[The pharmacogenetics of hypoglycemia and the glycemic variability at the patients ith type 2 diabetes mellitus].

Abstract:

AIM:To investigate the link between the hypoglycemia (registrated accurately by the professional Continuous Glucose Monitoring CGM; severe hypoglycemia at home) and the hetero-/homozygote carriage of single nucleotide polymorphisms (SNP) of cytochrome systems geneCYP2C9(rs1799853CYP2C9*2 иrs1057910CYP2C9*3) at the patients with Type 2 Diabetes Mellitus (T2DM) used sulphonylurea (SU). MATERIALS AND METHODS:In Study Case-Control 120 T2DM-SU-patients genotyped by SNPs of geneCYP2C9(using PCR-RT) had been done the professional CGM (System iPro2, Medtronic) recorded Time in Range of Hypoglycemia (TIR-HYPO), level of Minimal CGM-hypoglycemia (MinGl) and standard CGM-parameters of Glycemic Variability. Severe hypoglycemia at home was recorded from visit to visit. The odds ratio (OR) of metabolic disturbances had been assessed for carriage SNPs in comparison with wide alleles. RESULTS:The Study established that carriage of SNPsrs1799853andrs1057910geneCYP2C9at T2DM-SU-patients associated with rising of Glycemic Variability and frequency of CGM-hypoglycemia (MinGl decreasing, increasing of TIR-HYPO and number of Glycemia Excursion 4 mmol/L/h), as well as increasing severe hypoglycemia at home (p0.05). Thus, OR at the carriage ofrs1799853andrs1057910respectively equaled: for CGM-hypoglycemia 7.78 (3.0220.01) and 5.80 (0.23145.87); number of Glycemia Excursion 4 mmol/L/h 5.76 (2.2914.43) and 4.44 (1.4313.76); MinGl3.9 mmol/L 4.39 (1.7910.75) and 6.26 (1.8421.30); CV40% (vs30%) 3.63 (1.0412.62) and 15.22 (0.59393.94);p0.05. CONCLUSION:At the real clinical practice the assessment of carriage of SNPs of geneCYP2C9before inclusion of SU to glucose-lowering scheme of T2DM-therapy it necessary to carry out for the detecting patients with a higher risk of hypoglycemia and rising of Glycemic Variability. :Гипогликемии и высокая вариабельность гликемии значительно ухудшают качество гликемического контроля и прогноз пациентов с с сахарным диабетом 2-го типа (СД 2), принимающих препараты сульфонилмочевины (ПСМ), широко используемые вследствие высокой сахароснижающей мощности. Между тем, носительство полиморфных маркеров гена системы цитохромаCYP2C9[rs1799853 CYP2C9*2 С430Т Arg144cys (CT)иrs1057910 CYP2C9*3 А1075Сile359Leu (AC)]оказывает влияние на печеночный метаболизм ПСМ и частоту развития гипогликемий. При этом наиболее точная регистрация гипогликемий достигается при проведении профессионального непрерывного мониторирования гликемии (НМГ). Цель.Исследовать связь между развитием гипогликемий, зарегистрированных при проведении профессионального НМГ, тяжелых гипогликемий на дому и носительством гетеро-/гомозиготных вариантов полиморфных маркеров гена системы цитохромаCYP2C9(rs1799853иrs1057910)у пациентов с СД 2, принимающих ПСМ. Материалы и методы.В исследование случай-контроль включены 110 пациентов с СД 2, принимающих ПСМ, у которых методом PCR-RT оценено носительство полиморфных маркеров генаCYP2C9и выполнено профессиональное НМГ (система iPro2, Medtronic), регистрирующее время нахождения в диапазоне гипогликемии TIR-HYPO, уровень минимальной НМГ-гипогликемии MinGl, НМГ-показатели вариабельности гликемии. Данные о тяжелых гипогликемиях на дому сообщены при визитах. Рассчитано отношение шансов (ОШ) развития метаболических нарушений при носительстве полиморфных маркеров в сравнении с неизмененными аллелями генаCYP2C9. Результаты.Показано, что у пациентов с СД 2, принимающих ПСМ, носительство полиморфных маркеровrs1799853иrs1057910ассоциируется с повышением вариабельности гликемии и частоты развития НМГ-гипогликемий (отмечается снижение MinGl, увеличение TIR-HYPO, числа перепадов уровня НМГ-гликемии 4 ммоль/л/ч), а также развития тяжелых гипогликемий на дому (p0,05). Так, ОШ при носительстве полиморфных маркеровrs1799853иrs1057910в сравнении с неизмененным генотипом составило соответственно: при развитии НМГ-гипогликемий 7,78 (3,0220,01) и 5,80 (0,23145,87); перепадов гликемии 4 ммоль/л 5,76 (2,2914,43) и 4,44 (1,4313,76); MinGl3,9 ммоль/л 4,39 (1,7910,75) и 6,26 (1,8421,30); CV40% (vs30%) 3,63 (1,0412,62) и 15,22 (0,59393,94);p0,05. Заключение.В реальной клинической практике включению ПСМ в схему сахароснижающей терапии СД 2 должна предшествовать оценка носительства полиморфных маркеров генаCYP2C9для выявления пациентов, имеющих повышенный риск развития гипогликемий и повышения вариабельности гликемии.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Chernikova NA,Kamynina LL,Ametov AS,Sychev DA,Grishina EA,Ryzhikova KA

