[Brucellosis in the Stavropol Territory: Results of 15-year follow-up of epidemiological and clinical features].

Abstract:

AIM:To analyze the epidemiological situation of brucellosis in the Stavropol Territory and to determine the specific features of its acute form. MATERIALS AND METHODS:The epidemiological situation of brucellosis in the Stavropol Region was retrospectively analyzed using the 2000-2014 official statistics of the Russian Federation and Stavropol Territory for brucellosis cases, individual documents of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare Directorate in the Stavropol Territory and Russian Federation, and medical records of the Brucellosis Department, Stavropol Hospital Two. RESULTS:Brucellosis is a social problem in a group of focal zoonotic infections in the Russian Federation. In the North Caucasian Federal District, the largest number of new human brucellosis cases was notified in the Republic of Dagestan (59.3%) and Stavropol Territory (27.4%). The incidence of brucellosis in the Stavropol Territory was 5-10-fold higher than that in the Russian Federation as a whole. The true prevalence of brucellosis was 25% greater than the statistical data in terms of its clinical forms that were not included in official registration. Infection occurred in humans by contact with large and small cattle in 49.7% of cases. The disease mainly affected men (78.3%) and able-bodied people (67.7%); 78.5% of the patients seeking medical advice and as high as 79.9% of those being covered by serological examination of groups at risk for brucellosis were detected. There was a declining trend for the number of occupational brucellosis cases. At the same time, brucellosis accounted for 75% of the territory's total number of occupational diseases. In the past decade, brucellosis has exhibited a relatively benign course (91.3% for its moderate form), by predominantly involving the osteoarticular system (63%). Non-compliance with outpatient antibacterial therapy is one of the factors for brucellosis chronization. 28.2% of the patients who had undergone a complete therapy cycle developed chronic brucellosis less frequently (p < 0.005) than those who had stopped treatment for different reasons. CONCLUSION:Registration of brucellosis among humans is a result of the unfavorable epizootic situation of animal brucellosis. The highest incidence of brucellosis is observed in the northeastern areas of the Stavropol Territory, which border the Republic of Dagestan. The true prevalence of brucellosis greatly exceeds the official statistical data. Active detection of infection and timely diagnosis will be able to determine the real epidemic situation of brucellosis. Continuity of management and follow-up will provide a reduction in medical and social losses associated with this infection. :Цель исследования. Анализ эпидемиологической ситуации по бруцеллезу в Ставропольском крае и определение особенностей острой формы заболевания. Материалы и методы. Проведен ретроспективный анализ эпидемиологической ситуации по бруцеллезу в Ставропольском крае на основании статистических данных официальной регистрации заболеваемости бруцеллезом в Российской Федерации и Ставропольском крае за 2000-2014 гг.; отдельных документов Управления Роспотребнадзора по Российской Федерации и Ставропольскому краю, медицинской документации бруцеллезного отделения городской больницы Ставрополя. Результаты. Бруцеллез - социально значимая проблема в группе очаговых зоонозных инфекций на территории Российской Федерации. Наибольшее число случаев впервые выявленного бруцеллеза у человека на территории Северо-кавказского федерального округа регистрируется в Республике Дагестан (59,3%) и Ставропольском крае (27,4%). Заболеваемость бруцеллезом в Ставропольском крае превышает общероссийскую в 5-10 раз. Истинная распространенность бруцеллеза превышает данные статистки на 25% с учетом клинических форм, не включенных в официальную регистрацию. В 49,7% случаев человек инфицировался при контакте с крупным и мелким рогатым скотом. Преимущественно болеют мужчины (78,3%), лица трудоспособного возраста (67,7%); 78,5% больных выявлены при обращении за медицинской помощью при охвате серологическим обследованием групп риска инфицирования бруцеллезом до 79,9%. Отмечается тенденция к уменьшению числа больных с профессиональным бруцеллезом. При этом бруцеллез составляет 75% от общей профессиональной патологии края. За последние 10 лет бруцеллез характеризуется относительно доброкачественным течением (91,3% средней степени тяжести) с преимущественным поражением костно-суставной системы (63%). Одним из факторов хронизации бруцеллеза является не соблюдение режима антибактериальной терапии на амбулаторном этапе. У 28,2% больных, завершивших полный курс лечения, хронический бруцеллез формировался реже (p<0,005), чем в группе больных, которые перестали лечиться по различным причинам. Заключение. Регистрация бруцеллеза среди людей является следствием неблагополучной эпизоотической ситуации по бруцеллезу животных. Наиболее высокая заболеваемость бруцеллезом наблюдается в северо-восточных районах Ставропольского края, граничащих с Республикой Дагестан. Истинная распространенность бруцеллеза значительно превышает официальные статистические данные. Активное выявление инфекции, своевременная диагностика позволят определить истинную эпидемическую ситуацию по бруцеллезу. Преемственность ведения и диспансеризация обеспечат снижение медицинских и социальных потерь, связанных с этой инфекцией.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Sannikova IV,Makhinya OV,Maleev VV,Deineka DA,Golub OG,Kovalchuk IV,Lyamkin GI

doi

10.17116/terarkh2015871111-17

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

11-17

issue

11

eissn

0040-3660

issn

2309-5342

journal_volume

87

pub_type

杂志文章
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  • [Role of the hereditary factor in the genesis of chronic bronchitis].

