Abstract：
AIM:To evaluate the effect of ACE inhibitor enalapril, AR blocker candesartan and their combination on left ventricular hypertrophy (LVH) and content of biochemical markers of collagen balance in patients with hypertensive LV hypertrophy. MATERIAL AND METHODS. A total of 66 patients with arterial hypertension with LV hypertrophy were divided into two groups. Group 1 (n = 33) received candesartan (8-16 mg/day), group 2 (n = 33) received enalapril (10-20 mg/day). In effective hypotensive response to the initial treatment, it was continued for 6 months. If in two months of monotherapy the effect was unsatisfactory, the other drug was added. At baseline and upon 6 months of treatment all the patients were examined for myocardial mass index (MMI), matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of matrix metalloproteinase-1 (THMP-1) in the blood. RESULTS:In effective initial treatment with candesartan 6-month treatment lowered LV MMI by 13.9%, while in enalapril group--only by 1.5%. In addition of the second drug in ineffective initial therapy the reduction was 5.1%. THMP-1 did not change during the trial. CONCLUSION:In patients with hypertensive LVH candesartan more effectively treated LVH. The addition of the second RAS blocker in insufficient efficacy of the initial one significantly reduces LV MMI. A significant antifibrotic effect was achieved only in case of simultaneous use of two RAS blockers.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Ovchinnikov AG,Serbul VM,Ageev FTsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
64-71issue
5eissn
0040-3660issn
2309-5342journal_volume
81pub_type
临床试验,杂志文章abstract：:Enteropathies (EP) are the common name for pathological (inflammatory, hemorrhagic, erosive-ulcerative, and atrophic) changes in the small bowel. The paper describes the nosological entities of EP and the significance of laboratory and instrumental methods used for their diagnosis. It outlines the principles of etiotr...
journal_title：Terapevticheskii arkhiv
pub_type： 社论
doi：
更新日期：2014-01-01 00:00:00
abstract：AIM:To specify the risk of severe systemic manifestations and transformation into malignant lymphoma in Sjogren's disease (SD) patients with monoclonal mixed cryoglobulinemia (MMC). MATERIAL AND METHODS:A prospective study performed in 1985-1990 included 248 SD patients followed up after the initial detection of monoc...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：AIM:To study effects of ivabradin on clinicohemodynamic and prognostic parameters in patients after myocardial infarction (MI) with systolic chronic cardiac failure (SCCF). MATERIAL AND METHODS:A population-based randomized prospective trial enrolled 49 patients (40 males--81.6%, mean age 63.1 +/- 8.1 years) with sinu...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2011-01-01 00:00:00
abstract：AIM:To investigate the effect of acarbose, intestinal alpha-glucosidase inhibitor, on lipid metabolism in patients with non-insulin-dependent diabetes mellitus (NIDDM). MATERIAL AND METHODS:Glucobai was given for 6 months in a dose 300 mg/day to 63 NIDDM patients aged 40-69 years. The examination covered indices of gl...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：AIM:A comparative study of efficiency and safety of low-dose erythropoietin (EP) in two groups of patients with chronic renal failure (CRF): patients on chronic hemodialysis (CHD) and patients on continuous ambulatory hemodialysis (CAHD). MATERIALS AND METHODS:51 CRF adult patients with renal anemia on hemodialysis en...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：AIM:To examine clinical, immunological and morphological features of HGV- and TTV-infections in patients with chronic hepatic diseases (CHD) and assess efficiency of treatment of HGV-seropositive patients. MATERIAL AND METHODS:202 patients with CHD were examined for markers of HBV-, HCV-, HGV- and TTV-infections. Some...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：AIM:Assessment of efficacy of differential diagnosis between benign and malignant lesions in gastric mucosa by means of endoscopy. MATERIALS AND METHODS:Morphological verdicts upon investigation of operative specimens were compared to findings at preoperative duodenofibrogastroscopy with spot biopsy in 326 patients op...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：AIM:To evaluate the efficacy and safety of neyromidin in the treatment of Stage I hypertensive dyscirculatory encephalopathy (HDE) and to analyze long-term treatment results. SUBJECTS AND METHODS:Fifty-seven with Stage I dyscirculatory encephalopathy in the presence of grades 1-2 arterial hypertension were examined. C...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：AIM:To study the urinary excretion of the molecular factors regulating angiogenesis, such as vascular endothelial growth factor type A (VEGF-A), thrombospondin 1 (THBS1), and angiopoietin 2 (ANGPT2), versus that of the urinary markers of renal injury and fibrogenesis, such as neutrophil gelatinase-associated lipocalin ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.17116/terarkh201587675-82
更新日期：2015-01-01 00:00:00
abstract：:The paper is concerned with the results of investigation of water-electrolyte equilibrium in 72 patients with liver cirrhosis. Regulatory disorder of the stability of volume of intravascular liquid was shown manifesting itself in a loss of ability to react by raising the natriuretic factor (NUF) production and enhance...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:A computer-assisted staged system of a follow-up of factory workers with CHD and diabetes mellitus was developed. It included automated screening by questionnaire, ECG and biochemical screening, physical examination, investigation of the basic carbohydrate-lipid indices, more detailed examination in out- or inpatients...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：AIM:To study effects of pacemaker implantation on the course of coronary heart disease (CHD) with stable angina pectoris and choice of optimal regimen of pacing. MATERIAL AND METHODS:A total of 154 CHD patients with a pacemaker were examined. All the patients had angina of effort of functional class II-IV. RESULTS:Th...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：AIM:To investigate the frequency of extraesophageal syndromes in elderly patients with gastroesophageal reflux disease (GERD). MATERIALS AND METHODS:This cross-sectional study was conducted to compare the clinical manifestations of GERD in 1100 patients aged 60 to 75 years and in 453 patients aged 36 to 60 years. A co...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.17116/terarkh201688228-32