doi

10.26442/00403660.2020.10.000530

subject

Has Abstract

pub_date

2020-11-24 00:00:00

pages

54-62

issue

10

eissn

0040-3660

issn

2309-5342

journal_volume

92

pub_type

杂志文章
  • [Chronic cardiac failure in the XXI century].

    abstract::Wide clinical application of modern prophylactic, diagnostic and therapeutic methods has significantly improved clinical outcomes of cardiovascular disorders. However, much progress is not seen in survival of patients with chronic cardiac failure (CCF). Three possible causes of this situation are analysed: absence of ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,评审

    doi:

    authors: Tereshchenko SN,Zhirov IV

    更新日期:2011-01-01 00:00:00

  • [Clinicopathogenetic variants of anemia in patients with intestinal inflammation].

    abstract:AIM:To study factors of anemia pathogenesis in patients with ulcerative colitis (UC) and Crohn's disease (CD). MATERIAL AND METHODS:A total of 80 patients (56% males and 44% females, mean age 39 +/- 15.8 years) with UC and CD were divided into two groups: group 1--40 patients with anemia, group 2--40 controls free of ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:2012-01-01 00:00:00

  • [Characterization of the genotypes of patients with Gaucher disease type 1 in the Russian Federation].

    abstract:AIM:To characterize the genotype and genotype-phenotype correlations in patients with Gaucher disease (GD) in the Russian Federation. MATERIALS AND METHODS:One hundred adult patients with GD type 1 were examined. Their clinical study encompassed the evaluation of the severity of osteoarticular lesions from instrumenta...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Lukina KA,Fevraleva IS,Sysoeva EP,Mamonov BE,Sudarikov AB,Lukina EA

    更新日期:2013-01-01 00:00:00

  • [Placebo-controlled study of short-term hypotensive effect of intranasal ventilation with continuous positive pressure upper respiratory tract therapy in patients with stage I arterial hypertension].

    abstract:AIM:To compare a short-term hypotensive effect of intranasal ventilation with continuous positive airway pressure (CPAP-therapy) in patients with arterial hypertension stage I and placebo-control patients. MATERIAL AND METHODS:The CPAP-therapy and placebo-control groups consisted of 12 young men with arterial hyperten...

    journal_title:Terapevticheskii arkhiv

    pub_type: 临床试验,杂志文章

    doi:

    authors: Voronin IM,Belov AM,Chuchalin AG

    更新日期:2002-01-01 00:00:00

  • [The role of D2 vitamin metabolite paricalcitol in nephroprotective strategy in chronic disease of the kidneys].

    abstract::Calcitriol is important in nephroprotective strategy in chronic disease of the kidneys (CDK). However, its long-term use often results in hypercalciemia with metastatic calcification. Compared to calcitriol, paricalcitol (zemplar)--metabolite of vitamin D2--leads to hypercalciemia less frequently, has a more potent ne...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,评审

    doi:

    authors: Milovanov IuS,Kozlovskaia LV,Milovanova LIu

    更新日期:2011-01-01 00:00:00

  • [Results of decision support system implementation for prescribing anticoagulants to patients with atrial fibrillation in hospital].

