[Trends in heart rate variability in patients with ischemic heart disease and depression treated with antidepressant tianeptine].

Abstract:

AIM:To study heart rate variability (HRV) according to 24-h Holter monitoring of ECG in patients with ischemic heart disease (IHD) and to examine effects of tianeptine on HRV. MATERIAL AND METHODS:Twenty eight patients with IHD (17 males and 11 females aged 40-70 years) with a verified IHD diagnosis and atherosclerosis of the coronary arteries participated in the trial. Severity of depressive syndrome was assessed by CES-D questionnaire. HR V was assessed by weighted mean variation of the rhythmogram (WMVR) for 24 hours. RESULTS:Initial WMVR (m +/- sigma) in the study group (IHD with depression, n = 15) was 670 +/- 260 ms, in the control group (IHD without depression, n = 13) - 625 +/- 191 ms (the difference was insignificant (p = 0.72). Initial (m +/- sigma) WMVR in men of the study group (n = 6) before therapy was 460 +/- 139 ms that was less than in the control group (633 +/- 183 ms, n = 11). CONCLUSION:In men HRV depends on duration of the disease. There was a negative correlation between WMVR difference before and after treatment with tianeptine and difference of relevant depression indices with high correlation coefficient (-0.74, p = 0.03).

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Soboleva GN,Erpylova EA,Riabykina GV,Sobolev AV,Kozhemiakina ESh,Fedorova VI,Gorel'tseva SIu,Karpov IuA

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

56-60

issue

3

eissn

0040-3660

issn

2309-5342

journal_volume

78

pub_type

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