    abstract::Comparison of proband concordance of the phenotypic correlation coefficients according to the proneness to disease derived on analysis of the groups of mono- and dizygote twins born in 1930-1959 in the city of Yerevan presenting with chronic non-obstructive and chronic obstructive bronchitis revealed a substantial rol...

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    doi:

    authors: Amatuni VG,Pirumian MS

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  • [Changes in the function of external respiration and circulation in patients with acute pneumonia at the outpatient clinic stage of rehabilitation].

    abstract::External respiration, circulation and gas exchange trends were investigated in acute pneumonia convalescents followed up on an outpatient basis. It was found that 72% of patients admitted to hospital for acute pneumonia, upon discharge demonstrated residual clinicoroentgenological effects. Cardiorespiratory distress, ...

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    doi:

    authors: Shnipas PA,Chigate II

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  • [Gestational arterial hypertension: clinico-epidemiological study].

    abstract:AIM:Epidemiological assessment of prevalence of blood hypertension (BH) in pregnant women. MATERIALS AND METHODS:Blood pressure and urinary protein were measured in 5160 gravidae observed in female consultations in 4 cities of Russia. RESULTS:BH was found in 1042(20.2%) examinees. Chronic BH was diagnosed in 306 pati...

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    doi:

    authors: Vikhliaeva EM,Supriaga OM

    更新日期:1998-01-01 00:00:00

  • Various approaches for peforming an outpatient coronary angiography.

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  • [Pharmacoepidemiological study of the course of influenza and other acute respiratory viral infections in risk groups].

    abstract:AIM:To identify risk factors (RFs) for the development of bacterial complications and the prolonged course of influenza and other acute respiratory viral infections (ARVIs) among inpatients treated in Russian healthcare facilities in the post-pandemic period; to determine the clinical presentation of the disease (flu-l...

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  • Exudative-constrictive tuberculous pericarditis in combination with arthritis in cardiologist practice: thoracoscopic biopsy as a diagnosis and treatment method.

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  • Minimal hepatic encephalopathy: current clinical and pathogenetic aspects.

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    pub_type: 杂志文章,评审

    doi:10.26442/terarkh201890289-93

    authors: Damulin IV

    更新日期:2018-02-15 00:00:00

  • [The degree of coronary artery calcinosis as a prognostic factor of asymptomatic cardiovascular complications: results of meta-analysis].

    abstract:AIM:To investigate prognostic implications of the calcium index estimated tomographycally for identification of patients at high risk to develop cardiovascular complications (non-fatal myocardial infarction, lethal coronary hear disease, coronary revascularization) in the absence of clinical manifestations. MATERIAL A...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,meta分析

    doi:

    authors: Sinitsyn VE,Voronov DA,Morozov SP

    更新日期:2006-01-01 00:00:00

  • Clinical observation of a combination of diffuse alveolar-septal pulmonary lesion and amyloid cardiomyopathy in systemic AL-amyloidosis in the elderly.

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    journal_title:Terapevticheskii arkhiv

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  • [An outpatient study by stress echocardiography with dobutamine of myocardial function in patients with congestive heart failure (the first trial in Russia of the use of the dobutamine-echocardiography test)].

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    pub_type: 临床试验,杂志文章

    doi:

    authors: Volkov GV,Bashchinskiĭ SE,Osipov MA

    更新日期:1993-01-01 00:00:00

  • [Autonomic and emotional disorders in chronic obstructive bronchitis].

    abstract::The clinical picture of chronic obstructive bronchitis (COB) coupled with lung emphysema and diffuse pulmonary fibrosis studied in 198 patients was characterized by the autonomous and emotional syndrome which depended largely on the presence and degree of arterial hypoxemia, abnormality of lung ventilation, the degree...

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    doi:

    authors: Kulakov IuA

    更新日期:1985-01-01 00:00:00

  • [The use of a pulsed magnetic field in the treatment of lupus erythematosus].

    abstract::The authors review literature data on application of impulsed magnetic field (IMF) in clinical practice. IMF introduction in LE treatment is thought beneficial because IMF antiinflammatory, analgetic effects, positive action on microcirculation, immunological reactivity, the ability to upgrade the effect of combined t...