    abstract:BACKGROUND:In 819% of patients with atrial fibrillation (AF) with anticoagulant therapy (ACT), hemorrhagic complications occur, including due to excess doses of AC. At the same time, ACT is necessary for patients with AF, since anticoagulants effectively reduces the risk of ischemic stroke. To make a decision on the ap...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.26442/00403660.2020.08.000765

    authors: Chernov AA,Kleymenova EB,Sychev DA,Yashina LP,Nigmatkulova MD,Otdelenov VA,Payushchik SA

    更新日期:2020-09-03 00:00:00

  • [The effect of exercise on the content of biogenic amines and acetylcholine of the blood in bronchial asthma patients].

    abstract::The content of acetylcholine, histamine and the total amount of catecholamines were measured in blood of 33 patients with bronchial asthma, in 6 patients with preasthma and in 10 practically normal subjects before and after the use of graded exercise (bicycle ergometry). Subgroups of the patients with asthma of effort...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Mamedov DT,Goncharova VA,Dotsenko EK,Sinitsina TM

    更新日期:1989-01-01 00:00:00

  • [Clinical aspects of typhoid fever epidemic in migrants].

    abstract:AIM:To study clinical features of typhoid fever (TF) in migrants (subjects in military service in Tadjikistan). MATERIAL AND METHODS:In chronic water epidemic TF symptoms were studied in 547 young soldiers and officers serving in Tadjikistan with incomplete biological and/or professional adaptation. RESULTS:In most c...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Makhnev MV

    更新日期:2001-01-01 00:00:00

  • [Possibilities of eradicating the persistent HBsAg carrier state].

    abstract::Five HBsAg carriers were examined by clinical, biochemical, radionuclide, immunologic and histomorphologic methods. Different variants of structural and functional relations were established. Attempts were made to eradicate the persistent virus carrierstate with the aid of the antiviral drug virasol, the immunomodulat...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Farber NA,Ambrozaĭtis AK,Kelli EI,Vygodskiĭ VS,Savitskiĭ GI

    更新日期:1984-01-01 00:00:00

  • [Role of the hereditary factor in the genesis of chronic bronchitis].

    abstract::Comparison of proband concordance of the phenotypic correlation coefficients according to the proneness to disease derived on analysis of the groups of mono- and dizygote twins born in 1930-1959 in the city of Yerevan presenting with chronic non-obstructive and chronic obstructive bronchitis revealed a substantial rol...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Amatuni VG,Pirumian MS

    更新日期:1984-01-01 00:00:00

  • [The role of suprasegmental and segmental autonomic disorders in the development of muscular syndrome of rheumatoid arthritis].

    abstract:UNLABELLED:AID: To investigate the role of suprasegmental (anxious disorders) and segmental vegetative disorders (dysfunction of neuromuscular transmission and cutaneous microcirculation) in pathogenesis of muscular syndrome of rheumatoid arthritis (RA). MATERIAL AND METHODS:MMPI, Beck's questionnaire, Spilberger's te...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Ulanova EA,Mach ES,Korsakova IuO

    更新日期:2002-01-01 00:00:00

  • [Depression in cardiological practice: pilot results from a multicenter clinico-epidemiological trial in hypertensive patients with ischemic heart disease (koordinata)].

    abstract:AIM:To study effects of depression on the course and prognosis of arterial hypertension (AH) and coronary heart disease (CHD), potentialities of the combined treatment in a prospective multicenter trial. MATERIAL AND METHODS:A total of 376 patients with AH and/or CHD having depression (10 scores and higher by HADS sca...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Chazov EI,Oganov RG,Pogosova GV,Shal'nova SA,Romasenko LV,Shchurov DV

    更新日期:2006-01-01 00:00:00

  • [Gender features of cardiovascular events in patients with chronic glomerulonephritis at the pre-dialysis stage of the disease].

    abstract:AIM:To identify the gender differences of cardiovascular events in patients with chronic glomerulonephritis (CGN) at the pre-dialysis stage of chronic kidney disease (CKD). SUBJECTS AND METHODS:A total of 170 patients (median age 40±11 years) with CGN who did not receive hemodialysis were examined. According to gender...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.17116/terarkh201789656-61

    authors: Murkamilov IT,Aitbaev KA,Fomin VV

    更新日期:2017-01-01 00:00:00

  • [Clinical and laboratory evaluation of the efficiency of chronic hemodialysis treatment using acidosuccinate in patients with terminal renal failure].