更新日期：2016-01-01 00:00:00
abstract：AIM:To demonstrate great importance of intravital morphological examination of the liver for differential diagnosis of chronic diffuse diseases (CDD) of the liver. MATERIAL AND METHODS:A complete clinical examination, needle or intraoperative biopsy of the liver were made in 1045 patients with chronic diseases of the ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Overall 30 patients with multiple myeloma (MM) were examined for immunological and rheological parameters. MM was shown to be marked by imbalance of immunobiological reactivity, with the greatest changes being seen in the B cell immunity system. MM is also characterized by marked rheological shifts related to the immu...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The central hemodynamics and myocardial contractility were studied in 40 normal untrained men by tetrapolar chest rheography. The response to exercise was studied and compared in subjects with eu- and hypokinetic circulatory types. It was revealed that marked differences in the SI, CI, SPR recorded at rest lessen with...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:541 workers with long-term history of occupational contact with antibiotics and chemicals were examined by a dermatologist, ENT specialist, neuropathologist, surgeon, ophthalmologist. Many workers complained of occasional skin eruption, rhinitis, skin itching, sneezing, cough, Quincke's edema. Allergic examination rev...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The peculiarities of prevalence of coronary heart disease (CHD), its main risk factors and their interrelationships were studied on the basis of the results of epidemiological surveys of an organized population of men aged 20 to 59 engaged in research, and an unorganized male population in one of Moscow districts. A s...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Eighteen patients with relapsed or refractory Hodgkin's disease (HD) have been treated with high-dose chemotherapy (BEAM regimen) followed by autologous peripheral stem cells and/or bone marrow rescue. There were no treatment-related deaths. Overall response rate was 82%. With a median follow-up of 10 months (3-24 mon...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Clinical parameters have been studied in 45 peptic ulcer patients without and 47 ones with acute hemorrhage. Factors of acute hemorrhage risk in ulcer patients have been specified (old age, long history of the disease, previous hemorrhages, duodenal ulcer localization at the back and upper walls and gastric ulcer loca...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Liver is frequently involved in the pathological process. Wide range of clinical manifestations can be seen: from asymptomatic lesion with normal liver function tests to cirrhosis with portal hypertension. Biopsy plays the key role in diagnosis of...
journal_title：Terapevticheskii arkhiv
pub_type： 社论
doi：10.26442/00403660.2019.04.000179
更新日期：2019-05-15 00:00:00
abstract：:An analysis of the right ECG precordial leads in 61 patients with left ventricular posteroinferior myocardial infarction and in 55 patients with combined affection of the right and left ventricular posteroinferior walls revealed a high informative value of ST segment elevation for recognition of right ventricular myoc...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Rheumon-Gel was used for therapy of 51 patients with rheumatoid arthritis. It has been shown that the drug has a marked antiinflammatory and analgesic action, a positive effect on a number of subjective (pain in the joints and constrained movements in the morning), objective (body temperature, edema and joint function...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:A study was made of adrenal function in 2 groups of patients with chronic renal insufficiency on programmed hemodialytic therapy. Insufficiency of gluco- and mineralo-corticoid function of the adrenal glands and hyperfunction of their medulla developed in patients with normal BP and controlled hypertension. In patient...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：AIM:European Registry on the management of Helicobacter pylori infection («Hp-EuReg») - a multicenter prospective observational study initiated by the European Helicobacter and Microbiota Study Group, conducted in 27 European countries in order to evaluate the real clinical practice of diagnosis and treatment of H. pyl...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,多中心研究
doi：10.26442/terarkh201890235-42
更新日期：2018-02-15 00:00:00
abstract：AIM:To make a comparative clinical and economic assessment of a transdermal therapeutic system (TTS) for fendivia and traditional opioid analgesics in patients with malignant neoplasms (MN) during palliative care. MATERIALS AND METHODS:Pharmacoeconomic analysis of opioid analgesics used in patients with MN during anal...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Basing on computer processing of 126 primary clinical and laboratory parameters obtained from 92 patients with myelodysplasia and using multifactorial regression analysis, the authors have developed prognostic models of life span and probability of transformation into acute leukemia. The model of life span enabled rec...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Dobutamin stress-echocardiography has been tried outpatiently in the diagnostic center for feasible use in functional assessment of the myocardium in patients with congestive heart failure class 3-4 by classification of New York Heart Association. Eleven outpatients (a mean age 56 +/- 8 years) with left ventricular di...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Twenty patients suffering from severe systemic lupus erythematosus (SLE) underwent 52 sessions of splenoperfusion (SP) by means of extracorporeal perfusion of the patient's blood through isolated porcine spleen. It got prepared directly before the perfusion. The organ was obtained from a healthy animal in sterile cond...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：AIM:To assess the efficacy and safety of long-term treatment with nucleos(t)ide analogues in patients with chronic hepatitis B. MATERIALS AND METHODS:We conducted an observational study in 101 chronic hepatitis B (HBeAg-negative and HBeAg-positive) patients treated (≥3 years) with entecavir, tenofovir or telbivudine. ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/ 00403660.2019.02.000073
更新日期：2019-03-18 00:00:00