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    pub_type: 杂志文章

    doi:

    authors: Khamaganova IV,Berlin IuV,Volkov VE,Voĭnich ZV,Arutiunova ES

    更新日期:1995-01-01 00:00:00

  • [Experience with using high doses of cerebrolysin in vascular dementia].

    abstract::The efficacy and tolerability of high-dose neurotrophic drug cerebrolysin was studied in 20 patients with vascular dementia diagnosed by criteria NINDS-AIREN and DSM-IV. The drug was well tolerated, affected positively cognitive function, especially neurodynamic processes. EEG featured after treatment intensification ...

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    doi:

    authors: Iakhno NN,Damulin IV,Zakharov VV,Levin OS,Elkin MN

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  • [Science and clinical practice].

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    pub_type: 社论

    doi:

    authors: Chazov EI

    更新日期:2012-01-01 00:00:00

  • [Immunologic mechanisms of the development of nonspecific aortoarteritis].

    abstract::It has been shown that patients with nonspecific aortoarteritis undergoing acute and subacute stages of the process demonstrate sensitization to collagen, types I and III. The activity of inflammation was discovered to affect the disease progression and involvement of new arterial areas. Marked suppression of leukocyt...

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    doi:

    authors: Zotikov AE,Suslov AP,Minkina AE,Idel'son GL,Domogatskiĭ SP,Golovin VP

    更新日期:1990-01-01 00:00:00

  • [Pharmacotherapy for irritable bowel syndrome in the context of evidence-based medicine].

    abstract::The paper analyzes an evidence base for the pharmacotherapy of irritable bowel syndrome (IBS) A large number of randomized placebo-controlled trials (RPCTs) systematized in a number of meta-analyses suggest that monotherapy regimens with spasmolytics, antidepressants, dietary fibers, polyethylene glycol, rifaximin, pr...

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    doi:10.17116/terarkh20158724-10

    authors: Maev IV,Cheremushkin SV,Kucheryavyi YA,Cheremushkina NV

    更新日期:2015-01-01 00:00:00

  • [The prognostic criteria in the primary myelodysplastic syndrome].

    abstract::Basing on computer processing of 126 primary clinical and laboratory parameters obtained from 92 patients with myelodysplasia and using multifactorial regression analysis, the authors have developed prognostic models of life span and probability of transformation into acute leukemia. The model of life span enabled rec...

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    doi:

    authors: Tsvetaeva NV,Zavadenko MA,Popov VIu,Glasko EN,Gorodnicheva VF,Levina AA,Pochtar' ME,Vinogradova OIu,Alisova AM,Frank GA,Khoroshko ND

    更新日期:1996-01-01 00:00:00

  • [Physiological methods of treatment of patients with polycythemia vera].

    abstract::Based on an analysis of the data pertaining to changes in the level of erythropoietin, chalones and stress hormones in the blood of patients with polycythemia vera after bloodletings and cytapheresis it is concluded that chalones participate in the development of a remission owing to the inhibition of the clone of mut...

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    doi:

    authors: Neustroev GV

    更新日期:1985-01-01 00:00:00

  • [Na-Li countertransport and the diagnosis of hypertension and combined hypertension and renal artery stenosis].

    abstract::The rate of Na-Li countertransport was studied in inpatients with essential hypertension (n = 59), chronic diffuse glomerulonephritis (n = 30), chronic pyelonephritis (n = 26), renovascular hypertension (n = 15) and in those with associated renovascular hypertension and essential hypertension (n = 4). Multiple regress...

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    doi:

    authors: Petrov VV,Arabidze GG,Levitskiĭ DO,Eliseev AO,Grishenkov EA,Kaĭkov MI,Khalilov IE

    更新日期:1990-01-01 00:00:00

  • [The clinical manifestations and differential diagnosis of Yersinia hepatitis and viral hepatitis A and B].

    abstract::Hepatic involvement in yersiniosis is associated with clinical symptoms of hepatitis, sometimes dominant in the clinical picture. Such cases need differentiation of yersiniosis with viral hepatitides A and B. Clinical and biochemical findings were compared for matched patients with yersiniosis-induced hepatic lesions,...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Shakhgil'dian DI,Iushchuk ND,Karetkina GN,Braginskiĭ DM,Doroshenko NV,Sergeeva NA

    更新日期:1993-01-01 00:00:00

  • [Rheumatoid arthritis: achievements and unresolved issues].

    abstract::Success in a treatment of rheumatoid arthritis (RA), associated with a development of new medications and improving treatment strategies, allows to achieve remission in many patients. Despite this a lot of theoretical and clinical issues remain, including a definition of the term "remission", its characteristics and t...