    abstract:AIM:To evaluate the efficiency of using a succinate-containing dialysis solution (SCDS) in terminal renal failure patients treated with chronic hemodialysis (CHD). SUBJECTS AND METHODS:Ninety patients from two hemodialysis units took part in the crossover study and were allocated to 2 groups. For 6 months, study group...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:

    authors: Smirnov AV,Nesterova OB,Suglobova ED,Golubev RV,Vasil'ev AN,Vasil'eva IA,Verbitskaia EV,Korosteleva NIu,Kostereva EM,Lebedeva EB,Levykina EN,Starosel'skiĭ KG,Lazeba VA

    更新日期:2013-01-01 00:00:00

  • [Avelox efficacy in the treatment of acute purulent rhinosinusitis].

    abstract:AIM:To compare efficacy of avelox systemic antibiotic therapy with and without maxillary puncture in acute purulent rhinosinusitis (ARS). MATERIAL AND METHODS:A total of 40 ARS patients were divided into two groups: puncture was not made in 20 patients of the study group and was made in 20 patients of the control grou...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Ivanchenko OA,Chuchueva NG,Lopatin AS

    更新日期:2007-01-01 00:00:00

  • [The effect of allapinine on external respiratory function in patients with diseases of the cardiovascular system].

    abstract::The cardiorespiratory system was studied comprehensively in 27 patients with permanent atrial fibrillation (PAF) without the clinically marked signs of circulatory failure. After allapinine treatment 15 patients with bronchial obstruction manifestations demonstrated, in the presence of lasting PAF, a significant incre...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Smetnev AS,Kadyrova MM,Sobol' IuS,Sokolov SF,Kassirskiĭ SG

    更新日期:1990-01-01 00:00:00

  • [Humoral and cellular adaptation mechanisms in development of intoxication syndrome in patients with acute viral hepatitis].

    abstract:AIM:To study endotoxin-binding function of blood in patients with acute viral hepatitis (AVH) in the course of the disease. MATERIAL AND METHODS:A total of 335 patients with AVH were examined. The titers of IgG antiendotoxin antibodies to glycolipid of Re-chemotype were estimated in enzyme immunoassay (Diaendotox-2 ki...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Pak SG,Volchkova EV,Umbetova KT

    更新日期:2004-01-01 00:00:00

  • The prevalence of abdominal obesity and the association with socioeconomic status in Regions of the Russian Federation, the results of the epidemiological study - ESSE-RF.

    abstract:AIM:The aim of the study is to determine the prevalence of AO in the population and to assess the association with socioeconomic factors according to the data of the ESSE-RF study (Epidemiology of Cardiovascular diseases in the Regions of the Russian Federation). MATERIALS AND METHODS:The object of the study is a rand...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.26442/terarkh2018901014-22

    authors: Zhernakova YV,Zheleznova EA,Chazova IE,Oshchepkova EV,Dolgusheva YA,Yarovaya EB,Blinova NV,Orlovsky AA,Konosova ID,Shalnova SA,Rotar' OP,Konradi AO,Shlyakhto EV,Boytsov SA

    更新日期:2018-11-22 00:00:00

  • [Arthrotec treatment of rheumatoid arthritis].

    abstract:AIM:To try arthrotek, a combined drug, in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS:10 RA women aged 30 to 60 years with endoscopically verified minimal affection of gastroduodenal mucosa (not more than 25 hemorrhages and/or 5 erosions) received arthrotek (1 tablet 3 times a day for 3 months). The...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Iakushin SS,Filonenko SP,Dediunina RS,Lukina IM

    更新日期:2000-01-01 00:00:00

  • [Persistence of the measles virus genome in peripheral blood lymphocytes in patients with glomerulonephritis and systemic lupus erythematosus].

    abstract::Punctate hybridization was used to examine measles virus genome in peripheral blood lymphocytes from patients with glomerulonephritis (GN) and systemic lupus erythematosus (SLE). Measles virus genome was revealed in 47 (54%) out of 87 GN patients, in 27 (74%) out of 36 SLE patients and in none of the control group pat...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Nevraeva EG,Bogomolova NN,Chaplygina NM,Zavalishin IA,Filimonova RG

    更新日期:1991-01-01 00:00:00

  • [Pulmonary function of patients with bird-breeders' exogenous allergic alveolitis].

    abstract::A total of 59 bird fanciers suffering from alveolitis were examined, of them 23 with alveolitis of bronchitis type, 24 with alveolitis of pneumonic type and 11 alveolitis of fibrosing type. In all 3 variants of a course of alveolitis the obstructive syndrome was the main sign of functional disturbances. Intrapulmonary...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Nefedov VB,Shergina EA

