Abstract:
AIM:To compare the impact of cardiac resynchronization therapy (CRT) on survival in patients with ischemic and non-ischemic cardiomyopathy (CMP) in clinical practice. SUBJECTS AND METHODS:The study enrolled 206 patients with NYHA Functional Class II-IV chronic heart failure (CHF) and a left ventricular ejection fraction of < or = 35, including 107 patients implanted with CRT devices in combination with continuous drug therapy (DT). Among the 107 patients, 48 were diagnosed as having non-ischemic CMP (NCMP), 59 as coronary heart disease (CHD). The other 99 patients (12 with NCMP and 87 with CHD) were on DT only. Later on the patients from both groups were divided into subgroups according to the treatment policy of CHF: CRT + DT or DT only. The mean follow-up period was 24 +/- 18.1 months. RESULTS:The Kaplan-Meier survival analysis revealed that overall survival in the patients on CRT + DT was significantly higher than in those on DT (70 and 49%, respectively; p = 0.004). Analysis of the chosen treatment policy in the NCMP subgroup showed no significant differences in survival rates in the patients receiving CRT + DT or DT (74 versus 78%, respectively; p = 0.5). At the same time, the survival rates in the CHD patients on CRT + DT were significantly higher than those in the DT subgroup (68 versus 44%; p = 0.04). CONCLUSION:CRT significantly reduces overall mortality in patients with CHF in clinical practice. Our findings indicated that this effect was achieved mainly in patients with CHD, rather than in those with NCMP.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Kuznetzov VA,Vinogradova TO,Enina TN,Kolunin GV,Kharatz VE,Pavlov AV,Krinochkin DV,Belonogov DV,Gorbatenko EA,Efimova IuAsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
52-6issue
8eissn
0040-3660issn
2309-5342journal_volume
84pub_type
杂志文章abstract::The present work summarises the experience gained with the use of extracorporeal hemoperfusion in 45 patients suffering from rheumatic diseases. During hemoperfusion, there was a decrease in the initially activated LDH, CPK, AST, ALT and AP. The reduction of the content of phospholipids and cholesterol in plasma and r...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The atrial complex of ECG transbronchial leads (TB ECG) was in all cases recorded as two waves in line with right and left atrial contractions. Changes in atrial electrical activity reflect alterations in the lesser circulation. A new criterium of TB ECG atrial complex quantitation is suggested devised upon comparison...
journal_title:Terapevticheskii arkhiv
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abstract:AIM:To detect endogenic intoxication syndrome (EIS) and to assess its severity depending on clinical manifestations of rheumatoid arthritis (RA) using laboratory tests. MATERIAL AND METHODS:Laboratory tests including analysis of synovial fluid, blood count with estimation of leucocytic intoxication index, urinalysis, ...
journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
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journal_title:Terapevticheskii arkhiv
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更新日期:1999-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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doi:
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
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doi:
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
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更新日期:1989-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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doi:
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