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    pub_type: 杂志文章

    doi:10.26442/00403660.2019.05.000259

    authors: Nasonov EL,Lila AM

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  • [The effect of micronized phenofibrate on the lipoproteins of the blood plasma at different initial lipid levels].

    abstract::Novel antihyperlipidemic micronized phenofibrate lipantil 200 M was tested for safety and efficacy (one 200 mg capsule a day for 3 months) in 27 patients having cholesterol level above 6.5 mmol/l. The effect emerged upon 1 month of administration and persisted till the end of the treatment. In combined hyperlipidemia ...

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    pub_type: 临床试验,杂志文章

    doi:

    authors: Perova NV,Ozerova IN,Kalinina AM,Pavlova LI,Olfer'ev AM,Mel'kina OE,Golubev MA,Oganov RG

    更新日期:1996-01-01 00:00:00

  • [Enzyme clearance in intermittent hemofiltration in patients with acute renal failure].

    abstract:AIM:To characterize elimination of some enzymes in intermittent hemofiltration (HF) in patients with acute renal failure (ARF). MATERIAL AND METHODS:22 patients with oliguric ARF have undergone 52 procedures of intermittent HF. Before the procedure and after it the activity of enzymes (AA, AP, ACE, LAP, GGT, GDG, AlAT...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Timokhov VS,Kazakov IV,Selezneva SN,Komissarova IV,Smirnova LM

    更新日期:2000-01-01 00:00:00

  • [Contrast-induced acute kidney injury in patients with stable coronary artery disease: the most important risk factors and prevalence].

    abstract:AIM:The aim of our study was to assess the prevalence of contrast-induced acute kidney injury (CI-AKI) in patients with stable coronary artery disease (CAD) receiving optimal medical treatment with indications to coronary angiography and intraarterial administration of contrast agents. MATERIALS AND METHODS:1023 patie...

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    pub_type: 杂志文章

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  • [Russian multicenter clinical trials in acute leukemias].

    abstract::The paper describes the results of 15 consecutive Russian clinical trials in the treatment of different types of acute leukemias, conducted by Russian cooperative group within the last 27-years and included more than 25 hundred patients. It was shown that the 5-years overall survival in AML younger than 60 years patie...

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    更新日期:2019-07-15 00:00:00

  • [Clinical course, internal picture of the disease and pathogenic reactions in patients with bronchial asthma].

    abstract:AIM:To study clinical features of bronchial asthma (BA) associated with internal picture and nosogenic reactions. MATERIAL AND METHODS:Clinical features of BA were studied in 108 patients (38 males and 70 females, mean age 44.7 +/- 1.4 years, mean BA duration 6.6 +/- 0.76 years) treated in the clinic of the I. M. Sech...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Ovcharenko SI,Smulevich AB,Drobizhev MIu,Ishchenko EN,Bevz IA

    更新日期:2001-01-01 00:00:00

  • [Biliary tract in patients with chronic viral hepatitides].

    abstract:AIM:To characterize motor-kinetic and inflammatory changes in extrahepatic biliary tracts and gallbladder in patients with chronic viral hepatitis (CVH). To ascertain whether there is a pathogenetic correlation between affection of the biliary system and viral infection. MATERIAL AND METHODS:The condition of the bilia...

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    pub_type: 杂志文章

    doi:

    authors: Pal'tsev AI,Osipenko MF,Voloshina NB

    更新日期:2005-01-01 00:00:00

  • [Aortic coarctation and the bicuspid aortic valve].

    abstract::After the analysis of the long-term outcomes of aortic coarctation isolated resection the authors noted that many of the patients had valvular defects missed for diagnosis before the operation. ECG and X-ray of the heart established valvular defects in 37% of the operated patients. 61% of them had bicuspid valve assoc...

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    pub_type: 杂志文章

    doi:

    authors: Poliakova ND,Spiridonov AA

    更新日期:1996-01-01 00:00:00

  • [Economic assessment of efficacy of vasaprostan treatment of critical lower limbs ischemia].

    abstract:AIM:To estimate cost-effect efficacy of vasaprostan treatment of inpatients with arterial chronic obliteration (ACO) with critical ischemia of the lower limbs (Fonten stage III-IV). MATERIAL AND METHODS:Case histories of 105 ACO patients with critical ischemia of the lower limbs (mean age 65 +/- 11.8 years) were analy...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Vorob'ev PA,Dergach EV,Gerasimov VB,Avksent'eva MV

    更新日期:2001-01-01 00:00:00