clinical manifestations can be seen: from asymptomatic lesion with normal liver function tests to cirrhosis with portal hypertension. Biopsy plays the key role in diagnosis of...

journal_title：Terapevticheskii arkhiv

authors： Fomin VV,Brovko MY,Kalashnikov MV,Sholomova VI,Rozina TP,Akulkina LA,Pershina AE,Yanakayeva AS,Nekrasova TP

更新日期：2019-05-15 00:00:00

abstract：:В.И. Покровский - создатель ведущей отечественной школы по изучению инфекционных болезней и проблем эпидемиологии. Редколлегия журнала «Терапевтический архив» сердечно поздравляет юбиляра и желает ему крепкого здоровья, семейного благополучия, долгих лет жизни на благо пациентов и учеников. ...

journal_title：Terapevticheskii arkhiv

authors： - -

更新日期：2019-04-15 00:00:00

abstract：AIM:The aim of the study is to study the state of the immunological and hormonal background in patients with non-hospital pneumonia (NP) - liquidators of the accident at the Chernobyl nuclear power plant (ChNPP) after treatment. MATERIALS AND METHODS:Patients with NP were divided into 2 groups of liquidators of the Ch...

journal_title：Terapevticheskii arkhiv

authors： Selihova LG,Borzykh OA,Lavrenko AV,Digtiar NI,Gerasymenko ND

更新日期：2019-03-30 00:00:00

abstract：:Major advances in pharmacology of the 21st century include the development of a new class of drugs, which are low-molecular, chemically synthesized molecules (the so-called "small molecules"), the point of application of which is Janus kinase (Janus kinase, JAK) involved in intracellular cytokine signaling. The review...

journal_title：Terapevticheskii arkhiv

authors： Nasonov EL,Abdulganieva DI,Fairushina IF

更新日期：2019-03-18 00:00:00

abstract：AIM:To assess the efficacy and safety of long-term treatment with nucleos(t)ide analogues in patients with chronic hepatitis B. MATERIALS AND METHODS:We conducted an observational study in 101 chronic hepatitis B (HBeAg-negative and HBeAg-positive) patients treated (≥3 years) with entecavir, tenofovir or telbivudine. ...

journal_title：Terapevticheskii arkhiv

authors： Ibragimov EK,Abdurakhmanov DT,Rozina TP,Nikulkina EN,Tanaschuk EL,Odintsov AV,Panevkina SV,Moiseev SV

更新日期：2019-03-18 00:00:00

abstract：:In conditions of climate warming with an increase in heat waves associated with an increase in cardiovascular morbidity and mortality, the particular interest is the effect of cardiovascular drugs on adaptation to high temperatures. The review reflects the results of European and domestic studies on the safety of ther...

journal_title：Terapevticheskii arkhiv

authors： Smirnova MD,Svirida ON,Ageev FT

更新日期：2019-03-11 00:00:00

abstract：AIM:the study of comorbid status and characteristics of clinical course of ischemic heart disease (IHD) in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS:We conducted a retrospective analysis of case histories of 958 IHD patients aged 32 to 93 years (mean age of 60.8±10.2 years), inc...

journal_title：Terapevticheskii arkhiv

authors： Grigoryeva NY,Maiorova МV,Korolyova ME,Samolyuk MO

更新日期：2019-03-10 00:00:00

abstract：:A rare observation of systemic AL-amyloidosis with a debut in old age, accompanied by diffuse alveolar-septal lesion of the lungs and mediastinal lymphadenopathy in combination with amyloid cardiomyopathy in the absence of pathology of kidney and liver function. ...

journal_title：Terapevticheskii arkhiv

authors： Tret'yakov AY,Zakharchenko SP,Tret'yakova VA,Ermilov OV,Shekhovtsov SA,Khabibulin RR,Aleinikova KS,Dan VS,Leshcheva NA

更新日期：2018-12-30 00:00:00

abstract：AIM:To study the effectiveness of a fixed combination of perindopril and amlodipine, with the subsequent addition of indapamide-retard in male patients with arterial hypertension (AH), obesity and severe sleep apnea (OSAS). MATERIALS AND METHODS:The study included 43 male patients in whom antihypertensive therapy titr...

journal_title：Terapevticheskii arkhiv

authors： Elfimova EM,Litvin AY,Chazova IE

更新日期：2018-12-30 00:00:00