    更新日期:1987-01-01 00:00:00

  • [Antiretrovirus drugs impair kidneys in HIV-infection].

    abstract::Renal damage in HIV infection may result from direct action of HIV and from other causes including nephrotoxic action of medicines. HIV-infected patients receive a wide spectrum of medicines and can be placed in a risk group of drug-induced damage to the kidneys. Risk of nephrotoxicity should be considered in administ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Iushchuk ND,Volgina GV,Tomilina NA,Gadzhikulieva MM

    更新日期:2011-01-01 00:00:00

  • [A case of a long-term course of Brill-Symmers disease without active antineoplastic therapy].

    abstract::The paper is concerned with a case of Brill-Symmers' disease started with the thrombocytopenic syndrome relating to hypersplenism. After splenectomy the first benign stage of disease without eradication therapy lasted over 10 years. Signs of immunological incompetence (signs of secondary infection) and recurring immun...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Berliner GB

    更新日期:1987-01-01 00:00:00

  • Treatment of gastroparesis with botulinum toxin in patient after allogenic bone marrow  transplantation.

    abstract::The case report of botulinum toxin treatment of gastroparesis in a patient following allogenic bone marrow transplantation is described. The causes of gastroparesis and methods of prevention and treatment are discussed. It was noted that pyloric injection of botulinum toxin can improve symptoms and gastric emptying. ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:10.26442/terarkh201890160-64

    authors: Galstyan GM,Pashkova MV,Popova OY,Makarova PM,Dubnyak DS,Kuzmina LA,Parovichnikova EN

    更新日期:2018-02-14 00:00:00

  • [Effectiveness of the treatment of severe aplastic anemia (splenectomy and immunosuppression)].

    abstract::The authors appraise the efficacy of the treatment of severe aplastic anemia by splenectomy, antilymphocyte globulin and cyclophosphamide. A total of 120 patients were placed under observation. Of these, 103 patients had a severe disease pattern, one hundred and 112 patients with aplastic anemia including 96 with a se...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Idel'son LI,Pogorel'skaia EP,Il'in GP,Gorodetskiĭ VM

    更新日期:1984-01-01 00:00:00

  • [Science and clinical practice].

    abstract::The paper discusses issues related to the role of basic studies in the development of practical medicine and to the integration of basic science and medical treatment. ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 社论

    doi:

    authors: Chazov EI

    更新日期:2012-01-01 00:00:00

  • [New cases of helicobacter pylori associated duodenal ulcer].

    abstract:AIM:Generalization of the results obtained through analysis of examinations of new cases of duodenal ulcer (DU) with patients suffering from DU of different duration, made in two main aspects: the patients' Helicobacter pylori (HP) status determined by histological, bacteriological, immunological studies and rapid urea...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Minushkin ON,Vasil'eva NIu,Kudriavtseva LV

    更新日期:1998-01-01 00:00:00

  • [Diastolic heart failure: are problems in its diagnosis and treatment solvable?].

    abstract::The paper discusses the problem of chronic heart failure (CHF) in left ventricular diastolic dysfunction - diastolic heart failure (DHF). It considers whether DHF is an independent phenotype or nothing more than a step in the development of systolic heart failure. The results of a number of studies evaluating the effi...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,评审

    doi:

    authors: Tereshchenko SN,Zhirov IV

    更新日期:2009-01-01 00:00:00

  • [Interferon in rheumatoid arthritis].

    abstract::The paper is concerned with the role played by interferon (IF) in rheumatoid arthritis (RA). The content of IF was measured in the patients' blood serum and the possibility of the use of the preparations of exogenous interferon for the treatment of RA patients was demonstrated. Assay of serum IF in RA patients showed ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Balabanova RM,Dement'eva SP,Panasiuk AF,Mironova LL

    更新日期:1989-01-01 00:00:00

  • [Pharmacotherapy for rheumatoid arthritis in the early 21st century: Russian and international experience].

    abstract::The paper summarizes the data of international and Russian studies concerning current approaches to the pharmacotherapy of rheumatoid arthritis. Particular emphasis is placed on the substantiation of the treat-to-target concept, on the efficacy and safety of genetically engineered biological agents, including the inhi...

    journal_title:Terapevticheskii arkhiv

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Nasonov EL,Karateev DE,Lukina GV

    更新日期:2013-01-01 00:00:00